Amino acid dipepetide frequency for Gluconacetobacter sp. SXCC-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.868AlaAla: 15.868 ± 0.144	1.783AlaCys: 1.783 ± 0.047	6.536AlaAsp: 6.536 ± 0.074	5.762AlaGlu: 5.762 ± 0.085	3.857AlaPhe: 3.857 ± 0.065	11.49AlaGly: 11.49 ± 0.136	3.015AlaHis: 3.015 ± 0.059	5.589AlaIle: 5.589 ± 0.073	2.169AlaLys: 2.169 ± 0.05	12.744AlaLeu: 12.744 ± 0.136	3.797AlaMet: 3.797 ± 0.057	2.397AlaAsn: 2.397 ± 0.055	6.392AlaPro: 6.392 ± 0.083	4.375AlaGln: 4.375 ± 0.068	10.478AlaArg: 10.478 ± 0.119	6.128AlaSer: 6.128 ± 0.082	6.813AlaThr: 6.813 ± 0.084	7.897AlaVal: 7.897 ± 0.092	1.753AlaTrp: 1.753 ± 0.038	2.381AlaTyr: 2.381 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.491CysAla: 1.491 ± 0.04	0.218CysCys: 0.218 ± 0.013	0.571CysAsp: 0.571 ± 0.021	0.392CysGlu: 0.392 ± 0.019	0.409CysPhe: 0.409 ± 0.018	1.219CysGly: 1.219 ± 0.034	0.385CysHis: 0.385 ± 0.019	0.539CysIle: 0.539 ± 0.022	0.19CysLys: 0.19 ± 0.013	1.222CysLeu: 1.222 ± 0.036	0.331CysMet: 0.331 ± 0.017	0.293CysAsn: 0.293 ± 0.016	0.759CysPro: 0.759 ± 0.027	0.351CysGln: 0.351 ± 0.018	0.925CysArg: 0.925 ± 0.026	0.607CysSer: 0.607 ± 0.025	0.607CysThr: 0.607 ± 0.023	0.831CysVal: 0.831 ± 0.029	0.148CysTrp: 0.148 ± 0.011	0.24CysTyr: 0.24 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.444AspAla: 6.444 ± 0.083	0.55AspCys: 0.55 ± 0.025	2.867AspAsp: 2.867 ± 0.053	2.712AspGlu: 2.712 ± 0.054	1.846AspPhe: 1.846 ± 0.042	5.084AspGly: 5.084 ± 0.082	1.485AspHis: 1.485 ± 0.037	3.144AspIle: 3.144 ± 0.052	0.952AspLys: 0.952 ± 0.031	5.577AspLeu: 5.577 ± 0.071	1.904AspMet: 1.904 ± 0.04	1.345AspAsn: 1.345 ± 0.039	3.474AspPro: 3.474 ± 0.059	1.563AspGln: 1.563 ± 0.035	4.453AspArg: 4.453 ± 0.061	2.407AspSer: 2.407 ± 0.048	3.09AspThr: 3.09 ± 0.059	4.089AspVal: 4.089 ± 0.062	0.938AspTrp: 0.938 ± 0.028	1.369AspTyr: 1.369 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.677GluAla: 5.677 ± 0.096	0.414GluCys: 0.414 ± 0.02	2.348GluAsp: 2.348 ± 0.047	2.35GluGlu: 2.35 ± 0.059	1.362GluPhe: 1.362 ± 0.038	3.699GluGly: 3.699 ± 0.066	1.227GluHis: 1.227 ± 0.037	2.833GluIle: 2.833 ± 0.056	1.906GluLys: 1.906 ± 0.044	4.248GluLeu: 4.248 ± 0.066	1.36GluMet: 1.36 ± 0.032	1.545GluAsn: 1.545 ± 0.035	1.984GluPro: 1.984 ± 0.047	2.055GluGln: 2.055 ± 0.045	4.075GluArg: 4.075 ± 0.067	2.104GluSer: 2.104 ± 0.043	2.983GluThr: 2.983 ± 0.057	2.729GluVal: 2.729 ± 0.054	0.656GluTrp: 0.656 ± 0.025	0.94GluTyr: 0.94 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.718PheAla: 3.718 ± 0.058	0.518PheCys: 0.518 ± 0.021	2.028PheAsp: 2.028 ± 0.041	1.489PheGlu: 1.489 ± 0.038	1.369PhePhe: 1.369 ± 0.039	3.256PheGly: 3.256 ± 0.059	0.991PheHis: 0.991 ± 0.031	1.631PheIle: 1.631 ± 0.045	0.576PheLys: 0.576 ± 0.026	3.275PheLeu: 3.275 ± 0.053	1.075PheMet: 1.075 ± 0.032	1.012PheAsn: 1.012 ± 0.034	1.744PhePro: 1.744 ± 0.038	0.932PheGln: 0.932 ± 0.03	2.477PheArg: 2.477 ± 0.044	2.421PheSer: 2.421 ± 0.053	1.933PheThr: 1.933 ± 0.038	2.595PheVal: 2.595 ± 0.051	0.502PheTrp: 0.502 ± 0.021	0.908PheTyr: 0.908 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.951GlyAla: 8.951 ± 0.106	1.149GlyCys: 1.149 ± 0.034	3.847GlyAsp: 3.847 ± 0.07	3.702GlyGlu: 3.702 ± 0.052	3.269GlyPhe: 3.269 ± 0.053	7.68GlyGly: 7.68 ± 0.126	2.579GlyHis: 2.579 ± 0.051	4.519GlyIle: 4.519 ± 0.073	2.372GlyLys: 2.372 ± 0.055	9.015GlyLeu: 9.015 ± 0.094	3.144GlyMet: 3.144 ± 0.058	2.378GlyAsn: 2.378 ± 0.061	3.792GlyPro: 3.792 ± 0.067	3.585GlyGln: 3.585 ± 0.059	7.125GlyArg: 7.125 ± 0.091	4.597GlySer: 4.597 ± 0.071	5.385GlyThr: 5.385 ± 0.093	5.994GlyVal: 5.994 ± 0.07	1.511GlyTrp: 1.511 ± 0.033	2.278GlyTyr: 2.278 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	3.603HisAla: 3.603 ± 0.053	0.29HisCys: 0.29 ± 0.016	1.93HisAsp: 1.93 ± 0.042	1.442HisGlu: 1.442 ± 0.04	0.965HisPhe: 0.965 ± 0.033	2.551HisGly: 2.551 ± 0.054	0.824HisHis: 0.824 ± 0.028	1.248HisIle: 1.248 ± 0.034	0.507HisLys: 0.507 ± 0.02	2.383HisLeu: 2.383 ± 0.049	0.783HisMet: 0.783 ± 0.026	0.71HisAsn: 0.71 ± 0.027	1.774HisPro: 1.774 ± 0.037	0.695HisGln: 0.695 ± 0.023	1.707HisArg: 1.707 ± 0.039	1.127HisSer: 1.127 ± 0.027	1.3HisThr: 1.3 ± 0.034	2.101HisVal: 2.101 ± 0.045	0.398HisTrp: 0.398 ± 0.018	0.704HisTyr: 0.704 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.144IleAla: 6.144 ± 0.078	0.569IleCys: 0.569 ± 0.021	2.914IleAsp: 2.914 ± 0.051	2.555IleGlu: 2.555 ± 0.047	1.494IlePhe: 1.494 ± 0.039	4.542IleGly: 4.542 ± 0.074	1.184IleHis: 1.184 ± 0.035	2.238IleIle: 2.238 ± 0.049	0.996IleLys: 0.996 ± 0.03	4.311IleLeu: 4.311 ± 0.064	1.406IleMet: 1.406 ± 0.034	1.419IleAsn: 1.419 ± 0.033	2.575IlePro: 2.575 ± 0.044	1.284IleGln: 1.284 ± 0.033	3.781IleArg: 3.781 ± 0.054	2.943IleSer: 2.943 ± 0.059	3.011IleThr: 3.011 ± 0.063	3.698IleVal: 3.698 ± 0.059	0.632IleTrp: 0.632 ± 0.021	1.024IleTyr: 1.024 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.702LysAla: 2.702 ± 0.058	0.167LysCys: 0.167 ± 0.011	1.24LysAsp: 1.24 ± 0.031	1.116LysGlu: 1.116 ± 0.036	0.666LysPhe: 0.666 ± 0.026	1.952LysGly: 1.952 ± 0.044	0.477LysHis: 0.477 ± 0.021	1.296LysIle: 1.296 ± 0.04	1.033LysLys: 1.033 ± 0.034	2.183LysLeu: 2.183 ± 0.045	0.652LysMet: 0.652 ± 0.025	0.747LysAsn: 0.747 ± 0.031	1.423LysPro: 1.423 ± 0.039	0.783LysGln: 0.783 ± 0.026	1.64LysArg: 1.64 ± 0.04	1.258LysSer: 1.258 ± 0.035	1.559LysThr: 1.559 ± 0.042	1.612LysVal: 1.612 ± 0.052	0.328LysTrp: 0.328 ± 0.02	0.51LysTyr: 0.51 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.801LeuAla: 12.801 ± 0.15	1.3LeuCys: 1.3 ± 0.035	5.82LeuAsp: 5.82 ± 0.081	4.636LeuGlu: 4.636 ± 0.08	3.586LeuPhe: 3.586 ± 0.06	7.721LeuGly: 7.721 ± 0.085	2.784LeuHis: 2.784 ± 0.046	3.951LeuIle: 3.951 ± 0.067	2.525LeuLys: 2.525 ± 0.044	9.614LeuLeu: 9.614 ± 0.123	2.391LeuMet: 2.391 ± 0.039	2.457LeuAsn: 2.457 ± 0.048	6.895LeuPro: 6.895 ± 0.086	2.887LeuGln: 2.887 ± 0.043	7.82LeuArg: 7.82 ± 0.1	6.377LeuSer: 6.377 ± 0.077	5.358LeuThr: 5.358 ± 0.072	7.114LeuVal: 7.114 ± 0.081	1.298LeuTrp: 1.298 ± 0.032	2.17LeuTyr: 2.17 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	4.027MetAla: 4.027 ± 0.062	0.231MetCys: 0.231 ± 0.013	1.513MetAsp: 1.513 ± 0.035	1.333MetGlu: 1.333 ± 0.032	0.763MetPhe: 0.763 ± 0.028	2.304MetGly: 2.304 ± 0.046	0.678MetHis: 0.678 ± 0.023	1.415MetIle: 1.415 ± 0.039	0.941MetLys: 0.941 ± 0.025	3.046MetLeu: 3.046 ± 0.051	0.867MetMet: 0.867 ± 0.028	0.923MetAsn: 0.923 ± 0.029	2.101MetPro: 2.101 ± 0.038	1.106MetGln: 1.106 ± 0.03	2.125MetArg: 2.125 ± 0.044	1.558MetSer: 1.558 ± 0.035	2.173MetThr: 2.173 ± 0.048	2.061MetVal: 2.061 ± 0.041	0.273MetTrp: 0.273 ± 0.014	0.345MetTyr: 0.345 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.096AsnAla: 3.096 ± 0.06	0.268AsnCys: 0.268 ± 0.016	1.351AsnAsp: 1.351 ± 0.031	1.078AsnGlu: 1.078 ± 0.035	0.884AsnPhe: 0.884 ± 0.033	2.441AsnGly: 2.441 ± 0.055	0.661AsnHis: 0.661 ± 0.027	1.474AsnIle: 1.474 ± 0.045	0.541AsnLys: 0.541 ± 0.027	2.338AsnLeu: 2.338 ± 0.045	0.719AsnMet: 0.719 ± 0.025	0.758AsnAsn: 0.758 ± 0.029	1.794AsnPro: 1.794 ± 0.037	0.824AsnGln: 0.824 ± 0.028	2.018AsnArg: 2.018 ± 0.04	1.206AsnSer: 1.206 ± 0.042	1.541AsnThr: 1.541 ± 0.04	1.8AsnVal: 1.8 ± 0.043	0.413AsnTrp: 0.413 ± 0.023	0.645AsnTyr: 0.645 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.104ProAla: 8.104 ± 0.103	0.641ProCys: 0.641 ± 0.026	4.66ProAsp: 4.66 ± 0.073	3.339ProGlu: 3.339 ± 0.055	2.081ProPhe: 2.081 ± 0.043	5.266ProGly: 5.266 ± 0.06	1.561ProHis: 1.561 ± 0.035	1.898ProIle: 1.898 ± 0.043	1.009ProLys: 1.009 ± 0.028	5.116ProLeu: 5.116 ± 0.078	1.521ProMet: 1.521 ± 0.034	1.101ProAsn: 1.101 ± 0.032	3.771ProPro: 3.771 ± 0.081	1.928ProGln: 1.928 ± 0.042	3.606ProArg: 3.606 ± 0.057	2.786ProSer: 2.786 ± 0.049	2.791ProThr: 2.791 ± 0.049	5.34ProVal: 5.34 ± 0.07	0.861ProTrp: 0.861 ± 0.027	1.369ProTyr: 1.369 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.963GlnAla: 4.963 ± 0.082	0.295GlnCys: 0.295 ± 0.018	1.817GlnAsp: 1.817 ± 0.041	1.387GlnGlu: 1.387 ± 0.039	1.064GlnPhe: 1.064 ± 0.031	2.75GlnGly: 2.75 ± 0.045	0.889GlnHis: 0.889 ± 0.026	1.839GlnIle: 1.839 ± 0.039	1.088GlnLys: 1.088 ± 0.033	2.624GlnLeu: 2.624 ± 0.05	1.026GlnMet: 1.026 ± 0.03	0.866GlnAsn: 0.866 ± 0.031	2.18GlnPro: 2.18 ± 0.044	1.45GlnGln: 1.45 ± 0.038	2.298GlnArg: 2.298 ± 0.044	1.74GlnSer: 1.74 ± 0.045	1.865GlnThr: 1.865 ± 0.045	2.643GlnVal: 2.643 ± 0.047	0.519GlnTrp: 0.519 ± 0.022	0.749GlnTyr: 0.749 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.97ArgAla: 8.97 ± 0.094	0.709ArgCys: 0.709 ± 0.028	4.14ArgAsp: 4.14 ± 0.063	3.676ArgGlu: 3.676 ± 0.06	2.896ArgPhe: 2.896 ± 0.054	5.285ArgGly: 5.285 ± 0.074	2.552ArgHis: 2.552 ± 0.051	4.204ArgIle: 4.204 ± 0.057	2.072ArgLys: 2.072 ± 0.047	8.579ArgLeu: 8.579 ± 0.099	2.401ArgMet: 2.401 ± 0.049	2.222ArgAsn: 2.222 ± 0.047	4.493ArgPro: 4.493 ± 0.063	3.292ArgGln: 3.292 ± 0.058	6.692ArgArg: 6.692 ± 0.089	3.549ArgSer: 3.549 ± 0.06	4.067ArgThr: 4.067 ± 0.059	4.961ArgVal: 4.961 ± 0.069	1.176ArgTrp: 1.176 ± 0.033	1.892ArgTyr: 1.892 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.707SerAla: 5.707 ± 0.074	0.677SerCys: 0.677 ± 0.026	2.679SerAsp: 2.679 ± 0.045	2.052SerGlu: 2.052 ± 0.043	2.17SerPhe: 2.17 ± 0.049	5.367SerGly: 5.367 ± 0.078	1.34SerHis: 1.34 ± 0.035	2.681SerIle: 2.681 ± 0.046	1.007SerLys: 1.007 ± 0.032	5.384SerLeu: 5.384 ± 0.063	1.648SerMet: 1.648 ± 0.037	1.273SerAsn: 1.273 ± 0.043	3.201SerPro: 3.201 ± 0.055	1.551SerGln: 1.551 ± 0.042	4.025SerArg: 4.025 ± 0.059	2.916SerSer: 2.916 ± 0.06	2.967SerThr: 2.967 ± 0.059	4.053SerVal: 4.053 ± 0.072	0.797SerTrp: 0.797 ± 0.026	1.342SerTyr: 1.342 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.506ThrAla: 6.506 ± 0.085	0.642ThrCys: 0.642 ± 0.021	3.22ThrAsp: 3.22 ± 0.057	2.369ThrGlu: 2.369 ± 0.045	1.854ThrPhe: 1.854 ± 0.041	5.895ThrGly: 5.895 ± 0.087	1.488ThrHis: 1.488 ± 0.039	2.856ThrIle: 2.856 ± 0.052	1.093ThrLys: 1.093 ± 0.03	6.264ThrLeu: 6.264 ± 0.077	1.429ThrMet: 1.429 ± 0.034	1.34ThrAsn: 1.34 ± 0.048	4.0ThrPro: 4.0 ± 0.068	1.769ThrGln: 1.769 ± 0.038	4.049ThrArg: 4.049 ± 0.063	2.807ThrSer: 2.807 ± 0.053	3.254ThrThr: 3.254 ± 0.077	4.369ThrVal: 4.369 ± 0.083	0.819ThrTrp: 0.819 ± 0.025	1.293ThrTyr: 1.293 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.804ValAla: 8.804 ± 0.098	0.843ValCys: 0.843 ± 0.026	3.689ValAsp: 3.689 ± 0.061	3.556ValGlu: 3.556 ± 0.057	2.573ValPhe: 2.573 ± 0.045	5.106ValGly: 5.106 ± 0.072	1.739ValHis: 1.739 ± 0.038	3.718ValIle: 3.718 ± 0.068	1.435ValLys: 1.435 ± 0.036	7.639ValLeu: 7.639 ± 0.098	2.351ValMet: 2.351 ± 0.049	1.83ValAsn: 1.83 ± 0.043	4.388ValPro: 4.388 ± 0.064	2.18ValGln: 2.18 ± 0.046	5.211ValArg: 5.211 ± 0.07	4.291ValSer: 4.291 ± 0.067	4.673ValThr: 4.673 ± 0.079	5.599ValVal: 5.599 ± 0.079	0.941ValTrp: 0.941 ± 0.033	1.362ValTyr: 1.362 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.202TrpAla: 1.202 ± 0.035	0.19TrpCys: 0.19 ± 0.012	0.676TrpAsp: 0.676 ± 0.028	0.55TrpGlu: 0.55 ± 0.025	0.502TrpPhe: 0.502 ± 0.021	1.048TrpGly: 1.048 ± 0.035	0.535TrpHis: 0.535 ± 0.023	0.675TrpIle: 0.675 ± 0.025	0.487TrpLys: 0.487 ± 0.018	1.813TrpLeu: 1.813 ± 0.046	0.422TrpMet: 0.422 ± 0.018	0.515TrpAsn: 0.515 ± 0.021	0.785TrpPro: 0.785 ± 0.024	0.694TrpGln: 0.694 ± 0.025	1.379TrpArg: 1.379 ± 0.036	0.846TrpSer: 0.846 ± 0.029	0.803TrpThr: 0.803 ± 0.026	0.834TrpVal: 0.834 ± 0.03	0.234TrpTrp: 0.234 ± 0.015	0.322TrpTyr: 0.322 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.449TyrAla: 2.449 ± 0.039	0.274TyrCys: 0.274 ± 0.016	1.451TyrAsp: 1.451 ± 0.038	1.001TyrGlu: 1.001 ± 0.028	0.841TyrPhe: 0.841 ± 0.023	2.215TyrGly: 2.215 ± 0.049	0.646TyrHis: 0.646 ± 0.022	0.969TyrIle: 0.969 ± 0.035	0.446TyrLys: 0.446 ± 0.018	2.131TyrLeu: 2.131 ± 0.045	0.554TyrMet: 0.554 ± 0.021	0.716TyrAsn: 0.716 ± 0.034	1.225TyrPro: 1.225 ± 0.031	0.749TyrGln: 0.749 ± 0.026	1.943TyrArg: 1.943 ± 0.04	1.173TyrSer: 1.173 ± 0.035	1.142TyrThr: 1.142 ± 0.033	1.607TyrVal: 1.607 ± 0.034	0.311TyrTrp: 0.311 ± 0.017	0.629TyrTyr: 0.629 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4747 proteins (1206339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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