Amino acid dipepetide frequency for Leucobacter sp. 7(1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.54AlaAla: 21.54 ± 0.212	0.778AlaCys: 0.778 ± 0.033	7.624AlaAsp: 7.624 ± 0.102	9.501AlaGlu: 9.501 ± 0.114	3.885AlaPhe: 3.885 ± 0.063	12.598AlaGly: 12.598 ± 0.123	2.789AlaHis: 2.789 ± 0.053	5.893AlaIle: 5.893 ± 0.073	2.609AlaLys: 2.609 ± 0.06	14.574AlaLeu: 14.574 ± 0.149	2.714AlaMet: 2.714 ± 0.047	2.423AlaAsn: 2.423 ± 0.045	7.012AlaPro: 7.012 ± 0.12	4.737AlaGln: 4.737 ± 0.07	8.863AlaArg: 8.863 ± 0.119	6.735AlaSer: 6.735 ± 0.073	7.602AlaThr: 7.602 ± 0.089	10.765AlaVal: 10.765 ± 0.115	1.771AlaTrp: 1.771 ± 0.042	2.277AlaTyr: 2.277 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.836CysAla: 0.836 ± 0.031	0.051CysCys: 0.051 ± 0.007	0.346CysAsp: 0.346 ± 0.017	0.311CysGlu: 0.311 ± 0.017	0.199CysPhe: 0.199 ± 0.012	0.625CysGly: 0.625 ± 0.029	0.114CysHis: 0.114 ± 0.012	0.198CysIle: 0.198 ± 0.014	0.066CysLys: 0.066 ± 0.008	0.432CysLeu: 0.432 ± 0.021	0.094CysMet: 0.094 ± 0.009	0.106CysAsn: 0.106 ± 0.01	0.247CysPro: 0.247 ± 0.018	0.115CysGln: 0.115 ± 0.011	0.343CysArg: 0.343 ± 0.019	0.32CysSer: 0.32 ± 0.019	0.382CysThr: 0.382 ± 0.016	0.469CysVal: 0.469 ± 0.019	0.081CysTrp: 0.081 ± 0.008	0.105CysTyr: 0.105 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.053AspAla: 8.053 ± 0.096	0.225AspCys: 0.225 ± 0.015	2.782AspAsp: 2.782 ± 0.071	3.626AspGlu: 3.626 ± 0.066	1.762AspPhe: 1.762 ± 0.041	5.134AspGly: 5.134 ± 0.082	1.093AspHis: 1.093 ± 0.033	2.117AspIle: 2.117 ± 0.046	0.794AspLys: 0.794 ± 0.033	5.44AspLeu: 5.44 ± 0.067	0.807AspMet: 0.807 ± 0.028	0.815AspAsn: 0.815 ± 0.027	4.673AspPro: 4.673 ± 0.159	1.495AspGln: 1.495 ± 0.039	4.301AspArg: 4.301 ± 0.076	2.581AspSer: 2.581 ± 0.049	3.331AspThr: 3.331 ± 0.057	4.359AspVal: 4.359 ± 0.068	0.837AspTrp: 0.837 ± 0.028	1.145AspTyr: 1.145 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.473GluAla: 7.473 ± 0.109	0.301GluCys: 0.301 ± 0.018	2.74GluAsp: 2.74 ± 0.054	3.136GluGlu: 3.136 ± 0.062	2.093GluPhe: 2.093 ± 0.043	3.831GluGly: 3.831 ± 0.065	1.623GluHis: 1.623 ± 0.04	3.061GluIle: 3.061 ± 0.059	1.17GluLys: 1.17 ± 0.037	7.883GluLeu: 7.883 ± 0.103	1.145GluMet: 1.145 ± 0.032	1.327GluAsn: 1.327 ± 0.035	3.076GluPro: 3.076 ± 0.064	2.572GluGln: 2.572 ± 0.053	5.47GluArg: 5.47 ± 0.092	3.058GluSer: 3.058 ± 0.052	3.321GluThr: 3.321 ± 0.061	4.601GluVal: 4.601 ± 0.075	0.9GluTrp: 0.9 ± 0.031	1.189GluTyr: 1.189 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.5PheAla: 4.5 ± 0.064	0.186PheCys: 0.186 ± 0.013	2.09PheAsp: 2.09 ± 0.045	1.804PheGlu: 1.804 ± 0.046	1.102PhePhe: 1.102 ± 0.035	3.462PheGly: 3.462 ± 0.06	0.531PheHis: 0.531 ± 0.022	1.259PheIle: 1.259 ± 0.035	0.446PheLys: 0.446 ± 0.021	2.878PheLeu: 2.878 ± 0.058	0.53PheMet: 0.53 ± 0.022	0.638PheAsn: 0.638 ± 0.025	1.634PhePro: 1.634 ± 0.04	0.813PheGln: 0.813 ± 0.029	1.764PheArg: 1.764 ± 0.041	1.895PheSer: 1.895 ± 0.04	2.483PheThr: 2.483 ± 0.049	2.788PheVal: 2.788 ± 0.061	0.475PheTrp: 0.475 ± 0.022	0.623PheTyr: 0.623 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.27GlyAla: 11.27 ± 0.136	0.599GlyCys: 0.599 ± 0.027	4.665GlyAsp: 4.665 ± 0.074	5.199GlyGlu: 5.199 ± 0.077	3.335GlyPhe: 3.335 ± 0.066	7.715GlyGly: 7.715 ± 0.113	1.755GlyHis: 1.755 ± 0.044	5.006GlyIle: 5.006 ± 0.07	2.292GlyLys: 2.292 ± 0.054	8.839GlyLeu: 8.839 ± 0.108	2.027GlyMet: 2.027 ± 0.042	1.931GlyAsn: 1.931 ± 0.046	3.859GlyPro: 3.859 ± 0.058	2.58GlyGln: 2.58 ± 0.048	5.54GlyArg: 5.54 ± 0.077	5.675GlySer: 5.675 ± 0.074	6.261GlyThr: 6.261 ± 0.122	7.922GlyVal: 7.922 ± 0.08	1.517GlyTrp: 1.517 ± 0.043	2.051GlyTyr: 2.051 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.633HisAla: 2.633 ± 0.051	0.126HisCys: 0.126 ± 0.01	1.168HisAsp: 1.168 ± 0.032	1.263HisGlu: 1.263 ± 0.035	0.58HisPhe: 0.58 ± 0.024	1.956HisGly: 1.956 ± 0.048	0.525HisHis: 0.525 ± 0.022	0.719HisIle: 0.719 ± 0.022	0.275HisLys: 0.275 ± 0.016	2.051HisLeu: 2.051 ± 0.042	0.324HisMet: 0.324 ± 0.017	0.36HisAsn: 0.36 ± 0.017	1.496HisPro: 1.496 ± 0.037	0.551HisGln: 0.551 ± 0.026	1.647HisArg: 1.647 ± 0.041	1.066HisSer: 1.066 ± 0.031	1.345HisThr: 1.345 ± 0.037	1.502HisVal: 1.502 ± 0.036	0.293HisTrp: 0.293 ± 0.018	0.413HisTyr: 0.413 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.35IleAla: 7.35 ± 0.092	0.275IleCys: 0.275 ± 0.014	3.037IleAsp: 3.037 ± 0.048	2.891IleGlu: 2.891 ± 0.058	1.129IlePhe: 1.129 ± 0.037	4.52IleGly: 4.52 ± 0.077	0.734IleHis: 0.734 ± 0.025	1.849IleIle: 1.849 ± 0.047	0.72IleLys: 0.72 ± 0.028	4.117IleLeu: 4.117 ± 0.076	0.735IleMet: 0.735 ± 0.025	0.93IleAsn: 0.93 ± 0.025	2.724IlePro: 2.724 ± 0.054	1.011IleGln: 1.011 ± 0.028	2.781IleArg: 2.781 ± 0.058	2.612IleSer: 2.612 ± 0.051	3.229IleThr: 3.229 ± 0.061	4.543IleVal: 4.543 ± 0.073	0.512IleTrp: 0.512 ± 0.022	0.686IleTyr: 0.686 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	1.924LysAla: 1.924 ± 0.052	0.074LysCys: 0.074 ± 0.008	0.968LysAsp: 0.968 ± 0.034	0.856LysGlu: 0.856 ± 0.033	0.556LysPhe: 0.556 ± 0.029	1.303LysGly: 1.303 ± 0.038	0.445LysHis: 0.445 ± 0.021	1.034LysIle: 1.034 ± 0.029	0.696LysLys: 0.696 ± 0.029	2.063LysLeu: 2.063 ± 0.049	0.378LysMet: 0.378 ± 0.018	0.572LysAsn: 0.572 ± 0.023	1.201LysPro: 1.201 ± 0.044	0.756LysGln: 0.756 ± 0.027	1.55LysArg: 1.55 ± 0.041	1.177LysSer: 1.177 ± 0.04	1.205LysThr: 1.205 ± 0.033	1.412LysVal: 1.412 ± 0.042	0.25LysTrp: 0.25 ± 0.013	0.416LysTyr: 0.416 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.21LeuAla: 15.21 ± 0.143	0.558LeuCys: 0.558 ± 0.023	6.194LeuAsp: 6.194 ± 0.076	5.109LeuGlu: 5.109 ± 0.073	2.948LeuPhe: 2.948 ± 0.07	10.01LeuGly: 10.01 ± 0.122	1.889LeuHis: 1.889 ± 0.045	4.89LeuIle: 4.89 ± 0.072	1.651LeuLys: 1.651 ± 0.047	10.525LeuLeu: 10.525 ± 0.141	1.697LeuMet: 1.697 ± 0.04	1.972LeuAsn: 1.972 ± 0.041	5.772LeuPro: 5.772 ± 0.058	2.644LeuGln: 2.644 ± 0.051	7.686LeuArg: 7.686 ± 0.1	6.346LeuSer: 6.346 ± 0.081	6.902LeuThr: 6.902 ± 0.083	8.602LeuVal: 8.602 ± 0.095	1.193LeuTrp: 1.193 ± 0.034	1.443LeuTyr: 1.443 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.882MetAla: 1.882 ± 0.043	0.121MetCys: 0.121 ± 0.012	0.72MetAsp: 0.72 ± 0.026	0.719MetGlu: 0.719 ± 0.025	0.568MetPhe: 0.568 ± 0.024	1.37MetGly: 1.37 ± 0.036	0.388MetHis: 0.388 ± 0.021	1.039MetIle: 1.039 ± 0.03	0.41MetLys: 0.41 ± 0.016	2.077MetLeu: 2.077 ± 0.045	0.341MetMet: 0.341 ± 0.019	0.561MetAsn: 0.561 ± 0.023	1.08MetPro: 1.08 ± 0.031	0.648MetGln: 0.648 ± 0.024	1.408MetArg: 1.408 ± 0.031	1.517MetSer: 1.517 ± 0.035	1.685MetThr: 1.685 ± 0.04	1.265MetVal: 1.265 ± 0.035	0.195MetTrp: 0.195 ± 0.013	0.337MetTyr: 0.337 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.693AsnAla: 2.693 ± 0.052	0.109AsnCys: 0.109 ± 0.01	1.015AsnAsp: 1.015 ± 0.031	1.082AsnGlu: 1.082 ± 0.031	0.655AsnPhe: 0.655 ± 0.027	1.908AsnGly: 1.908 ± 0.05	0.361AsnHis: 0.361 ± 0.016	0.886AsnIle: 0.886 ± 0.029	0.362AsnLys: 0.362 ± 0.018	1.902AsnLeu: 1.902 ± 0.045	0.385AsnMet: 0.385 ± 0.02	0.446AsnAsn: 0.446 ± 0.022	1.617AsnPro: 1.617 ± 0.038	0.593AsnGln: 0.593 ± 0.025	1.327AsnArg: 1.327 ± 0.036	1.075AsnSer: 1.075 ± 0.035	1.337AsnThr: 1.337 ± 0.041	1.663AsnVal: 1.663 ± 0.039	0.363AsnTrp: 0.363 ± 0.018	0.498AsnTyr: 0.498 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.724ProAla: 7.724 ± 0.114	0.196ProCys: 0.196 ± 0.011	3.559ProAsp: 3.559 ± 0.057	4.891ProGlu: 4.891 ± 0.068	1.663ProPhe: 1.663 ± 0.043	5.702ProGly: 5.702 ± 0.155	1.212ProHis: 1.212 ± 0.035	2.23ProIle: 2.23 ± 0.042	1.157ProLys: 1.157 ± 0.036	4.998ProLeu: 4.998 ± 0.072	0.881ProMet: 0.881 ± 0.03	1.213ProAsn: 1.213 ± 0.041	2.152ProPro: 2.152 ± 0.06	1.679ProGln: 1.679 ± 0.043	3.336ProArg: 3.336 ± 0.061	3.03ProSer: 3.03 ± 0.058	3.28ProThr: 3.28 ± 0.065	4.935ProVal: 4.935 ± 0.074	0.749ProTrp: 0.749 ± 0.027	0.95ProTyr: 0.95 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.767GlnAla: 3.767 ± 0.063	0.114GlnCys: 0.114 ± 0.011	1.432GlnAsp: 1.432 ± 0.035	1.587GlnGlu: 1.587 ± 0.041	0.989GlnPhe: 0.989 ± 0.031	2.237GlnGly: 2.237 ± 0.049	0.792GlnHis: 0.792 ± 0.029	1.681GlnIle: 1.681 ± 0.041	0.624GlnLys: 0.624 ± 0.026	3.784GlnLeu: 3.784 ± 0.062	0.556GlnMet: 0.556 ± 0.021	0.682GlnAsn: 0.682 ± 0.026	1.594GlnPro: 1.594 ± 0.049	1.373GlnGln: 1.373 ± 0.039	2.696GlnArg: 2.696 ± 0.054	1.629GlnSer: 1.629 ± 0.037	1.583GlnThr: 1.583 ± 0.036	2.341GlnVal: 2.341 ± 0.047	0.452GlnTrp: 0.452 ± 0.018	0.611GlnTyr: 0.611 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.19ArgAla: 9.19 ± 0.118	0.349ArgCys: 0.349 ± 0.018	4.104ArgAsp: 4.104 ± 0.062	4.633ArgGlu: 4.633 ± 0.079	2.389ArgPhe: 2.389 ± 0.047	5.523ArgGly: 5.523 ± 0.086	1.44ArgHis: 1.44 ± 0.042	3.762ArgIle: 3.762 ± 0.064	1.396ArgLys: 1.396 ± 0.036	6.81ArgLeu: 6.81 ± 0.095	1.525ArgMet: 1.525 ± 0.036	1.394ArgAsn: 1.394 ± 0.033	3.343ArgPro: 3.343 ± 0.059	1.891ArgGln: 1.891 ± 0.042	5.503ArgArg: 5.503 ± 0.074	4.128ArgSer: 4.128 ± 0.076	4.272ArgThr: 4.272 ± 0.072	6.22ArgVal: 6.22 ± 0.092	1.114ArgTrp: 1.114 ± 0.033	1.454ArgTyr: 1.454 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.386SerAla: 7.386 ± 0.094	0.313SerCys: 0.313 ± 0.019	3.14SerAsp: 3.14 ± 0.053	3.491SerGlu: 3.491 ± 0.053	1.957SerPhe: 1.957 ± 0.042	6.342SerGly: 6.342 ± 0.089	1.076SerHis: 1.076 ± 0.033	2.381SerIle: 2.381 ± 0.052	1.045SerLys: 1.045 ± 0.033	5.348SerLeu: 5.348 ± 0.064	1.126SerMet: 1.126 ± 0.027	1.11SerAsn: 1.11 ± 0.031	3.099SerPro: 3.099 ± 0.054	1.585SerGln: 1.585 ± 0.04	3.731SerArg: 3.731 ± 0.058	3.267SerSer: 3.267 ± 0.056	3.378SerThr: 3.378 ± 0.063	4.671SerVal: 4.671 ± 0.053	0.96SerTrp: 0.96 ± 0.028	1.245SerTyr: 1.245 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	8.153ThrAla: 8.153 ± 0.102	0.266ThrCys: 0.266 ± 0.016	3.447ThrAsp: 3.447 ± 0.11	3.763ThrGlu: 3.763 ± 0.061	1.864ThrPhe: 1.864 ± 0.043	6.192ThrGly: 6.192 ± 0.089	1.383ThrHis: 1.383 ± 0.037	2.898ThrIle: 2.898 ± 0.056	1.151ThrLys: 1.151 ± 0.038	6.648ThrLeu: 6.648 ± 0.083	1.016ThrMet: 1.016 ± 0.032	1.268ThrAsn: 1.268 ± 0.039	4.513ThrPro: 4.513 ± 0.064	1.915ThrGln: 1.915 ± 0.048	4.012ThrArg: 4.012 ± 0.066	3.402ThrSer: 3.402 ± 0.055	3.819ThrThr: 3.819 ± 0.076	5.935ThrVal: 5.935 ± 0.093	0.785ThrTrp: 0.785 ± 0.027	0.99ThrTyr: 0.99 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	11.118ValAla: 11.118 ± 0.106	0.561ValCys: 0.561 ± 0.025	4.483ValAsp: 4.483 ± 0.073	4.365ValGlu: 4.365 ± 0.073	2.948ValPhe: 2.948 ± 0.057	6.678ValGly: 6.678 ± 0.086	1.527ValHis: 1.527 ± 0.034	4.198ValIle: 4.198 ± 0.064	1.411ValLys: 1.411 ± 0.042	9.292ValLeu: 9.292 ± 0.101	1.474ValMet: 1.474 ± 0.039	1.73ValAsn: 1.73 ± 0.038	4.804ValPro: 4.804 ± 0.064	2.449ValGln: 2.449 ± 0.049	5.743ValArg: 5.743 ± 0.084	5.261ValSer: 5.261 ± 0.078	6.077ValThr: 6.077 ± 0.093	7.233ValVal: 7.233 ± 0.084	1.126ValTrp: 1.126 ± 0.034	1.447ValTyr: 1.447 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.675TrpAla: 1.675 ± 0.043	0.102TrpCys: 0.102 ± 0.01	0.762TrpAsp: 0.762 ± 0.026	0.679TrpGlu: 0.679 ± 0.023	0.581TrpPhe: 0.581 ± 0.023	1.142TrpGly: 1.142 ± 0.031	0.315TrpHis: 0.315 ± 0.019	0.69TrpIle: 0.69 ± 0.027	0.269TrpLys: 0.269 ± 0.014	1.562TrpLeu: 1.562 ± 0.04	0.296TrpMet: 0.296 ± 0.016	0.404TrpAsn: 0.404 ± 0.021	0.658TrpPro: 0.658 ± 0.026	0.549TrpGln: 0.549 ± 0.022	1.086TrpArg: 1.086 ± 0.03	0.841TrpSer: 0.841 ± 0.032	0.761TrpThr: 0.761 ± 0.029	1.242TrpVal: 1.242 ± 0.033	0.29TrpTrp: 0.29 ± 0.017	0.257TrpTyr: 0.257 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.315TyrAla: 2.315 ± 0.042	0.138TyrCys: 0.138 ± 0.014	1.091TyrAsp: 1.091 ± 0.033	1.062TyrGlu: 1.062 ± 0.036	0.698TyrPhe: 0.698 ± 0.024	1.793TyrGly: 1.793 ± 0.041	0.298TyrHis: 0.298 ± 0.016	0.593TyrIle: 0.593 ± 0.022	0.292TyrLys: 0.292 ± 0.018	2.017TyrLeu: 2.017 ± 0.044	0.278TyrMet: 0.278 ± 0.017	0.396TyrAsn: 0.396 ± 0.02	0.984TyrPro: 0.984 ± 0.027	0.567TyrGln: 0.567 ± 0.022	1.654TyrArg: 1.654 ± 0.042	1.038TyrSer: 1.038 ± 0.031	1.164TyrThr: 1.164 ± 0.039	1.458TyrVal: 1.458 ± 0.04	0.299TyrTrp: 0.299 ± 0.017	0.436TyrTyr: 0.436 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3533 proteins (1161179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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