Amino acid dipepetide frequency for Streptococcus phage Javan137

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.668AlaAla: 3.668 ± 1.076
0.459AlaCys: 0.459 ± 0.188
3.852AlaAsp: 3.852 ± 0.553
4.861AlaGlu: 4.861 ± 0.722
2.293AlaPhe: 2.293 ± 0.488
3.485AlaGly: 3.485 ± 0.728
0.642AlaHis: 0.642 ± 0.239
5.869AlaIle: 5.869 ± 0.626
6.878AlaLys: 6.878 ± 1.016
6.145AlaLeu: 6.145 ± 1.269
1.651AlaMet: 1.651 ± 0.321
4.952AlaAsn: 4.952 ± 0.685
1.651AlaPro: 1.651 ± 0.428
4.31AlaGln: 4.31 ± 0.771
2.935AlaArg: 2.935 ± 0.531
4.952AlaSer: 4.952 ± 1.224
3.026AlaThr: 3.026 ± 0.507
4.035AlaVal: 4.035 ± 0.643
0.459AlaTrp: 0.459 ± 0.198
2.293AlaTyr: 2.293 ± 0.468
0.0AlaXaa: 0.0 ± 0.0
Cys
0.275CysAla: 0.275 ± 0.157
0.092CysCys: 0.092 ± 0.104
0.092CysAsp: 0.092 ± 0.075
0.642CysGlu: 0.642 ± 0.268
0.183CysPhe: 0.183 ± 0.125
0.642CysGly: 0.642 ± 0.238
0.183CysHis: 0.183 ± 0.116
0.734CysIle: 0.734 ± 0.231
0.459CysLys: 0.459 ± 0.212
0.092CysLeu: 0.092 ± 0.096
0.183CysMet: 0.183 ± 0.134
0.183CysAsn: 0.183 ± 0.119
0.092CysPro: 0.092 ± 0.104
0.092CysGln: 0.092 ± 0.104
0.092CysArg: 0.092 ± 0.1
0.183CysSer: 0.183 ± 0.147
0.092CysThr: 0.092 ± 0.085
0.275CysVal: 0.275 ± 0.164
0.183CysTrp: 0.183 ± 0.134
0.367CysTyr: 0.367 ± 0.207
0.0CysXaa: 0.0 ± 0.0
Asp
3.76AspAla: 3.76 ± 0.558
0.55AspCys: 0.55 ± 0.224
4.219AspAsp: 4.219 ± 0.678
4.861AspGlu: 4.861 ± 0.635
3.668AspPhe: 3.668 ± 0.488
4.127AspGly: 4.127 ± 0.706
0.55AspHis: 0.55 ± 0.209
5.136AspIle: 5.136 ± 0.902
7.428AspLys: 7.428 ± 0.7
5.869AspLeu: 5.869 ± 0.681
2.109AspMet: 2.109 ± 0.448
3.393AspAsn: 3.393 ± 0.458
1.559AspPro: 1.559 ± 0.376
1.559AspGln: 1.559 ± 0.355
1.376AspArg: 1.376 ± 0.382
4.677AspSer: 4.677 ± 0.501
3.393AspThr: 3.393 ± 0.643
4.035AspVal: 4.035 ± 0.636
1.192AspTrp: 1.192 ± 0.277
3.21AspTyr: 3.21 ± 0.589
0.0AspXaa: 0.0 ± 0.0
Glu
5.594GluAla: 5.594 ± 1.142
0.459GluCys: 0.459 ± 0.222
3.577GluAsp: 3.577 ± 0.543
7.245GluGlu: 7.245 ± 1.116
2.568GluPhe: 2.568 ± 0.554
3.026GluGly: 3.026 ± 0.472
1.101GluHis: 1.101 ± 0.287
7.337GluIle: 7.337 ± 0.773
6.328GluLys: 6.328 ± 0.886
9.079GluLeu: 9.079 ± 0.964
1.559GluMet: 1.559 ± 0.353
3.026GluAsn: 3.026 ± 0.451
1.926GluPro: 1.926 ± 0.422
3.026GluGln: 3.026 ± 0.715
3.21GluArg: 3.21 ± 0.44
5.594GluSer: 5.594 ± 0.644
4.677GluThr: 4.677 ± 0.647
5.136GluVal: 5.136 ± 0.749
1.009GluTrp: 1.009 ± 0.266
1.834GluTyr: 1.834 ± 0.384
0.0GluXaa: 0.0 ± 0.0
Phe
1.467PheAla: 1.467 ± 0.319
0.092PheCys: 0.092 ± 0.086
4.31PheAsp: 4.31 ± 0.673
3.393PheGlu: 3.393 ± 0.716
1.834PhePhe: 1.834 ± 0.456
3.118PheGly: 3.118 ± 0.48
0.734PheHis: 0.734 ± 0.285
2.66PheIle: 2.66 ± 0.493
4.585PheLys: 4.585 ± 0.584
2.018PheLeu: 2.018 ± 0.384
1.101PheMet: 1.101 ± 0.285
2.66PheAsn: 2.66 ± 0.635
0.642PhePro: 0.642 ± 0.255
1.192PheGln: 1.192 ± 0.264
2.018PheArg: 2.018 ± 0.382
1.559PheSer: 1.559 ± 0.411
3.118PheThr: 3.118 ± 0.518
2.751PheVal: 2.751 ± 0.497
0.367PheTrp: 0.367 ± 0.167
1.376PheTyr: 1.376 ± 0.334
0.0PheXaa: 0.0 ± 0.0
Gly
2.66GlyAla: 2.66 ± 0.487
0.183GlyCys: 0.183 ± 0.116
3.852GlyAsp: 3.852 ± 0.646
4.494GlyGlu: 4.494 ± 0.679
2.751GlyPhe: 2.751 ± 0.469
3.118GlyGly: 3.118 ± 0.515
0.642GlyHis: 0.642 ± 0.197
4.219GlyIle: 4.219 ± 0.641
5.686GlyLys: 5.686 ± 0.631
5.961GlyLeu: 5.961 ± 0.79
2.018GlyMet: 2.018 ± 0.316
3.485GlyAsn: 3.485 ± 0.447
1.467GlyPro: 1.467 ± 0.417
3.577GlyGln: 3.577 ± 0.678
2.751GlyArg: 2.751 ± 0.489
3.302GlySer: 3.302 ± 0.606
3.302GlyThr: 3.302 ± 0.764
2.66GlyVal: 2.66 ± 0.553
1.009GlyTrp: 1.009 ± 0.28
2.384GlyTyr: 2.384 ± 0.567
0.0GlyXaa: 0.0 ± 0.0
His
1.009HisAla: 1.009 ± 0.336
0.0HisCys: 0.0 ± 0.0
0.734HisAsp: 0.734 ± 0.357
1.376HisGlu: 1.376 ± 0.305
0.734HisPhe: 0.734 ± 0.246
1.192HisGly: 1.192 ± 0.271
0.275HisHis: 0.275 ± 0.142
0.642HisIle: 0.642 ± 0.234
0.734HisLys: 0.734 ± 0.257
0.734HisLeu: 0.734 ± 0.223
0.367HisMet: 0.367 ± 0.17
0.734HisAsn: 0.734 ± 0.24
0.734HisPro: 0.734 ± 0.236
0.55HisGln: 0.55 ± 0.232
0.642HisArg: 0.642 ± 0.222
0.55HisSer: 0.55 ± 0.216
1.009HisThr: 1.009 ± 0.315
1.009HisVal: 1.009 ± 0.375
0.183HisTrp: 0.183 ± 0.144
0.367HisTyr: 0.367 ± 0.214
0.0HisXaa: 0.0 ± 0.0
Ile
5.044IleAla: 5.044 ± 0.572
0.275IleCys: 0.275 ± 0.148
5.778IleAsp: 5.778 ± 0.758
5.961IleGlu: 5.961 ± 0.672
2.66IlePhe: 2.66 ± 0.659
4.585IleGly: 4.585 ± 0.564
1.009IleHis: 1.009 ± 0.272
3.577IleIle: 3.577 ± 0.575
8.529IleLys: 8.529 ± 0.936
4.035IleLeu: 4.035 ± 0.723
1.009IleMet: 1.009 ± 0.306
5.136IleAsn: 5.136 ± 0.887
2.751IlePro: 2.751 ± 0.527
1.467IleGln: 1.467 ± 0.324
2.843IleArg: 2.843 ± 0.41
3.852IleSer: 3.852 ± 0.627
4.769IleThr: 4.769 ± 0.525
4.585IleVal: 4.585 ± 0.661
0.092IleTrp: 0.092 ± 0.071
3.118IleTyr: 3.118 ± 0.501
0.0IleXaa: 0.0 ± 0.0
Lys
7.337LysAla: 7.337 ± 0.877
0.642LysCys: 0.642 ± 0.221
6.603LysAsp: 6.603 ± 0.596
8.621LysGlu: 8.621 ± 1.022
2.751LysPhe: 2.751 ± 0.536
5.594LysGly: 5.594 ± 0.924
1.559LysHis: 1.559 ± 0.324
7.337LysIle: 7.337 ± 0.819
7.245LysLys: 7.245 ± 0.723
7.979LysLeu: 7.979 ± 0.768
2.201LysMet: 2.201 ± 0.447
5.686LysAsn: 5.686 ± 0.625
2.018LysPro: 2.018 ± 0.401
4.677LysGln: 4.677 ± 0.657
4.219LysArg: 4.219 ± 0.643
6.053LysSer: 6.053 ± 0.635
4.769LysThr: 4.769 ± 0.613
6.603LysVal: 6.603 ± 0.952
1.284LysTrp: 1.284 ± 0.367
2.476LysTyr: 2.476 ± 0.54
0.0LysXaa: 0.0 ± 0.0
Leu
6.053LeuAla: 6.053 ± 0.893
0.183LeuCys: 0.183 ± 0.126
5.686LeuAsp: 5.686 ± 0.629
7.337LeuGlu: 7.337 ± 1.175
2.476LeuPhe: 2.476 ± 0.465
5.044LeuGly: 5.044 ± 0.857
0.55LeuHis: 0.55 ± 0.261
5.227LeuIle: 5.227 ± 0.726
10.547LeuLys: 10.547 ± 0.932
7.062LeuLeu: 7.062 ± 0.715
1.926LeuMet: 1.926 ± 0.571
4.219LeuAsn: 4.219 ± 0.686
3.118LeuPro: 3.118 ± 0.502
2.935LeuGln: 2.935 ± 0.442
2.568LeuArg: 2.568 ± 0.514
6.236LeuSer: 6.236 ± 0.724
6.328LeuThr: 6.328 ± 0.717
4.219LeuVal: 4.219 ± 0.466
0.825LeuTrp: 0.825 ± 0.262
2.201LeuTyr: 2.201 ± 0.47
0.0LeuXaa: 0.0 ± 0.0
Met
1.192MetAla: 1.192 ± 0.311
0.092MetCys: 0.092 ± 0.104
1.376MetAsp: 1.376 ± 0.454
1.926MetGlu: 1.926 ± 0.349
1.192MetPhe: 1.192 ± 0.253
1.101MetGly: 1.101 ± 0.261
0.0MetHis: 0.0 ± 0.0
2.66MetIle: 2.66 ± 0.459
1.926MetLys: 1.926 ± 0.429
2.201MetLeu: 2.201 ± 0.493
0.825MetMet: 0.825 ± 0.267
0.825MetAsn: 0.825 ± 0.284
0.55MetPro: 0.55 ± 0.223
0.642MetGln: 0.642 ± 0.24
1.559MetArg: 1.559 ± 0.413
1.559MetSer: 1.559 ± 0.331
2.568MetThr: 2.568 ± 0.418
1.284MetVal: 1.284 ± 0.365
0.183MetTrp: 0.183 ± 0.137
0.734MetTyr: 0.734 ± 0.239
0.0MetXaa: 0.0 ± 0.0
Asn
3.852AsnAla: 3.852 ± 0.687
0.55AsnCys: 0.55 ± 0.226
3.577AsnAsp: 3.577 ± 0.489
2.568AsnGlu: 2.568 ± 0.486
2.293AsnPhe: 2.293 ± 0.462
3.76AsnGly: 3.76 ± 0.458
1.101AsnHis: 1.101 ± 0.257
3.118AsnIle: 3.118 ± 0.661
4.769AsnLys: 4.769 ± 0.704
4.219AsnLeu: 4.219 ± 0.583
1.834AsnMet: 1.834 ± 0.413
3.118AsnAsn: 3.118 ± 0.454
2.384AsnPro: 2.384 ± 0.376
2.935AsnGln: 2.935 ± 0.569
2.476AsnArg: 2.476 ± 0.42
3.485AsnSer: 3.485 ± 0.608
3.026AsnThr: 3.026 ± 0.468
3.118AsnVal: 3.118 ± 0.58
1.101AsnTrp: 1.101 ± 0.307
2.66AsnTyr: 2.66 ± 0.5
0.0AsnXaa: 0.0 ± 0.0
Pro
1.742ProAla: 1.742 ± 0.339
0.183ProCys: 0.183 ± 0.121
1.651ProAsp: 1.651 ± 0.456
2.109ProGlu: 2.109 ± 0.371
1.192ProPhe: 1.192 ± 0.347
1.376ProGly: 1.376 ± 0.291
0.55ProHis: 0.55 ± 0.211
1.559ProIle: 1.559 ± 0.458
3.21ProLys: 3.21 ± 0.471
1.834ProLeu: 1.834 ± 0.436
0.459ProMet: 0.459 ± 0.236
1.101ProAsn: 1.101 ± 0.351
0.459ProPro: 0.459 ± 0.172
1.467ProGln: 1.467 ± 0.424
1.376ProArg: 1.376 ± 0.364
1.926ProSer: 1.926 ± 0.425
1.559ProThr: 1.559 ± 0.32
1.742ProVal: 1.742 ± 0.346
0.459ProTrp: 0.459 ± 0.195
0.459ProTyr: 0.459 ± 0.183
0.0ProXaa: 0.0 ± 0.0
Gln
3.393GlnAla: 3.393 ± 0.534
0.275GlnCys: 0.275 ± 0.145
2.018GlnAsp: 2.018 ± 0.416
3.026GlnGlu: 3.026 ± 0.434
1.559GlnPhe: 1.559 ± 0.411
1.559GlnGly: 1.559 ± 0.407
0.459GlnHis: 0.459 ± 0.206
3.026GlnIle: 3.026 ± 0.408
4.677GlnLys: 4.677 ± 0.823
4.769GlnLeu: 4.769 ± 0.864
0.642GlnMet: 0.642 ± 0.31
2.293GlnAsn: 2.293 ± 0.497
0.734GlnPro: 0.734 ± 0.275
1.651GlnGln: 1.651 ± 0.423
1.651GlnArg: 1.651 ± 0.385
3.668GlnSer: 3.668 ± 0.529
2.568GlnThr: 2.568 ± 0.507
2.293GlnVal: 2.293 ± 0.436
0.092GlnTrp: 0.092 ± 0.091
1.376GlnTyr: 1.376 ± 0.358
0.0GlnXaa: 0.0 ± 0.0
Arg
3.21ArgAla: 3.21 ± 0.54
0.459ArgCys: 0.459 ± 0.227
3.21ArgAsp: 3.21 ± 0.439
2.66ArgGlu: 2.66 ± 0.494
1.834ArgPhe: 1.834 ± 0.32
1.834ArgGly: 1.834 ± 0.391
0.825ArgHis: 0.825 ± 0.304
2.568ArgIle: 2.568 ± 0.502
3.393ArgLys: 3.393 ± 0.542
4.127ArgLeu: 4.127 ± 0.595
1.009ArgMet: 1.009 ± 0.251
2.293ArgAsn: 2.293 ± 0.524
0.55ArgPro: 0.55 ± 0.177
1.834ArgGln: 1.834 ± 0.342
2.018ArgArg: 2.018 ± 0.534
1.559ArgSer: 1.559 ± 0.286
1.834ArgThr: 1.834 ± 0.343
2.018ArgVal: 2.018 ± 0.362
1.101ArgTrp: 1.101 ± 0.276
2.293ArgTyr: 2.293 ± 0.409
0.0ArgXaa: 0.0 ± 0.0
Ser
4.677SerAla: 4.677 ± 0.751
0.092SerCys: 0.092 ± 0.091
4.31SerAsp: 4.31 ± 0.698
3.852SerGlu: 3.852 ± 0.504
3.393SerPhe: 3.393 ± 0.573
4.769SerGly: 4.769 ± 0.913
0.459SerHis: 0.459 ± 0.231
4.494SerIle: 4.494 ± 0.719
4.769SerLys: 4.769 ± 0.69
5.411SerLeu: 5.411 ± 0.63
1.284SerMet: 1.284 ± 0.305
4.035SerAsn: 4.035 ± 0.674
1.651SerPro: 1.651 ± 0.39
2.66SerGln: 2.66 ± 0.574
2.66SerArg: 2.66 ± 0.415
3.577SerSer: 3.577 ± 0.592
3.118SerThr: 3.118 ± 0.45
4.31SerVal: 4.31 ± 0.642
0.55SerTrp: 0.55 ± 0.274
1.926SerTyr: 1.926 ± 0.432
0.0SerXaa: 0.0 ± 0.0
Thr
5.503ThrAla: 5.503 ± 1.057
0.275ThrCys: 0.275 ± 0.207
3.76ThrAsp: 3.76 ± 0.718
3.393ThrGlu: 3.393 ± 0.614
2.843ThrPhe: 2.843 ± 0.523
4.31ThrGly: 4.31 ± 0.714
0.825ThrHis: 0.825 ± 0.22
3.76ThrIle: 3.76 ± 0.611
5.044ThrLys: 5.044 ± 0.732
5.136ThrLeu: 5.136 ± 0.612
0.917ThrMet: 0.917 ± 0.294
3.026ThrAsn: 3.026 ± 0.493
2.018ThrPro: 2.018 ± 0.359
2.293ThrGln: 2.293 ± 0.355
1.834ThrArg: 1.834 ± 0.4
4.035ThrSer: 4.035 ± 0.584
3.944ThrThr: 3.944 ± 0.754
3.302ThrVal: 3.302 ± 0.538
0.55ThrTrp: 0.55 ± 0.245
1.926ThrTyr: 1.926 ± 0.449
0.0ThrXaa: 0.0 ± 0.0
Val
5.136ValAla: 5.136 ± 0.681
0.092ValCys: 0.092 ± 0.081
4.585ValAsp: 4.585 ± 0.643
4.952ValGlu: 4.952 ± 0.604
2.751ValPhe: 2.751 ± 0.444
3.76ValGly: 3.76 ± 0.573
0.642ValHis: 0.642 ± 0.226
4.494ValIle: 4.494 ± 0.637
5.319ValLys: 5.319 ± 0.512
4.127ValLeu: 4.127 ± 0.553
1.834ValMet: 1.834 ± 0.44
2.751ValAsn: 2.751 ± 0.495
1.009ValPro: 1.009 ± 0.302
2.476ValGln: 2.476 ± 0.509
2.843ValArg: 2.843 ± 0.442
3.302ValSer: 3.302 ± 0.54
3.76ValThr: 3.76 ± 0.622
4.494ValVal: 4.494 ± 0.709
0.642ValTrp: 0.642 ± 0.219
1.559ValTyr: 1.559 ± 0.407
0.0ValXaa: 0.0 ± 0.0
Trp
0.367TrpAla: 0.367 ± 0.164
0.0TrpCys: 0.0 ± 0.0
1.009TrpAsp: 1.009 ± 0.342
1.192TrpGlu: 1.192 ± 0.278
0.734TrpPhe: 0.734 ± 0.237
0.917TrpGly: 0.917 ± 0.323
0.459TrpHis: 0.459 ± 0.201
0.825TrpIle: 0.825 ± 0.233
1.192TrpLys: 1.192 ± 0.294
0.917TrpLeu: 0.917 ± 0.27
0.367TrpMet: 0.367 ± 0.182
0.55TrpAsn: 0.55 ± 0.244
0.092TrpPro: 0.092 ± 0.085
0.734TrpGln: 0.734 ± 0.252
0.183TrpArg: 0.183 ± 0.13
0.642TrpSer: 0.642 ± 0.218
0.642TrpThr: 0.642 ± 0.218
0.367TrpVal: 0.367 ± 0.198
0.092TrpTrp: 0.092 ± 0.08
0.55TrpTyr: 0.55 ± 0.224
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.476TyrAla: 2.476 ± 0.505
0.183TyrCys: 0.183 ± 0.119
2.476TyrAsp: 2.476 ± 0.437
2.843TyrGlu: 2.843 ± 0.411
1.284TyrPhe: 1.284 ± 0.406
2.201TyrGly: 2.201 ± 0.453
1.009TyrHis: 1.009 ± 0.302
1.834TyrIle: 1.834 ± 0.541
3.026TyrLys: 3.026 ± 0.539
3.026TyrLeu: 3.026 ± 0.558
1.009TyrMet: 1.009 ± 0.314
2.476TyrAsn: 2.476 ± 0.451
1.009TyrPro: 1.009 ± 0.321
1.651TyrGln: 1.651 ± 0.442
1.376TyrArg: 1.376 ± 0.386
1.284TyrSer: 1.284 ± 0.306
1.192TyrThr: 1.192 ± 0.377
2.293TyrVal: 2.293 ± 0.508
0.459TyrTrp: 0.459 ± 0.207
1.651TyrTyr: 1.651 ± 0.39
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (10905 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski