Amino acid dipepetide frequency for Moraxella phage Mcat7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.404AlaAla: 4.404 ± 1.023
0.691AlaCys: 0.691 ± 0.288
4.231AlaAsp: 4.231 ± 0.581
4.145AlaGlu: 4.145 ± 0.655
3.195AlaPhe: 3.195 ± 0.634
5.267AlaGly: 5.267 ± 0.807
1.9AlaHis: 1.9 ± 0.492
7.167AlaIle: 7.167 ± 0.726
6.908AlaLys: 6.908 ± 1.15
6.735AlaLeu: 6.735 ± 0.637
2.849AlaMet: 2.849 ± 0.643
4.058AlaAsn: 4.058 ± 0.714
2.849AlaPro: 2.849 ± 0.552
4.576AlaGln: 4.576 ± 0.621
3.454AlaArg: 3.454 ± 0.574
6.822AlaSer: 6.822 ± 0.872
6.908AlaThr: 6.908 ± 1.138
5.181AlaVal: 5.181 ± 0.601
1.9AlaTrp: 1.9 ± 0.385
2.677AlaTyr: 2.677 ± 0.587
0.0AlaXaa: 0.0 ± 0.0
Cys
0.691CysAla: 0.691 ± 0.248
0.086CysCys: 0.086 ± 0.1
0.604CysAsp: 0.604 ± 0.225
0.863CysGlu: 0.863 ± 0.318
0.173CysPhe: 0.173 ± 0.123
0.691CysGly: 0.691 ± 0.381
0.345CysHis: 0.345 ± 0.162
0.691CysIle: 0.691 ± 0.264
0.345CysLys: 0.345 ± 0.16
0.777CysLeu: 0.777 ± 0.251
0.0CysMet: 0.0 ± 0.0
0.259CysAsn: 0.259 ± 0.142
0.518CysPro: 0.518 ± 0.243
0.173CysGln: 0.173 ± 0.121
0.518CysArg: 0.518 ± 0.255
0.691CysSer: 0.691 ± 0.281
0.432CysThr: 0.432 ± 0.246
0.259CysVal: 0.259 ± 0.138
0.086CysTrp: 0.086 ± 0.08
0.777CysTyr: 0.777 ± 0.296
0.0CysXaa: 0.0 ± 0.0
Asp
4.49AspAla: 4.49 ± 0.657
0.691AspCys: 0.691 ± 0.305
5.44AspAsp: 5.44 ± 0.922
4.145AspGlu: 4.145 ± 0.634
2.677AspPhe: 2.677 ± 0.436
5.008AspGly: 5.008 ± 0.708
0.691AspHis: 0.691 ± 0.245
4.145AspIle: 4.145 ± 0.603
6.217AspLys: 6.217 ± 0.753
4.576AspLeu: 4.576 ± 0.819
1.727AspMet: 1.727 ± 0.404
4.145AspAsn: 4.145 ± 0.508
1.9AspPro: 1.9 ± 0.497
1.468AspGln: 1.468 ± 0.299
2.159AspArg: 2.159 ± 0.462
2.677AspSer: 2.677 ± 0.517
3.109AspThr: 3.109 ± 0.798
3.281AspVal: 3.281 ± 0.49
1.123AspTrp: 1.123 ± 0.302
1.295AspTyr: 1.295 ± 0.422
0.0AspXaa: 0.0 ± 0.0
Glu
3.799GluAla: 3.799 ± 0.786
0.432GluCys: 0.432 ± 0.206
1.641GluAsp: 1.641 ± 0.408
1.209GluGlu: 1.209 ± 0.385
2.072GluPhe: 2.072 ± 0.586
1.9GluGly: 1.9 ± 0.392
1.295GluHis: 1.295 ± 0.335
4.663GluIle: 4.663 ± 0.606
3.627GluLys: 3.627 ± 0.734
6.562GluLeu: 6.562 ± 0.66
1.9GluMet: 1.9 ± 0.359
1.9GluAsn: 1.9 ± 0.356
1.986GluPro: 1.986 ± 0.465
3.972GluGln: 3.972 ± 0.625
3.972GluArg: 3.972 ± 0.585
2.849GluSer: 2.849 ± 0.501
2.418GluThr: 2.418 ± 0.311
2.763GluVal: 2.763 ± 0.621
0.95GluTrp: 0.95 ± 0.287
2.418GluTyr: 2.418 ± 0.505
0.0GluXaa: 0.0 ± 0.0
Phe
3.195PheAla: 3.195 ± 0.41
0.432PheCys: 0.432 ± 0.175
2.504PheAsp: 2.504 ± 0.462
2.331PheGlu: 2.331 ± 0.31
0.95PhePhe: 0.95 ± 0.285
2.418PheGly: 2.418 ± 0.383
0.95PheHis: 0.95 ± 0.302
2.763PheIle: 2.763 ± 0.613
1.727PheLys: 1.727 ± 0.348
2.418PheLeu: 2.418 ± 0.566
1.554PheMet: 1.554 ± 0.265
1.468PheAsn: 1.468 ± 0.251
0.518PhePro: 0.518 ± 0.158
0.259PheGln: 0.259 ± 0.177
1.209PheArg: 1.209 ± 0.271
2.418PheSer: 2.418 ± 0.49
1.813PheThr: 1.813 ± 0.321
2.418PheVal: 2.418 ± 0.476
0.604PheTrp: 0.604 ± 0.2
1.036PheTyr: 1.036 ± 0.228
0.0PheXaa: 0.0 ± 0.0
Gly
4.231GlyAla: 4.231 ± 0.635
0.345GlyCys: 0.345 ± 0.161
4.576GlyAsp: 4.576 ± 0.526
5.181GlyGlu: 5.181 ± 0.766
3.109GlyPhe: 3.109 ± 0.359
4.836GlyGly: 4.836 ± 0.695
0.777GlyHis: 0.777 ± 0.203
5.526GlyIle: 5.526 ± 0.652
4.922GlyLys: 4.922 ± 0.513
5.44GlyLeu: 5.44 ± 0.592
1.123GlyMet: 1.123 ± 0.24
2.936GlyAsn: 2.936 ± 0.454
0.0GlyPro: 0.0 ± 0.0
2.849GlyGln: 2.849 ± 0.48
3.109GlyArg: 3.109 ± 0.559
3.195GlySer: 3.195 ± 0.547
3.195GlyThr: 3.195 ± 0.629
4.836GlyVal: 4.836 ± 0.627
1.382GlyTrp: 1.382 ± 0.294
2.245GlyTyr: 2.245 ± 0.489
0.0GlyXaa: 0.0 ± 0.0
His
2.677HisAla: 2.677 ± 0.789
0.259HisCys: 0.259 ± 0.143
1.813HisAsp: 1.813 ± 0.354
1.554HisGlu: 1.554 ± 0.286
0.863HisPhe: 0.863 ± 0.27
1.554HisGly: 1.554 ± 0.476
0.691HisHis: 0.691 ± 0.431
1.295HisIle: 1.295 ± 0.345
1.641HisLys: 1.641 ± 0.401
1.986HisLeu: 1.986 ± 0.517
0.432HisMet: 0.432 ± 0.205
1.123HisAsn: 1.123 ± 0.323
0.95HisPro: 0.95 ± 0.32
1.209HisGln: 1.209 ± 0.312
1.123HisArg: 1.123 ± 0.354
1.382HisSer: 1.382 ± 0.353
1.727HisThr: 1.727 ± 0.486
1.209HisVal: 1.209 ± 0.302
0.086HisTrp: 0.086 ± 0.075
0.518HisTyr: 0.518 ± 0.226
0.0HisXaa: 0.0 ± 0.0
Ile
5.785IleAla: 5.785 ± 0.703
0.691IleCys: 0.691 ± 0.344
5.267IleAsp: 5.267 ± 0.74
3.886IleGlu: 3.886 ± 0.658
1.813IlePhe: 1.813 ± 0.423
4.49IleGly: 4.49 ± 0.562
1.209IleHis: 1.209 ± 0.445
4.231IleIle: 4.231 ± 0.716
5.785IleLys: 5.785 ± 0.827
3.972IleLeu: 3.972 ± 0.739
1.209IleMet: 1.209 ± 0.403
5.785IleAsn: 5.785 ± 1.208
1.813IlePro: 1.813 ± 0.375
2.504IleGln: 2.504 ± 0.328
3.281IleArg: 3.281 ± 0.532
5.181IleSer: 5.181 ± 0.899
6.044IleThr: 6.044 ± 0.848
3.886IleVal: 3.886 ± 0.492
0.345IleTrp: 0.345 ± 0.202
2.504IleTyr: 2.504 ± 0.485
0.0IleXaa: 0.0 ± 0.0
Lys
6.649LysAla: 6.649 ± 0.777
0.95LysCys: 0.95 ± 0.242
3.713LysAsp: 3.713 ± 0.534
3.627LysGlu: 3.627 ± 0.571
1.9LysPhe: 1.9 ± 0.38
3.368LysGly: 3.368 ± 0.438
1.727LysHis: 1.727 ± 0.379
4.663LysIle: 4.663 ± 0.615
3.972LysLys: 3.972 ± 0.656
6.217LysLeu: 6.217 ± 0.628
2.245LysMet: 2.245 ± 0.527
2.504LysAsn: 2.504 ± 0.455
3.195LysPro: 3.195 ± 0.605
4.317LysGln: 4.317 ± 0.546
3.368LysArg: 3.368 ± 0.665
5.354LysSer: 5.354 ± 0.706
4.922LysThr: 4.922 ± 0.781
4.058LysVal: 4.058 ± 0.626
0.604LysTrp: 0.604 ± 0.2
1.9LysTyr: 1.9 ± 0.276
0.0LysXaa: 0.0 ± 0.0
Leu
7.944LeuAla: 7.944 ± 1.18
0.604LeuCys: 0.604 ± 0.25
6.131LeuAsp: 6.131 ± 0.82
3.627LeuGlu: 3.627 ± 0.544
2.072LeuPhe: 2.072 ± 0.455
5.267LeuGly: 5.267 ± 0.883
1.9LeuHis: 1.9 ± 0.558
5.526LeuIle: 5.526 ± 0.874
5.613LeuLys: 5.613 ± 0.6
5.267LeuLeu: 5.267 ± 0.647
1.554LeuMet: 1.554 ± 0.326
5.613LeuAsn: 5.613 ± 0.783
3.022LeuPro: 3.022 ± 0.528
3.886LeuGln: 3.886 ± 0.419
2.763LeuArg: 2.763 ± 0.451
6.822LeuSer: 6.822 ± 0.809
5.872LeuThr: 5.872 ± 0.86
5.008LeuVal: 5.008 ± 0.716
1.209LeuTrp: 1.209 ± 0.262
3.109LeuTyr: 3.109 ± 0.41
0.0LeuXaa: 0.0 ± 0.0
Met
2.418MetAla: 2.418 ± 0.553
0.086MetCys: 0.086 ± 0.087
0.518MetAsp: 0.518 ± 0.181
0.518MetGlu: 0.518 ± 0.204
0.863MetPhe: 0.863 ± 0.217
1.295MetGly: 1.295 ± 0.408
0.345MetHis: 0.345 ± 0.227
1.468MetIle: 1.468 ± 0.369
1.295MetLys: 1.295 ± 0.26
2.59MetLeu: 2.59 ± 0.57
0.777MetMet: 0.777 ± 0.309
1.468MetAsn: 1.468 ± 0.313
1.641MetPro: 1.641 ± 0.416
1.468MetGln: 1.468 ± 0.366
0.863MetArg: 0.863 ± 0.343
2.59MetSer: 2.59 ± 0.614
1.813MetThr: 1.813 ± 0.39
1.295MetVal: 1.295 ± 0.338
0.086MetTrp: 0.086 ± 0.09
0.259MetTyr: 0.259 ± 0.17
0.0MetXaa: 0.0 ± 0.0
Asn
3.972AsnAla: 3.972 ± 0.834
0.345AsnCys: 0.345 ± 0.17
2.245AsnAsp: 2.245 ± 0.446
3.022AsnGlu: 3.022 ± 0.317
1.641AsnPhe: 1.641 ± 0.346
4.058AsnGly: 4.058 ± 0.592
1.295AsnHis: 1.295 ± 0.386
2.331AsnIle: 2.331 ± 0.532
3.281AsnLys: 3.281 ± 0.697
3.713AsnLeu: 3.713 ± 0.59
1.295AsnMet: 1.295 ± 0.33
3.627AsnAsn: 3.627 ± 0.524
2.331AsnPro: 2.331 ± 0.459
2.763AsnGln: 2.763 ± 0.551
2.936AsnArg: 2.936 ± 0.501
4.749AsnSer: 4.749 ± 0.919
3.022AsnThr: 3.022 ± 0.849
1.986AsnVal: 1.986 ± 0.316
0.518AsnTrp: 0.518 ± 0.188
2.245AsnTyr: 2.245 ± 0.365
0.0AsnXaa: 0.0 ± 0.0
Pro
2.418ProAla: 2.418 ± 0.56
0.259ProCys: 0.259 ± 0.137
2.331ProAsp: 2.331 ± 0.535
2.331ProGlu: 2.331 ± 0.695
1.295ProPhe: 1.295 ± 0.36
0.518ProGly: 0.518 ± 0.221
0.518ProHis: 0.518 ± 0.236
2.763ProIle: 2.763 ± 0.417
3.022ProLys: 3.022 ± 0.519
3.454ProLeu: 3.454 ± 0.705
0.345ProMet: 0.345 ± 0.191
2.245ProAsn: 2.245 ± 0.355
1.036ProPro: 1.036 ± 0.286
0.95ProGln: 0.95 ± 0.323
1.986ProArg: 1.986 ± 0.439
2.936ProSer: 2.936 ± 0.575
3.022ProThr: 3.022 ± 0.541
1.813ProVal: 1.813 ± 0.38
0.345ProTrp: 0.345 ± 0.166
0.777ProTyr: 0.777 ± 0.247
0.0ProXaa: 0.0 ± 0.0
Gln
4.49GlnAla: 4.49 ± 0.731
0.432GlnCys: 0.432 ± 0.198
1.986GlnAsp: 1.986 ± 0.467
1.554GlnGlu: 1.554 ± 0.365
1.641GlnPhe: 1.641 ± 0.331
3.022GlnGly: 3.022 ± 0.744
0.95GlnHis: 0.95 ± 0.234
4.145GlnIle: 4.145 ± 0.524
3.627GlnLys: 3.627 ± 0.428
4.145GlnLeu: 4.145 ± 0.672
1.382GlnMet: 1.382 ± 0.396
2.072GlnAsn: 2.072 ± 0.362
1.295GlnPro: 1.295 ± 0.422
1.9GlnGln: 1.9 ± 0.494
2.331GlnArg: 2.331 ± 0.504
3.799GlnSer: 3.799 ± 0.854
4.058GlnThr: 4.058 ± 0.635
2.59GlnVal: 2.59 ± 0.412
0.691GlnTrp: 0.691 ± 0.226
1.9GlnTyr: 1.9 ± 0.451
0.0GlnXaa: 0.0 ± 0.0
Arg
4.49ArgAla: 4.49 ± 0.917
0.432ArgCys: 0.432 ± 0.189
2.159ArgAsp: 2.159 ± 0.399
2.072ArgGlu: 2.072 ± 0.409
1.641ArgPhe: 1.641 ± 0.376
2.331ArgGly: 2.331 ± 0.436
1.554ArgHis: 1.554 ± 0.303
3.627ArgIle: 3.627 ± 0.637
2.936ArgLys: 2.936 ± 0.673
4.231ArgLeu: 4.231 ± 0.566
1.295ArgMet: 1.295 ± 0.479
1.209ArgAsn: 1.209 ± 0.252
2.245ArgPro: 2.245 ± 0.445
3.195ArgGln: 3.195 ± 0.54
2.677ArgArg: 2.677 ± 0.461
2.331ArgSer: 2.331 ± 0.482
3.627ArgThr: 3.627 ± 0.535
2.331ArgVal: 2.331 ± 0.366
0.604ArgTrp: 0.604 ± 0.188
2.072ArgTyr: 2.072 ± 0.518
0.0ArgXaa: 0.0 ± 0.0
Ser
6.994SerAla: 6.994 ± 0.849
0.345SerCys: 0.345 ± 0.162
4.836SerAsp: 4.836 ± 0.723
4.058SerGlu: 4.058 ± 0.535
2.331SerPhe: 2.331 ± 0.39
4.49SerGly: 4.49 ± 0.727
2.936SerHis: 2.936 ± 0.781
4.058SerIle: 4.058 ± 0.996
3.454SerLys: 3.454 ± 0.619
5.526SerLeu: 5.526 ± 0.893
1.382SerMet: 1.382 ± 0.372
3.799SerAsn: 3.799 ± 0.889
2.418SerPro: 2.418 ± 0.56
3.281SerGln: 3.281 ± 0.53
3.109SerArg: 3.109 ± 0.431
5.267SerSer: 5.267 ± 1.353
3.886SerThr: 3.886 ± 0.506
5.699SerVal: 5.699 ± 0.875
1.468SerTrp: 1.468 ± 0.36
1.554SerTyr: 1.554 ± 0.395
0.0SerXaa: 0.0 ± 0.0
Thr
6.908ThrAla: 6.908 ± 0.874
0.432ThrCys: 0.432 ± 0.195
4.49ThrAsp: 4.49 ± 0.76
3.54ThrGlu: 3.54 ± 0.469
1.468ThrPhe: 1.468 ± 0.349
4.836ThrGly: 4.836 ± 0.579
2.677ThrHis: 2.677 ± 0.51
4.231ThrIle: 4.231 ± 0.525
5.008ThrLys: 5.008 ± 0.84
6.822ThrLeu: 6.822 ± 0.707
1.123ThrMet: 1.123 ± 0.217
2.849ThrAsn: 2.849 ± 0.702
2.849ThrPro: 2.849 ± 0.437
3.022ThrGln: 3.022 ± 0.649
2.159ThrArg: 2.159 ± 0.443
3.886ThrSer: 3.886 ± 0.709
5.181ThrThr: 5.181 ± 0.957
3.627ThrVal: 3.627 ± 0.596
0.691ThrTrp: 0.691 ± 0.243
1.209ThrTyr: 1.209 ± 0.367
0.0ThrXaa: 0.0 ± 0.0
Val
6.217ValAla: 6.217 ± 0.757
0.604ValCys: 0.604 ± 0.228
3.195ValAsp: 3.195 ± 0.667
1.813ValGlu: 1.813 ± 0.526
1.813ValPhe: 1.813 ± 0.422
6.044ValGly: 6.044 ± 0.657
1.295ValHis: 1.295 ± 0.369
3.972ValIle: 3.972 ± 0.568
3.886ValLys: 3.886 ± 0.744
4.145ValLeu: 4.145 ± 0.659
0.863ValMet: 0.863 ± 0.271
2.418ValAsn: 2.418 ± 0.383
2.159ValPro: 2.159 ± 0.381
3.109ValGln: 3.109 ± 0.465
3.195ValArg: 3.195 ± 0.473
5.095ValSer: 5.095 ± 0.738
3.281ValThr: 3.281 ± 0.771
4.317ValVal: 4.317 ± 0.61
0.518ValTrp: 0.518 ± 0.229
2.245ValTyr: 2.245 ± 0.458
0.0ValXaa: 0.0 ± 0.0
Trp
1.209TrpAla: 1.209 ± 0.295
0.345TrpCys: 0.345 ± 0.188
0.777TrpAsp: 0.777 ± 0.247
1.036TrpGlu: 1.036 ± 0.265
0.432TrpPhe: 0.432 ± 0.21
0.518TrpGly: 0.518 ± 0.231
0.259TrpHis: 0.259 ± 0.152
0.259TrpIle: 0.259 ± 0.139
0.518TrpLys: 0.518 ± 0.221
1.468TrpLeu: 1.468 ± 0.326
0.173TrpMet: 0.173 ± 0.132
0.432TrpAsn: 0.432 ± 0.187
0.086TrpPro: 0.086 ± 0.086
1.295TrpGln: 1.295 ± 0.412
0.95TrpArg: 0.95 ± 0.338
0.95TrpSer: 0.95 ± 0.296
0.863TrpThr: 0.863 ± 0.299
1.295TrpVal: 1.295 ± 0.303
0.259TrpTrp: 0.259 ± 0.19
0.604TrpTyr: 0.604 ± 0.225
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.936TyrAla: 2.936 ± 0.47
0.518TyrCys: 0.518 ± 0.202
2.504TyrAsp: 2.504 ± 0.515
1.813TyrGlu: 1.813 ± 0.221
1.036TyrPhe: 1.036 ± 0.308
1.9TyrGly: 1.9 ± 0.401
0.777TyrHis: 0.777 ± 0.303
2.159TyrIle: 2.159 ± 0.425
1.468TyrLys: 1.468 ± 0.355
2.763TyrLeu: 2.763 ± 0.488
0.345TyrMet: 0.345 ± 0.147
1.468TyrAsn: 1.468 ± 0.373
1.641TyrPro: 1.641 ± 0.477
1.813TyrGln: 1.813 ± 0.39
1.9TyrArg: 1.9 ± 0.46
1.9TyrSer: 1.9 ± 0.475
1.813TyrThr: 1.813 ± 0.366
2.331TyrVal: 2.331 ± 0.381
0.259TyrTrp: 0.259 ± 0.151
1.554TyrTyr: 1.554 ± 0.437
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (11582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski