Amino acid dipepetide frequency for Desulfonatronum sp. SC1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.215AlaAla: 10.215 ± 0.134
1.279AlaCys: 1.279 ± 0.038
5.047AlaAsp: 5.047 ± 0.089
6.046AlaGlu: 6.046 ± 0.085
3.713AlaPhe: 3.713 ± 0.064
7.729AlaGly: 7.729 ± 0.094
1.94AlaHis: 1.94 ± 0.043
4.004AlaIle: 4.004 ± 0.068
3.694AlaLys: 3.694 ± 0.057
11.456AlaLeu: 11.456 ± 0.137
2.99AlaMet: 2.99 ± 0.053
2.506AlaAsn: 2.506 ± 0.051
3.931AlaPro: 3.931 ± 0.071
3.66AlaGln: 3.66 ± 0.059
6.497AlaArg: 6.497 ± 0.086
4.943AlaSer: 4.943 ± 0.062
4.334AlaThr: 4.334 ± 0.08
7.592AlaVal: 7.592 ± 0.098
1.397AlaTrp: 1.397 ± 0.037
2.323AlaTyr: 2.323 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.083CysAla: 1.083 ± 0.031
0.209CysCys: 0.209 ± 0.014
0.544CysAsp: 0.544 ± 0.025
0.486CysGlu: 0.486 ± 0.021
0.453CysPhe: 0.453 ± 0.017
1.095CysGly: 1.095 ± 0.033
0.354CysHis: 0.354 ± 0.025
0.58CysIle: 0.58 ± 0.024
0.384CysLys: 0.384 ± 0.017
1.338CysLeu: 1.338 ± 0.033
0.263CysMet: 0.263 ± 0.014
0.311CysAsn: 0.311 ± 0.015
0.849CysPro: 0.849 ± 0.029
0.349CysGln: 0.349 ± 0.017
0.91CysArg: 0.91 ± 0.031
0.769CysSer: 0.769 ± 0.028
0.576CysThr: 0.576 ± 0.024
0.852CysVal: 0.852 ± 0.028
0.161CysTrp: 0.161 ± 0.013
0.272CysTyr: 0.272 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.882AspAla: 4.882 ± 0.073
0.597AspCys: 0.597 ± 0.024
2.841AspAsp: 2.841 ± 0.06
3.318AspGlu: 3.318 ± 0.057
2.578AspPhe: 2.578 ± 0.051
4.115AspGly: 4.115 ± 0.069
1.368AspHis: 1.368 ± 0.038
3.209AspIle: 3.209 ± 0.053
2.063AspLys: 2.063 ± 0.041
6.463AspLeu: 6.463 ± 0.085
1.538AspMet: 1.538 ± 0.037
1.512AspAsn: 1.512 ± 0.044
3.191AspPro: 3.191 ± 0.058
2.494AspGln: 2.494 ± 0.048
3.49AspArg: 3.49 ± 0.058
2.36AspSer: 2.36 ± 0.046
2.207AspThr: 2.207 ± 0.043
4.227AspVal: 4.227 ± 0.05
0.836AspTrp: 0.836 ± 0.03
1.571AspTyr: 1.571 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.28GluAla: 6.28 ± 0.087
0.558GluCys: 0.558 ± 0.021
3.307GluAsp: 3.307 ± 0.055
4.159GluGlu: 4.159 ± 0.066
2.076GluPhe: 2.076 ± 0.042
3.847GluGly: 3.847 ± 0.06
1.564GluHis: 1.564 ± 0.038
3.746GluIle: 3.746 ± 0.056
2.823GluLys: 2.823 ± 0.053
6.876GluLeu: 6.876 ± 0.09
1.878GluMet: 1.878 ± 0.043
2.041GluAsn: 2.041 ± 0.039
2.696GluPro: 2.696 ± 0.047
3.196GluGln: 3.196 ± 0.062
4.696GluArg: 4.696 ± 0.067
3.19GluSer: 3.19 ± 0.055
3.242GluThr: 3.242 ± 0.054
4.309GluVal: 4.309 ± 0.061
0.664GluTrp: 0.664 ± 0.026
1.538GluTyr: 1.538 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.489PheAla: 3.489 ± 0.059
0.573PheCys: 0.573 ± 0.021
2.167PheAsp: 2.167 ± 0.044
2.061PheGlu: 2.061 ± 0.047
2.3PhePhe: 2.3 ± 0.057
3.256PheGly: 3.256 ± 0.051
0.944PheHis: 0.944 ± 0.029
2.036PheIle: 2.036 ± 0.05
1.259PheLys: 1.259 ± 0.036
4.756PheLeu: 4.756 ± 0.076
0.948PheMet: 0.948 ± 0.029
1.273PheAsn: 1.273 ± 0.035
2.082PhePro: 2.082 ± 0.046
1.639PheGln: 1.639 ± 0.041
2.463PheArg: 2.463 ± 0.045
2.957PheSer: 2.957 ± 0.056
2.332PheThr: 2.332 ± 0.049
2.817PheVal: 2.817 ± 0.056
0.7PheTrp: 0.7 ± 0.024
1.149PheTyr: 1.149 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
6.373GlyAla: 6.373 ± 0.087
1.13GlyCys: 1.13 ± 0.031
3.82GlyAsp: 3.82 ± 0.064
4.566GlyGlu: 4.566 ± 0.069
3.547GlyPhe: 3.547 ± 0.065
5.961GlyGly: 5.961 ± 0.101
1.858GlyHis: 1.858 ± 0.037
4.303GlyIle: 4.303 ± 0.063
3.525GlyLys: 3.525 ± 0.057
9.471GlyLeu: 9.471 ± 0.093
2.656GlyMet: 2.656 ± 0.057
2.274GlyAsn: 2.274 ± 0.054
3.163GlyPro: 3.163 ± 0.055
3.132GlyGln: 3.132 ± 0.059
5.562GlyArg: 5.562 ± 0.077
4.115GlySer: 4.115 ± 0.064
3.967GlyThr: 3.967 ± 0.081
5.917GlyVal: 5.917 ± 0.083
1.191GlyTrp: 1.191 ± 0.034
2.312GlyTyr: 2.312 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.112HisAla: 2.112 ± 0.042
0.332HisCys: 0.332 ± 0.018
1.358HisAsp: 1.358 ± 0.032
1.256HisGlu: 1.256 ± 0.033
0.974HisPhe: 0.974 ± 0.033
2.122HisGly: 2.122 ± 0.042
0.656HisHis: 0.656 ± 0.027
1.027HisIle: 1.027 ± 0.028
0.692HisLys: 0.692 ± 0.026
2.508HisLeu: 2.508 ± 0.04
0.462HisMet: 0.462 ± 0.02
0.576HisAsn: 0.576 ± 0.022
1.65HisPro: 1.65 ± 0.042
0.887HisGln: 0.887 ± 0.026
1.502HisArg: 1.502 ± 0.033
1.106HisSer: 1.106 ± 0.027
0.899HisThr: 0.899 ± 0.028
1.692HisVal: 1.692 ± 0.038
0.313HisTrp: 0.313 ± 0.017
0.623HisTyr: 0.623 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
4.693IleAla: 4.693 ± 0.073
0.654IleCys: 0.654 ± 0.024
2.592IleAsp: 2.592 ± 0.056
2.725IleGlu: 2.725 ± 0.044
2.251IlePhe: 2.251 ± 0.041
3.99IleGly: 3.99 ± 0.071
1.265IleHis: 1.265 ± 0.031
2.835IleIle: 2.835 ± 0.059
1.95IleLys: 1.95 ± 0.046
6.068IleLeu: 6.068 ± 0.084
1.24IleMet: 1.24 ± 0.037
1.751IleAsn: 1.751 ± 0.045
2.889IlePro: 2.889 ± 0.046
2.102IleGln: 2.102 ± 0.043
3.632IleArg: 3.632 ± 0.067
3.283IleSer: 3.283 ± 0.06
2.832IleThr: 2.832 ± 0.06
3.675IleVal: 3.675 ± 0.06
0.63IleTrp: 0.63 ± 0.023
1.248IleTyr: 1.248 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.741LysAla: 3.741 ± 0.061
0.369LysCys: 0.369 ± 0.02
2.167LysAsp: 2.167 ± 0.049
2.46LysGlu: 2.46 ± 0.043
1.079LysPhe: 1.079 ± 0.033
2.772LysGly: 2.772 ± 0.055
0.79LysHis: 0.79 ± 0.026
2.285LysIle: 2.285 ± 0.053
1.95LysLys: 1.95 ± 0.049
3.563LysLeu: 3.563 ± 0.058
1.069LysMet: 1.069 ± 0.032
1.4LysAsn: 1.4 ± 0.038
2.007LysPro: 2.007 ± 0.039
1.439LysGln: 1.439 ± 0.035
2.355LysArg: 2.355 ± 0.044
2.134LysSer: 2.134 ± 0.046
2.27LysThr: 2.27 ± 0.046
2.656LysVal: 2.656 ± 0.049
0.393LysTrp: 0.393 ± 0.02
0.989LysTyr: 0.989 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
12.167LeuAla: 12.167 ± 0.145
1.252LeuCys: 1.252 ± 0.03
6.63LeuAsp: 6.63 ± 0.083
7.617LeuGlu: 7.617 ± 0.098
4.658LeuPhe: 4.658 ± 0.081
8.924LeuGly: 8.924 ± 0.097
2.45LeuHis: 2.45 ± 0.048
5.346LeuIle: 5.346 ± 0.081
3.912LeuLys: 3.912 ± 0.074
12.34LeuLeu: 12.34 ± 0.152
2.294LeuMet: 2.294 ± 0.046
3.352LeuAsn: 3.352 ± 0.052
5.867LeuPro: 5.867 ± 0.078
3.522LeuGln: 3.522 ± 0.068
8.078LeuArg: 8.078 ± 0.104
6.465LeuSer: 6.465 ± 0.074
5.92LeuThr: 5.92 ± 0.073
7.731LeuVal: 7.731 ± 0.096
1.165LeuTrp: 1.165 ± 0.039
2.223LeuTyr: 2.223 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
2.844MetAla: 2.844 ± 0.053
0.187MetCys: 0.187 ± 0.013
1.683MetAsp: 1.683 ± 0.038
1.689MetGlu: 1.689 ± 0.036
0.853MetPhe: 0.853 ± 0.027
1.96MetGly: 1.96 ± 0.041
0.648MetHis: 0.648 ± 0.022
1.485MetIle: 1.485 ± 0.037
1.019MetLys: 1.019 ± 0.031
2.705MetLeu: 2.705 ± 0.051
0.561MetMet: 0.561 ± 0.022
0.971MetAsn: 0.971 ± 0.026
1.455MetPro: 1.455 ± 0.036
0.891MetGln: 0.891 ± 0.03
1.703MetArg: 1.703 ± 0.039
1.494MetSer: 1.494 ± 0.033
1.663MetThr: 1.663 ± 0.038
1.989MetVal: 1.989 ± 0.044
0.191MetTrp: 0.191 ± 0.012
0.501MetTyr: 0.501 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.728AsnAla: 2.728 ± 0.046
0.412AsnCys: 0.412 ± 0.02
1.369AsnAsp: 1.369 ± 0.039
1.469AsnGlu: 1.469 ± 0.039
1.146AsnPhe: 1.146 ± 0.032
2.014AsnGly: 2.014 ± 0.045
0.683AsnHis: 0.683 ± 0.025
1.991AsnIle: 1.991 ± 0.042
1.103AsnLys: 1.103 ± 0.031
3.673AsnLeu: 3.673 ± 0.065
0.855AsnMet: 0.855 ± 0.027
1.01AsnAsn: 1.01 ± 0.033
2.141AsnPro: 2.141 ± 0.04
1.171AsnGln: 1.171 ± 0.03
2.003AsnArg: 2.003 ± 0.04
1.467AsnSer: 1.467 ± 0.045
1.496AsnThr: 1.496 ± 0.033
2.186AsnVal: 2.186 ± 0.05
0.438AsnTrp: 0.438 ± 0.019
0.782AsnTyr: 0.782 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
4.375ProAla: 4.375 ± 0.077
0.569ProCys: 0.569 ± 0.022
3.681ProAsp: 3.681 ± 0.055
4.668ProGlu: 4.668 ± 0.07
1.979ProPhe: 1.979 ± 0.043
4.645ProGly: 4.645 ± 0.064
1.054ProHis: 1.054 ± 0.032
1.989ProIle: 1.989 ± 0.048
1.94ProLys: 1.94 ± 0.042
5.069ProLeu: 5.069 ± 0.065
1.256ProMet: 1.256 ± 0.034
1.354ProAsn: 1.354 ± 0.035
2.44ProPro: 2.44 ± 0.056
1.574ProGln: 1.574 ± 0.037
2.924ProArg: 2.924 ± 0.05
2.947ProSer: 2.947 ± 0.056
2.318ProThr: 2.318 ± 0.044
3.952ProVal: 3.952 ± 0.062
0.762ProTrp: 0.762 ± 0.022
1.208ProTyr: 1.208 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.934GlnAla: 4.934 ± 0.066
0.401GlnCys: 0.401 ± 0.018
2.218GlnAsp: 2.218 ± 0.051
2.651GlnGlu: 2.651 ± 0.057
1.155GlnPhe: 1.155 ± 0.032
3.485GlnGly: 3.485 ± 0.055
0.67GlnHis: 0.67 ± 0.024
1.8GlnIle: 1.8 ± 0.038
1.37GlnLys: 1.37 ± 0.04
2.94GlnLeu: 2.94 ± 0.052
0.903GlnMet: 0.903 ± 0.028
1.128GlnAsn: 1.128 ± 0.032
1.77GlnPro: 1.77 ± 0.043
1.321GlnGln: 1.321 ± 0.04
2.759GlnArg: 2.759 ± 0.053
2.135GlnSer: 2.135 ± 0.039
2.007GlnThr: 2.007 ± 0.041
2.858GlnVal: 2.858 ± 0.055
0.476GlnTrp: 0.476 ± 0.021
0.725GlnTyr: 0.725 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
5.426ArgAla: 5.426 ± 0.077
0.739ArgCys: 0.739 ± 0.025
3.981ArgAsp: 3.981 ± 0.068
5.042ArgGlu: 5.042 ± 0.069
3.093ArgPhe: 3.093 ± 0.054
4.277ArgGly: 4.277 ± 0.068
1.707ArgHis: 1.707 ± 0.039
4.393ArgIle: 4.393 ± 0.059
2.958ArgLys: 2.958 ± 0.056
7.814ArgLeu: 7.814 ± 0.109
1.975ArgMet: 1.975 ± 0.04
2.129ArgAsn: 2.129 ± 0.043
3.152ArgPro: 3.152 ± 0.054
2.603ArgGln: 2.603 ± 0.052
4.648ArgArg: 4.648 ± 0.077
3.546ArgSer: 3.546 ± 0.055
3.505ArgThr: 3.505 ± 0.047
4.511ArgVal: 4.511 ± 0.077
0.807ArgTrp: 0.807 ± 0.023
1.682ArgTyr: 1.682 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.848SerAla: 4.848 ± 0.06
0.674SerCys: 0.674 ± 0.025
2.613SerAsp: 2.613 ± 0.05
3.258SerGlu: 3.258 ± 0.06
2.385SerPhe: 2.385 ± 0.051
5.63SerGly: 5.63 ± 0.078
1.16SerHis: 1.16 ± 0.029
2.861SerIle: 2.861 ± 0.058
1.931SerLys: 1.931 ± 0.044
6.147SerLeu: 6.147 ± 0.076
1.567SerMet: 1.567 ± 0.038
1.434SerAsn: 1.434 ± 0.036
3.103SerPro: 3.103 ± 0.049
1.984SerGln: 1.984 ± 0.04
3.976SerArg: 3.976 ± 0.058
3.527SerSer: 3.527 ± 0.062
2.86SerThr: 2.86 ± 0.044
3.798SerVal: 3.798 ± 0.061
0.84SerTrp: 0.84 ± 0.032
1.266SerTyr: 1.266 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.89ThrAla: 4.89 ± 0.074
0.531ThrCys: 0.531 ± 0.023
2.595ThrAsp: 2.595 ± 0.053
2.71ThrGlu: 2.71 ± 0.04
2.098ThrPhe: 2.098 ± 0.05
4.727ThrGly: 4.727 ± 0.089
1.054ThrHis: 1.054 ± 0.025
2.819ThrIle: 2.819 ± 0.054
1.706ThrLys: 1.706 ± 0.044
5.68ThrLeu: 5.68 ± 0.08
1.403ThrMet: 1.403 ± 0.03
1.478ThrAsn: 1.478 ± 0.045
3.093ThrPro: 3.093 ± 0.059
1.575ThrGln: 1.575 ± 0.039
2.962ThrArg: 2.962 ± 0.049
2.913ThrSer: 2.913 ± 0.056
2.809ThrThr: 2.809 ± 0.054
3.922ThrVal: 3.922 ± 0.06
0.666ThrTrp: 0.666 ± 0.027
1.28ThrTyr: 1.28 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
6.804ValAla: 6.804 ± 0.084
0.931ValCys: 0.931 ± 0.029
4.151ValAsp: 4.151 ± 0.058
4.469ValGlu: 4.469 ± 0.068
3.184ValPhe: 3.184 ± 0.05
5.396ValGly: 5.396 ± 0.074
1.722ValHis: 1.722 ± 0.035
3.85ValIle: 3.85 ± 0.064
2.256ValLys: 2.256 ± 0.046
8.689ValLeu: 8.689 ± 0.104
1.77ValMet: 1.77 ± 0.041
2.323ValAsn: 2.323 ± 0.051
3.218ValPro: 3.218 ± 0.048
2.702ValGln: 2.702 ± 0.051
5.185ValArg: 5.185 ± 0.074
4.281ValSer: 4.281 ± 0.065
3.699ValThr: 3.699 ± 0.07
5.842ValVal: 5.842 ± 0.08
0.848ValTrp: 0.848 ± 0.026
1.717ValTyr: 1.717 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.078TrpAla: 1.078 ± 0.032
0.122TrpCys: 0.122 ± 0.011
0.738TrpAsp: 0.738 ± 0.024
0.792TrpGlu: 0.792 ± 0.027
0.518TrpPhe: 0.518 ± 0.024
0.886TrpGly: 0.886 ± 0.032
0.288TrpHis: 0.288 ± 0.016
0.705TrpIle: 0.705 ± 0.027
0.57TrpLys: 0.57 ± 0.023
1.436TrpLeu: 1.436 ± 0.041
0.366TrpMet: 0.366 ± 0.017
0.521TrpAsn: 0.521 ± 0.022
0.71TrpPro: 0.71 ± 0.025
0.518TrpGln: 0.518 ± 0.022
0.977TrpArg: 0.977 ± 0.03
0.816TrpSer: 0.816 ± 0.03
0.732TrpThr: 0.732 ± 0.028
0.802TrpVal: 0.802 ± 0.027
0.225TrpTrp: 0.225 ± 0.014
0.309TrpTyr: 0.309 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.334TyrAla: 2.334 ± 0.041
0.318TyrCys: 0.318 ± 0.018
1.359TyrAsp: 1.359 ± 0.036
1.244TyrGlu: 1.244 ± 0.029
1.159TyrPhe: 1.159 ± 0.034
2.013TyrGly: 2.013 ± 0.046
0.572TyrHis: 0.572 ± 0.023
1.04TyrIle: 1.04 ± 0.032
0.781TyrLys: 0.781 ± 0.023
2.923TyrLeu: 2.923 ± 0.051
0.495TyrMet: 0.495 ± 0.022
0.796TyrAsn: 0.796 ± 0.028
1.296TyrPro: 1.296 ± 0.03
0.947TyrGln: 0.947 ± 0.028
1.669TyrArg: 1.669 ± 0.041
1.411TyrSer: 1.411 ± 0.039
1.243TyrThr: 1.243 ± 0.043
1.708TyrVal: 1.708 ± 0.037
0.409TyrTrp: 0.409 ± 0.017
0.778TyrTyr: 0.778 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3695 proteins (1206423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski