Amino acid dipepetide frequency for Human papillomavirus type 88

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.428AlaAla: 2.428 ± 0.875
1.619AlaCys: 1.619 ± 1.0
4.452AlaAsp: 4.452 ± 1.824
5.666AlaGlu: 5.666 ± 1.311
3.238AlaPhe: 3.238 ± 0.729
3.642AlaGly: 3.642 ± 1.548
0.809AlaHis: 0.809 ± 0.473
4.047AlaIle: 4.047 ± 1.291
2.833AlaLys: 2.833 ± 1.291
4.856AlaLeu: 4.856 ± 1.868
0.405AlaMet: 0.405 ± 0.325
2.833AlaAsn: 2.833 ± 1.356
4.047AlaPro: 4.047 ± 1.347
1.214AlaGln: 1.214 ± 0.554
3.238AlaArg: 3.238 ± 0.682
2.833AlaSer: 2.833 ± 0.955
5.261AlaThr: 5.261 ± 1.171
4.047AlaVal: 4.047 ± 0.577
0.405AlaTrp: 0.405 ± 0.375
0.809AlaTyr: 0.809 ± 0.651
0.0AlaXaa: 0.0 ± 0.0
Cys
0.809CysAla: 0.809 ± 0.697
1.214CysCys: 1.214 ± 1.036
0.405CysAsp: 0.405 ± 0.325
0.405CysGlu: 0.405 ± 0.693
2.833CysPhe: 2.833 ± 1.18
0.405CysGly: 0.405 ± 0.512
0.405CysHis: 0.405 ± 0.325
1.619CysIle: 1.619 ± 1.044
0.405CysLys: 0.405 ± 0.38
0.405CysLeu: 0.405 ± 0.325
0.809CysMet: 0.809 ± 0.567
0.809CysAsn: 0.809 ± 0.651
1.619CysPro: 1.619 ± 0.873
0.809CysGln: 0.809 ± 0.525
1.619CysArg: 1.619 ± 1.514
3.642CysSer: 3.642 ± 2.112
1.214CysThr: 1.214 ± 0.79
1.214CysVal: 1.214 ± 0.563
1.214CysTrp: 1.214 ± 0.424
0.405CysTyr: 0.405 ± 0.512
0.0CysXaa: 0.0 ± 0.0
Asp
3.238AspAla: 3.238 ± 1.227
2.428AspCys: 2.428 ± 0.893
4.047AspAsp: 4.047 ± 1.718
4.047AspGlu: 4.047 ± 0.901
4.047AspPhe: 4.047 ± 0.906
2.833AspGly: 2.833 ± 1.095
0.809AspHis: 0.809 ± 0.473
5.666AspIle: 5.666 ± 2.562
2.023AspLys: 2.023 ± 1.046
4.856AspLeu: 4.856 ± 1.641
0.0AspMet: 0.0 ± 0.0
2.833AspAsn: 2.833 ± 0.526
5.666AspPro: 5.666 ± 1.474
2.833AspGln: 2.833 ± 0.984
2.428AspArg: 2.428 ± 0.63
3.238AspSer: 3.238 ± 0.589
3.642AspThr: 3.642 ± 1.329
4.047AspVal: 4.047 ± 1.29
0.809AspTrp: 0.809 ± 0.406
2.428AspTyr: 2.428 ± 1.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.261GluAla: 5.261 ± 1.308
1.214GluCys: 1.214 ± 1.036
5.666GluAsp: 5.666 ± 1.539
7.285GluGlu: 7.285 ± 3.519
2.428GluPhe: 2.428 ± 1.431
2.428GluGly: 2.428 ± 1.088
1.619GluHis: 1.619 ± 0.849
4.856GluIle: 4.856 ± 1.723
2.023GluLys: 2.023 ± 0.984
4.452GluLeu: 4.452 ± 1.092
0.809GluMet: 0.809 ± 0.406
4.856GluAsn: 4.856 ± 0.968
4.452GluPro: 4.452 ± 1.938
2.023GluGln: 2.023 ± 1.1
4.856GluArg: 4.856 ± 2.186
4.452GluSer: 4.452 ± 1.983
4.452GluThr: 4.452 ± 1.319
1.619GluVal: 1.619 ± 0.973
1.214GluTrp: 1.214 ± 0.635
1.619GluTyr: 1.619 ± 0.687
0.0GluXaa: 0.0 ± 0.0
Phe
2.833PheAla: 2.833 ± 0.849
1.619PheCys: 1.619 ± 1.469
3.238PheAsp: 3.238 ± 0.931
2.833PheGlu: 2.833 ± 1.82
2.023PhePhe: 2.023 ± 1.007
2.428PheGly: 2.428 ± 0.63
1.214PheHis: 1.214 ± 0.563
0.809PheIle: 0.809 ± 0.525
3.642PheLys: 3.642 ± 1.464
6.88PheLeu: 6.88 ± 1.439
1.619PheMet: 1.619 ± 0.563
2.023PheAsn: 2.023 ± 1.013
1.619PhePro: 1.619 ± 0.548
1.619PheGln: 1.619 ± 0.94
2.023PheArg: 2.023 ± 1.051
3.642PheSer: 3.642 ± 1.609
2.428PheThr: 2.428 ± 0.532
3.642PheVal: 3.642 ± 0.715
0.809PheTrp: 0.809 ± 0.396
1.619PheTyr: 1.619 ± 1.081
0.0PheXaa: 0.0 ± 0.0
Gly
3.642GlyAla: 3.642 ± 0.936
1.214GlyCys: 1.214 ± 0.865
2.833GlyAsp: 2.833 ± 2.014
6.475GlyGlu: 6.475 ± 2.114
1.619GlyPhe: 1.619 ± 0.59
4.452GlyGly: 4.452 ± 1.466
1.214GlyHis: 1.214 ± 0.736
3.642GlyIle: 3.642 ± 1.119
2.428GlyLys: 2.428 ± 1.105
4.452GlyLeu: 4.452 ± 0.932
0.0GlyMet: 0.0 ± 0.0
5.666GlyAsn: 5.666 ± 1.288
2.023GlyPro: 2.023 ± 0.385
0.405GlyGln: 0.405 ± 0.375
3.642GlyArg: 3.642 ± 1.318
3.642GlySer: 3.642 ± 0.558
5.666GlyThr: 5.666 ± 2.221
2.023GlyVal: 2.023 ± 0.729
0.0GlyTrp: 0.0 ± 0.0
1.619GlyTyr: 1.619 ± 0.948
0.0GlyXaa: 0.0 ± 0.0
His
1.214HisAla: 1.214 ± 0.688
0.809HisCys: 0.809 ± 0.406
0.0HisAsp: 0.0 ± 0.0
0.405HisGlu: 0.405 ± 0.375
2.023HisPhe: 2.023 ± 0.613
0.809HisGly: 0.809 ± 0.697
0.0HisHis: 0.0 ± 0.0
0.809HisIle: 0.809 ± 0.409
0.405HisLys: 0.405 ± 0.375
2.833HisLeu: 2.833 ± 0.846
0.405HisMet: 0.405 ± 0.434
1.619HisAsn: 1.619 ± 0.81
2.428HisPro: 2.428 ± 0.708
0.809HisGln: 0.809 ± 0.651
0.809HisArg: 0.809 ± 0.409
0.405HisSer: 0.405 ± 0.325
0.809HisThr: 0.809 ± 0.432
1.214HisVal: 1.214 ± 0.697
0.0HisTrp: 0.0 ± 0.0
0.809HisTyr: 0.809 ± 0.47
0.0HisXaa: 0.0 ± 0.0
Ile
2.428IleAla: 2.428 ± 1.259
0.809IleCys: 0.809 ± 0.698
2.833IleAsp: 2.833 ± 0.546
6.475IleGlu: 6.475 ± 2.83
3.642IlePhe: 3.642 ± 1.518
3.238IleGly: 3.238 ± 1.241
0.809IleHis: 0.809 ± 0.627
4.856IleIle: 4.856 ± 1.505
2.833IleLys: 2.833 ± 1.081
4.047IleLeu: 4.047 ± 1.091
0.0IleMet: 0.0 ± 0.0
2.428IleAsn: 2.428 ± 0.726
3.642IlePro: 3.642 ± 1.513
2.023IleGln: 2.023 ± 0.981
3.238IleArg: 3.238 ± 1.303
4.452IleSer: 4.452 ± 1.72
3.238IleThr: 3.238 ± 1.66
2.428IleVal: 2.428 ± 1.431
0.0IleTrp: 0.0 ± 0.0
1.214IleTyr: 1.214 ± 0.474
0.0IleXaa: 0.0 ± 0.0
Lys
1.619LysAla: 1.619 ± 0.865
2.023LysCys: 2.023 ± 0.681
1.619LysAsp: 1.619 ± 0.739
2.428LysGlu: 2.428 ± 1.022
3.238LysPhe: 3.238 ± 1.284
3.238LysGly: 3.238 ± 0.924
2.023LysHis: 2.023 ± 1.237
2.833LysIle: 2.833 ± 0.936
2.023LysLys: 2.023 ± 1.021
4.047LysLeu: 4.047 ± 1.653
2.023LysMet: 2.023 ± 1.0
2.833LysAsn: 2.833 ± 0.841
2.023LysPro: 2.023 ± 0.616
1.619LysGln: 1.619 ± 0.761
6.07LysArg: 6.07 ± 0.905
4.047LysSer: 4.047 ± 1.799
1.214LysThr: 1.214 ± 0.576
1.619LysVal: 1.619 ± 0.59
0.0LysTrp: 0.0 ± 0.0
0.809LysTyr: 0.809 ± 0.473
0.0LysXaa: 0.0 ± 0.0
Leu
4.047LeuAla: 4.047 ± 1.503
0.809LeuCys: 0.809 ± 0.525
7.285LeuAsp: 7.285 ± 1.885
5.666LeuGlu: 5.666 ± 1.303
5.666LeuPhe: 5.666 ± 1.61
7.689LeuGly: 7.689 ± 2.579
1.619LeuHis: 1.619 ± 0.545
4.452LeuIle: 4.452 ± 1.573
4.856LeuLys: 4.856 ± 1.603
7.285LeuLeu: 7.285 ± 2.081
1.214LeuMet: 1.214 ± 0.656
3.642LeuAsn: 3.642 ± 0.663
6.475LeuPro: 6.475 ± 1.803
7.689LeuGln: 7.689 ± 2.273
3.642LeuArg: 3.642 ± 0.88
6.475LeuSer: 6.475 ± 2.182
3.238LeuThr: 3.238 ± 0.618
7.689LeuVal: 7.689 ± 1.983
0.405LeuTrp: 0.405 ± 0.349
2.428LeuTyr: 2.428 ± 0.806
0.0LeuXaa: 0.0 ± 0.0
Met
2.428MetAla: 2.428 ± 0.771
0.405MetCys: 0.405 ± 0.325
1.214MetAsp: 1.214 ± 0.672
1.214MetGlu: 1.214 ± 0.617
0.405MetPhe: 0.405 ± 0.38
1.619MetGly: 1.619 ± 1.068
0.0MetHis: 0.0 ± 0.0
0.809MetIle: 0.809 ± 0.856
1.214MetLys: 1.214 ± 0.585
1.214MetLeu: 1.214 ± 0.714
0.405MetMet: 0.405 ± 0.456
0.809MetAsn: 0.809 ± 0.396
0.0MetPro: 0.0 ± 0.0
0.809MetGln: 0.809 ± 0.573
0.405MetArg: 0.405 ± 0.456
0.809MetSer: 0.809 ± 0.573
0.0MetThr: 0.0 ± 0.0
1.214MetVal: 1.214 ± 0.629
0.0MetTrp: 0.0 ± 0.0
1.619MetTyr: 1.619 ± 0.545
0.0MetXaa: 0.0 ± 0.0
Asn
3.238AsnAla: 3.238 ± 1.284
1.214AsnCys: 1.214 ± 0.559
2.833AsnAsp: 2.833 ± 1.021
3.238AsnGlu: 3.238 ± 1.083
3.238AsnPhe: 3.238 ± 1.669
2.833AsnGly: 2.833 ± 1.17
0.0AsnHis: 0.0 ± 0.0
2.023AsnIle: 2.023 ± 0.746
3.238AsnLys: 3.238 ± 1.186
5.666AsnLeu: 5.666 ± 1.116
1.214AsnMet: 1.214 ± 0.56
1.619AsnAsn: 1.619 ± 0.612
2.023AsnPro: 2.023 ± 1.333
1.619AsnGln: 1.619 ± 0.995
2.833AsnArg: 2.833 ± 0.744
5.666AsnSer: 5.666 ± 1.489
5.666AsnThr: 5.666 ± 2.205
4.047AsnVal: 4.047 ± 1.32
0.405AsnTrp: 0.405 ± 0.325
0.405AsnTyr: 0.405 ± 0.349
0.0AsnXaa: 0.0 ± 0.0
Pro
5.666ProAla: 5.666 ± 1.963
1.619ProCys: 1.619 ± 1.0
6.07ProAsp: 6.07 ± 2.732
3.238ProGlu: 3.238 ± 1.024
1.214ProPhe: 1.214 ± 0.674
2.023ProGly: 2.023 ± 1.045
0.809ProHis: 0.809 ± 0.913
3.642ProIle: 3.642 ± 2.07
3.238ProLys: 3.238 ± 0.444
5.261ProLeu: 5.261 ± 1.046
0.809ProMet: 0.809 ± 0.557
3.642ProAsn: 3.642 ± 1.217
9.713ProPro: 9.713 ± 2.898
2.428ProGln: 2.428 ± 0.62
4.047ProArg: 4.047 ± 1.462
3.238ProSer: 3.238 ± 1.52
6.07ProThr: 6.07 ± 2.461
1.619ProVal: 1.619 ± 0.545
0.405ProTrp: 0.405 ± 0.375
2.023ProTyr: 2.023 ± 0.981
0.0ProXaa: 0.0 ± 0.0
Gln
2.023GlnAla: 2.023 ± 0.757
0.405GlnCys: 0.405 ± 0.325
2.833GlnAsp: 2.833 ± 1.069
2.023GlnGlu: 2.023 ± 1.04
1.214GlnPhe: 1.214 ± 0.369
1.619GlnGly: 1.619 ± 0.741
0.0GlnHis: 0.0 ± 0.0
1.619GlnIle: 1.619 ± 0.72
1.214GlnLys: 1.214 ± 0.617
6.07GlnLeu: 6.07 ± 2.153
1.619GlnMet: 1.619 ± 1.122
1.619GlnAsn: 1.619 ± 0.819
2.023GlnPro: 2.023 ± 1.393
2.023GlnGln: 2.023 ± 1.085
1.619GlnArg: 1.619 ± 0.53
2.833GlnSer: 2.833 ± 1.432
2.023GlnThr: 2.023 ± 0.665
2.023GlnVal: 2.023 ± 0.901
1.619GlnTrp: 1.619 ± 1.065
2.428GlnTyr: 2.428 ± 0.98
0.0GlnXaa: 0.0 ± 0.0
Arg
1.619ArgAla: 1.619 ± 0.668
2.023ArgCys: 2.023 ± 1.081
2.023ArgAsp: 2.023 ± 0.697
3.238ArgGlu: 3.238 ± 1.245
2.428ArgPhe: 2.428 ± 0.846
2.428ArgGly: 2.428 ± 1.461
2.023ArgHis: 2.023 ± 0.845
0.809ArgIle: 0.809 ± 0.76
5.261ArgLys: 5.261 ± 0.814
6.88ArgLeu: 6.88 ± 0.928
1.214ArgMet: 1.214 ± 1.144
4.856ArgAsn: 4.856 ± 1.412
4.856ArgPro: 4.856 ± 2.857
1.214ArgGln: 1.214 ± 0.629
5.261ArgArg: 5.261 ± 1.723
4.856ArgSer: 4.856 ± 1.601
5.261ArgThr: 5.261 ± 1.414
2.833ArgVal: 2.833 ± 1.093
0.809ArgTrp: 0.809 ± 0.565
2.023ArgTyr: 2.023 ± 0.586
0.0ArgXaa: 0.0 ± 0.0
Ser
5.261SerAla: 5.261 ± 1.059
1.214SerCys: 1.214 ± 1.352
2.023SerAsp: 2.023 ± 0.906
2.428SerGlu: 2.428 ± 0.534
2.833SerPhe: 2.833 ± 1.312
6.07SerGly: 6.07 ± 1.36
1.214SerHis: 1.214 ± 0.369
4.452SerIle: 4.452 ± 1.772
2.428SerLys: 2.428 ± 1.121
9.713SerLeu: 9.713 ± 1.367
1.214SerMet: 1.214 ± 0.635
4.047SerAsn: 4.047 ± 0.933
4.856SerPro: 4.856 ± 1.561
2.428SerGln: 2.428 ± 1.039
5.261SerArg: 5.261 ± 1.381
6.475SerSer: 6.475 ± 2.455
4.856SerThr: 4.856 ± 1.133
3.642SerVal: 3.642 ± 1.099
0.405SerTrp: 0.405 ± 0.325
1.619SerTyr: 1.619 ± 0.471
0.0SerXaa: 0.0 ± 0.0
Thr
4.452ThrAla: 4.452 ± 0.849
0.405ThrCys: 0.405 ± 0.512
4.047ThrAsp: 4.047 ± 1.314
4.047ThrGlu: 4.047 ± 0.853
2.023ThrPhe: 2.023 ± 1.008
4.452ThrGly: 4.452 ± 2.323
1.214ThrHis: 1.214 ± 0.585
2.428ThrIle: 2.428 ± 1.417
2.023ThrLys: 2.023 ± 0.421
5.666ThrLeu: 5.666 ± 1.74
1.214ThrMet: 1.214 ± 0.919
2.023ThrAsn: 2.023 ± 0.73
3.238ThrPro: 3.238 ± 1.593
3.238ThrGln: 3.238 ± 1.07
4.047ThrArg: 4.047 ± 0.804
5.261ThrSer: 5.261 ± 1.041
6.07ThrThr: 6.07 ± 2.457
7.285ThrVal: 7.285 ± 1.607
0.809ThrTrp: 0.809 ± 0.573
0.809ThrTyr: 0.809 ± 0.473
0.0ThrXaa: 0.0 ± 0.0
Val
3.642ValAla: 3.642 ± 0.889
1.214ValCys: 1.214 ± 0.617
5.666ValAsp: 5.666 ± 1.679
2.833ValGlu: 2.833 ± 1.495
2.023ValPhe: 2.023 ± 0.66
2.023ValGly: 2.023 ± 0.521
2.428ValHis: 2.428 ± 1.004
2.428ValIle: 2.428 ± 0.63
2.023ValLys: 2.023 ± 0.586
3.238ValLeu: 3.238 ± 2.098
0.809ValMet: 0.809 ± 0.396
2.428ValAsn: 2.428 ± 0.63
4.856ValPro: 4.856 ± 0.644
2.023ValGln: 2.023 ± 0.984
3.238ValArg: 3.238 ± 1.225
6.07ValSer: 6.07 ± 1.246
2.023ValThr: 2.023 ± 0.757
2.023ValVal: 2.023 ± 0.945
1.214ValTrp: 1.214 ± 0.643
3.238ValTyr: 3.238 ± 1.179
0.0ValXaa: 0.0 ± 0.0
Trp
0.809TrpAla: 0.809 ± 0.651
0.0TrpCys: 0.0 ± 0.0
1.214TrpAsp: 1.214 ± 0.589
0.809TrpGlu: 0.809 ± 0.75
0.405TrpPhe: 0.405 ± 0.38
0.405TrpGly: 0.405 ± 0.349
0.405TrpHis: 0.405 ± 0.375
1.214TrpIle: 1.214 ± 0.638
0.809TrpLys: 0.809 ± 0.396
1.619TrpLeu: 1.619 ± 0.792
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.809TrpGln: 0.809 ± 0.698
1.619TrpArg: 1.619 ± 1.254
0.405TrpSer: 0.405 ± 0.375
0.405TrpThr: 0.405 ± 0.375
0.809TrpVal: 0.809 ± 0.651
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.023TyrAla: 2.023 ± 0.579
0.0TyrCys: 0.0 ± 0.0
1.619TyrAsp: 1.619 ± 0.668
2.833TyrGlu: 2.833 ± 0.966
2.023TyrPhe: 2.023 ± 0.579
2.023TyrGly: 2.023 ± 0.853
0.0TyrHis: 0.0 ± 0.0
1.619TyrIle: 1.619 ± 0.587
2.428TyrLys: 2.428 ± 0.519
2.833TyrLeu: 2.833 ± 0.457
0.405TyrMet: 0.405 ± 0.325
2.428TyrAsn: 2.428 ± 0.688
1.214TyrPro: 1.214 ± 0.688
1.214TyrGln: 1.214 ± 0.617
2.428TyrArg: 2.428 ± 0.652
0.0TyrSer: 0.0 ± 0.0
1.214TyrThr: 1.214 ± 0.742
0.405TyrVal: 0.405 ± 0.349
1.214TyrTrp: 1.214 ± 0.742
2.023TyrTyr: 2.023 ± 1.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2472 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski