Amino acid dipepetide frequency for Sulfolobus spindle-shaped virus 7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.342AlaAla: 0.342 ± 0.377
0.171AlaCys: 0.171 ± 0.189
1.197AlaAsp: 1.197 ± 0.536
1.71AlaGlu: 1.71 ± 0.559
2.223AlaPhe: 2.223 ± 0.687
4.276AlaGly: 4.276 ± 1.022
0.342AlaHis: 0.342 ± 0.235
4.447AlaIle: 4.447 ± 1.071
3.25AlaLys: 3.25 ± 0.879
5.473AlaLeu: 5.473 ± 0.85
1.197AlaMet: 1.197 ± 0.357
2.565AlaAsn: 2.565 ± 0.691
1.539AlaPro: 1.539 ± 0.435
2.052AlaGln: 2.052 ± 0.593
1.197AlaArg: 1.197 ± 0.439
3.079AlaSer: 3.079 ± 0.956
3.592AlaThr: 3.592 ± 0.822
3.592AlaVal: 3.592 ± 0.72
1.026AlaTrp: 1.026 ± 0.504
2.223AlaTyr: 2.223 ± 0.592
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.342CysAsp: 0.342 ± 0.202
0.171CysGlu: 0.171 ± 0.179
0.684CysPhe: 0.684 ± 0.483
0.513CysGly: 0.513 ± 0.308
0.171CysHis: 0.171 ± 0.163
0.684CysIle: 0.684 ± 0.39
0.342CysLys: 0.342 ± 0.222
0.855CysLeu: 0.855 ± 0.381
0.171CysMet: 0.171 ± 0.182
0.171CysAsn: 0.171 ± 0.161
0.855CysPro: 0.855 ± 0.511
0.171CysGln: 0.171 ± 0.138
0.0CysArg: 0.0 ± 0.0
0.342CysSer: 0.342 ± 0.377
0.171CysThr: 0.171 ± 0.163
0.684CysVal: 0.684 ± 0.348
0.342CysTrp: 0.342 ± 0.248
0.513CysTyr: 0.513 ± 0.244
0.0CysXaa: 0.0 ± 0.0
Asp
2.052AspAla: 2.052 ± 0.731
0.171AspCys: 0.171 ± 0.182
2.223AspAsp: 2.223 ± 0.648
3.421AspGlu: 3.421 ± 0.916
1.71AspPhe: 1.71 ± 0.468
3.763AspGly: 3.763 ± 0.815
1.026AspHis: 1.026 ± 0.41
3.079AspIle: 3.079 ± 0.756
2.052AspLys: 2.052 ± 0.657
2.736AspLeu: 2.736 ± 0.788
0.342AspMet: 0.342 ± 0.286
1.539AspAsn: 1.539 ± 0.506
1.539AspPro: 1.539 ± 0.657
0.513AspGln: 0.513 ± 0.371
2.052AspArg: 2.052 ± 0.602
1.881AspSer: 1.881 ± 0.623
1.026AspThr: 1.026 ± 0.424
2.394AspVal: 2.394 ± 0.655
0.684AspTrp: 0.684 ± 0.292
1.881AspTyr: 1.881 ± 0.605
0.0AspXaa: 0.0 ± 0.0
Glu
3.079GluAla: 3.079 ± 0.847
1.026GluCys: 1.026 ± 0.445
2.223GluAsp: 2.223 ± 0.703
5.986GluGlu: 5.986 ± 1.528
1.881GluPhe: 1.881 ± 0.596
2.907GluGly: 2.907 ± 0.992
0.855GluHis: 0.855 ± 0.331
5.302GluIle: 5.302 ± 1.331
4.96GluLys: 4.96 ± 1.097
7.012GluLeu: 7.012 ± 1.469
2.394GluMet: 2.394 ± 0.697
3.763GluAsn: 3.763 ± 1.15
0.855GluPro: 0.855 ± 0.494
1.71GluGln: 1.71 ± 0.573
2.223GluArg: 2.223 ± 0.786
2.052GluSer: 2.052 ± 0.771
2.907GluThr: 2.907 ± 0.789
4.96GluVal: 4.96 ± 1.121
1.197GluTrp: 1.197 ± 0.478
2.736GluTyr: 2.736 ± 0.807
0.0GluXaa: 0.0 ± 0.0
Phe
1.881PheAla: 1.881 ± 0.468
0.513PheCys: 0.513 ± 0.353
2.394PheAsp: 2.394 ± 0.562
2.394PheGlu: 2.394 ± 0.697
3.079PhePhe: 3.079 ± 0.732
2.736PheGly: 2.736 ± 0.532
0.342PheHis: 0.342 ± 0.22
3.934PheIle: 3.934 ± 0.96
2.736PheLys: 2.736 ± 0.699
3.592PheLeu: 3.592 ± 0.9
1.197PheMet: 1.197 ± 0.452
1.71PheAsn: 1.71 ± 0.54
0.684PhePro: 0.684 ± 0.31
1.197PheGln: 1.197 ± 0.464
1.026PheArg: 1.026 ± 0.38
3.421PheSer: 3.421 ± 0.703
4.447PheThr: 4.447 ± 0.81
4.96PheVal: 4.96 ± 1.263
0.684PheTrp: 0.684 ± 0.364
3.421PheTyr: 3.421 ± 0.885
0.0PheXaa: 0.0 ± 0.0
Gly
2.907GlyAla: 2.907 ± 0.731
0.0GlyCys: 0.0 ± 0.0
1.368GlyAsp: 1.368 ± 0.496
3.079GlyGlu: 3.079 ± 0.948
4.96GlyPhe: 4.96 ± 1.058
3.421GlyGly: 3.421 ± 0.865
0.513GlyHis: 0.513 ± 0.31
4.447GlyIle: 4.447 ± 0.783
5.473GlyLys: 5.473 ± 0.972
6.67GlyLeu: 6.67 ± 1.486
1.368GlyMet: 1.368 ± 0.586
2.052GlyAsn: 2.052 ± 0.601
1.71GlyPro: 1.71 ± 0.754
1.881GlyGln: 1.881 ± 0.822
2.907GlyArg: 2.907 ± 0.729
4.789GlySer: 4.789 ± 1.132
4.105GlyThr: 4.105 ± 1.016
5.302GlyVal: 5.302 ± 0.962
1.197GlyTrp: 1.197 ± 0.319
3.421GlyTyr: 3.421 ± 0.743
0.0GlyXaa: 0.0 ± 0.0
His
0.684HisAla: 0.684 ± 0.308
0.0HisCys: 0.0 ± 0.0
0.171HisAsp: 0.171 ± 0.179
0.342HisGlu: 0.342 ± 0.26
0.684HisPhe: 0.684 ± 0.275
0.513HisGly: 0.513 ± 0.28
0.342HisHis: 0.342 ± 0.242
1.539HisIle: 1.539 ± 0.571
0.513HisLys: 0.513 ± 0.272
1.539HisLeu: 1.539 ± 0.562
0.171HisMet: 0.171 ± 0.153
0.513HisAsn: 0.513 ± 0.345
0.342HisPro: 0.342 ± 0.244
0.513HisGln: 0.513 ± 0.315
0.684HisArg: 0.684 ± 0.421
0.855HisSer: 0.855 ± 0.402
1.197HisThr: 1.197 ± 0.433
1.368HisVal: 1.368 ± 0.504
0.0HisTrp: 0.0 ± 0.0
1.026HisTyr: 1.026 ± 0.287
0.0HisXaa: 0.0 ± 0.0
Ile
3.592IleAla: 3.592 ± 0.577
0.513IleCys: 0.513 ± 0.295
2.223IleAsp: 2.223 ± 0.383
5.131IleGlu: 5.131 ± 1.126
3.934IlePhe: 3.934 ± 0.913
4.276IleGly: 4.276 ± 0.66
1.368IleHis: 1.368 ± 0.47
6.157IleIle: 6.157 ± 1.109
6.499IleLys: 6.499 ± 1.629
7.525IleLeu: 7.525 ± 1.659
2.223IleMet: 2.223 ± 0.552
5.131IleAsn: 5.131 ± 1.155
3.934IlePro: 3.934 ± 0.8
2.907IleGln: 2.907 ± 1.077
5.131IleArg: 5.131 ± 1.163
6.841IleSer: 6.841 ± 1.122
5.986IleThr: 5.986 ± 1.411
5.302IleVal: 5.302 ± 1.047
0.855IleTrp: 0.855 ± 0.402
6.157IleTyr: 6.157 ± 0.912
0.0IleXaa: 0.0 ± 0.0
Lys
3.421LysAla: 3.421 ± 0.706
0.342LysCys: 0.342 ± 0.322
3.934LysAsp: 3.934 ± 1.202
5.131LysGlu: 5.131 ± 1.252
3.763LysPhe: 3.763 ± 0.709
2.565LysGly: 2.565 ± 0.484
1.197LysHis: 1.197 ± 0.354
5.473LysIle: 5.473 ± 1.258
8.722LysLys: 8.722 ± 1.804
8.38LysLeu: 8.38 ± 1.425
2.565LysMet: 2.565 ± 0.642
1.881LysAsn: 1.881 ± 0.528
1.368LysPro: 1.368 ± 0.562
3.079LysGln: 3.079 ± 0.659
2.223LysArg: 2.223 ± 0.654
4.96LysSer: 4.96 ± 1.136
5.644LysThr: 5.644 ± 0.775
4.105LysVal: 4.105 ± 0.694
1.368LysTrp: 1.368 ± 0.492
3.421LysTyr: 3.421 ± 0.768
0.0LysXaa: 0.0 ± 0.0
Leu
4.96LeuAla: 4.96 ± 0.711
0.513LeuCys: 0.513 ± 0.293
4.105LeuAsp: 4.105 ± 1.115
5.302LeuGlu: 5.302 ± 1.278
4.789LeuPhe: 4.789 ± 1.167
5.815LeuGly: 5.815 ± 1.127
0.855LeuHis: 0.855 ± 0.388
8.893LeuIle: 8.893 ± 1.572
6.841LeuLys: 6.841 ± 1.43
11.117LeuLeu: 11.117 ± 1.449
3.079LeuMet: 3.079 ± 0.824
6.841LeuAsn: 6.841 ± 1.18
4.447LeuPro: 4.447 ± 0.854
2.907LeuGln: 2.907 ± 0.775
5.302LeuArg: 5.302 ± 1.055
8.038LeuSer: 8.038 ± 0.958
6.499LeuThr: 6.499 ± 1.104
5.815LeuVal: 5.815 ± 1.408
1.368LeuTrp: 1.368 ± 0.534
5.644LeuTyr: 5.644 ± 0.998
0.0LeuXaa: 0.0 ± 0.0
Met
1.368MetAla: 1.368 ± 0.542
0.342MetCys: 0.342 ± 0.255
0.684MetAsp: 0.684 ± 0.42
1.539MetGlu: 1.539 ± 0.563
1.197MetPhe: 1.197 ± 0.48
2.394MetGly: 2.394 ± 0.609
0.342MetHis: 0.342 ± 0.227
2.052MetIle: 2.052 ± 0.44
1.881MetLys: 1.881 ± 0.576
2.565MetLeu: 2.565 ± 0.636
1.026MetMet: 1.026 ± 0.458
0.684MetAsn: 0.684 ± 0.281
0.684MetPro: 0.684 ± 0.388
0.342MetGln: 0.342 ± 0.209
2.052MetArg: 2.052 ± 0.595
1.539MetSer: 1.539 ± 0.498
1.539MetThr: 1.539 ± 0.462
1.368MetVal: 1.368 ± 0.577
0.171MetTrp: 0.171 ± 0.15
0.684MetTyr: 0.684 ± 0.375
0.0MetXaa: 0.0 ± 0.0
Asn
3.421AsnAla: 3.421 ± 0.773
0.171AsnCys: 0.171 ± 0.162
1.71AsnAsp: 1.71 ± 0.62
2.736AsnGlu: 2.736 ± 0.691
2.565AsnPhe: 2.565 ± 0.561
4.618AsnGly: 4.618 ± 1.257
0.513AsnHis: 0.513 ± 0.269
4.96AsnIle: 4.96 ± 1.361
2.223AsnLys: 2.223 ± 0.417
3.421AsnLeu: 3.421 ± 0.739
0.342AsnMet: 0.342 ± 0.236
4.105AsnAsn: 4.105 ± 0.836
2.394AsnPro: 2.394 ± 0.583
2.736AsnGln: 2.736 ± 0.707
2.052AsnArg: 2.052 ± 0.558
3.592AsnSer: 3.592 ± 0.921
3.25AsnThr: 3.25 ± 0.919
3.934AsnVal: 3.934 ± 1.148
1.026AsnTrp: 1.026 ± 0.315
3.25AsnTyr: 3.25 ± 0.801
0.0AsnXaa: 0.0 ± 0.0
Pro
2.052ProAla: 2.052 ± 0.621
0.0ProCys: 0.0 ± 0.0
1.026ProAsp: 1.026 ± 0.431
2.052ProGlu: 2.052 ± 0.545
2.223ProPhe: 2.223 ± 0.563
1.881ProGly: 1.881 ± 0.614
0.684ProHis: 0.684 ± 0.347
1.881ProIle: 1.881 ± 0.629
2.907ProLys: 2.907 ± 0.769
2.736ProLeu: 2.736 ± 0.666
0.513ProMet: 0.513 ± 0.295
2.223ProAsn: 2.223 ± 0.457
2.223ProPro: 2.223 ± 0.944
1.71ProGln: 1.71 ± 0.609
0.684ProArg: 0.684 ± 0.328
2.736ProSer: 2.736 ± 0.655
3.079ProThr: 3.079 ± 0.846
2.223ProVal: 2.223 ± 0.651
0.684ProTrp: 0.684 ± 0.477
1.881ProTyr: 1.881 ± 0.609
0.0ProXaa: 0.0 ± 0.0
Gln
0.855GlnAla: 0.855 ± 0.304
0.342GlnCys: 0.342 ± 0.2
0.684GlnAsp: 0.684 ± 0.267
3.079GlnGlu: 3.079 ± 1.023
2.052GlnPhe: 2.052 ± 0.842
1.71GlnGly: 1.71 ± 0.506
0.684GlnHis: 0.684 ± 0.379
5.131GlnIle: 5.131 ± 1.062
2.394GlnLys: 2.394 ± 0.626
3.25GlnLeu: 3.25 ± 0.867
0.684GlnMet: 0.684 ± 0.291
2.052GlnAsn: 2.052 ± 0.489
1.368GlnPro: 1.368 ± 0.742
0.684GlnGln: 0.684 ± 0.349
0.684GlnArg: 0.684 ± 0.26
1.026GlnSer: 1.026 ± 0.412
1.197GlnThr: 1.197 ± 0.37
2.736GlnVal: 2.736 ± 0.785
0.342GlnTrp: 0.342 ± 0.204
1.368GlnTyr: 1.368 ± 0.726
0.0GlnXaa: 0.0 ± 0.0
Arg
1.71ArgAla: 1.71 ± 0.497
0.171ArgCys: 0.171 ± 0.153
3.763ArgAsp: 3.763 ± 0.924
3.079ArgGlu: 3.079 ± 0.819
1.197ArgPhe: 1.197 ± 0.547
2.223ArgGly: 2.223 ± 0.762
0.513ArgHis: 0.513 ± 0.302
3.25ArgIle: 3.25 ± 0.868
4.789ArgLys: 4.789 ± 1.005
3.934ArgLeu: 3.934 ± 0.863
0.513ArgMet: 0.513 ± 0.312
2.394ArgAsn: 2.394 ± 0.692
1.026ArgPro: 1.026 ± 0.642
1.539ArgGln: 1.539 ± 0.569
2.736ArgArg: 2.736 ± 0.737
1.368ArgSer: 1.368 ± 0.605
1.881ArgThr: 1.881 ± 0.716
2.565ArgVal: 2.565 ± 0.693
0.513ArgTrp: 0.513 ± 0.345
1.197ArgTyr: 1.197 ± 0.476
0.0ArgXaa: 0.0 ± 0.0
Ser
3.25SerAla: 3.25 ± 0.834
0.171SerCys: 0.171 ± 0.162
1.881SerAsp: 1.881 ± 0.449
4.276SerGlu: 4.276 ± 1.181
3.25SerPhe: 3.25 ± 0.596
4.618SerGly: 4.618 ± 0.864
0.855SerHis: 0.855 ± 0.484
5.473SerIle: 5.473 ± 1.352
4.276SerLys: 4.276 ± 0.781
6.157SerLeu: 6.157 ± 1.043
1.197SerMet: 1.197 ± 0.487
4.447SerAsn: 4.447 ± 0.833
2.736SerPro: 2.736 ± 0.624
3.079SerGln: 3.079 ± 0.48
2.223SerArg: 2.223 ± 0.561
7.696SerSer: 7.696 ± 1.835
4.789SerThr: 4.789 ± 1.17
5.473SerVal: 5.473 ± 1.09
0.855SerTrp: 0.855 ± 0.29
3.934SerTyr: 3.934 ± 0.805
0.0SerXaa: 0.0 ± 0.0
Thr
3.763ThrAla: 3.763 ± 0.993
0.342ThrCys: 0.342 ± 0.222
2.223ThrAsp: 2.223 ± 0.643
3.934ThrGlu: 3.934 ± 1.154
1.881ThrPhe: 1.881 ± 0.567
4.105ThrGly: 4.105 ± 1.093
1.197ThrHis: 1.197 ± 0.479
6.499ThrIle: 6.499 ± 1.612
3.421ThrLys: 3.421 ± 0.797
9.236ThrLeu: 9.236 ± 1.097
1.881ThrMet: 1.881 ± 0.723
3.421ThrAsn: 3.421 ± 1.126
2.736ThrPro: 2.736 ± 0.647
2.052ThrGln: 2.052 ± 0.795
2.223ThrArg: 2.223 ± 0.821
4.618ThrSer: 4.618 ± 0.739
6.157ThrThr: 6.157 ± 1.908
4.96ThrVal: 4.96 ± 1.012
0.342ThrTrp: 0.342 ± 0.3
4.105ThrTyr: 4.105 ± 0.872
0.0ThrXaa: 0.0 ± 0.0
Val
3.25ValAla: 3.25 ± 0.639
1.368ValCys: 1.368 ± 0.565
1.71ValAsp: 1.71 ± 0.697
2.565ValGlu: 2.565 ± 0.642
2.052ValPhe: 2.052 ± 0.488
5.815ValGly: 5.815 ± 1.095
0.684ValHis: 0.684 ± 0.356
6.157ValIle: 6.157 ± 1.325
5.815ValLys: 5.815 ± 0.975
8.038ValLeu: 8.038 ± 1.377
1.368ValMet: 1.368 ± 0.656
3.934ValAsn: 3.934 ± 1.088
2.565ValPro: 2.565 ± 0.646
1.71ValGln: 1.71 ± 0.513
2.394ValArg: 2.394 ± 0.579
6.328ValSer: 6.328 ± 1.162
7.012ValThr: 7.012 ± 1.173
4.96ValVal: 4.96 ± 1.031
1.539ValTrp: 1.539 ± 0.439
3.763ValTyr: 3.763 ± 0.724
0.0ValXaa: 0.0 ± 0.0
Trp
0.684TrpAla: 0.684 ± 0.362
0.0TrpCys: 0.0 ± 0.0
0.342TrpAsp: 0.342 ± 0.207
1.026TrpGlu: 1.026 ± 0.387
0.684TrpPhe: 0.684 ± 0.29
1.026TrpGly: 1.026 ± 0.486
0.0TrpHis: 0.0 ± 0.0
0.684TrpIle: 0.684 ± 0.254
1.197TrpLys: 1.197 ± 0.602
2.394TrpLeu: 2.394 ± 0.541
0.684TrpMet: 0.684 ± 0.376
0.342TrpAsn: 0.342 ± 0.222
0.342TrpPro: 0.342 ± 0.258
0.342TrpGln: 0.342 ± 0.231
0.342TrpArg: 0.342 ± 0.272
1.026TrpSer: 1.026 ± 0.518
1.026TrpThr: 1.026 ± 0.452
1.197TrpVal: 1.197 ± 0.365
0.0TrpTrp: 0.0 ± 0.0
1.539TrpTyr: 1.539 ± 0.621
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.223TyrAla: 2.223 ± 0.592
1.026TyrCys: 1.026 ± 0.445
1.881TyrAsp: 1.881 ± 0.675
3.25TyrGlu: 3.25 ± 0.736
1.539TyrPhe: 1.539 ± 0.438
2.394TyrGly: 2.394 ± 0.723
0.513TyrHis: 0.513 ± 0.281
5.644TyrIle: 5.644 ± 1.292
3.25TyrLys: 3.25 ± 0.785
6.499TyrLeu: 6.499 ± 0.946
1.368TyrMet: 1.368 ± 0.501
3.25TyrAsn: 3.25 ± 0.868
2.052TyrPro: 2.052 ± 0.914
1.197TyrGln: 1.197 ± 0.307
2.223TyrArg: 2.223 ± 0.576
4.447TyrSer: 4.447 ± 1.086
3.592TyrThr: 3.592 ± 0.791
5.131TyrVal: 5.131 ± 0.872
0.684TyrTrp: 0.684 ± 0.359
2.565TyrTyr: 2.565 ± 0.684
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 33 proteins (5848 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski