Amino acid dipepetide frequency for East African cassava mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.005AlaAla: 1.005 ± 0.768
1.005AlaCys: 1.005 ± 0.859
2.01AlaAsp: 2.01 ± 1.537
4.02AlaGlu: 4.02 ± 3.583
1.005AlaPhe: 1.005 ± 0.91
2.01AlaGly: 2.01 ± 0.836
1.005AlaHis: 1.005 ± 1.065
1.005AlaIle: 1.005 ± 0.768
3.015AlaLys: 3.015 ± 1.403
6.03AlaLeu: 6.03 ± 2.222
0.0AlaMet: 0.0 ± 0.0
2.01AlaAsn: 2.01 ± 0.836
4.02AlaPro: 4.02 ± 0.931
5.025AlaGln: 5.025 ± 2.055
5.025AlaArg: 5.025 ± 2.678
4.02AlaSer: 4.02 ± 2.041
4.02AlaThr: 4.02 ± 2.607
3.015AlaVal: 3.015 ± 1.717
1.005AlaTrp: 1.005 ± 0.768
1.005AlaTyr: 1.005 ± 0.768
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
2.01CysCys: 2.01 ± 2.131
0.0CysAsp: 0.0 ± 0.0
2.01CysGlu: 2.01 ± 1.244
0.0CysPhe: 0.0 ± 0.0
2.01CysGly: 2.01 ± 1.066
1.005CysHis: 1.005 ± 1.218
2.01CysIle: 2.01 ± 1.067
1.005CysLys: 1.005 ± 0.859
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
1.005CysAsn: 1.005 ± 0.768
5.025CysPro: 5.025 ± 3.721
0.0CysGln: 0.0 ± 0.0
1.005CysArg: 1.005 ± 0.768
5.025CysSer: 5.025 ± 2.37
1.005CysThr: 1.005 ± 0.859
2.01CysVal: 2.01 ± 1.717
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
5.025AspAla: 5.025 ± 1.54
0.0AspCys: 0.0 ± 0.0
3.015AspAsp: 3.015 ± 1.357
2.01AspGlu: 2.01 ± 0.836
3.015AspPhe: 3.015 ± 1.717
1.005AspGly: 1.005 ± 0.768
0.0AspHis: 0.0 ± 0.0
2.01AspIle: 2.01 ± 1.067
1.005AspLys: 1.005 ± 0.768
7.035AspLeu: 7.035 ± 1.426
0.0AspMet: 0.0 ± 0.0
1.005AspAsn: 1.005 ± 0.859
4.02AspPro: 4.02 ± 1.519
2.01AspGln: 2.01 ± 0.836
3.015AspArg: 3.015 ± 0.906
3.015AspSer: 3.015 ± 0.885
2.01AspThr: 2.01 ± 1.53
7.035AspVal: 7.035 ± 1.708
1.005AspTrp: 1.005 ± 0.768
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
5.025GluAla: 5.025 ± 2.908
1.005GluCys: 1.005 ± 0.859
1.005GluAsp: 1.005 ± 0.768
4.02GluGlu: 4.02 ± 1.519
2.01GluPhe: 2.01 ± 1.537
3.015GluGly: 3.015 ± 1.357
1.005GluHis: 1.005 ± 1.218
4.02GluIle: 4.02 ± 1.57
3.015GluLys: 3.015 ± 1.58
3.015GluLeu: 3.015 ± 1.414
0.0GluMet: 0.0 ± 0.0
4.02GluAsn: 4.02 ± 2.311
4.02GluPro: 4.02 ± 1.133
3.015GluGln: 3.015 ± 1.853
0.0GluArg: 0.0 ± 0.0
1.005GluSer: 1.005 ± 1.065
2.01GluThr: 2.01 ± 1.419
2.01GluVal: 2.01 ± 1.035
1.005GluTrp: 1.005 ± 1.218
3.015GluTyr: 3.015 ± 1.938
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
1.005PheCys: 1.005 ± 0.859
3.015PheAsp: 3.015 ± 1.511
1.005PheGlu: 1.005 ± 0.91
4.02PhePhe: 4.02 ± 1.672
1.005PheGly: 1.005 ± 0.859
3.015PheHis: 3.015 ± 1.403
4.02PheIle: 4.02 ± 2.258
2.01PheLys: 2.01 ± 1.035
6.03PheLeu: 6.03 ± 2.222
2.01PheMet: 2.01 ± 1.035
4.02PheAsn: 4.02 ± 2.629
1.005PhePro: 1.005 ± 1.065
4.02PheGln: 4.02 ± 1.995
2.01PheArg: 2.01 ± 1.244
3.015PheSer: 3.015 ± 1.791
2.01PheThr: 2.01 ± 1.066
0.0PheVal: 0.0 ± 0.0
0.0PheTrp: 0.0 ± 0.0
3.015PheTyr: 3.015 ± 1.71
0.0PheXaa: 0.0 ± 0.0
Gly
6.03GlyAla: 6.03 ± 2.371
2.01GlyCys: 2.01 ± 1.327
3.015GlyAsp: 3.015 ± 0.885
3.015GlyGlu: 3.015 ± 1.58
3.015GlyPhe: 3.015 ± 1.977
3.015GlyGly: 3.015 ± 1.357
1.005GlyHis: 1.005 ± 0.768
3.015GlyIle: 3.015 ± 1.357
5.025GlyLys: 5.025 ± 2.286
0.0GlyLeu: 0.0 ± 0.0
1.005GlyMet: 1.005 ± 0.859
1.005GlyAsn: 1.005 ± 0.859
5.025GlyPro: 5.025 ± 2.286
3.015GlyGln: 3.015 ± 0.906
1.005GlyArg: 1.005 ± 0.768
1.005GlySer: 1.005 ± 0.859
2.01GlyThr: 2.01 ± 1.731
1.005GlyVal: 1.005 ± 1.065
1.005GlyTrp: 1.005 ± 0.768
1.005GlyTyr: 1.005 ± 1.218
0.0GlyXaa: 0.0 ± 0.0
His
1.005HisAla: 1.005 ± 0.859
3.015HisCys: 3.015 ± 1.977
4.02HisAsp: 4.02 ± 3.061
2.01HisGlu: 2.01 ± 1.327
1.005HisPhe: 1.005 ± 0.768
2.01HisGly: 2.01 ± 1.731
3.015HisHis: 3.015 ± 2.398
1.005HisIle: 1.005 ± 1.218
1.005HisLys: 1.005 ± 0.91
4.02HisLeu: 4.02 ± 1.451
0.0HisMet: 0.0 ± 0.0
4.02HisAsn: 4.02 ± 1.46
2.01HisPro: 2.01 ± 1.035
2.01HisGln: 2.01 ± 1.244
4.02HisArg: 4.02 ± 3.565
1.005HisSer: 1.005 ± 1.218
3.015HisThr: 3.015 ± 2.576
2.01HisVal: 2.01 ± 1.244
0.0HisTrp: 0.0 ± 0.0
1.005HisTyr: 1.005 ± 0.768
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
0.0IleCys: 0.0 ± 0.0
3.015IleAsp: 3.015 ± 1.283
3.015IleGlu: 3.015 ± 1.58
5.025IlePhe: 5.025 ± 1.949
1.005IleGly: 1.005 ± 1.065
2.01IleHis: 2.01 ± 1.327
5.025IleIle: 5.025 ± 1.787
7.035IleLys: 7.035 ± 1.995
4.02IleLeu: 4.02 ± 2.069
0.0IleMet: 0.0 ± 0.0
3.015IleAsn: 3.015 ± 0.885
2.01IlePro: 2.01 ± 1.035
6.03IleGln: 6.03 ± 2.187
5.025IleArg: 5.025 ± 0.851
4.02IleSer: 4.02 ± 2.041
3.015IleThr: 3.015 ± 0.868
2.01IleVal: 2.01 ± 0.836
4.02IleTrp: 4.02 ± 1.86
7.035IleTyr: 7.035 ± 2.351
0.0IleXaa: 0.0 ± 0.0
Lys
2.01LysAla: 2.01 ± 1.066
0.0LysCys: 0.0 ± 0.0
1.005LysAsp: 1.005 ± 0.768
6.03LysGlu: 6.03 ± 2.222
2.01LysPhe: 2.01 ± 0.836
4.02LysGly: 4.02 ± 1.244
2.01LysHis: 2.01 ± 0.836
5.025LysIle: 5.025 ± 1.25
1.005LysLys: 1.005 ± 0.859
1.005LysLeu: 1.005 ± 1.218
0.0LysMet: 0.0 ± 0.0
7.035LysAsn: 7.035 ± 2.44
4.02LysPro: 4.02 ± 0.963
2.01LysGln: 2.01 ± 1.244
3.015LysArg: 3.015 ± 2.576
7.035LysSer: 7.035 ± 1.995
2.01LysThr: 2.01 ± 1.035
2.01LysVal: 2.01 ± 1.717
0.0LysTrp: 0.0 ± 0.0
3.015LysTyr: 3.015 ± 0.906
0.0LysXaa: 0.0 ± 0.0
Leu
2.01LeuAla: 2.01 ± 1.019
3.015LeuCys: 3.015 ± 1.58
3.015LeuAsp: 3.015 ± 2.305
3.015LeuGlu: 3.015 ± 0.906
3.015LeuPhe: 3.015 ± 1.403
2.01LeuGly: 2.01 ± 0.836
3.015LeuHis: 3.015 ± 1.977
5.025LeuIle: 5.025 ± 3.27
3.015LeuLys: 3.015 ± 2.305
5.025LeuLeu: 5.025 ± 2.74
1.005LeuMet: 1.005 ± 0.954
6.03LeuAsn: 6.03 ± 2.06
0.0LeuPro: 0.0 ± 0.0
3.015LeuGln: 3.015 ± 1.403
5.025LeuArg: 5.025 ± 2.503
7.035LeuSer: 7.035 ± 2.946
2.01LeuThr: 2.01 ± 1.537
2.01LeuVal: 2.01 ± 1.067
0.0LeuTrp: 0.0 ± 0.0
3.015LeuTyr: 3.015 ± 1.48
0.0LeuXaa: 0.0 ± 0.0
Met
1.005MetAla: 1.005 ± 0.859
0.0MetCys: 0.0 ± 0.0
2.01MetAsp: 2.01 ± 1.067
0.0MetGlu: 0.0 ± 0.0
3.015MetPhe: 3.015 ± 1.71
3.015MetGly: 3.015 ± 1.401
1.005MetHis: 1.005 ± 0.91
1.005MetIle: 1.005 ± 0.91
0.0MetLys: 0.0 ± 0.0
1.005MetLeu: 1.005 ± 1.065
1.005MetMet: 1.005 ± 0.91
1.005MetAsn: 1.005 ± 0.91
1.005MetPro: 1.005 ± 0.768
0.0MetGln: 0.0 ± 0.0
1.005MetArg: 1.005 ± 1.218
1.005MetSer: 1.005 ± 0.859
0.0MetThr: 0.0 ± 0.0
1.005MetVal: 1.005 ± 0.859
2.01MetTrp: 2.01 ± 1.019
4.02MetTyr: 4.02 ± 2.311
0.0MetXaa: 0.0 ± 0.0
Asn
5.025AsnAla: 5.025 ± 2.769
1.005AsnCys: 1.005 ± 1.218
3.015AsnAsp: 3.015 ± 0.906
1.005AsnGlu: 1.005 ± 0.859
1.005AsnPhe: 1.005 ± 0.859
1.005AsnGly: 1.005 ± 0.91
7.035AsnHis: 7.035 ± 3.376
5.025AsnIle: 5.025 ± 1.877
2.01AsnLys: 2.01 ± 1.327
3.015AsnLeu: 3.015 ± 1.253
4.02AsnMet: 4.02 ± 1.792
3.015AsnAsn: 3.015 ± 1.414
4.02AsnPro: 4.02 ± 0.931
0.0AsnGln: 0.0 ± 0.0
3.015AsnArg: 3.015 ± 1.71
3.015AsnSer: 3.015 ± 1.58
2.01AsnThr: 2.01 ± 1.019
3.015AsnVal: 3.015 ± 1.457
1.005AsnTrp: 1.005 ± 0.768
5.025AsnTyr: 5.025 ± 2.781
0.0AsnXaa: 0.0 ± 0.0
Pro
1.005ProAla: 1.005 ± 0.768
3.015ProCys: 3.015 ± 0.906
3.015ProAsp: 3.015 ± 1.48
3.015ProGlu: 3.015 ± 1.253
3.015ProPhe: 3.015 ± 1.791
2.01ProGly: 2.01 ± 0.836
3.015ProHis: 3.015 ± 1.457
5.025ProIle: 5.025 ± 2.249
5.025ProLys: 5.025 ± 1.441
3.015ProLeu: 3.015 ± 1.253
3.015ProMet: 3.015 ± 0.885
3.015ProAsn: 3.015 ± 1.58
3.015ProPro: 3.015 ± 2.156
6.03ProGln: 6.03 ± 3.162
8.04ProArg: 8.04 ± 2.197
5.025ProSer: 5.025 ± 1.25
4.02ProThr: 4.02 ± 1.672
2.01ProVal: 2.01 ± 1.717
1.005ProTrp: 1.005 ± 0.768
2.01ProTyr: 2.01 ± 1.717
0.0ProXaa: 0.0 ± 0.0
Gln
7.035GlnAla: 7.035 ± 2.312
0.0GlnCys: 0.0 ± 0.0
2.01GlnAsp: 2.01 ± 1.244
3.015GlnGlu: 3.015 ± 2.151
2.01GlnPhe: 2.01 ± 1.537
2.01GlnGly: 2.01 ± 1.019
2.01GlnHis: 2.01 ± 1.066
4.02GlnIle: 4.02 ± 2.258
2.01GlnLys: 2.01 ± 1.731
3.015GlnLeu: 3.015 ± 2.156
0.0GlnMet: 0.0 ± 0.0
5.025GlnAsn: 5.025 ± 2.635
3.015GlnPro: 3.015 ± 1.717
3.015GlnGln: 3.015 ± 2.798
2.01GlnArg: 2.01 ± 0.836
4.02GlnSer: 4.02 ± 0.993
2.01GlnThr: 2.01 ± 1.066
6.03GlnVal: 6.03 ± 2.714
0.0GlnTrp: 0.0 ± 0.0
2.01GlnTyr: 2.01 ± 1.067
0.0GlnXaa: 0.0 ± 0.0
Arg
2.01ArgAla: 2.01 ± 1.066
5.025ArgCys: 5.025 ± 2.014
5.025ArgAsp: 5.025 ± 2.131
0.0ArgGlu: 0.0 ± 0.0
5.025ArgPhe: 5.025 ± 1.441
4.02ArgGly: 4.02 ± 1.133
3.015ArgHis: 3.015 ± 2.798
6.03ArgIle: 6.03 ± 2.247
2.01ArgLys: 2.01 ± 1.717
1.005ArgLeu: 1.005 ± 0.859
3.015ArgMet: 3.015 ± 1.71
1.005ArgAsn: 1.005 ± 0.91
5.025ArgPro: 5.025 ± 2.286
3.015ArgGln: 3.015 ± 1.401
11.055ArgArg: 11.055 ± 2.892
7.035ArgSer: 7.035 ± 1.019
4.02ArgThr: 4.02 ± 2.07
4.02ArgVal: 4.02 ± 2.311
0.0ArgTrp: 0.0 ± 0.0
2.01ArgTyr: 2.01 ± 1.731
0.0ArgXaa: 0.0 ± 0.0
Ser
4.02SerAla: 4.02 ± 0.993
1.005SerCys: 1.005 ± 1.218
3.015SerAsp: 3.015 ± 1.357
3.015SerGlu: 3.015 ± 1.457
2.01SerPhe: 2.01 ± 1.537
3.015SerGly: 3.015 ± 1.511
1.005SerHis: 1.005 ± 1.218
5.025SerIle: 5.025 ± 3.139
6.03SerLys: 6.03 ± 2.016
4.02SerLeu: 4.02 ± 3.073
2.01SerMet: 2.01 ± 1.026
4.02SerAsn: 4.02 ± 2.041
12.06SerPro: 12.06 ± 2.235
3.015SerGln: 3.015 ± 1.403
3.015SerArg: 3.015 ± 1.58
15.075SerSer: 15.075 ± 6.535
3.015SerThr: 3.015 ± 0.868
1.005SerVal: 1.005 ± 1.218
0.0SerTrp: 0.0 ± 0.0
6.03SerTyr: 6.03 ± 1.524
0.0SerXaa: 0.0 ± 0.0
Thr
2.01ThrAla: 2.01 ± 1.067
0.0ThrCys: 0.0 ± 0.0
0.0ThrAsp: 0.0 ± 0.0
2.01ThrGlu: 2.01 ± 0.836
1.005ThrPhe: 1.005 ± 0.91
4.02ThrGly: 4.02 ± 0.931
5.025ThrHis: 5.025 ± 2.66
3.015ThrIle: 3.015 ± 1.357
3.015ThrLys: 3.015 ± 1.403
2.01ThrLeu: 2.01 ± 1.067
1.005ThrMet: 1.005 ± 0.768
4.02ThrAsn: 4.02 ± 1.382
2.01ThrPro: 2.01 ± 1.067
2.01ThrGln: 2.01 ± 1.537
4.02ThrArg: 4.02 ± 2.488
1.005ThrSer: 1.005 ± 0.768
2.01ThrThr: 2.01 ± 0.836
4.02ThrVal: 4.02 ± 2.488
0.0ThrTrp: 0.0 ± 0.0
2.01ThrTyr: 2.01 ± 1.537
0.0ThrXaa: 0.0 ± 0.0
Val
1.005ValAla: 1.005 ± 0.859
2.01ValCys: 2.01 ± 1.537
2.01ValAsp: 2.01 ± 1.537
2.01ValGlu: 2.01 ± 1.419
1.005ValPhe: 1.005 ± 0.859
3.015ValGly: 3.015 ± 1.853
2.01ValHis: 2.01 ± 1.419
1.005ValIle: 1.005 ± 0.768
5.025ValLys: 5.025 ± 2.194
3.015ValLeu: 3.015 ± 0.906
1.005ValMet: 1.005 ± 0.859
0.0ValAsn: 0.0 ± 0.0
3.015ValPro: 3.015 ± 1.357
5.025ValGln: 5.025 ± 2.798
4.02ValArg: 4.02 ± 3.435
6.03ValSer: 6.03 ± 1.813
3.015ValThr: 3.015 ± 2.576
1.005ValVal: 1.005 ± 0.859
1.005ValTrp: 1.005 ± 0.768
2.01ValTyr: 2.01 ± 0.836
0.0ValXaa: 0.0 ± 0.0
Trp
3.015TrpAla: 3.015 ± 1.357
0.0TrpCys: 0.0 ± 0.0
2.01TrpAsp: 2.01 ± 2.131
1.005TrpGlu: 1.005 ± 0.91
0.0TrpPhe: 0.0 ± 0.0
1.005TrpGly: 1.005 ± 0.768
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
1.005TrpMet: 1.005 ± 0.859
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.005TrpGln: 1.005 ± 0.768
2.01TrpArg: 2.01 ± 1.066
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
1.005TrpVal: 1.005 ± 0.768
0.0TrpTrp: 0.0 ± 0.0
1.005TrpTyr: 1.005 ± 0.768
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.015TyrAla: 3.015 ± 1.511
0.0TyrCys: 0.0 ± 0.0
2.01TyrAsp: 2.01 ± 1.244
2.01TyrGlu: 2.01 ± 1.717
4.02TyrPhe: 4.02 ± 1.57
2.01TyrGly: 2.01 ± 0.836
0.0TyrHis: 0.0 ± 0.0
4.02TyrIle: 4.02 ± 0.963
2.01TyrLys: 2.01 ± 0.836
5.025TyrLeu: 5.025 ± 2.055
3.015TyrMet: 3.015 ± 2.001
3.015TyrAsn: 3.015 ± 1.253
4.02TyrPro: 4.02 ± 1.995
1.005TyrGln: 1.005 ± 0.859
6.03TyrArg: 6.03 ± 2.747
3.015TyrSer: 3.015 ± 2.156
1.005TyrThr: 1.005 ± 0.768
2.01TyrVal: 2.01 ± 1.019
0.0TyrTrp: 0.0 ± 0.0
2.01TyrTyr: 2.01 ± 1.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (996 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski