Amino acid dipepetide frequency for Natrinema altunense JCM 12890

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.301AlaAla: 14.301 ± 0.204	0.718AlaCys: 0.718 ± 0.03	10.835AlaAsp: 10.835 ± 0.14	8.338AlaGlu: 8.338 ± 0.09	3.912AlaPhe: 3.912 ± 0.072	9.374AlaGly: 9.374 ± 0.091	1.778AlaHis: 1.778 ± 0.039	5.514AlaIle: 5.514 ± 0.082	1.696AlaLys: 1.696 ± 0.043	10.192AlaLeu: 10.192 ± 0.127	2.029AlaMet: 2.029 ± 0.049	2.243AlaAsn: 2.243 ± 0.051	3.692AlaPro: 3.692 ± 0.069	2.08AlaGln: 2.08 ± 0.04	6.186AlaArg: 6.186 ± 0.079	5.248AlaSer: 5.248 ± 0.073	7.501AlaThr: 7.501 ± 0.117	10.623AlaVal: 10.623 ± 0.128	1.058AlaTrp: 1.058 ± 0.033	2.594AlaTyr: 2.594 ± 0.055	0.002AlaXaa: 0.002 ± 0.001
Cys	0.609CysAla: 0.609 ± 0.028	0.097CysCys: 0.097 ± 0.01	0.632CysAsp: 0.632 ± 0.024	0.62CysGlu: 0.62 ± 0.027	0.231CysPhe: 0.231 ± 0.015	0.851CysGly: 0.851 ± 0.033	0.204CysHis: 0.204 ± 0.015	0.259CysIle: 0.259 ± 0.018	0.111CysLys: 0.111 ± 0.01	0.655CysLeu: 0.655 ± 0.026	0.113CysMet: 0.113 ± 0.009	0.195CysAsn: 0.195 ± 0.014	0.543CysPro: 0.543 ± 0.027	0.168CysGln: 0.168 ± 0.014	0.543CysArg: 0.543 ± 0.024	0.471CysSer: 0.471 ± 0.025	0.47CysThr: 0.47 ± 0.021	0.475CysVal: 0.475 ± 0.019	0.103CysTrp: 0.103 ± 0.011	0.221CysTyr: 0.221 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	10.417AspAla: 10.417 ± 0.13	0.761AspCys: 0.761 ± 0.032	8.714AspAsp: 8.714 ± 0.135	8.478AspGlu: 8.478 ± 0.103	1.946AspPhe: 1.946 ± 0.041	8.681AspGly: 8.681 ± 0.124	1.994AspHis: 1.994 ± 0.046	3.393AspIle: 3.393 ± 0.068	0.97AspLys: 0.97 ± 0.033	7.317AspLeu: 7.317 ± 0.092	1.196AspMet: 1.196 ± 0.033	1.311AspAsn: 1.311 ± 0.042	4.754AspPro: 4.754 ± 0.074	1.569AspGln: 1.569 ± 0.04	7.484AspArg: 7.484 ± 0.115	3.855AspSer: 3.855 ± 0.072	3.982AspThr: 3.982 ± 0.062	7.202AspVal: 7.202 ± 0.09	1.077AspTrp: 1.077 ± 0.035	1.969AspTyr: 1.969 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.445GluAla: 8.445 ± 0.102	0.555GluCys: 0.555 ± 0.028	5.67GluAsp: 5.67 ± 0.095	6.254GluGlu: 6.254 ± 0.13	2.979GluPhe: 2.979 ± 0.057	5.345GluGly: 5.345 ± 0.084	1.939GluHis: 1.939 ± 0.05	4.401GluIle: 4.401 ± 0.081	1.778GluLys: 1.778 ± 0.055	7.325GluLeu: 7.325 ± 0.095	1.807GluMet: 1.807 ± 0.051	2.363GluAsn: 2.363 ± 0.056	4.562GluPro: 4.562 ± 0.082	2.581GluGln: 2.581 ± 0.056	8.062GluArg: 8.062 ± 0.121	5.409GluSer: 5.409 ± 0.086	7.49GluThr: 7.49 ± 0.097	5.093GluVal: 5.093 ± 0.081	1.117GluTrp: 1.117 ± 0.033	2.929GluTyr: 2.929 ± 0.058	0.001GluXaa: 0.001 ± 0.001
Phe	3.612PheAla: 3.612 ± 0.068	0.28PheCys: 0.28 ± 0.016	3.387PheAsp: 3.387 ± 0.054	3.106PheGlu: 3.106 ± 0.06	1.018PhePhe: 1.018 ± 0.034	3.058PheGly: 3.058 ± 0.056	0.632PheHis: 0.632 ± 0.027	1.055PheIle: 1.055 ± 0.036	0.436PheLys: 0.436 ± 0.02	2.795PheLeu: 2.795 ± 0.061	0.507PheMet: 0.507 ± 0.021	0.685PheAsn: 0.685 ± 0.027	1.265PhePro: 1.265 ± 0.037	0.732PheGln: 0.732 ± 0.03	1.737PheArg: 1.737 ± 0.043	1.537PheSer: 1.537 ± 0.039	1.802PheThr: 1.802 ± 0.041	3.208PheVal: 3.208 ± 0.064	0.389PheTrp: 0.389 ± 0.022	0.862PheTyr: 0.862 ± 0.031	0.001PheXaa: 0.001 ± 0.001
Gly	7.657GlyAla: 7.657 ± 0.101	0.762GlyCys: 0.762 ± 0.03	7.148GlyAsp: 7.148 ± 0.108	6.649GlyGlu: 6.649 ± 0.081	3.018GlyPhe: 3.018 ± 0.067	7.04GlyGly: 7.04 ± 0.11	1.672GlyHis: 1.672 ± 0.042	4.446GlyIle: 4.446 ± 0.073	1.747GlyLys: 1.747 ± 0.05	7.553GlyLeu: 7.553 ± 0.113	1.69GlyMet: 1.69 ± 0.047	1.932GlyAsn: 1.932 ± 0.049	3.526GlyPro: 3.526 ± 0.064	1.939GlyGln: 1.939 ± 0.047	4.989GlyArg: 4.989 ± 0.084	5.35GlySer: 5.35 ± 0.085	6.348GlyThr: 6.348 ± 0.093	7.023GlyVal: 7.023 ± 0.092	1.091GlyTrp: 1.091 ± 0.035	2.609GlyTyr: 2.609 ± 0.056	0.006GlyXaa: 0.006 ± 0.002
His	1.981HisAla: 1.981 ± 0.044	0.229HisCys: 0.229 ± 0.016	1.91HisAsp: 1.91 ± 0.047	1.712HisGlu: 1.712 ± 0.043	0.524HisPhe: 0.524 ± 0.023	2.05HisGly: 2.05 ± 0.046	0.514HisHis: 0.514 ± 0.023	0.702HisIle: 0.702 ± 0.025	0.282HisLys: 0.282 ± 0.019	1.726HisLeu: 1.726 ± 0.045	0.326HisMet: 0.326 ± 0.02	0.409HisAsn: 0.409 ± 0.021	1.161HisPro: 1.161 ± 0.033	0.434HisGln: 0.434 ± 0.023	1.362HisArg: 1.362 ± 0.035	0.814HisSer: 0.814 ± 0.027	0.994HisThr: 0.994 ± 0.033	1.905HisVal: 1.905 ± 0.047	0.23HisTrp: 0.23 ± 0.016	0.554HisTyr: 0.554 ± 0.023	0.001HisXaa: 0.001 ± 0.001
Ile	5.487IleAla: 5.487 ± 0.082	0.28IleCys: 0.28 ± 0.016	4.795IleAsp: 4.795 ± 0.076	4.47IleGlu: 4.47 ± 0.078	0.94IlePhe: 0.94 ± 0.039	4.423IleGly: 4.423 ± 0.083	0.859IleHis: 0.859 ± 0.029	1.352IleIle: 1.352 ± 0.044	0.699IleLys: 0.699 ± 0.029	2.933IleLeu: 2.933 ± 0.067	0.53IleMet: 0.53 ± 0.024	1.012IleAsn: 1.012 ± 0.031	1.942IlePro: 1.942 ± 0.055	1.038IleGln: 1.038 ± 0.035	2.629IleArg: 2.629 ± 0.056	2.159IleSer: 2.159 ± 0.059	2.549IleThr: 2.549 ± 0.059	4.281IleVal: 4.281 ± 0.076	0.352IleTrp: 0.352 ± 0.02	0.925IleTyr: 0.925 ± 0.03	0.001IleXaa: 0.001 ± 0.001
Lys	1.684LysAla: 1.684 ± 0.05	0.111LysCys: 0.111 ± 0.011	1.017LysAsp: 1.017 ± 0.031	1.191LysGlu: 1.191 ± 0.041	0.452LysPhe: 0.452 ± 0.022	1.235LysGly: 1.235 ± 0.033	0.468LysHis: 0.468 ± 0.021	0.795LysIle: 0.795 ± 0.03	0.506LysLys: 0.506 ± 0.027	1.591LysLeu: 1.591 ± 0.039	0.348LysMet: 0.348 ± 0.019	0.538LysAsn: 0.538 ± 0.026	0.905LysPro: 0.905 ± 0.033	0.699LysGln: 0.699 ± 0.031	1.561LysArg: 1.561 ± 0.038	1.043LysSer: 1.043 ± 0.031	1.211LysThr: 1.211 ± 0.04	1.061LysVal: 1.061 ± 0.034	0.202LysTrp: 0.202 ± 0.015	0.574LysTyr: 0.574 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	10.975LeuAla: 10.975 ± 0.119	0.661LeuCys: 0.661 ± 0.024	5.962LeuAsp: 5.962 ± 0.079	10.737LeuGlu: 10.737 ± 0.11	3.072LeuPhe: 3.072 ± 0.068	7.15LeuGly: 7.15 ± 0.112	1.425LeuHis: 1.425 ± 0.039	3.047LeuIle: 3.047 ± 0.068	1.35LeuLys: 1.35 ± 0.041	8.601LeuLeu: 8.601 ± 0.13	1.188LeuMet: 1.188 ± 0.038	1.644LeuAsn: 1.644 ± 0.045	4.025LeuPro: 4.025 ± 0.07	1.932LeuGln: 1.932 ± 0.049	5.2LeuArg: 5.2 ± 0.081	5.482LeuSer: 5.482 ± 0.079	5.253LeuThr: 5.253 ± 0.071	8.01LeuVal: 8.01 ± 0.124	0.861LeuTrp: 0.861 ± 0.031	2.126LeuTyr: 2.126 ± 0.055	0.002LeuXaa: 0.002 ± 0.001
Met	1.868MetAla: 1.868 ± 0.041	0.121MetCys: 0.121 ± 0.011	1.174MetAsp: 1.174 ± 0.033	1.1MetGlu: 1.1 ± 0.032	0.467MetPhe: 0.467 ± 0.026	1.406MetGly: 1.406 ± 0.036	0.35MetHis: 0.35 ± 0.019	0.727MetIle: 0.727 ± 0.03	0.399MetLys: 0.399 ± 0.019	1.517MetLeu: 1.517 ± 0.041	0.314MetMet: 0.314 ± 0.02	0.596MetAsn: 0.596 ± 0.024	0.812MetPro: 0.812 ± 0.029	0.546MetGln: 0.546 ± 0.023	1.086MetArg: 1.086 ± 0.033	1.444MetSer: 1.444 ± 0.039	1.556MetThr: 1.556 ± 0.037	1.159MetVal: 1.159 ± 0.039	0.183MetTrp: 0.183 ± 0.013	0.401MetTyr: 0.401 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.559AsnAla: 2.559 ± 0.048	0.228AsnCys: 0.228 ± 0.014	1.701AsnAsp: 1.701 ± 0.043	1.873AsnGlu: 1.873 ± 0.057	0.601AsnPhe: 0.601 ± 0.025	2.099AsnGly: 2.099 ± 0.046	0.516AsnHis: 0.516 ± 0.02	0.882AsnIle: 0.882 ± 0.032	0.419AsnLys: 0.419 ± 0.024	1.733AsnLeu: 1.733 ± 0.045	0.419AsnMet: 0.419 ± 0.019	0.506AsnAsn: 0.506 ± 0.027	1.423AsnPro: 1.423 ± 0.039	0.598AsnGln: 0.598 ± 0.027	1.599AsnArg: 1.599 ± 0.038	0.94AsnSer: 0.94 ± 0.035	1.22AsnThr: 1.22 ± 0.038	2.112AsnVal: 2.112 ± 0.052	0.317AsnTrp: 0.317 ± 0.016	0.662AsnTyr: 0.662 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.944ProAla: 4.944 ± 0.078	0.282ProCys: 0.282 ± 0.019	5.133ProAsp: 5.133 ± 0.09	4.164ProGlu: 4.164 ± 0.06	1.532ProPhe: 1.532 ± 0.039	3.618ProGly: 3.618 ± 0.072	0.88ProHis: 0.88 ± 0.031	2.168ProIle: 2.168 ± 0.049	0.823ProLys: 0.823 ± 0.031	3.698ProLeu: 3.698 ± 0.061	0.92ProMet: 0.92 ± 0.032	1.107ProAsn: 1.107 ± 0.035	2.24ProPro: 2.24 ± 0.052	0.968ProGln: 0.968 ± 0.034	2.377ProArg: 2.377 ± 0.048	2.693ProSer: 2.693 ± 0.053	3.352ProThr: 3.352 ± 0.064	4.123ProVal: 4.123 ± 0.069	0.527ProTrp: 0.527 ± 0.021	1.126ProTyr: 1.126 ± 0.034	0.001ProXaa: 0.001 ± 0.001
Gln	2.282GlnAla: 2.282 ± 0.054	0.159GlnCys: 0.159 ± 0.014	1.316GlnAsp: 1.316 ± 0.041	1.657GlnGlu: 1.657 ± 0.048	1.004GlnPhe: 1.004 ± 0.031	1.602GlnGly: 1.602 ± 0.044	0.499GlnHis: 0.499 ± 0.025	0.949GlnIle: 0.949 ± 0.034	0.546GlnLys: 0.546 ± 0.025	2.323GlnLeu: 2.323 ± 0.06	0.488GlnMet: 0.488 ± 0.023	0.616GlnAsn: 0.616 ± 0.026	1.126GlnPro: 1.126 ± 0.034	1.011GlnGln: 1.011 ± 0.044	2.085GlnArg: 2.085 ± 0.054	1.6GlnSer: 1.6 ± 0.043	1.424GlnThr: 1.424 ± 0.042	1.671GlnVal: 1.671 ± 0.043	0.333GlnTrp: 0.333 ± 0.018	0.857GlnTyr: 0.857 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.476ArgAla: 6.476 ± 0.09	0.506ArgCys: 0.506 ± 0.025	5.565ArgAsp: 5.565 ± 0.076	6.531ArgGlu: 6.531 ± 0.096	2.338ArgPhe: 2.338 ± 0.057	4.467ArgGly: 4.467 ± 0.081	1.291ArgHis: 1.291 ± 0.036	3.294ArgIle: 3.294 ± 0.06	1.316ArgLys: 1.316 ± 0.037	6.422ArgLeu: 6.422 ± 0.091	1.273ArgMet: 1.273 ± 0.035	1.647ArgAsn: 1.647 ± 0.037	2.787ArgPro: 2.787 ± 0.057	1.725ArgGln: 1.725 ± 0.044	5.173ArgArg: 5.173 ± 0.09	4.112ArgSer: 4.112 ± 0.076	4.699ArgThr: 4.699 ± 0.068	5.048ArgVal: 5.048 ± 0.072	0.779ArgTrp: 0.779 ± 0.028	2.057ArgTyr: 2.057 ± 0.048	0.004ArgXaa: 0.004 ± 0.003
Ser	5.359SerAla: 5.359 ± 0.085	0.342SerCys: 0.342 ± 0.018	4.854SerAsp: 4.854 ± 0.088	4.194SerGlu: 4.194 ± 0.062	1.82SerPhe: 1.82 ± 0.047	5.206SerGly: 5.206 ± 0.077	0.993SerHis: 0.993 ± 0.036	2.65SerIle: 2.65 ± 0.054	1.144SerLys: 1.144 ± 0.041	4.917SerLeu: 4.917 ± 0.078	1.139SerMet: 1.139 ± 0.029	1.389SerAsn: 1.389 ± 0.036	2.563SerPro: 2.563 ± 0.052	1.371SerGln: 1.371 ± 0.045	3.471SerArg: 3.471 ± 0.061	3.386SerSer: 3.386 ± 0.068	3.514SerThr: 3.514 ± 0.06	4.8SerVal: 4.8 ± 0.066	0.612SerTrp: 0.612 ± 0.025	1.473SerTyr: 1.473 ± 0.038	0.003SerXaa: 0.003 ± 0.002
Thr	7.803ThrAla: 7.803 ± 0.103	0.425ThrCys: 0.425 ± 0.018	6.2ThrAsp: 6.2 ± 0.095	4.917ThrGlu: 4.917 ± 0.078	2.072ThrPhe: 2.072 ± 0.051	6.049ThrGly: 6.049 ± 0.094	1.254ThrHis: 1.254 ± 0.039	3.309ThrIle: 3.309 ± 0.055	1.002ThrLys: 1.002 ± 0.031	5.693ThrLeu: 5.693 ± 0.078	1.072ThrMet: 1.072 ± 0.029	1.514ThrAsn: 1.514 ± 0.045	3.176ThrPro: 3.176 ± 0.058	1.318ThrGln: 1.318 ± 0.037	3.524ThrArg: 3.524 ± 0.059	2.836ThrSer: 2.836 ± 0.061	4.421ThrThr: 4.421 ± 0.07	7.365ThrVal: 7.365 ± 0.102	0.629ThrTrp: 0.629 ± 0.025	1.711ThrTyr: 1.711 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	9.733ValAla: 9.733 ± 0.134	0.672ValCys: 0.672 ± 0.025	7.529ValAsp: 7.529 ± 0.095	6.735ValGlu: 6.735 ± 0.089	2.879ValPhe: 2.879 ± 0.064	7.411ValGly: 7.411 ± 0.11	1.632ValHis: 1.632 ± 0.041	3.425ValIle: 3.425 ± 0.063	1.262ValLys: 1.262 ± 0.041	8.021ValLeu: 8.021 ± 0.106	1.278ValMet: 1.278 ± 0.04	1.73ValAsn: 1.73 ± 0.039	4.463ValPro: 4.463 ± 0.071	1.763ValGln: 1.763 ± 0.042	5.594ValArg: 5.594 ± 0.078	5.021ValSer: 5.021 ± 0.072	6.217ValThr: 6.217 ± 0.083	8.286ValVal: 8.286 ± 0.116	0.799ValTrp: 0.799 ± 0.027	2.13ValTyr: 2.13 ± 0.039	0.001ValXaa: 0.001 ± 0.001
Trp	0.948TrpAla: 0.948 ± 0.032	0.1TrpCys: 0.1 ± 0.01	0.812TrpAsp: 0.812 ± 0.029	0.79TrpGlu: 0.79 ± 0.029	0.456TrpPhe: 0.456 ± 0.024	0.779TrpGly: 0.779 ± 0.024	0.252TrpHis: 0.252 ± 0.016	0.539TrpIle: 0.539 ± 0.024	0.278TrpLys: 0.278 ± 0.018	1.318TrpLeu: 1.318 ± 0.039	0.224TrpMet: 0.224 ± 0.015	0.335TrpAsn: 0.335 ± 0.017	0.453TrpPro: 0.453 ± 0.023	0.356TrpGln: 0.356 ± 0.016	0.808TrpArg: 0.808 ± 0.028	0.598TrpSer: 0.598 ± 0.025	0.784TrpThr: 0.784 ± 0.026	0.788TrpVal: 0.788 ± 0.028	0.192TrpTrp: 0.192 ± 0.014	0.368TrpTyr: 0.368 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.059	0.281TyrCys: 0.281 ± 0.018	2.714TyrAsp: 2.714 ± 0.051	2.586TyrGlu: 2.586 ± 0.057	0.842TyrPhe: 0.842 ± 0.03	2.349TyrGly: 2.349 ± 0.044	0.667TyrHis: 0.667 ± 0.026	0.749TyrIle: 0.749 ± 0.027	0.427TyrLys: 0.427 ± 0.022	2.366TyrLeu: 2.366 ± 0.055	0.363TyrMet: 0.363 ± 0.02	0.632TyrAsn: 0.632 ± 0.026	1.258TyrPro: 1.258 ± 0.037	0.721TyrGln: 0.721 ± 0.033	2.044TyrArg: 2.044 ± 0.048	1.2TyrSer: 1.2 ± 0.032	1.501TyrThr: 1.501 ± 0.04	2.345TyrVal: 2.345 ± 0.045	0.329TyrTrp: 0.329 ± 0.022	0.892TyrTyr: 0.892 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.002	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.003XaaAsn: 0.003 ± 0.002	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.002XaaArg: 0.002 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3732 proteins (1035287 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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