Amino acid dipepetide frequency for Candidatus Paraburkholderia kirkii UZHbot1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.86AlaAla: 14.86 ± 0.211	1.464AlaCys: 1.464 ± 0.055	6.357AlaAsp: 6.357 ± 0.108	6.261AlaGlu: 6.261 ± 0.112	4.041AlaPhe: 4.041 ± 0.093	9.068AlaGly: 9.068 ± 0.132	2.797AlaHis: 2.797 ± 0.068	5.312AlaIle: 5.312 ± 0.101	4.695AlaLys: 4.695 ± 0.111	13.084AlaLeu: 13.084 ± 0.185	3.216AlaMet: 3.216 ± 0.08	3.434AlaAsn: 3.434 ± 0.072	5.523AlaPro: 5.523 ± 0.127	5.161AlaGln: 5.161 ± 0.115	8.949AlaArg: 8.949 ± 0.164	7.021AlaSer: 7.021 ± 0.118	5.8AlaThr: 5.8 ± 0.102	7.712AlaVal: 7.712 ± 0.128	1.494AlaTrp: 1.494 ± 0.058	2.579AlaTyr: 2.579 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	1.221CysAla: 1.221 ± 0.052	0.134CysCys: 0.134 ± 0.016	0.59CysAsp: 0.59 ± 0.032	0.597CysGlu: 0.597 ± 0.032	0.327CysPhe: 0.327 ± 0.025	1.113CysGly: 1.113 ± 0.052	0.369CysHis: 0.369 ± 0.027	0.459CysIle: 0.459 ± 0.03	0.273CysLys: 0.273 ± 0.027	0.894CysLeu: 0.894 ± 0.035	0.2CysMet: 0.2 ± 0.021	0.253CysAsn: 0.253 ± 0.021	0.521CysPro: 0.521 ± 0.036	0.211CysGln: 0.211 ± 0.018	0.812CysArg: 0.812 ± 0.041	0.604CysSer: 0.604 ± 0.039	0.527CysThr: 0.527 ± 0.034	0.89CysVal: 0.89 ± 0.045	0.107CysTrp: 0.107 ± 0.013	0.231CysTyr: 0.231 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	7.505AspAla: 7.505 ± 0.123	0.515AspCys: 0.515 ± 0.028	3.112AspAsp: 3.112 ± 0.096	3.842AspGlu: 3.842 ± 0.083	2.088AspPhe: 2.088 ± 0.061	4.254AspGly: 4.254 ± 0.098	1.127AspHis: 1.127 ± 0.043	2.901AspIle: 2.901 ± 0.072	1.952AspLys: 1.952 ± 0.06	5.057AspLeu: 5.057 ± 0.102	1.283AspMet: 1.283 ± 0.045	1.419AspAsn: 1.419 ± 0.046	2.834AspPro: 2.834 ± 0.067	1.65AspGln: 1.65 ± 0.06	3.431AspArg: 3.431 ± 0.067	2.651AspSer: 2.651 ± 0.068	2.874AspThr: 2.874 ± 0.064	4.425AspVal: 4.425 ± 0.102	0.895AspTrp: 0.895 ± 0.039	1.559AspTyr: 1.559 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	6.912GluAla: 6.912 ± 0.122	0.461GluCys: 0.461 ± 0.03	2.411GluAsp: 2.411 ± 0.059	3.072GluGlu: 3.072 ± 0.087	1.992GluPhe: 1.992 ± 0.065	3.759GluGly: 3.759 ± 0.094	1.512GluHis: 1.512 ± 0.058	3.238GluIle: 3.238 ± 0.077	2.475GluLys: 2.475 ± 0.067	5.671GluLeu: 5.671 ± 0.109	1.457GluMet: 1.457 ± 0.051	1.719GluAsn: 1.719 ± 0.057	2.623GluPro: 2.623 ± 0.075	2.519GluGln: 2.519 ± 0.063	5.02GluArg: 5.02 ± 0.101	2.877GluSer: 2.877 ± 0.074	3.057GluThr: 3.057 ± 0.079	3.925GluVal: 3.925 ± 0.085	0.726GluTrp: 0.726 ± 0.038	1.308GluTyr: 1.308 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	4.496PheAla: 4.496 ± 0.09	0.461PheCys: 0.461 ± 0.03	2.735PheAsp: 2.735 ± 0.063	2.286PheGlu: 2.286 ± 0.056	1.509PhePhe: 1.509 ± 0.062	3.627PheGly: 3.627 ± 0.081	0.907PheHis: 0.907 ± 0.034	1.729PheIle: 1.729 ± 0.054	1.204PheLys: 1.204 ± 0.046	3.05PheLeu: 3.05 ± 0.074	0.87PheMet: 0.87 ± 0.041	1.167PheAsn: 1.167 ± 0.045	1.578PhePro: 1.578 ± 0.051	0.996PheGln: 0.996 ± 0.039	2.069PheArg: 2.069 ± 0.065	2.324PheSer: 2.324 ± 0.072	1.975PheThr: 1.975 ± 0.06	3.116PheVal: 3.116 ± 0.083	0.456PheTrp: 0.456 ± 0.035	0.964PheTyr: 0.964 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	8.657GlyAla: 8.657 ± 0.122	0.885GlyCys: 0.885 ± 0.044	4.033GlyAsp: 4.033 ± 0.082	4.522GlyGlu: 4.522 ± 0.086	3.339GlyPhe: 3.339 ± 0.075	6.218GlyGly: 6.218 ± 0.141	1.855GlyHis: 1.855 ± 0.06	4.33GlyIle: 4.33 ± 0.087	3.704GlyLys: 3.704 ± 0.092	7.388GlyLeu: 7.388 ± 0.109	2.22GlyMet: 2.22 ± 0.06	2.262GlyAsn: 2.262 ± 0.068	2.663GlyPro: 2.663 ± 0.07	2.619GlyGln: 2.619 ± 0.07	5.269GlyArg: 5.269 ± 0.109	4.152GlySer: 4.152 ± 0.077	4.122GlyThr: 4.122 ± 0.092	6.27GlyVal: 6.27 ± 0.123	1.137GlyTrp: 1.137 ± 0.049	2.12GlyTyr: 2.12 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	3.04HisAla: 3.04 ± 0.071	0.384HisCys: 0.384 ± 0.027	1.419HisAsp: 1.419 ± 0.046	1.316HisGlu: 1.316 ± 0.049	0.996HisPhe: 0.996 ± 0.045	2.0HisGly: 2.0 ± 0.064	0.76HisHis: 0.76 ± 0.04	1.139HisIle: 1.139 ± 0.042	0.654HisLys: 0.654 ± 0.034	2.203HisLeu: 2.203 ± 0.067	0.515HisMet: 0.515 ± 0.028	0.708HisAsn: 0.708 ± 0.038	1.365HisPro: 1.365 ± 0.048	0.679HisGln: 0.679 ± 0.032	1.839HisArg: 1.839 ± 0.056	1.325HisSer: 1.325 ± 0.058	1.211HisThr: 1.211 ± 0.046	1.678HisVal: 1.678 ± 0.045	0.352HisTrp: 0.352 ± 0.026	0.728HisTyr: 0.728 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.863IleAla: 6.863 ± 0.112	0.495IleCys: 0.495 ± 0.029	3.845IleAsp: 3.845 ± 0.088	3.738IleGlu: 3.738 ± 0.073	1.605IlePhe: 1.605 ± 0.05	4.989IleGly: 4.989 ± 0.099	1.026IleHis: 1.026 ± 0.042	2.022IleIle: 2.022 ± 0.06	1.777IleLys: 1.777 ± 0.066	3.701IleLeu: 3.701 ± 0.09	0.961IleMet: 0.961 ± 0.046	1.533IleAsn: 1.533 ± 0.053	2.089IlePro: 2.089 ± 0.054	1.306IleGln: 1.306 ± 0.054	2.894IleArg: 2.894 ± 0.072	2.552IleSer: 2.552 ± 0.071	2.576IleThr: 2.576 ± 0.068	4.767IleVal: 4.767 ± 0.094	0.516IleTrp: 0.516 ± 0.029	1.093IleTyr: 1.093 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.256LysAla: 4.256 ± 0.075	0.236LysCys: 0.236 ± 0.02	1.953LysAsp: 1.953 ± 0.056	2.012LysGlu: 2.012 ± 0.07	1.14LysPhe: 1.14 ± 0.04	2.596LysGly: 2.596 ± 0.082	0.874LysHis: 0.874 ± 0.038	2.103LysIle: 2.103 ± 0.06	1.876LysLys: 1.876 ± 0.071	4.07LysLeu: 4.07 ± 0.086	1.043LysMet: 1.043 ± 0.047	1.204LysAsn: 1.204 ± 0.046	2.425LysPro: 2.425 ± 0.068	1.541LysGln: 1.541 ± 0.055	2.928LysArg: 2.928 ± 0.061	2.339LysSer: 2.339 ± 0.066	2.151LysThr: 2.151 ± 0.068	2.725LysVal: 2.725 ± 0.086	0.401LysTrp: 0.401 ± 0.028	0.87LysTyr: 0.87 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	13.022LeuAla: 13.022 ± 0.21	0.914LeuCys: 0.914 ± 0.042	5.839LeuAsp: 5.839 ± 0.093	5.22LeuGlu: 5.22 ± 0.094	3.478LeuPhe: 3.478 ± 0.087	7.225LeuGly: 7.225 ± 0.121	2.339LeuHis: 2.339 ± 0.062	4.814LeuIle: 4.814 ± 0.097	3.796LeuLys: 3.796 ± 0.08	8.981LeuLeu: 8.981 ± 0.161	2.259LeuMet: 2.259 ± 0.063	3.1LeuAsn: 3.1 ± 0.065	5.596LeuPro: 5.596 ± 0.11	3.201LeuGln: 3.201 ± 0.075	7.002LeuArg: 7.002 ± 0.121	5.897LeuSer: 5.897 ± 0.101	5.195LeuThr: 5.195 ± 0.089	6.766LeuVal: 6.766 ± 0.11	1.003LeuTrp: 1.003 ± 0.044	2.126LeuTyr: 2.126 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.557MetAla: 2.557 ± 0.061	0.193MetCys: 0.193 ± 0.017	0.966MetAsp: 0.966 ± 0.041	1.11MetGlu: 1.11 ± 0.047	0.842MetPhe: 0.842 ± 0.04	1.541MetGly: 1.541 ± 0.054	0.612MetHis: 0.612 ± 0.032	1.221MetIle: 1.221 ± 0.044	1.137MetLys: 1.137 ± 0.044	2.784MetLeu: 2.784 ± 0.067	0.706MetMet: 0.706 ± 0.039	0.966MetAsn: 0.966 ± 0.045	1.595MetPro: 1.595 ± 0.049	1.082MetGln: 1.082 ± 0.045	2.057MetArg: 2.057 ± 0.064	1.806MetSer: 1.806 ± 0.055	1.767MetThr: 1.767 ± 0.053	1.471MetVal: 1.471 ± 0.049	0.211MetTrp: 0.211 ± 0.019	0.476MetTyr: 0.476 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.614AsnAla: 3.614 ± 0.079	0.27AsnCys: 0.27 ± 0.024	1.601AsnAsp: 1.601 ± 0.059	1.591AsnGlu: 1.591 ± 0.052	1.236AsnPhe: 1.236 ± 0.046	2.539AsnGly: 2.539 ± 0.068	0.582AsnHis: 0.582 ± 0.031	1.435AsnIle: 1.435 ± 0.049	0.979AsnLys: 0.979 ± 0.042	2.807AsnLeu: 2.807 ± 0.073	0.667AsnMet: 0.667 ± 0.028	0.917AsnAsn: 0.917 ± 0.043	2.021AsnPro: 2.021 ± 0.067	0.905AsnGln: 0.905 ± 0.045	2.056AsnArg: 2.056 ± 0.061	1.403AsnSer: 1.403 ± 0.055	1.471AsnThr: 1.471 ± 0.053	2.438AsnVal: 2.438 ± 0.066	0.466AsnTrp: 0.466 ± 0.029	0.773AsnTyr: 0.773 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.909ProAla: 5.909 ± 0.137	0.476ProCys: 0.476 ± 0.029	3.214ProAsp: 3.214 ± 0.078	3.188ProGlu: 3.188 ± 0.086	1.814ProPhe: 1.814 ± 0.054	3.848ProGly: 3.848 ± 0.08	1.227ProHis: 1.227 ± 0.045	2.262ProIle: 2.262 ± 0.058	1.863ProLys: 1.863 ± 0.06	4.839ProLeu: 4.839 ± 0.096	1.127ProMet: 1.127 ± 0.043	1.538ProAsn: 1.538 ± 0.05	2.507ProPro: 2.507 ± 0.07	1.826ProGln: 1.826 ± 0.051	3.08ProArg: 3.08 ± 0.086	2.981ProSer: 2.981 ± 0.072	2.453ProThr: 2.453 ± 0.065	4.06ProVal: 4.06 ± 0.084	0.587ProTrp: 0.587 ± 0.029	1.162ProTyr: 1.162 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	4.07GlnAla: 4.07 ± 0.083	0.305GlnCys: 0.305 ± 0.022	1.435GlnAsp: 1.435 ± 0.047	1.553GlnGlu: 1.553 ± 0.05	1.274GlnPhe: 1.274 ± 0.05	2.514GlnGly: 2.514 ± 0.064	0.884GlnHis: 0.884 ± 0.034	2.13GlnIle: 2.13 ± 0.067	1.534GlnLys: 1.534 ± 0.057	3.536GlnLeu: 3.536 ± 0.082	1.06GlnMet: 1.06 ± 0.037	1.016GlnAsn: 1.016 ± 0.042	1.831GlnPro: 1.831 ± 0.058	1.65GlnGln: 1.65 ± 0.071	2.859GlnArg: 2.859 ± 0.079	1.947GlnSer: 1.947 ± 0.058	1.89GlnThr: 1.89 ± 0.06	2.396GlnVal: 2.396 ± 0.074	0.575GlnTrp: 0.575 ± 0.029	0.947GlnTyr: 0.947 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	8.174ArgAla: 8.174 ± 0.142	0.728ArgCys: 0.728 ± 0.04	3.91ArgAsp: 3.91 ± 0.08	4.665ArgGlu: 4.665 ± 0.089	3.142ArgPhe: 3.142 ± 0.075	5.027ArgGly: 5.027 ± 0.095	2.049ArgHis: 2.049 ± 0.065	3.987ArgIle: 3.987 ± 0.08	2.4ArgLys: 2.4 ± 0.06	6.722ArgLeu: 6.722 ± 0.123	1.95ArgMet: 1.95 ± 0.056	2.017ArgAsn: 2.017 ± 0.066	3.027ArgPro: 3.027 ± 0.067	2.515ArgGln: 2.515 ± 0.065	5.676ArgArg: 5.676 ± 0.11	3.726ArgSer: 3.726 ± 0.086	3.458ArgThr: 3.458 ± 0.09	5.428ArgVal: 5.428 ± 0.1	1.006ArgTrp: 1.006 ± 0.041	1.885ArgTyr: 1.885 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	6.457SerAla: 6.457 ± 0.143	0.644SerCys: 0.644 ± 0.036	2.871SerAsp: 2.871 ± 0.071	2.815SerGlu: 2.815 ± 0.072	2.203SerPhe: 2.203 ± 0.06	4.994SerGly: 4.994 ± 0.102	1.407SerHis: 1.407 ± 0.056	2.854SerIle: 2.854 ± 0.066	2.237SerLys: 2.237 ± 0.055	5.535SerLeu: 5.535 ± 0.106	1.544SerMet: 1.544 ± 0.051	1.732SerAsn: 1.732 ± 0.06	2.765SerPro: 2.765 ± 0.077	1.89SerGln: 1.89 ± 0.055	3.966SerArg: 3.966 ± 0.095	3.568SerSer: 3.568 ± 0.097	2.884SerThr: 2.884 ± 0.081	4.118SerVal: 4.118 ± 0.087	0.667SerTrp: 0.667 ± 0.033	1.234SerTyr: 1.234 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.445ThrAla: 5.445 ± 0.096	0.579ThrCys: 0.579 ± 0.033	2.763ThrAsp: 2.763 ± 0.067	2.614ThrGlu: 2.614 ± 0.067	1.943ThrPhe: 1.943 ± 0.051	4.432ThrGly: 4.432 ± 0.096	1.393ThrHis: 1.393 ± 0.045	2.629ThrIle: 2.629 ± 0.071	1.744ThrLys: 1.744 ± 0.057	5.968ThrLeu: 5.968 ± 0.101	1.403ThrMet: 1.403 ± 0.053	1.466ThrAsn: 1.466 ± 0.05	3.491ThrPro: 3.491 ± 0.072	1.789ThrGln: 1.789 ± 0.053	3.528ThrArg: 3.528 ± 0.07	2.778ThrSer: 2.778 ± 0.069	2.83ThrThr: 2.83 ± 0.072	3.951ThrVal: 3.951 ± 0.079	0.535ThrTrp: 0.535 ± 0.032	1.186ThrTyr: 1.186 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	8.258ValAla: 8.258 ± 0.117	0.815ValCys: 0.815 ± 0.042	4.365ValAsp: 4.365 ± 0.095	4.439ValGlu: 4.439 ± 0.097	2.849ValPhe: 2.849 ± 0.069	5.116ValGly: 5.116 ± 0.102	1.665ValHis: 1.665 ± 0.059	4.076ValIle: 4.076 ± 0.094	3.161ValLys: 3.161 ± 0.083	7.35ValLeu: 7.35 ± 0.138	1.769ValMet: 1.769 ± 0.047	2.22ValAsn: 2.22 ± 0.061	3.803ValPro: 3.803 ± 0.081	2.46ValGln: 2.46 ± 0.069	5.015ValArg: 5.015 ± 0.088	4.482ValSer: 4.482 ± 0.097	4.392ValThr: 4.392 ± 0.083	6.332ValVal: 6.332 ± 0.114	0.966ValTrp: 0.966 ± 0.043	1.655ValTyr: 1.655 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.941TrpAla: 0.941 ± 0.041	0.136TrpCys: 0.136 ± 0.018	0.537TrpAsp: 0.537 ± 0.028	0.527TrpGlu: 0.527 ± 0.028	0.585TrpPhe: 0.585 ± 0.033	0.8TrpGly: 0.8 ± 0.035	0.367TrpHis: 0.367 ± 0.024	0.748TrpIle: 0.748 ± 0.042	0.473TrpLys: 0.473 ± 0.027	1.729TrpLeu: 1.729 ± 0.062	0.329TrpMet: 0.329 ± 0.026	0.421TrpAsn: 0.421 ± 0.029	0.575TrpPro: 0.575 ± 0.035	0.597TrpGln: 0.597 ± 0.03	1.164TrpArg: 1.164 ± 0.047	0.689TrpSer: 0.689 ± 0.033	0.607TrpThr: 0.607 ± 0.036	0.875TrpVal: 0.875 ± 0.038	0.191TrpTrp: 0.191 ± 0.02	0.312TrpTyr: 0.312 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.572TyrAla: 2.572 ± 0.069	0.24TyrCys: 0.24 ± 0.02	1.417TyrAsp: 1.417 ± 0.048	1.368TyrGlu: 1.368 ± 0.055	1.115TyrPhe: 1.115 ± 0.051	2.103TyrGly: 2.103 ± 0.058	0.558TyrHis: 0.558 ± 0.029	0.959TyrIle: 0.959 ± 0.039	0.808TyrLys: 0.808 ± 0.042	2.405TyrLeu: 2.405 ± 0.058	0.518TyrMet: 0.518 ± 0.03	0.681TyrAsn: 0.681 ± 0.029	1.132TyrPro: 1.132 ± 0.047	0.808TyrGln: 0.808 ± 0.043	1.878TyrArg: 1.878 ± 0.056	1.264TyrSer: 1.264 ± 0.051	1.229TyrThr: 1.229 ± 0.045	1.845TyrVal: 1.845 ± 0.061	0.309TyrTrp: 0.309 ± 0.025	0.687TyrTyr: 0.687 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2015 proteins (596368 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---