Amino acid dipepetide frequency for Segetibacter aerophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.336AlaAla: 6.336 ± 0.087	0.667AlaCys: 0.667 ± 0.023	3.829AlaAsp: 3.829 ± 0.055	4.201AlaGlu: 4.201 ± 0.055	3.605AlaPhe: 3.605 ± 0.049	5.736AlaGly: 5.736 ± 0.065	1.161AlaHis: 1.161 ± 0.027	5.393AlaIle: 5.393 ± 0.061	4.706AlaLys: 4.706 ± 0.06	6.462AlaLeu: 6.462 ± 0.059	1.668AlaMet: 1.668 ± 0.033	3.883AlaAsn: 3.883 ± 0.051	2.55AlaPro: 2.55 ± 0.043	2.513AlaGln: 2.513 ± 0.045	2.643AlaArg: 2.643 ± 0.044	4.882AlaSer: 4.882 ± 0.058	4.556AlaThr: 4.556 ± 0.055	4.972AlaVal: 4.972 ± 0.059	0.787AlaTrp: 0.787 ± 0.024	2.556AlaTyr: 2.556 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.505CysAla: 0.505 ± 0.018	0.128CysCys: 0.128 ± 0.009	0.386CysAsp: 0.386 ± 0.016	0.425CysGlu: 0.425 ± 0.019	0.449CysPhe: 0.449 ± 0.017	0.623CysGly: 0.623 ± 0.023	0.198CysHis: 0.198 ± 0.013	0.661CysIle: 0.661 ± 0.018	0.524CysLys: 0.524 ± 0.018	0.765CysLeu: 0.765 ± 0.022	0.182CysMet: 0.182 ± 0.011	0.41CysAsn: 0.41 ± 0.017	0.327CysPro: 0.327 ± 0.015	0.21CysGln: 0.21 ± 0.012	0.313CysArg: 0.313 ± 0.016	0.571CysSer: 0.571 ± 0.018	0.467CysThr: 0.467 ± 0.018	0.511CysVal: 0.511 ± 0.019	0.095CysTrp: 0.095 ± 0.007	0.314CysTyr: 0.314 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.744AspAla: 3.744 ± 0.046	0.4AspCys: 0.4 ± 0.019	2.414AspAsp: 2.414 ± 0.047	3.43AspGlu: 3.43 ± 0.054	2.958AspPhe: 2.958 ± 0.046	3.546AspGly: 3.546 ± 0.064	0.872AspHis: 0.872 ± 0.025	3.745AspIle: 3.745 ± 0.052	3.885AspLys: 3.885 ± 0.056	4.719AspLeu: 4.719 ± 0.053	1.049AspMet: 1.049 ± 0.026	2.71AspAsn: 2.71 ± 0.041	2.045AspPro: 2.045 ± 0.037	1.557AspGln: 1.557 ± 0.032	2.07AspArg: 2.07 ± 0.037	2.861AspSer: 2.861 ± 0.047	2.643AspThr: 2.643 ± 0.05	3.641AspVal: 3.641 ± 0.044	0.798AspTrp: 0.798 ± 0.024	2.379AspTyr: 2.379 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.392GluAla: 4.392 ± 0.057	0.383GluCys: 0.383 ± 0.018	2.918GluAsp: 2.918 ± 0.046	4.215GluGlu: 4.215 ± 0.063	2.473GluPhe: 2.473 ± 0.041	3.721GluGly: 3.721 ± 0.049	1.035GluHis: 1.035 ± 0.026	4.318GluIle: 4.318 ± 0.051	5.267GluLys: 5.267 ± 0.071	5.527GluLeu: 5.527 ± 0.069	1.632GluMet: 1.632 ± 0.036	3.483GluAsn: 3.483 ± 0.061	1.785GluPro: 1.785 ± 0.034	2.5GluGln: 2.5 ± 0.044	2.663GluArg: 2.663 ± 0.046	2.699GluSer: 2.699 ± 0.039	3.181GluThr: 3.181 ± 0.046	4.114GluVal: 4.114 ± 0.057	0.785GluTrp: 0.785 ± 0.02	2.1GluTyr: 2.1 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.428PheAla: 3.428 ± 0.047	0.456PheCys: 0.456 ± 0.016	2.879PheAsp: 2.879 ± 0.043	2.822PheGlu: 2.822 ± 0.043	2.564PhePhe: 2.564 ± 0.04	3.431PheGly: 3.431 ± 0.05	0.849PheHis: 0.849 ± 0.025	3.647PheIle: 3.647 ± 0.049	3.381PheLys: 3.381 ± 0.046	4.428PheLeu: 4.428 ± 0.056	1.021PheMet: 1.021 ± 0.025	2.935PheAsn: 2.935 ± 0.052	1.883PhePro: 1.883 ± 0.038	1.498PheGln: 1.498 ± 0.031	1.847PheArg: 1.847 ± 0.034	3.833PheSer: 3.833 ± 0.047	3.179PheThr: 3.179 ± 0.05	3.166PheVal: 3.166 ± 0.044	0.604PheTrp: 0.604 ± 0.02	1.988PheTyr: 1.988 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	4.691GlyAla: 4.691 ± 0.057	0.662GlyCys: 0.662 ± 0.028	3.354GlyAsp: 3.354 ± 0.051	3.671GlyGlu: 3.671 ± 0.056	3.657GlyPhe: 3.657 ± 0.048	5.144GlyGly: 5.144 ± 0.08	1.244GlyHis: 1.244 ± 0.029	4.969GlyIle: 4.969 ± 0.054	5.379GlyLys: 5.379 ± 0.06	6.069GlyLeu: 6.069 ± 0.068	1.677GlyMet: 1.677 ± 0.034	3.782GlyAsn: 3.782 ± 0.061	1.761GlyPro: 1.761 ± 0.036	2.172GlyGln: 2.172 ± 0.046	2.84GlyArg: 2.84 ± 0.044	4.658GlySer: 4.658 ± 0.068	4.159GlyThr: 4.159 ± 0.076	4.643GlyVal: 4.643 ± 0.059	1.034GlyTrp: 1.034 ± 0.026	2.905GlyTyr: 2.905 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.124HisAla: 1.124 ± 0.027	0.194HisCys: 0.194 ± 0.011	0.859HisAsp: 0.859 ± 0.023	1.026HisGlu: 1.026 ± 0.025	1.125HisPhe: 1.125 ± 0.026	1.139HisGly: 1.139 ± 0.028	0.485HisHis: 0.485 ± 0.02	1.241HisIle: 1.241 ± 0.03	1.03HisLys: 1.03 ± 0.023	1.857HisLeu: 1.857 ± 0.038	0.337HisMet: 0.337 ± 0.014	0.921HisAsn: 0.921 ± 0.028	1.057HisPro: 1.057 ± 0.027	0.682HisGln: 0.682 ± 0.024	0.765HisArg: 0.765 ± 0.023	1.12HisSer: 1.12 ± 0.032	0.962HisThr: 0.962 ± 0.023	1.028HisVal: 1.028 ± 0.024	0.255HisTrp: 0.255 ± 0.012	0.817HisTyr: 0.817 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.629IleAla: 5.629 ± 0.064	0.698IleCys: 0.698 ± 0.021	4.139IleAsp: 4.139 ± 0.054	4.383IleGlu: 4.383 ± 0.061	3.04IlePhe: 3.04 ± 0.049	4.792IleGly: 4.792 ± 0.056	1.314IleHis: 1.314 ± 0.028	4.997IleIle: 4.997 ± 0.063	5.044IleLys: 5.044 ± 0.052	5.911IleLeu: 5.911 ± 0.067	1.253IleMet: 1.253 ± 0.028	4.184IleAsn: 4.184 ± 0.054	3.028IlePro: 3.028 ± 0.047	2.271IleGln: 2.271 ± 0.039	2.759IleArg: 2.759 ± 0.039	5.008IleSer: 5.008 ± 0.061	4.481IleThr: 4.481 ± 0.055	4.639IleVal: 4.639 ± 0.06	0.639IleTrp: 0.639 ± 0.02	2.442IleTyr: 2.442 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.282LysAla: 5.282 ± 0.062	0.348LysCys: 0.348 ± 0.015	4.285LysAsp: 4.285 ± 0.055	5.388LysGlu: 5.388 ± 0.066	2.704LysPhe: 2.704 ± 0.039	4.866LysGly: 4.866 ± 0.053	1.242LysHis: 1.242 ± 0.028	4.932LysIle: 4.932 ± 0.055	5.875LysLys: 5.875 ± 0.078	5.939LysLeu: 5.939 ± 0.068	1.95LysMet: 1.95 ± 0.036	4.306LysAsn: 4.306 ± 0.048	2.78LysPro: 2.78 ± 0.046	3.016LysGln: 3.016 ± 0.051	3.02LysArg: 3.02 ± 0.049	4.105LysSer: 4.105 ± 0.053	4.144LysThr: 4.144 ± 0.055	4.99LysVal: 4.99 ± 0.063	0.91LysTrp: 0.91 ± 0.024	2.773LysTyr: 2.773 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.512LeuAla: 6.512 ± 0.074	0.751LeuCys: 0.751 ± 0.022	4.409LeuAsp: 4.409 ± 0.052	5.012LeuGlu: 5.012 ± 0.067	4.587LeuPhe: 4.587 ± 0.062	5.631LeuGly: 5.631 ± 0.06	1.801LeuHis: 1.801 ± 0.039	5.982LeuIle: 5.982 ± 0.068	6.99LeuLys: 6.99 ± 0.071	9.009LeuLeu: 9.009 ± 0.089	1.964LeuMet: 1.964 ± 0.033	5.012LeuAsn: 5.012 ± 0.063	4.052LeuPro: 4.052 ± 0.056	4.16LeuGln: 4.16 ± 0.064	3.731LeuArg: 3.731 ± 0.048	6.466LeuSer: 6.466 ± 0.077	5.21LeuThr: 5.21 ± 0.065	5.77LeuVal: 5.77 ± 0.067	0.917LeuTrp: 0.917 ± 0.029	3.193LeuTyr: 3.193 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.743MetAla: 1.743 ± 0.038	0.138MetCys: 0.138 ± 0.009	1.057MetAsp: 1.057 ± 0.023	1.382MetGlu: 1.382 ± 0.031	0.939MetPhe: 0.939 ± 0.024	1.422MetGly: 1.422 ± 0.03	0.448MetHis: 0.448 ± 0.016	1.498MetIle: 1.498 ± 0.028	1.972MetLys: 1.972 ± 0.043	2.08MetLeu: 2.08 ± 0.035	0.616MetMet: 0.616 ± 0.021	1.25MetAsn: 1.25 ± 0.027	1.043MetPro: 1.043 ± 0.023	1.05MetGln: 1.05 ± 0.026	0.961MetArg: 0.961 ± 0.019	1.369MetSer: 1.369 ± 0.03	1.143MetThr: 1.143 ± 0.029	1.452MetVal: 1.452 ± 0.029	0.225MetTrp: 0.225 ± 0.012	0.693MetTyr: 0.693 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.905AsnAla: 3.905 ± 0.058	0.452AsnCys: 0.452 ± 0.02	2.86AsnAsp: 2.86 ± 0.049	3.309AsnGlu: 3.309 ± 0.051	2.808AsnPhe: 2.808 ± 0.043	3.994AsnGly: 3.994 ± 0.066	0.943AsnHis: 0.943 ± 0.026	4.155AsnIle: 4.155 ± 0.051	4.02AsnLys: 4.02 ± 0.049	4.933AsnLeu: 4.933 ± 0.071	1.17AsnMet: 1.17 ± 0.027	3.666AsnAsn: 3.666 ± 0.057	2.62AsnPro: 2.62 ± 0.038	1.911AsnGln: 1.911 ± 0.036	2.351AsnArg: 2.351 ± 0.04	3.577AsnSer: 3.577 ± 0.055	3.436AsnThr: 3.436 ± 0.053	3.487AsnVal: 3.487 ± 0.051	0.802AsnTrp: 0.802 ± 0.025	2.607AsnTyr: 2.607 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.319ProAla: 3.319 ± 0.048	0.229ProCys: 0.229 ± 0.01	2.292ProAsp: 2.292 ± 0.036	2.565ProGlu: 2.565 ± 0.044	2.108ProPhe: 2.108 ± 0.04	2.857ProGly: 2.857 ± 0.04	0.732ProHis: 0.732 ± 0.026	2.417ProIle: 2.417 ± 0.036	2.264ProLys: 2.264 ± 0.036	3.421ProLeu: 3.421 ± 0.051	0.783ProMet: 0.783 ± 0.022	2.105ProAsn: 2.105 ± 0.038	1.249ProPro: 1.249 ± 0.037	1.329ProGln: 1.329 ± 0.029	1.161ProArg: 1.161 ± 0.028	2.447ProSer: 2.447 ± 0.032	2.319ProThr: 2.319 ± 0.036	3.304ProVal: 3.304 ± 0.05	0.441ProTrp: 0.441 ± 0.02	1.588ProTyr: 1.588 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.419GlnAla: 2.419 ± 0.041	0.208GlnCys: 0.208 ± 0.012	1.508GlnAsp: 1.508 ± 0.033	1.995GlnGlu: 1.995 ± 0.035	1.824GlnPhe: 1.824 ± 0.033	2.053GlnGly: 2.053 ± 0.039	0.76GlnHis: 0.76 ± 0.022	2.263GlnIle: 2.263 ± 0.033	2.925GlnLys: 2.925 ± 0.051	4.029GlnLeu: 4.029 ± 0.067	0.974GlnMet: 0.974 ± 0.029	2.027GlnAsn: 2.027 ± 0.036	1.52GlnPro: 1.52 ± 0.03	2.137GlnGln: 2.137 ± 0.048	1.568GlnArg: 1.568 ± 0.033	2.108GlnSer: 2.108 ± 0.039	2.048GlnThr: 2.048 ± 0.039	2.371GlnVal: 2.371 ± 0.038	0.481GlnTrp: 0.481 ± 0.018	1.45GlnTyr: 1.45 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.444ArgAla: 2.444 ± 0.038	0.27ArgCys: 0.27 ± 0.013	1.98ArgAsp: 1.98 ± 0.037	2.387ArgGlu: 2.387 ± 0.042	2.199ArgPhe: 2.199 ± 0.038	2.304ArgGly: 2.304 ± 0.045	0.694ArgHis: 0.694 ± 0.024	3.05ArgIle: 3.05 ± 0.042	3.112ArgLys: 3.112 ± 0.045	3.913ArgLeu: 3.913 ± 0.054	1.046ArgMet: 1.046 ± 0.024	2.453ArgAsn: 2.453 ± 0.037	1.46ArgPro: 1.46 ± 0.033	1.604ArgGln: 1.604 ± 0.033	1.817ArgArg: 1.817 ± 0.037	2.382ArgSer: 2.382 ± 0.04	2.159ArgThr: 2.159 ± 0.038	2.499ArgVal: 2.499 ± 0.041	0.559ArgTrp: 0.559 ± 0.021	1.716ArgTyr: 1.716 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.609SerAla: 4.609 ± 0.057	0.595SerCys: 0.595 ± 0.019	3.044SerAsp: 3.044 ± 0.04	3.229SerGlu: 3.229 ± 0.043	3.831SerPhe: 3.831 ± 0.047	4.739SerGly: 4.739 ± 0.072	1.118SerHis: 1.118 ± 0.031	4.961SerIle: 4.961 ± 0.058	4.348SerLys: 4.348 ± 0.05	6.07SerLeu: 6.07 ± 0.067	1.355SerMet: 1.355 ± 0.027	3.714SerAsn: 3.714 ± 0.053	2.417SerPro: 2.417 ± 0.036	2.059SerGln: 2.059 ± 0.043	2.444SerArg: 2.444 ± 0.044	4.573SerSer: 4.573 ± 0.065	3.951SerThr: 3.951 ± 0.056	4.194SerVal: 4.194 ± 0.056	0.797SerTrp: 0.797 ± 0.021	2.743SerTyr: 2.743 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.678ThrAla: 4.678 ± 0.066	0.401ThrCys: 0.401 ± 0.017	3.022ThrAsp: 3.022 ± 0.046	3.099ThrGlu: 3.099 ± 0.043	2.963ThrPhe: 2.963 ± 0.045	4.803ThrGly: 4.803 ± 0.065	0.95ThrHis: 0.95 ± 0.027	4.478ThrIle: 4.478 ± 0.056	3.592ThrLys: 3.592 ± 0.049	5.155ThrLeu: 5.155 ± 0.065	1.108ThrMet: 1.108 ± 0.028	3.23ThrAsn: 3.23 ± 0.053	2.724ThrPro: 2.724 ± 0.047	1.782ThrGln: 1.782 ± 0.034	2.031ThrArg: 2.031 ± 0.036	4.047ThrSer: 4.047 ± 0.056	4.025ThrThr: 4.025 ± 0.068	4.055ThrVal: 4.055 ± 0.054	0.675ThrTrp: 0.675 ± 0.02	2.297ThrTyr: 2.297 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.087ValAla: 5.087 ± 0.062	0.63ValCys: 0.63 ± 0.02	3.532ValAsp: 3.532 ± 0.053	3.925ValGlu: 3.925 ± 0.055	3.218ValPhe: 3.218 ± 0.044	4.23ValGly: 4.23 ± 0.055	1.109ValHis: 1.109 ± 0.031	4.821ValIle: 4.821 ± 0.06	4.753ValLys: 4.753 ± 0.06	6.026ValLeu: 6.026 ± 0.064	1.539ValMet: 1.539 ± 0.029	3.665ValAsn: 3.665 ± 0.054	2.651ValPro: 2.651 ± 0.046	2.172ValGln: 2.172 ± 0.035	2.671ValArg: 2.671 ± 0.047	4.519ValSer: 4.519 ± 0.058	4.089ValThr: 4.089 ± 0.058	4.803ValVal: 4.803 ± 0.059	0.723ValTrp: 0.723 ± 0.02	2.449ValTyr: 2.449 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.725TrpAla: 0.725 ± 0.021	0.1TrpCys: 0.1 ± 0.008	0.661TrpAsp: 0.661 ± 0.021	0.654TrpGlu: 0.654 ± 0.019	0.611TrpPhe: 0.611 ± 0.018	0.826TrpGly: 0.826 ± 0.023	0.282TrpHis: 0.282 ± 0.015	0.764TrpIle: 0.764 ± 0.024	0.992TrpLys: 0.992 ± 0.026	1.189TrpLeu: 1.189 ± 0.028	0.415TrpMet: 0.415 ± 0.016	0.759TrpAsn: 0.759 ± 0.019	0.366TrpPro: 0.366 ± 0.015	0.562TrpGln: 0.562 ± 0.019	0.57TrpArg: 0.57 ± 0.019	0.746TrpSer: 0.746 ± 0.019	0.633TrpThr: 0.633 ± 0.023	0.742TrpVal: 0.742 ± 0.024	0.235TrpTrp: 0.235 ± 0.012	0.455TrpTyr: 0.455 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.536TyrAla: 2.536 ± 0.043	0.354TyrCys: 0.354 ± 0.014	2.036TyrAsp: 2.036 ± 0.038	2.07TyrGlu: 2.07 ± 0.04	2.178TyrPhe: 2.178 ± 0.038	2.611TyrGly: 2.611 ± 0.044	0.787TyrHis: 0.787 ± 0.024	2.359TyrIle: 2.359 ± 0.034	2.796TyrLys: 2.796 ± 0.042	3.66TyrLeu: 3.66 ± 0.049	0.742TyrMet: 0.742 ± 0.02	2.512TyrAsn: 2.512 ± 0.046	1.613TyrPro: 1.613 ± 0.035	1.485TyrGln: 1.485 ± 0.031	1.822TyrArg: 1.822 ± 0.032	2.818TyrSer: 2.818 ± 0.041	2.327TyrThr: 2.327 ± 0.042	2.233TyrVal: 2.233 ± 0.034	0.524TyrTrp: 0.524 ± 0.019	1.766TyrTyr: 1.766 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4800 proteins (1634465 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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