Amino acid dipepetide frequency for Pandoravirus inopinatum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.287AlaAla: 20.287 ± 0.35
3.917AlaCys: 3.917 ± 0.097
7.335AlaAsp: 7.335 ± 0.116
3.993AlaGlu: 3.993 ± 0.097
3.068AlaPhe: 3.068 ± 0.079
8.243AlaGly: 8.243 ± 0.152
4.258AlaHis: 4.258 ± 0.103
4.864AlaIle: 4.864 ± 0.108
2.734AlaLys: 2.734 ± 0.084
12.363AlaLeu: 12.363 ± 0.196
2.871AlaMet: 2.871 ± 0.073
2.655AlaAsn: 2.655 ± 0.073
7.959AlaPro: 7.959 ± 0.132
3.668AlaGln: 3.668 ± 0.098
12.234AlaArg: 12.234 ± 0.186
8.615AlaSer: 8.615 ± 0.148
8.199AlaThr: 8.199 ± 0.148
9.391AlaVal: 9.391 ± 0.135
2.484AlaTrp: 2.484 ± 0.069
2.585AlaTyr: 2.585 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
4.49CysAla: 4.49 ± 0.111
0.905CysCys: 0.905 ± 0.048
1.682CysAsp: 1.682 ± 0.064
0.934CysGlu: 0.934 ± 0.043
0.818CysPhe: 0.818 ± 0.038
2.292CysGly: 2.292 ± 0.078
0.731CysHis: 0.731 ± 0.039
0.835CysIle: 0.835 ± 0.043
0.59CysLys: 0.59 ± 0.034
2.581CysLeu: 2.581 ± 0.101
0.632CysMet: 0.632 ± 0.033
0.623CysAsn: 0.623 ± 0.033
2.377CysPro: 2.377 ± 0.104
0.621CysGln: 0.621 ± 0.037
3.092CysArg: 3.092 ± 0.095
1.452CysSer: 1.452 ± 0.056
1.686CysThr: 1.686 ± 0.061
2.24CysVal: 2.24 ± 0.073
0.488CysTrp: 0.488 ± 0.031
0.407CysTyr: 0.407 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
9.15AspAla: 9.15 ± 0.155
1.325AspCys: 1.325 ± 0.061
7.946AspAsp: 7.946 ± 0.241
2.992AspGlu: 2.992 ± 0.081
1.321AspPhe: 1.321 ± 0.044
6.577AspGly: 6.577 ± 0.154
1.986AspHis: 1.986 ± 0.076
2.145AspIle: 2.145 ± 0.067
1.398AspLys: 1.398 ± 0.046
4.66AspLeu: 4.66 ± 0.096
1.419AspMet: 1.419 ± 0.055
2.181AspAsn: 2.181 ± 0.071
4.173AspPro: 4.173 ± 0.094
1.669AspGln: 1.669 ± 0.054
5.102AspArg: 5.102 ± 0.096
3.149AspSer: 3.149 ± 0.079
3.357AspThr: 3.357 ± 0.085
4.612AspVal: 4.612 ± 0.091
1.089AspTrp: 1.089 ± 0.047
1.128AspTyr: 1.128 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.096GluAla: 5.096 ± 0.115
0.921GluCys: 0.921 ± 0.046
1.896GluAsp: 1.896 ± 0.063
1.413GluGlu: 1.413 ± 0.065
0.658GluPhe: 0.658 ± 0.035
2.59GluGly: 2.59 ± 0.075
1.131GluHis: 1.131 ± 0.051
1.491GluIle: 1.491 ± 0.048
1.446GluLys: 1.446 ± 0.056
1.28GluLeu: 1.28 ± 0.054
0.809GluMet: 0.809 ± 0.042
0.704GluAsn: 0.704 ± 0.036
2.336GluPro: 2.336 ± 0.074
1.067GluGln: 1.067 ± 0.044
4.0GluArg: 4.0 ± 0.085
2.167GluSer: 2.167 ± 0.063
2.213GluThr: 2.213 ± 0.055
1.885GluVal: 1.885 ± 0.065
1.076GluTrp: 1.076 ± 0.05
0.63GluTyr: 0.63 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.267PheAla: 3.267 ± 0.076
1.214PheCys: 1.214 ± 0.052
1.826PheAsp: 1.826 ± 0.058
0.982PheGlu: 0.982 ± 0.039
3.692PhePhe: 3.692 ± 0.156
2.404PheGly: 2.404 ± 0.08
0.532PheHis: 0.532 ± 0.032
0.704PheIle: 0.704 ± 0.032
0.433PheLys: 0.433 ± 0.028
3.261PheLeu: 3.261 ± 0.108
0.617PheMet: 0.617 ± 0.033
0.461PheAsn: 0.461 ± 0.03
1.135PhePro: 1.135 ± 0.05
0.459PheGln: 0.459 ± 0.034
1.415PheArg: 1.415 ± 0.054
2.132PheSer: 2.132 ± 0.082
0.962PheThr: 0.962 ± 0.047
2.743PheVal: 2.743 ± 0.079
0.652PheTrp: 0.652 ± 0.036
0.796PheTyr: 0.796 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
9.546GlyAla: 9.546 ± 0.166
2.574GlyCys: 2.574 ± 0.115
5.544GlyAsp: 5.544 ± 0.128
2.356GlyGlu: 2.356 ± 0.068
1.723GlyPhe: 1.723 ± 0.056
7.25GlyGly: 7.25 ± 0.199
3.891GlyHis: 3.891 ± 0.13
2.329GlyIle: 2.329 ± 0.067
1.912GlyLys: 1.912 ± 0.061
5.481GlyLeu: 5.481 ± 0.115
1.391GlyMet: 1.391 ± 0.053
1.841GlyAsn: 1.841 ± 0.058
5.109GlyPro: 5.109 ± 0.126
2.607GlyGln: 2.607 ± 0.073
7.935GlyArg: 7.935 ± 0.138
4.748GlySer: 4.748 ± 0.093
4.66GlyThr: 4.66 ± 0.116
5.122GlyVal: 5.122 ± 0.125
1.402GlyTrp: 1.402 ± 0.055
1.522GlyTyr: 1.522 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
3.904HisAla: 3.904 ± 0.08
0.772HisCys: 0.772 ± 0.039
2.036HisAsp: 2.036 ± 0.053
1.244HisGlu: 1.244 ± 0.053
0.844HisPhe: 0.844 ± 0.044
3.687HisGly: 3.687 ± 0.132
1.17HisHis: 1.17 ± 0.047
1.111HisIle: 1.111 ± 0.046
0.848HisLys: 0.848 ± 0.043
2.69HisLeu: 2.69 ± 0.102
0.696HisMet: 0.696 ± 0.033
0.8HisAsn: 0.8 ± 0.039
1.76HisPro: 1.76 ± 0.046
0.84HisGln: 0.84 ± 0.043
2.85HisArg: 2.85 ± 0.085
1.17HisSer: 1.17 ± 0.049
1.732HisThr: 1.732 ± 0.057
2.36HisVal: 2.36 ± 0.068
0.566HisTrp: 0.566 ± 0.036
0.695HisTyr: 0.695 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
4.352IleAla: 4.352 ± 0.112
0.636IleCys: 0.636 ± 0.033
3.007IleAsp: 3.007 ± 0.088
2.005IleGlu: 2.005 ± 0.065
0.951IlePhe: 0.951 ± 0.047
2.539IleGly: 2.539 ± 0.064
0.744IleHis: 0.744 ± 0.04
1.104IleIle: 1.104 ± 0.049
0.87IleLys: 0.87 ± 0.039
2.701IleLeu: 2.701 ± 0.07
0.641IleMet: 0.641 ± 0.037
0.883IleAsn: 0.883 ± 0.041
1.277IlePro: 1.277 ± 0.05
0.761IleGln: 0.761 ± 0.038
1.802IleArg: 1.802 ± 0.052
1.374IleSer: 1.374 ± 0.057
1.496IleThr: 1.496 ± 0.055
3.147IleVal: 3.147 ± 0.081
0.374IleTrp: 0.374 ± 0.028
0.879IleTyr: 0.879 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
2.581LysAla: 2.581 ± 0.071
0.56LysCys: 0.56 ± 0.038
1.365LysAsp: 1.365 ± 0.055
1.478LysGlu: 1.478 ± 0.064
0.315LysPhe: 0.315 ± 0.026
2.202LysGly: 2.202 ± 0.082
0.825LysHis: 0.825 ± 0.043
0.824LysIle: 0.824 ± 0.042
3.119LysLys: 3.119 ± 0.149
0.696LysLeu: 0.696 ± 0.037
0.558LysMet: 0.558 ± 0.033
0.848LysAsn: 0.848 ± 0.048
1.216LysPro: 1.216 ± 0.045
0.755LysGln: 0.755 ± 0.038
3.105LysArg: 3.105 ± 0.085
1.524LysSer: 1.524 ± 0.051
1.492LysThr: 1.492 ± 0.061
1.231LysVal: 1.231 ± 0.046
0.553LysTrp: 0.553 ± 0.042
0.416LysTyr: 0.416 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.887LeuAla: 11.887 ± 0.194
3.444LeuCys: 3.444 ± 0.084
6.104LeuAsp: 6.104 ± 0.118
2.051LeuGlu: 2.051 ± 0.055
4.017LeuPhe: 4.017 ± 0.108
5.686LeuGly: 5.686 ± 0.103
2.069LeuHis: 2.069 ± 0.064
2.036LeuIle: 2.036 ± 0.06
1.269LeuLys: 1.269 ± 0.055
7.604LeuLeu: 7.604 ± 0.144
1.437LeuMet: 1.437 ± 0.054
1.146LeuAsn: 1.146 ± 0.046
5.607LeuPro: 5.607 ± 0.119
1.835LeuGln: 1.835 ± 0.067
5.341LeuArg: 5.341 ± 0.1
5.266LeuSer: 5.266 ± 0.103
3.409LeuThr: 3.409 ± 0.082
7.134LeuVal: 7.134 ± 0.114
2.126LeuTrp: 2.126 ± 0.06
1.999LeuTyr: 1.999 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
3.27MetAla: 3.27 ± 0.084
0.573MetCys: 0.573 ± 0.032
1.446MetAsp: 1.446 ± 0.051
0.768MetGlu: 0.768 ± 0.037
0.367MetPhe: 0.367 ± 0.026
1.564MetGly: 1.564 ± 0.051
0.658MetHis: 0.658 ± 0.034
0.641MetIle: 0.641 ± 0.04
0.313MetLys: 0.313 ± 0.024
1.524MetLeu: 1.524 ± 0.058
0.339MetMet: 0.339 ± 0.028
0.328MetAsn: 0.328 ± 0.024
1.614MetPro: 1.614 ± 0.063
0.597MetGln: 0.597 ± 0.034
2.102MetArg: 2.102 ± 0.06
1.223MetSer: 1.223 ± 0.046
1.277MetThr: 1.277 ± 0.047
1.249MetVal: 1.249 ± 0.05
0.442MetTrp: 0.442 ± 0.032
0.26MetTyr: 0.26 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.397AsnAla: 2.397 ± 0.069
0.391AsnCys: 0.391 ± 0.026
1.813AsnAsp: 1.813 ± 0.064
0.77AsnGlu: 0.77 ± 0.032
0.438AsnPhe: 0.438 ± 0.032
3.175AsnGly: 3.175 ± 0.116
0.58AsnHis: 0.58 ± 0.031
0.66AsnIle: 0.66 ± 0.037
0.831AsnLys: 0.831 ± 0.041
1.369AsnLeu: 1.369 ± 0.058
0.348AsnMet: 0.348 ± 0.026
1.269AsnAsn: 1.269 ± 0.074
1.159AsnPro: 1.159 ± 0.05
0.58AsnGln: 0.58 ± 0.035
1.684AsnArg: 1.684 ± 0.049
1.021AsnSer: 1.021 ± 0.047
1.089AsnThr: 1.089 ± 0.047
1.522AsnVal: 1.522 ± 0.055
0.263AsnTrp: 0.263 ± 0.021
0.37AsnTyr: 0.37 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
7.152ProAla: 7.152 ± 0.136
2.075ProCys: 2.075 ± 0.071
3.759ProAsp: 3.759 ± 0.094
2.041ProGlu: 2.041 ± 0.062
2.318ProPhe: 2.318 ± 0.073
3.607ProGly: 3.607 ± 0.102
2.104ProHis: 2.104 ± 0.062
2.041ProIle: 2.041 ± 0.069
1.511ProLys: 1.511 ± 0.062
5.912ProLeu: 5.912 ± 0.108
1.671ProMet: 1.671 ± 0.056
1.268ProAsn: 1.268 ± 0.047
6.227ProPro: 6.227 ± 0.157
1.704ProGln: 1.704 ± 0.058
5.461ProArg: 5.461 ± 0.116
5.194ProSer: 5.194 ± 0.111
5.166ProThr: 5.166 ± 0.109
4.157ProVal: 4.157 ± 0.094
1.881ProTrp: 1.881 ± 0.075
1.275ProTyr: 1.275 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.878GlnAla: 2.878 ± 0.081
0.82GlnCys: 0.82 ± 0.045
1.301GlnAsp: 1.301 ± 0.045
1.12GlnGlu: 1.12 ± 0.046
0.555GlnPhe: 0.555 ± 0.036
2.172GlnGly: 2.172 ± 0.076
0.886GlnHis: 0.886 ± 0.042
0.748GlnIle: 0.748 ± 0.035
1.301GlnLys: 1.301 ± 0.056
1.393GlnLeu: 1.393 ± 0.057
0.577GlnMet: 0.577 ± 0.03
0.52GlnAsn: 0.52 ± 0.032
1.927GlnPro: 1.927 ± 0.076
1.551GlnGln: 1.551 ± 0.102
3.246GlnArg: 3.246 ± 0.087
1.667GlnSer: 1.667 ± 0.056
1.739GlnThr: 1.739 ± 0.06
1.402GlnVal: 1.402 ± 0.056
1.063GlnTrp: 1.063 ± 0.067
0.49GlnTyr: 0.49 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
11.512ArgAla: 11.512 ± 0.168
2.426ArgCys: 2.426 ± 0.077
4.588ArgAsp: 4.588 ± 0.092
2.585ArgGlu: 2.585 ± 0.084
2.145ArgPhe: 2.145 ± 0.062
6.832ArgGly: 6.832 ± 0.125
3.679ArgHis: 3.679 ± 0.096
2.524ArgIle: 2.524 ± 0.074
2.161ArgLys: 2.161 ± 0.081
7.88ArgLeu: 7.88 ± 0.13
1.723ArgMet: 1.723 ± 0.061
1.494ArgAsn: 1.494 ± 0.053
6.959ArgPro: 6.959 ± 0.139
3.327ArgGln: 3.327 ± 0.08
11.372ArgArg: 11.372 ± 0.187
4.881ArgSer: 4.881 ± 0.11
4.604ArgThr: 4.604 ± 0.093
5.616ArgVal: 5.616 ± 0.102
2.39ArgTrp: 2.39 ± 0.06
1.748ArgTyr: 1.748 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
7.064SerAla: 7.064 ± 0.122
1.614SerCys: 1.614 ± 0.072
3.746SerAsp: 3.746 ± 0.097
1.557SerGlu: 1.557 ± 0.05
2.025SerPhe: 2.025 ± 0.079
4.779SerGly: 4.779 ± 0.122
1.638SerHis: 1.638 ± 0.069
1.994SerIle: 1.994 ± 0.064
1.282SerLys: 1.282 ± 0.054
5.509SerLeu: 5.509 ± 0.107
1.404SerMet: 1.404 ± 0.057
1.266SerAsn: 1.266 ± 0.051
4.385SerPro: 4.385 ± 0.103
1.275SerGln: 1.275 ± 0.046
4.908SerArg: 4.908 ± 0.098
5.078SerSer: 5.078 ± 0.258
4.523SerThr: 4.523 ± 0.106
4.286SerVal: 4.286 ± 0.089
1.185SerTrp: 1.185 ± 0.047
0.779SerTyr: 0.779 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
7.296ThrAla: 7.296 ± 0.13
1.726ThrCys: 1.726 ± 0.074
3.315ThrAsp: 3.315 ± 0.095
1.918ThrGlu: 1.918 ± 0.062
1.369ThrPhe: 1.369 ± 0.053
4.175ThrGly: 4.175 ± 0.083
1.54ThrHis: 1.54 ± 0.06
2.099ThrIle: 2.099 ± 0.065
1.664ThrLys: 1.664 ± 0.069
4.859ThrLeu: 4.859 ± 0.103
1.332ThrMet: 1.332 ± 0.048
1.393ThrAsn: 1.393 ± 0.048
4.21ThrPro: 4.21 ± 0.098
1.432ThrGln: 1.432 ± 0.047
4.906ThrArg: 4.906 ± 0.107
3.497ThrSer: 3.497 ± 0.084
5.188ThrThr: 5.188 ± 0.148
4.21ThrVal: 4.21 ± 0.103
1.144ThrTrp: 1.144 ± 0.055
1.247ThrTyr: 1.247 ± 0.066
0.002ThrXaa: 0.002 ± 0.002
Val
10.216ValAla: 10.216 ± 0.152
2.524ValCys: 2.524 ± 0.078
5.665ValAsp: 5.665 ± 0.095
2.883ValGlu: 2.883 ± 0.076
2.102ValPhe: 2.102 ± 0.068
5.977ValGly: 5.977 ± 0.111
2.04ValHis: 2.04 ± 0.062
2.204ValIle: 2.204 ± 0.07
1.12ValLys: 1.12 ± 0.05
6.056ValLeu: 6.056 ± 0.114
1.14ValMet: 1.14 ± 0.053
1.205ValAsn: 1.205 ± 0.043
4.58ValPro: 4.58 ± 0.097
1.656ValGln: 1.656 ± 0.068
5.772ValArg: 5.772 ± 0.114
3.698ValSer: 3.698 ± 0.092
3.173ValThr: 3.173 ± 0.085
6.172ValVal: 6.172 ± 0.12
1.218ValTrp: 1.218 ± 0.053
1.691ValTyr: 1.691 ± 0.066
0.002ValXaa: 0.002 ± 0.002
Trp
2.474TrpAla: 2.474 ± 0.086
0.617TrpCys: 0.617 ± 0.034
1.369TrpAsp: 1.369 ± 0.071
0.601TrpGlu: 0.601 ± 0.035
0.426TrpPhe: 0.426 ± 0.028
1.137TrpGly: 1.137 ± 0.052
0.822TrpHis: 0.822 ± 0.041
0.614TrpIle: 0.614 ± 0.035
0.394TrpLys: 0.394 ± 0.032
2.226TrpLeu: 2.226 ± 0.069
0.492TrpMet: 0.492 ± 0.03
0.381TrpAsn: 0.381 ± 0.027
1.642TrpPro: 1.642 ± 0.063
0.547TrpGln: 0.547 ± 0.033
2.5TrpArg: 2.5 ± 0.071
1.533TrpSer: 1.533 ± 0.059
1.544TrpThr: 1.544 ± 0.064
1.12TrpVal: 1.12 ± 0.052
0.442TrpTrp: 0.442 ± 0.031
0.337TrpTyr: 0.337 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.902TyrAla: 2.902 ± 0.085
0.442TyrCys: 0.442 ± 0.032
1.636TyrAsp: 1.636 ± 0.067
1.118TyrGlu: 1.118 ± 0.054
0.54TyrPhe: 0.54 ± 0.032
2.054TyrGly: 2.054 ± 0.079
0.486TyrHis: 0.486 ± 0.029
0.577TyrIle: 0.577 ± 0.032
0.466TyrLys: 0.466 ± 0.027
1.421TyrLeu: 1.421 ± 0.057
0.457TyrMet: 0.457 ± 0.032
0.466TyrAsn: 0.466 ± 0.032
0.873TyrPro: 0.873 ± 0.045
0.403TyrGln: 0.403 ± 0.028
1.618TyrArg: 1.618 ± 0.063
0.908TyrSer: 0.908 ± 0.04
1.01TyrThr: 1.01 ± 0.05
1.498TyrVal: 1.498 ± 0.052
0.38TyrTrp: 0.38 ± 0.023
0.529TyrTyr: 0.529 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.004XaaThr: 0.004 ± 0.003
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.015XaaXaa: 0.015 ± 0.013
Statistics based on 1839 proteins (542761 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski