Amino acid dipepetide frequency for Halogeometricum pallidum JCM 14848

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.135AlaAla: 14.135 ± 0.176	0.729AlaCys: 0.729 ± 0.034	9.59AlaAsp: 9.59 ± 0.118	8.968AlaGlu: 8.968 ± 0.096	4.347AlaPhe: 4.347 ± 0.075	9.758AlaGly: 9.758 ± 0.118	1.842AlaHis: 1.842 ± 0.043	3.776AlaIle: 3.776 ± 0.053	1.979AlaLys: 1.979 ± 0.042	9.965AlaLeu: 9.965 ± 0.12	2.047AlaMet: 2.047 ± 0.042	2.497AlaAsn: 2.497 ± 0.046	4.139AlaPro: 4.139 ± 0.063	2.109AlaGln: 2.109 ± 0.043	6.502AlaArg: 6.502 ± 0.084	5.943AlaSer: 5.943 ± 0.072	6.675AlaThr: 6.675 ± 0.091	11.284AlaVal: 11.284 ± 0.113	1.168AlaTrp: 1.168 ± 0.033	2.823AlaTyr: 2.823 ± 0.052	0.002AlaXaa: 0.002 ± 0.002
Cys	0.659CysAla: 0.659 ± 0.029	0.078CysCys: 0.078 ± 0.008	0.528CysAsp: 0.528 ± 0.02	0.61CysGlu: 0.61 ± 0.024	0.201CysPhe: 0.201 ± 0.013	0.834CysGly: 0.834 ± 0.028	0.178CysHis: 0.178 ± 0.011	0.233CysIle: 0.233 ± 0.014	0.104CysLys: 0.104 ± 0.01	0.542CysLeu: 0.542 ± 0.022	0.102CysMet: 0.102 ± 0.01	0.156CysAsn: 0.156 ± 0.013	0.486CysPro: 0.486 ± 0.018	0.147CysGln: 0.147 ± 0.012	0.492CysArg: 0.492 ± 0.02	0.424CysSer: 0.424 ± 0.019	0.387CysThr: 0.387 ± 0.017	0.515CysVal: 0.515 ± 0.021	0.087CysTrp: 0.087 ± 0.009	0.193CysTyr: 0.193 ± 0.013	0.001CysXaa: 0.001 ± 0.001
Asp	10.79AspAla: 10.79 ± 0.145	0.651AspCys: 0.651 ± 0.026	7.395AspAsp: 7.395 ± 0.099	7.659AspGlu: 7.659 ± 0.097	1.997AspPhe: 1.997 ± 0.039	8.27AspGly: 8.27 ± 0.1	1.572AspHis: 1.572 ± 0.044	3.026AspIle: 3.026 ± 0.056	0.934AspLys: 0.934 ± 0.033	6.21AspLeu: 6.21 ± 0.082	1.176AspMet: 1.176 ± 0.031	1.183AspAsn: 1.183 ± 0.036	4.489AspPro: 4.489 ± 0.066	1.376AspGln: 1.376 ± 0.039	6.088AspArg: 6.088 ± 0.075	3.83AspSer: 3.83 ± 0.063	3.565AspThr: 3.565 ± 0.059	7.762AspVal: 7.762 ± 0.083	0.894AspTrp: 0.894 ± 0.029	1.985AspTyr: 1.985 ± 0.047	0.002AspXaa: 0.002 ± 0.001
Glu	8.825GluAla: 8.825 ± 0.104	0.507GluCys: 0.507 ± 0.02	5.554GluAsp: 5.554 ± 0.079	7.742GluGlu: 7.742 ± 0.108	3.086GluPhe: 3.086 ± 0.058	5.813GluGly: 5.813 ± 0.077	1.942GluHis: 1.942 ± 0.04	3.151GluIle: 3.151 ± 0.063	2.012GluLys: 2.012 ± 0.04	7.373GluLeu: 7.373 ± 0.087	2.084GluMet: 2.084 ± 0.039	2.511GluAsn: 2.511 ± 0.043	3.24GluPro: 3.24 ± 0.053	2.24GluGln: 2.24 ± 0.052	7.719GluArg: 7.719 ± 0.108	5.604GluSer: 5.604 ± 0.074	6.658GluThr: 6.658 ± 0.089	5.766GluVal: 5.766 ± 0.089	1.231GluTrp: 1.231 ± 0.033	2.548GluTyr: 2.548 ± 0.049	0.002GluXaa: 0.002 ± 0.001
Phe	3.941PheAla: 3.941 ± 0.064	0.274PheCys: 0.274 ± 0.017	3.313PheAsp: 3.313 ± 0.057	3.379PheGlu: 3.379 ± 0.057	1.153PhePhe: 1.153 ± 0.04	3.444PheGly: 3.444 ± 0.062	0.66PheHis: 0.66 ± 0.028	0.941PheIle: 0.941 ± 0.029	0.496PheLys: 0.496 ± 0.019	3.044PheLeu: 3.044 ± 0.055	0.501PheMet: 0.501 ± 0.021	0.67PheAsn: 0.67 ± 0.023	1.452PhePro: 1.452 ± 0.034	0.755PheGln: 0.755 ± 0.027	1.928PheArg: 1.928 ± 0.038	1.875PheSer: 1.875 ± 0.046	1.828PheThr: 1.828 ± 0.044	3.707PheVal: 3.707 ± 0.072	0.427PheTrp: 0.427 ± 0.021	0.885PheTyr: 0.885 ± 0.026	0.002PheXaa: 0.002 ± 0.001
Gly	8.687GlyAla: 8.687 ± 0.108	0.663GlyCys: 0.663 ± 0.023	6.817GlyAsp: 6.817 ± 0.078	7.446GlyGlu: 7.446 ± 0.087	3.201GlyPhe: 3.201 ± 0.058	7.983GlyGly: 7.983 ± 0.117	1.699GlyHis: 1.699 ± 0.039	3.726GlyIle: 3.726 ± 0.053	1.879GlyLys: 1.879 ± 0.037	7.377GlyLeu: 7.377 ± 0.087	1.681GlyMet: 1.681 ± 0.043	2.019GlyAsn: 2.019 ± 0.046	3.479GlyPro: 3.479 ± 0.055	1.816GlyGln: 1.816 ± 0.036	5.57GlyArg: 5.57 ± 0.073	5.17GlySer: 5.17 ± 0.071	5.794GlyThr: 5.794 ± 0.078	8.221GlyVal: 8.221 ± 0.097	1.157GlyTrp: 1.157 ± 0.029	2.788GlyTyr: 2.788 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.057HisAla: 2.057 ± 0.041	0.191HisCys: 0.191 ± 0.014	1.621HisAsp: 1.621 ± 0.035	1.616HisGlu: 1.616 ± 0.04	0.551HisPhe: 0.551 ± 0.021	1.876HisGly: 1.876 ± 0.04	0.471HisHis: 0.471 ± 0.02	0.6HisIle: 0.6 ± 0.023	0.306HisLys: 0.306 ± 0.016	1.767HisLeu: 1.767 ± 0.038	0.283HisMet: 0.283 ± 0.016	0.441HisAsn: 0.441 ± 0.02	1.25HisPro: 1.25 ± 0.033	0.422HisGln: 0.422 ± 0.016	1.336HisArg: 1.336 ± 0.034	0.844HisSer: 0.844 ± 0.027	0.993HisThr: 0.993 ± 0.031	1.925HisVal: 1.925 ± 0.043	0.238HisTrp: 0.238 ± 0.013	0.583HisTyr: 0.583 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	3.961IleAla: 3.961 ± 0.066	0.224IleCys: 0.224 ± 0.015	3.157IleAsp: 3.157 ± 0.053	3.349IleGlu: 3.349 ± 0.057	0.924IlePhe: 0.924 ± 0.029	3.223IleGly: 3.223 ± 0.061	0.744IleHis: 0.744 ± 0.023	1.201IleIle: 1.201 ± 0.034	0.624IleLys: 0.624 ± 0.025	2.839IleLeu: 2.839 ± 0.061	0.419IleMet: 0.419 ± 0.018	0.858IleAsn: 0.858 ± 0.026	1.898IlePro: 1.898 ± 0.039	0.932IleGln: 0.932 ± 0.03	2.444IleArg: 2.444 ± 0.052	1.953IleSer: 1.953 ± 0.038	2.012IleThr: 2.012 ± 0.043	3.125IleVal: 3.125 ± 0.058	0.297IleTrp: 0.297 ± 0.017	0.797IleTyr: 0.797 ± 0.029	0.001IleXaa: 0.001 ± 0.001
Lys	1.752LysAla: 1.752 ± 0.04	0.124LysCys: 0.124 ± 0.01	1.027LysAsp: 1.027 ± 0.029	1.435LysGlu: 1.435 ± 0.039	0.543LysPhe: 0.543 ± 0.023	1.397LysGly: 1.397 ± 0.035	0.481LysHis: 0.481 ± 0.02	0.719LysIle: 0.719 ± 0.025	0.536LysLys: 0.536 ± 0.022	1.736LysLeu: 1.736 ± 0.041	0.401LysMet: 0.401 ± 0.019	0.602LysAsn: 0.602 ± 0.023	0.975LysPro: 0.975 ± 0.028	0.727LysGln: 0.727 ± 0.024	1.743LysArg: 1.743 ± 0.042	1.233LysSer: 1.233 ± 0.034	1.345LysThr: 1.345 ± 0.038	1.25LysVal: 1.25 ± 0.034	0.257LysTrp: 0.257 ± 0.014	0.615LysTyr: 0.615 ± 0.025	0.001LysXaa: 0.001 ± 0.001
Leu	10.357LeuAla: 10.357 ± 0.125	0.592LeuCys: 0.592 ± 0.022	7.166LeuAsp: 7.166 ± 0.088	6.082LeuGlu: 6.082 ± 0.099	3.321LeuPhe: 3.321 ± 0.07	7.807LeuGly: 7.807 ± 0.103	1.484LeuHis: 1.484 ± 0.033	2.565LeuIle: 2.565 ± 0.071	1.623LeuLys: 1.623 ± 0.038	8.494LeuLeu: 8.494 ± 0.115	1.366LeuMet: 1.366 ± 0.031	1.976LeuAsn: 1.976 ± 0.046	4.252LeuPro: 4.252 ± 0.065	1.861LeuGln: 1.861 ± 0.036	5.962LeuArg: 5.962 ± 0.076	6.193LeuSer: 6.193 ± 0.078	5.292LeuThr: 5.292 ± 0.079	8.616LeuVal: 8.616 ± 0.11	0.891LeuTrp: 0.891 ± 0.025	2.208LeuTyr: 2.208 ± 0.049	0.003LeuXaa: 0.003 ± 0.002
Met	1.787MetAla: 1.787 ± 0.038	0.119MetCys: 0.119 ± 0.011	1.265MetAsp: 1.265 ± 0.035	1.125MetGlu: 1.125 ± 0.029	0.604MetPhe: 0.604 ± 0.023	1.439MetGly: 1.439 ± 0.036	0.378MetHis: 0.378 ± 0.018	0.562MetIle: 0.562 ± 0.022	0.488MetLys: 0.488 ± 0.022	1.534MetLeu: 1.534 ± 0.039	0.343MetMet: 0.343 ± 0.019	0.657MetAsn: 0.657 ± 0.024	0.828MetPro: 0.828 ± 0.026	0.469MetGln: 0.469 ± 0.018	1.23MetArg: 1.23 ± 0.029	1.546MetSer: 1.546 ± 0.036	1.514MetThr: 1.514 ± 0.033	1.313MetVal: 1.313 ± 0.035	0.182MetTrp: 0.182 ± 0.013	0.447MetTyr: 0.447 ± 0.02	0.001MetXaa: 0.001 ± 0.001
Asn	2.816AsnAla: 2.816 ± 0.045	0.22AsnCys: 0.22 ± 0.013	1.787AsnAsp: 1.787 ± 0.04	1.816AsnGlu: 1.816 ± 0.043	0.733AsnPhe: 0.733 ± 0.021	2.162AsnGly: 2.162 ± 0.045	0.508AsnHis: 0.508 ± 0.022	0.887AsnIle: 0.887 ± 0.03	0.413AsnLys: 0.413 ± 0.022	2.094AsnLeu: 2.094 ± 0.044	0.429AsnMet: 0.429 ± 0.022	0.566AsnAsn: 0.566 ± 0.024	1.619AsnPro: 1.619 ± 0.04	0.592AsnGln: 0.592 ± 0.021	1.702AsnArg: 1.702 ± 0.041	1.078AsnSer: 1.078 ± 0.033	1.272AsnThr: 1.272 ± 0.036	2.448AsnVal: 2.448 ± 0.044	0.321AsnTrp: 0.321 ± 0.018	0.692AsnTyr: 0.692 ± 0.023	0.001AsnXaa: 0.001 ± 0.001
Pro	4.594ProAla: 4.594 ± 0.058	0.223ProCys: 0.223 ± 0.013	4.566ProAsp: 4.566 ± 0.072	4.501ProGlu: 4.501 ± 0.068	1.717ProPhe: 1.717 ± 0.043	3.808ProGly: 3.808 ± 0.059	0.883ProHis: 0.883 ± 0.025	1.592ProIle: 1.592 ± 0.037	0.883ProLys: 0.883 ± 0.028	3.757ProLeu: 3.757 ± 0.057	0.856ProMet: 0.856 ± 0.029	1.288ProAsn: 1.288 ± 0.036	2.165ProPro: 2.165 ± 0.047	0.941ProGln: 0.941 ± 0.026	2.471ProArg: 2.471 ± 0.053	2.833ProSer: 2.833 ± 0.045	3.2ProThr: 3.2 ± 0.052	4.191ProVal: 4.191 ± 0.061	0.597ProTrp: 0.597 ± 0.02	1.198ProTyr: 1.198 ± 0.031	0.005ProXaa: 0.005 ± 0.002
Gln	2.08GlnAla: 2.08 ± 0.039	0.156GlnCys: 0.156 ± 0.011	1.095GlnAsp: 1.095 ± 0.034	1.57GlnGlu: 1.57 ± 0.041	1.075GlnPhe: 1.075 ± 0.03	1.412GlnGly: 1.412 ± 0.034	0.464GlnHis: 0.464 ± 0.017	0.973GlnIle: 0.973 ± 0.032	0.577GlnLys: 0.577 ± 0.024	2.06GlnLeu: 2.06 ± 0.044	0.593GlnMet: 0.593 ± 0.022	0.728GlnAsn: 0.728 ± 0.024	0.896GlnPro: 0.896 ± 0.028	0.871GlnGln: 0.871 ± 0.037	1.777GlnArg: 1.777 ± 0.047	1.617GlnSer: 1.617 ± 0.042	1.644GlnThr: 1.644 ± 0.036	1.708GlnVal: 1.708 ± 0.041	0.359GlnTrp: 0.359 ± 0.018	0.768GlnTyr: 0.768 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.798ArgAla: 6.798 ± 0.095	0.467ArgCys: 0.467 ± 0.02	5.152ArgAsp: 5.152 ± 0.078	6.903ArgGlu: 6.903 ± 0.093	2.528ArgPhe: 2.528 ± 0.044	4.984ArgGly: 4.984 ± 0.069	1.231ArgHis: 1.231 ± 0.031	2.781ArgIle: 2.781 ± 0.053	1.437ArgLys: 1.437 ± 0.04	6.295ArgLeu: 6.295 ± 0.089	1.404ArgMet: 1.404 ± 0.032	1.685ArgAsn: 1.685 ± 0.04	2.842ArgPro: 2.842 ± 0.052	1.665ArgGln: 1.665 ± 0.041	5.787ArgArg: 5.787 ± 0.111	3.829ArgSer: 3.829 ± 0.064	4.457ArgThr: 4.457 ± 0.067	5.945ArgVal: 5.945 ± 0.078	0.848ArgTrp: 0.848 ± 0.03	1.989ArgTyr: 1.989 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.699SerAla: 5.699 ± 0.074	0.3SerCys: 0.3 ± 0.016	4.66SerAsp: 4.66 ± 0.073	4.786SerGlu: 4.786 ± 0.072	2.085SerPhe: 2.085 ± 0.046	5.581SerGly: 5.581 ± 0.082	1.009SerHis: 1.009 ± 0.028	2.074SerIle: 2.074 ± 0.043	1.303SerLys: 1.303 ± 0.033	5.431SerLeu: 5.431 ± 0.068	1.123SerMet: 1.123 ± 0.029	1.533SerAsn: 1.533 ± 0.036	2.718SerPro: 2.718 ± 0.048	1.321SerGln: 1.321 ± 0.034	3.391SerArg: 3.391 ± 0.049	3.274SerSer: 3.274 ± 0.057	3.671SerThr: 3.671 ± 0.058	5.577SerVal: 5.577 ± 0.074	0.667SerTrp: 0.667 ± 0.026	1.467SerTyr: 1.467 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	6.846ThrAla: 6.846 ± 0.085	0.355ThrCys: 0.355 ± 0.017	5.224ThrAsp: 5.224 ± 0.066	4.861ThrGlu: 4.861 ± 0.074	2.18ThrPhe: 2.18 ± 0.039	5.775ThrGly: 5.775 ± 0.079	1.191ThrHis: 1.191 ± 0.031	2.253ThrIle: 2.253 ± 0.043	1.09ThrLys: 1.09 ± 0.029	5.808ThrLeu: 5.808 ± 0.073	1.082ThrMet: 1.082 ± 0.029	1.495ThrAsn: 1.495 ± 0.036	3.375ThrPro: 3.375 ± 0.05	1.282ThrGln: 1.282 ± 0.033	3.593ThrArg: 3.593 ± 0.057	2.911ThrSer: 2.911 ± 0.045	4.062ThrThr: 4.062 ± 0.072	6.979ThrVal: 6.979 ± 0.098	0.706ThrTrp: 0.706 ± 0.028	1.762ThrTyr: 1.762 ± 0.041	0.002ThrXaa: 0.002 ± 0.001
Val	10.643ValAla: 10.643 ± 0.124	0.774ValCys: 0.774 ± 0.028	7.604ValAsp: 7.604 ± 0.1	8.288ValGlu: 8.288 ± 0.11	3.041ValPhe: 3.041 ± 0.053	8.324ValGly: 8.324 ± 0.107	1.777ValHis: 1.777 ± 0.036	2.716ValIle: 2.716 ± 0.061	1.507ValLys: 1.507 ± 0.044	8.066ValLeu: 8.066 ± 0.1	1.317ValMet: 1.317 ± 0.038	2.211ValAsn: 2.211 ± 0.048	4.442ValPro: 4.442 ± 0.063	1.811ValGln: 1.811 ± 0.039	6.338ValArg: 6.338 ± 0.082	5.603ValSer: 5.603 ± 0.079	6.13ValThr: 6.13 ± 0.077	10.123ValVal: 10.123 ± 0.105	0.896ValTrp: 0.896 ± 0.027	2.21ValTyr: 2.21 ± 0.048	0.002ValXaa: 0.002 ± 0.002
Trp	1.003TrpAla: 1.003 ± 0.032	0.091TrpCys: 0.091 ± 0.008	0.802TrpAsp: 0.802 ± 0.031	0.877TrpGlu: 0.877 ± 0.029	0.493TrpPhe: 0.493 ± 0.023	0.888TrpGly: 0.888 ± 0.03	0.241TrpHis: 0.241 ± 0.013	0.445TrpIle: 0.445 ± 0.019	0.286TrpLys: 0.286 ± 0.015	1.118TrpLeu: 1.118 ± 0.035	0.255TrpMet: 0.255 ± 0.015	0.435TrpAsn: 0.435 ± 0.019	0.469TrpPro: 0.469 ± 0.022	0.362TrpGln: 0.362 ± 0.016	0.937TrpArg: 0.937 ± 0.029	0.687TrpSer: 0.687 ± 0.026	0.888TrpThr: 0.888 ± 0.03	0.913TrpVal: 0.913 ± 0.028	0.206TrpTrp: 0.206 ± 0.014	0.405TrpTyr: 0.405 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.843TyrAla: 2.843 ± 0.046	0.216TyrCys: 0.216 ± 0.014	2.53TyrAsp: 2.53 ± 0.064	2.598TyrGlu: 2.598 ± 0.051	0.891TyrPhe: 0.891 ± 0.027	2.395TyrGly: 2.395 ± 0.044	0.615TyrHis: 0.615 ± 0.021	0.758TyrIle: 0.758 ± 0.026	0.424TyrLys: 0.424 ± 0.02	2.601TyrLeu: 2.601 ± 0.051	0.367TyrMet: 0.367 ± 0.017	0.645TyrAsn: 0.645 ± 0.024	1.254TyrPro: 1.254 ± 0.037	0.727TyrGln: 0.727 ± 0.026	2.016TyrArg: 2.016 ± 0.045	1.222TyrSer: 1.222 ± 0.032	1.439TyrThr: 1.439 ± 0.037	2.45TyrVal: 2.45 ± 0.044	0.372TyrTrp: 0.372 ± 0.019	0.879TyrTyr: 0.879 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.002XaaSer: 0.002 ± 0.002	0.003XaaThr: 0.003 ± 0.002	0.004XaaVal: 0.004 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4246 proteins (1220474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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