Amino acid dipepetide frequency for Cyberlindnera fabianii (Yeast) (Hansenula fabianii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.507AlaAla: 5.507 ± 0.068	0.7AlaCys: 0.7 ± 0.018	3.526AlaAsp: 3.526 ± 0.041	4.106AlaGlu: 4.106 ± 0.046	2.672AlaPhe: 2.672 ± 0.04	3.852AlaGly: 3.852 ± 0.051	1.366AlaHis: 1.366 ± 0.021	4.125AlaIle: 4.125 ± 0.046	4.399AlaLys: 4.399 ± 0.049	6.514AlaLeu: 6.514 ± 0.058	1.433AlaMet: 1.433 ± 0.025	2.774AlaAsn: 2.774 ± 0.039	3.221AlaPro: 3.221 ± 0.054	2.626AlaGln: 2.626 ± 0.035	2.881AlaArg: 2.881 ± 0.032	5.736AlaSer: 5.736 ± 0.067	4.362AlaThr: 4.362 ± 0.046	4.22AlaVal: 4.22 ± 0.049	0.606AlaTrp: 0.606 ± 0.015	1.963AlaTyr: 1.963 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.676CysAla: 0.676 ± 0.017	0.199CysCys: 0.199 ± 0.009	0.595CysAsp: 0.595 ± 0.014	0.498CysGlu: 0.498 ± 0.014	0.557CysPhe: 0.557 ± 0.017	0.79CysGly: 0.79 ± 0.021	0.262CysHis: 0.262 ± 0.012	0.677CysIle: 0.677 ± 0.017	0.535CysLys: 0.535 ± 0.016	1.073CysLeu: 1.073 ± 0.024	0.225CysMet: 0.225 ± 0.009	0.393CysAsn: 0.393 ± 0.012	0.459CysPro: 0.459 ± 0.015	0.319CysGln: 0.319 ± 0.01	0.401CysArg: 0.401 ± 0.013	0.818CysSer: 0.818 ± 0.019	0.576CysThr: 0.576 ± 0.017	0.741CysVal: 0.741 ± 0.021	0.135CysTrp: 0.135 ± 0.007	0.381CysTyr: 0.381 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.995AspAla: 3.995 ± 0.043	0.535AspCys: 0.535 ± 0.014	5.455AspAsp: 5.455 ± 0.084	5.449AspGlu: 5.449 ± 0.066	2.66AspPhe: 2.66 ± 0.034	3.362AspGly: 3.362 ± 0.043	1.283AspHis: 1.283 ± 0.024	3.892AspIle: 3.892 ± 0.045	3.462AspLys: 3.462 ± 0.04	5.777AspLeu: 5.777 ± 0.055	1.215AspMet: 1.215 ± 0.02	2.514AspAsn: 2.514 ± 0.037	2.74AspPro: 2.74 ± 0.034	2.015AspGln: 2.015 ± 0.029	2.147AspArg: 2.147 ± 0.031	4.54AspSer: 4.54 ± 0.053	3.343AspThr: 3.343 ± 0.033	4.145AspVal: 4.145 ± 0.04	0.683AspTrp: 0.683 ± 0.016	2.154AspTyr: 2.154 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	4.353GluAla: 4.353 ± 0.048	0.547GluCys: 0.547 ± 0.015	4.556GluAsp: 4.556 ± 0.058	6.198GluGlu: 6.198 ± 0.095	2.772GluPhe: 2.772 ± 0.033	3.06GluGly: 3.06 ± 0.039	1.349GluHis: 1.349 ± 0.027	3.988GluIle: 3.988 ± 0.042	5.23GluLys: 5.23 ± 0.055	6.576GluLeu: 6.576 ± 0.061	1.452GluMet: 1.452 ± 0.024	3.1GluAsn: 3.1 ± 0.038	2.271GluPro: 2.271 ± 0.029	2.697GluGln: 2.697 ± 0.04	3.031GluArg: 3.031 ± 0.037	4.908GluSer: 4.908 ± 0.053	3.876GluThr: 3.876 ± 0.045	3.926GluVal: 3.926 ± 0.041	0.687GluTrp: 0.687 ± 0.017	2.126GluTyr: 2.126 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	2.771PheAla: 2.771 ± 0.036	0.473PheCys: 0.473 ± 0.016	2.885PheAsp: 2.885 ± 0.033	2.885PheGlu: 2.885 ± 0.037	2.039PhePhe: 2.039 ± 0.037	2.896PheGly: 2.896 ± 0.06	0.943PheHis: 0.943 ± 0.021	2.664PheIle: 2.664 ± 0.037	2.918PheLys: 2.918 ± 0.038	3.823PheLeu: 3.823 ± 0.055	0.922PheMet: 0.922 ± 0.02	2.175PheAsn: 2.175 ± 0.031	1.738PhePro: 1.738 ± 0.026	1.623PheGln: 1.623 ± 0.027	1.589PheArg: 1.589 ± 0.028	3.245PheSer: 3.245 ± 0.043	2.643PheThr: 2.643 ± 0.035	2.781PheVal: 2.781 ± 0.038	0.519PheTrp: 0.519 ± 0.016	1.454PheTyr: 1.454 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	3.8GlyAla: 3.8 ± 0.049	0.684GlyCys: 0.684 ± 0.017	3.33GlyAsp: 3.33 ± 0.044	3.232GlyGlu: 3.232 ± 0.039	2.693GlyPhe: 2.693 ± 0.038	3.752GlyGly: 3.752 ± 0.067	1.25GlyHis: 1.25 ± 0.025	3.459GlyIle: 3.459 ± 0.043	3.508GlyLys: 3.508 ± 0.044	5.165GlyLeu: 5.165 ± 0.049	1.127GlyMet: 1.127 ± 0.021	2.303GlyAsn: 2.303 ± 0.032	1.919GlyPro: 1.919 ± 0.033	1.855GlyGln: 1.855 ± 0.03	2.365GlyArg: 2.365 ± 0.037	5.067GlySer: 5.067 ± 0.057	3.262GlyThr: 3.262 ± 0.048	3.975GlyVal: 3.975 ± 0.05	0.736GlyTrp: 0.736 ± 0.02	2.078GlyTyr: 2.078 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.328HisAla: 1.328 ± 0.023	0.27HisCys: 0.27 ± 0.011	1.278HisAsp: 1.278 ± 0.021	1.306HisGlu: 1.306 ± 0.026	0.949HisPhe: 0.949 ± 0.021	1.262HisGly: 1.262 ± 0.024	0.739HisHis: 0.739 ± 0.02	1.381HisIle: 1.381 ± 0.025	1.276HisLys: 1.276 ± 0.023	2.079HisLeu: 2.079 ± 0.031	0.439HisMet: 0.439 ± 0.015	1.04HisAsn: 1.04 ± 0.02	1.185HisPro: 1.185 ± 0.023	0.995HisGln: 0.995 ± 0.026	1.065HisArg: 1.065 ± 0.021	1.768HisSer: 1.768 ± 0.03	1.357HisThr: 1.357 ± 0.022	1.253HisVal: 1.253 ± 0.023	0.253HisTrp: 0.253 ± 0.01	0.796HisTyr: 0.796 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.084IleAla: 4.084 ± 0.052	0.707IleCys: 0.707 ± 0.015	3.985IleAsp: 3.985 ± 0.043	3.83IleGlu: 3.83 ± 0.046	2.4IlePhe: 2.4 ± 0.038	3.398IleGly: 3.398 ± 0.049	1.366IleHis: 1.366 ± 0.024	3.554IleIle: 3.554 ± 0.05	3.943IleLys: 3.943 ± 0.042	5.23IleLeu: 5.23 ± 0.056	1.193IleMet: 1.193 ± 0.025	2.861IleAsn: 2.861 ± 0.037	3.205IlePro: 3.205 ± 0.037	2.255IleGln: 2.255 ± 0.029	2.518IleArg: 2.518 ± 0.029	4.894IleSer: 4.894 ± 0.051	3.935IleThr: 3.935 ± 0.038	3.867IleVal: 3.867 ± 0.042	0.644IleTrp: 0.644 ± 0.015	1.781IleTyr: 1.781 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.191LysAla: 4.191 ± 0.043	0.596LysCys: 0.596 ± 0.016	3.93LysAsp: 3.93 ± 0.04	4.87LysGlu: 4.87 ± 0.063	2.806LysPhe: 2.806 ± 0.036	3.106LysGly: 3.106 ± 0.04	1.442LysHis: 1.442 ± 0.023	3.857LysIle: 3.857 ± 0.036	6.236LysLys: 6.236 ± 0.077	6.347LysLeu: 6.347 ± 0.054	1.429LysMet: 1.429 ± 0.024	3.262LysAsn: 3.262 ± 0.031	2.909LysPro: 2.909 ± 0.043	2.612LysGln: 2.612 ± 0.036	3.811LysArg: 3.811 ± 0.047	5.15LysSer: 5.15 ± 0.051	4.14LysThr: 4.14 ± 0.042	4.074LysVal: 4.074 ± 0.039	0.726LysTrp: 0.726 ± 0.017	2.287LysTyr: 2.287 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	6.321LeuAla: 6.321 ± 0.059	1.041LeuCys: 1.041 ± 0.02	5.49LeuAsp: 5.49 ± 0.053	6.127LeuGlu: 6.127 ± 0.064	4.002LeuPhe: 4.002 ± 0.051	4.916LeuGly: 4.916 ± 0.047	2.046LeuHis: 2.046 ± 0.031	5.409LeuIle: 5.409 ± 0.053	6.94LeuLys: 6.94 ± 0.058	8.817LeuLeu: 8.817 ± 0.096	1.985LeuMet: 1.985 ± 0.028	4.718LeuAsn: 4.718 ± 0.045	4.424LeuPro: 4.424 ± 0.04	3.787LeuGln: 3.787 ± 0.043	4.572LeuArg: 4.572 ± 0.049	8.1LeuSer: 8.1 ± 0.067	5.761LeuThr: 5.761 ± 0.048	5.718LeuVal: 5.718 ± 0.052	0.917LeuTrp: 0.917 ± 0.022	2.79LeuTyr: 2.79 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	1.524MetAla: 1.524 ± 0.027	0.238MetCys: 0.238 ± 0.008	1.233MetAsp: 1.233 ± 0.021	1.243MetGlu: 1.243 ± 0.022	0.919MetPhe: 0.919 ± 0.02	1.206MetGly: 1.206 ± 0.023	0.348MetHis: 0.348 ± 0.013	1.204MetIle: 1.204 ± 0.023	1.414MetLys: 1.414 ± 0.026	1.85MetLeu: 1.85 ± 0.03	0.545MetMet: 0.545 ± 0.016	1.082MetAsn: 1.082 ± 0.022	0.837MetPro: 0.837 ± 0.018	0.642MetGln: 0.642 ± 0.016	0.946MetArg: 0.946 ± 0.019	2.14MetSer: 2.14 ± 0.028	1.353MetThr: 1.353 ± 0.021	1.225MetVal: 1.225 ± 0.022	0.192MetTrp: 0.192 ± 0.008	0.604MetTyr: 0.604 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.046AsnAla: 3.046 ± 0.036	0.445AsnCys: 0.445 ± 0.015	3.003AsnAsp: 3.003 ± 0.034	2.926AsnGlu: 2.926 ± 0.037	2.05AsnPhe: 2.05 ± 0.033	2.876AsnGly: 2.876 ± 0.039	0.975AsnHis: 0.975 ± 0.02	2.845AsnIle: 2.845 ± 0.035	2.851AsnLys: 2.851 ± 0.03	4.062AsnLeu: 4.062 ± 0.044	1.029AsnMet: 1.029 ± 0.019	2.513AsnAsn: 2.513 ± 0.053	2.164AsnPro: 2.164 ± 0.031	1.625AsnGln: 1.625 ± 0.028	1.776AsnArg: 1.776 ± 0.031	3.703AsnSer: 3.703 ± 0.045	2.969AsnThr: 2.969 ± 0.038	3.056AsnVal: 3.056 ± 0.035	0.552AsnTrp: 0.552 ± 0.016	1.617AsnTyr: 1.617 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.001ProAla: 3.001 ± 0.046	0.308ProCys: 0.308 ± 0.013	2.515ProAsp: 2.515 ± 0.031	3.328ProGlu: 3.328 ± 0.037	1.86ProPhe: 1.86 ± 0.026	2.321ProGly: 2.321 ± 0.032	1.078ProHis: 1.078 ± 0.02	2.507ProIle: 2.507 ± 0.034	2.853ProLys: 2.853 ± 0.038	4.306ProLeu: 4.306 ± 0.046	0.841ProMet: 0.841 ± 0.021	1.917ProAsn: 1.917 ± 0.029	2.958ProPro: 2.958 ± 0.08	2.356ProGln: 2.356 ± 0.05	1.929ProArg: 1.929 ± 0.034	4.511ProSer: 4.511 ± 0.069	3.207ProThr: 3.207 ± 0.043	3.12ProVal: 3.12 ± 0.039	0.462ProTrp: 0.462 ± 0.013	1.397ProTyr: 1.397 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	2.45GlnAla: 2.45 ± 0.042	0.378GlnCys: 0.378 ± 0.012	2.034GlnAsp: 2.034 ± 0.033	2.502GlnGlu: 2.502 ± 0.035	1.626GlnPhe: 1.626 ± 0.023	1.954GlnGly: 1.954 ± 0.031	1.001GlnHis: 1.001 ± 0.026	2.261GlnIle: 2.261 ± 0.03	2.72GlnLys: 2.72 ± 0.035	3.966GlnLeu: 3.966 ± 0.045	0.917GlnMet: 0.917 ± 0.02	1.768GlnAsn: 1.768 ± 0.03	1.856GlnPro: 1.856 ± 0.041	2.904GlnGln: 2.904 ± 0.088	2.118GlnArg: 2.118 ± 0.031	3.072GlnSer: 3.072 ± 0.042	2.243GlnThr: 2.243 ± 0.033	2.206GlnVal: 2.206 ± 0.03	0.448GlnTrp: 0.448 ± 0.013	1.252GlnTyr: 1.252 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.191ArgAla: 3.191 ± 0.034	0.473ArgCys: 0.473 ± 0.014	2.633ArgAsp: 2.633 ± 0.041	2.92ArgGlu: 2.92 ± 0.038	2.004ArgPhe: 2.004 ± 0.03	2.428ArgGly: 2.428 ± 0.04	1.039ArgHis: 1.039 ± 0.019	2.503ArgIle: 2.503 ± 0.032	3.101ArgLys: 3.101 ± 0.039	4.424ArgLeu: 4.424 ± 0.04	0.897ArgMet: 0.897 ± 0.02	1.947ArgAsn: 1.947 ± 0.029	1.928ArgPro: 1.928 ± 0.03	1.779ArgGln: 1.779 ± 0.029	2.894ArgArg: 2.894 ± 0.044	3.635ArgSer: 3.635 ± 0.042	2.456ArgThr: 2.456 ± 0.032	2.876ArgVal: 2.876 ± 0.032	0.491ArgTrp: 0.491 ± 0.014	1.508ArgTyr: 1.508 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	5.358SerAla: 5.358 ± 0.058	0.765SerCys: 0.765 ± 0.023	4.702SerAsp: 4.702 ± 0.059	4.763SerGlu: 4.763 ± 0.066	3.54SerPhe: 3.54 ± 0.043	4.67SerGly: 4.67 ± 0.052	1.848SerHis: 1.848 ± 0.03	5.053SerIle: 5.053 ± 0.049	5.432SerLys: 5.432 ± 0.052	8.065SerLeu: 8.065 ± 0.07	1.682SerMet: 1.682 ± 0.025	3.873SerAsn: 3.873 ± 0.051	4.15SerPro: 4.15 ± 0.067	3.404SerGln: 3.404 ± 0.044	3.704SerArg: 3.704 ± 0.043	9.82SerSer: 9.82 ± 0.184	6.391SerThr: 6.391 ± 0.081	5.017SerVal: 5.017 ± 0.054	0.832SerTrp: 0.832 ± 0.019	2.413SerTyr: 2.413 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.217ThrAla: 4.217 ± 0.044	0.613ThrCys: 0.613 ± 0.017	3.33ThrAsp: 3.33 ± 0.038	3.718ThrGlu: 3.718 ± 0.038	2.497ThrPhe: 2.497 ± 0.036	3.681ThrGly: 3.681 ± 0.05	1.379ThrHis: 1.379 ± 0.025	3.803ThrIle: 3.803 ± 0.042	3.972ThrLys: 3.972 ± 0.042	5.77ThrLeu: 5.77 ± 0.049	1.161ThrMet: 1.161 ± 0.021	2.824ThrAsn: 2.824 ± 0.036	3.94ThrPro: 3.94 ± 0.05	2.388ThrGln: 2.388 ± 0.034	2.76ThrArg: 2.76 ± 0.039	5.814ThrSer: 5.814 ± 0.083	4.989ThrThr: 4.989 ± 0.094	3.958ThrVal: 3.958 ± 0.046	0.632ThrTrp: 0.632 ± 0.015	1.8ThrTyr: 1.8 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	4.102ValAla: 4.102 ± 0.049	0.733ValCys: 0.733 ± 0.018	4.0ValAsp: 4.0 ± 0.043	4.2ValGlu: 4.2 ± 0.049	2.921ValPhe: 2.921 ± 0.039	3.417ValGly: 3.417 ± 0.04	1.314ValHis: 1.314 ± 0.023	3.84ValIle: 3.84 ± 0.044	4.256ValLys: 4.256 ± 0.046	6.004ValLeu: 6.004 ± 0.051	1.358ValMet: 1.358 ± 0.026	2.793ValAsn: 2.793 ± 0.03	3.166ValPro: 3.166 ± 0.038	2.201ValGln: 2.201 ± 0.031	2.646ValArg: 2.646 ± 0.029	5.36ValSer: 5.36 ± 0.053	3.731ValThr: 3.731 ± 0.053	4.489ValVal: 4.489 ± 0.054	0.659ValTrp: 0.659 ± 0.019	2.042ValTyr: 2.042 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.668TrpAla: 0.668 ± 0.017	0.184TrpCys: 0.184 ± 0.009	0.731TrpAsp: 0.731 ± 0.018	0.61TrpGlu: 0.61 ± 0.016	0.532TrpPhe: 0.532 ± 0.015	0.628TrpGly: 0.628 ± 0.017	0.202TrpHis: 0.202 ± 0.009	0.695TrpIle: 0.695 ± 0.016	0.796TrpLys: 0.796 ± 0.018	0.994TrpLeu: 0.994 ± 0.022	0.256TrpMet: 0.256 ± 0.009	0.564TrpAsn: 0.564 ± 0.015	0.336TrpPro: 0.336 ± 0.012	0.312TrpGln: 0.312 ± 0.011	0.598TrpArg: 0.598 ± 0.015	0.838TrpSer: 0.838 ± 0.02	0.601TrpThr: 0.601 ± 0.016	0.659TrpVal: 0.659 ± 0.017	0.184TrpTrp: 0.184 ± 0.009	0.367TrpTyr: 0.367 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.007TyrAla: 2.007 ± 0.028	0.417TyrCys: 0.417 ± 0.012	2.154TyrAsp: 2.154 ± 0.032	1.993TyrGlu: 1.993 ± 0.029	1.489TyrPhe: 1.489 ± 0.028	1.987TyrGly: 1.987 ± 0.034	0.79TyrHis: 0.79 ± 0.021	1.934TyrIle: 1.934 ± 0.031	1.941TyrLys: 1.941 ± 0.031	3.039TyrLeu: 3.039 ± 0.037	0.641TyrMet: 0.641 ± 0.015	1.662TyrAsn: 1.662 ± 0.029	1.368TyrPro: 1.368 ± 0.025	1.281TyrGln: 1.281 ± 0.022	1.375TyrArg: 1.375 ± 0.025	2.364TyrSer: 2.364 ± 0.034	2.048TyrThr: 2.048 ± 0.029	1.925TyrVal: 1.925 ± 0.032	0.393TyrTrp: 0.393 ± 0.014	1.225TyrTyr: 1.225 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5507 proteins (2608749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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