Amino acid dipepetide frequency for Planktotalea frisia

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.388AlaAla: 13.388 ± 0.152	1.086AlaCys: 1.086 ± 0.031	6.495AlaAsp: 6.495 ± 0.076	6.733AlaGlu: 6.733 ± 0.086	4.369AlaPhe: 4.369 ± 0.066	9.292AlaGly: 9.292 ± 0.107	2.456AlaHis: 2.456 ± 0.05	6.185AlaIle: 6.185 ± 0.078	4.703AlaLys: 4.703 ± 0.072	12.794AlaLeu: 12.794 ± 0.121	3.752AlaMet: 3.752 ± 0.061	3.148AlaAsn: 3.148 ± 0.053	5.008AlaPro: 5.008 ± 0.073	4.637AlaGln: 4.637 ± 0.065	7.016AlaArg: 7.016 ± 0.075	6.057AlaSer: 6.057 ± 0.072	5.563AlaThr: 5.563 ± 0.073	7.321AlaVal: 7.321 ± 0.089	1.329AlaTrp: 1.329 ± 0.034	2.538AlaTyr: 2.538 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.142CysAla: 1.142 ± 0.033	0.115CysCys: 0.115 ± 0.009	0.659CysAsp: 0.659 ± 0.022	0.538CysGlu: 0.538 ± 0.022	0.401CysPhe: 0.401 ± 0.017	0.971CysGly: 0.971 ± 0.031	0.267CysHis: 0.267 ± 0.016	0.509CysIle: 0.509 ± 0.019	0.303CysLys: 0.303 ± 0.015	0.837CysLeu: 0.837 ± 0.028	0.224CysMet: 0.224 ± 0.012	0.276CysAsn: 0.276 ± 0.014	0.498CysPro: 0.498 ± 0.023	0.25CysGln: 0.25 ± 0.014	0.454CysArg: 0.454 ± 0.018	0.505CysSer: 0.505 ± 0.021	0.496CysThr: 0.496 ± 0.021	0.723CysVal: 0.723 ± 0.022	0.126CysTrp: 0.126 ± 0.01	0.261CysTyr: 0.261 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.384AspAla: 7.384 ± 0.083	0.525AspCys: 0.525 ± 0.018	3.49AspAsp: 3.49 ± 0.089	3.693AspGlu: 3.693 ± 0.064	2.416AspPhe: 2.416 ± 0.049	5.306AspGly: 5.306 ± 0.073	1.322AspHis: 1.322 ± 0.034	3.457AspIle: 3.457 ± 0.059	2.086AspLys: 2.086 ± 0.049	6.133AspLeu: 6.133 ± 0.075	1.795AspMet: 1.795 ± 0.034	1.472AspAsn: 1.472 ± 0.037	3.25AspPro: 3.25 ± 0.051	1.919AspGln: 1.919 ± 0.039	3.331AspArg: 3.331 ± 0.055	2.195AspSer: 2.195 ± 0.049	3.134AspThr: 3.134 ± 0.063	4.829AspVal: 4.829 ± 0.061	1.075AspTrp: 1.075 ± 0.03	1.513AspTyr: 1.513 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.875GluAla: 6.875 ± 0.101	0.41GluCys: 0.41 ± 0.017	3.23GluAsp: 3.23 ± 0.053	3.322GluGlu: 3.322 ± 0.064	1.983GluPhe: 1.983 ± 0.042	4.533GluGly: 4.533 ± 0.062	1.349GluHis: 1.349 ± 0.036	3.77GluIle: 3.77 ± 0.06	2.501GluLys: 2.501 ± 0.051	5.321GluLeu: 5.321 ± 0.075	1.974GluMet: 1.974 ± 0.041	2.113GluAsn: 2.113 ± 0.039	2.466GluPro: 2.466 ± 0.051	2.295GluGln: 2.295 ± 0.05	4.137GluArg: 4.137 ± 0.068	2.344GluSer: 2.344 ± 0.045	3.924GluThr: 3.924 ± 0.064	4.115GluVal: 4.115 ± 0.06	0.806GluTrp: 0.806 ± 0.027	1.222GluTyr: 1.222 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.661PheAla: 4.661 ± 0.063	0.477PheCys: 0.477 ± 0.021	2.861PheAsp: 2.861 ± 0.049	2.752PheGlu: 2.752 ± 0.053	1.628PhePhe: 1.628 ± 0.047	3.899PheGly: 3.899 ± 0.054	0.784PheHis: 0.784 ± 0.025	1.975PheIle: 1.975 ± 0.041	1.369PheLys: 1.369 ± 0.036	3.473PheLeu: 3.473 ± 0.064	1.081PheMet: 1.081 ± 0.035	1.19PheAsn: 1.19 ± 0.034	1.594PhePro: 1.594 ± 0.036	1.117PheGln: 1.117 ± 0.03	1.867PheArg: 1.867 ± 0.043	2.383PheSer: 2.383 ± 0.045	2.231PheThr: 2.231 ± 0.041	2.733PheVal: 2.733 ± 0.053	0.626PheTrp: 0.626 ± 0.025	1.012PheTyr: 1.012 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.202GlyAla: 9.202 ± 0.102	0.884GlyCys: 0.884 ± 0.029	4.642GlyAsp: 4.642 ± 0.073	4.462GlyGlu: 4.462 ± 0.061	3.892GlyPhe: 3.892 ± 0.061	7.122GlyGly: 7.122 ± 0.102	1.808GlyHis: 1.808 ± 0.04	4.634GlyIle: 4.634 ± 0.065	3.588GlyLys: 3.588 ± 0.062	8.351GlyLeu: 8.351 ± 0.11	2.707GlyMet: 2.707 ± 0.052	2.292GlyAsn: 2.292 ± 0.047	3.276GlyPro: 3.276 ± 0.054	2.975GlyGln: 2.975 ± 0.056	4.654GlyArg: 4.654 ± 0.063	4.484GlySer: 4.484 ± 0.07	4.723GlyThr: 4.723 ± 0.074	6.383GlyVal: 6.383 ± 0.08	1.327GlyTrp: 1.327 ± 0.035	2.391GlyTyr: 2.391 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.169HisAla: 2.169 ± 0.043	0.246HisCys: 0.246 ± 0.014	1.252HisAsp: 1.252 ± 0.031	1.162HisGlu: 1.162 ± 0.033	0.904HisPhe: 0.904 ± 0.03	1.865HisGly: 1.865 ± 0.046	0.608HisHis: 0.608 ± 0.023	1.2HisIle: 1.2 ± 0.033	0.728HisLys: 0.728 ± 0.023	2.137HisLeu: 2.137 ± 0.04	0.649HisMet: 0.649 ± 0.023	0.545HisAsn: 0.545 ± 0.025	1.261HisPro: 1.261 ± 0.037	0.656HisGln: 0.656 ± 0.023	1.142HisArg: 1.142 ± 0.034	1.103HisSer: 1.103 ± 0.034	0.994HisThr: 0.994 ± 0.031	1.571HisVal: 1.571 ± 0.038	0.357HisTrp: 0.357 ± 0.017	0.59HisTyr: 0.59 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.452IleAla: 7.452 ± 0.089	0.743IleCys: 0.743 ± 0.031	3.68IleAsp: 3.68 ± 0.057	3.985IleGlu: 3.985 ± 0.061	2.026IlePhe: 2.026 ± 0.045	5.239IleGly: 5.239 ± 0.076	0.982IleHis: 0.982 ± 0.028	2.908IleIle: 2.908 ± 0.055	2.151IleLys: 2.151 ± 0.044	5.091IleLeu: 5.091 ± 0.073	1.336IleMet: 1.336 ± 0.036	1.723IleAsn: 1.723 ± 0.04	2.435IlePro: 2.435 ± 0.048	1.363IleGln: 1.363 ± 0.034	2.794IleArg: 2.794 ± 0.048	3.475IleSer: 3.475 ± 0.053	3.314IleThr: 3.314 ± 0.05	4.079IleVal: 4.079 ± 0.06	0.827IleTrp: 0.827 ± 0.029	1.329IleTyr: 1.329 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.655LysAla: 4.655 ± 0.069	0.253LysCys: 0.253 ± 0.014	2.36LysAsp: 2.36 ± 0.046	2.063LysGlu: 2.063 ± 0.042	1.225LysPhe: 1.225 ± 0.032	3.263LysGly: 3.263 ± 0.054	0.855LysHis: 0.855 ± 0.025	2.215LysIle: 2.215 ± 0.051	1.587LysLys: 1.587 ± 0.042	3.707LysLeu: 3.707 ± 0.06	1.213LysMet: 1.213 ± 0.028	1.158LysAsn: 1.158 ± 0.03	2.117LysPro: 2.117 ± 0.049	1.183LysGln: 1.183 ± 0.034	2.746LysArg: 2.746 ± 0.055	2.356LysSer: 2.356 ± 0.045	2.464LysThr: 2.464 ± 0.041	2.672LysVal: 2.672 ± 0.044	0.486LysTrp: 0.486 ± 0.023	0.806LysTyr: 0.806 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.274LeuAla: 11.274 ± 0.128	1.035LeuCys: 1.035 ± 0.027	5.784LeuAsp: 5.784 ± 0.081	5.451LeuGlu: 5.451 ± 0.065	3.674LeuPhe: 3.674 ± 0.061	8.132LeuGly: 8.132 ± 0.101	1.791LeuHis: 1.791 ± 0.041	5.732LeuIle: 5.732 ± 0.085	4.013LeuLys: 4.013 ± 0.057	8.478LeuLeu: 8.478 ± 0.106	2.883LeuMet: 2.883 ± 0.047	3.154LeuAsn: 3.154 ± 0.056	4.962LeuPro: 4.962 ± 0.061	2.852LeuGln: 2.852 ± 0.046	6.062LeuArg: 6.062 ± 0.08	7.12LeuSer: 7.12 ± 0.092	5.623LeuThr: 5.623 ± 0.064	6.347LeuVal: 6.347 ± 0.078	1.187LeuTrp: 1.187 ± 0.037	1.928LeuTyr: 1.928 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.161MetAla: 3.161 ± 0.06	0.267MetCys: 0.267 ± 0.014	1.564MetAsp: 1.564 ± 0.037	1.451MetGlu: 1.451 ± 0.038	0.978MetPhe: 0.978 ± 0.029	2.528MetGly: 2.528 ± 0.046	0.588MetHis: 0.588 ± 0.02	1.812MetIle: 1.812 ± 0.044	1.299MetLys: 1.299 ± 0.034	2.813MetLeu: 2.813 ± 0.051	0.923MetMet: 0.923 ± 0.032	1.092MetAsn: 1.092 ± 0.031	1.565MetPro: 1.565 ± 0.032	1.108MetGln: 1.108 ± 0.028	2.011MetArg: 2.011 ± 0.04	2.195MetSer: 2.195 ± 0.043	2.071MetThr: 2.071 ± 0.038	1.781MetVal: 1.781 ± 0.039	0.296MetTrp: 0.296 ± 0.015	0.447MetTyr: 0.447 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.766AsnAla: 3.766 ± 0.062	0.323AsnCys: 0.323 ± 0.017	1.83AsnAsp: 1.83 ± 0.043	1.562AsnGlu: 1.562 ± 0.035	1.144AsnPhe: 1.144 ± 0.035	2.745AsnGly: 2.745 ± 0.049	0.568AsnHis: 0.568 ± 0.022	1.762AsnIle: 1.762 ± 0.038	1.009AsnLys: 1.009 ± 0.03	2.754AsnLeu: 2.754 ± 0.045	0.85AsnMet: 0.85 ± 0.025	0.89AsnAsn: 0.89 ± 0.03	1.902AsnPro: 1.902 ± 0.037	0.844AsnGln: 0.844 ± 0.03	1.645AsnArg: 1.645 ± 0.035	1.571AsnSer: 1.571 ± 0.033	1.72AsnThr: 1.72 ± 0.043	2.28AsnVal: 2.28 ± 0.05	0.514AsnTrp: 0.514 ± 0.022	0.77AsnTyr: 0.77 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.597ProAla: 4.597 ± 0.062	0.353ProCys: 0.353 ± 0.018	3.54ProAsp: 3.54 ± 0.06	3.75ProGlu: 3.75 ± 0.057	2.055ProPhe: 2.055 ± 0.041	2.942ProGly: 2.942 ± 0.053	1.03ProHis: 1.03 ± 0.029	2.548ProIle: 2.548 ± 0.041	2.155ProLys: 2.155 ± 0.044	4.335ProLeu: 4.335 ± 0.059	1.378ProMet: 1.378 ± 0.04	1.765ProAsn: 1.765 ± 0.036	1.725ProPro: 1.725 ± 0.043	1.517ProGln: 1.517 ± 0.038	2.284ProArg: 2.284 ± 0.05	2.848ProSer: 2.848 ± 0.046	2.437ProThr: 2.437 ± 0.046	3.669ProVal: 3.669 ± 0.062	0.618ProTrp: 0.618 ± 0.025	1.14ProTyr: 1.14 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.784GlnAla: 3.784 ± 0.064	0.246GlnCys: 0.246 ± 0.014	1.76GlnAsp: 1.76 ± 0.038	1.666GlnGlu: 1.666 ± 0.036	1.208GlnPhe: 1.208 ± 0.031	2.569GlnGly: 2.569 ± 0.049	0.676GlnHis: 0.676 ± 0.024	2.29GlnIle: 2.29 ± 0.044	1.326GlnLys: 1.326 ± 0.033	2.921GlnLeu: 2.921 ± 0.05	1.21GlnMet: 1.21 ± 0.031	1.268GlnAsn: 1.268 ± 0.032	1.431GlnPro: 1.431 ± 0.035	1.11GlnGln: 1.11 ± 0.033	2.054GlnArg: 2.054 ± 0.045	2.161GlnSer: 2.161 ± 0.043	2.081GlnThr: 2.081 ± 0.042	2.29GlnVal: 2.29 ± 0.043	0.404GlnTrp: 0.404 ± 0.017	0.661GlnTyr: 0.661 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.762ArgAla: 6.762 ± 0.083	0.46ArgCys: 0.46 ± 0.019	3.639ArgAsp: 3.639 ± 0.065	3.536ArgGlu: 3.536 ± 0.053	2.461ArgPhe: 2.461 ± 0.05	3.963ArgGly: 3.963 ± 0.057	1.315ArgHis: 1.315 ± 0.032	3.511ArgIle: 3.511 ± 0.053	2.524ArgLys: 2.524 ± 0.045	5.875ArgLeu: 5.875 ± 0.075	1.808ArgMet: 1.808 ± 0.04	1.662ArgAsn: 1.662 ± 0.038	2.442ArgPro: 2.442 ± 0.046	1.924ArgGln: 1.924 ± 0.041	3.731ArgArg: 3.731 ± 0.057	3.24ArgSer: 3.24 ± 0.047	2.828ArgThr: 2.828 ± 0.045	4.182ArgVal: 4.182 ± 0.065	0.821ArgTrp: 0.821 ± 0.025	1.478ArgTyr: 1.478 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.402SerAla: 6.402 ± 0.079	0.474SerCys: 0.474 ± 0.019	3.841SerAsp: 3.841 ± 0.062	3.449SerGlu: 3.449 ± 0.053	2.566SerPhe: 2.566 ± 0.054	5.57SerGly: 5.57 ± 0.07	1.196SerHis: 1.196 ± 0.032	3.048SerIle: 3.048 ± 0.056	2.401SerLys: 2.401 ± 0.04	5.311SerLeu: 5.311 ± 0.081	1.63SerMet: 1.63 ± 0.036	1.838SerAsn: 1.838 ± 0.043	2.388SerPro: 2.388 ± 0.042	1.859SerGln: 1.859 ± 0.036	2.851SerArg: 2.851 ± 0.052	3.095SerSer: 3.095 ± 0.054	2.863SerThr: 2.863 ± 0.05	4.126SerVal: 4.126 ± 0.053	0.691SerTrp: 0.691 ± 0.022	1.487SerTyr: 1.487 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.741ThrAla: 5.741 ± 0.068	0.556ThrCys: 0.556 ± 0.021	3.169ThrAsp: 3.169 ± 0.055	2.742ThrGlu: 2.742 ± 0.046	2.153ThrPhe: 2.153 ± 0.039	5.221ThrGly: 5.221 ± 0.062	1.282ThrHis: 1.282 ± 0.031	3.031ThrIle: 3.031 ± 0.056	1.882ThrLys: 1.882 ± 0.039	6.274ThrLeu: 6.274 ± 0.079	1.415ThrMet: 1.415 ± 0.035	1.541ThrAsn: 1.541 ± 0.04	3.343ThrPro: 3.343 ± 0.052	1.939ThrGln: 1.939 ± 0.042	3.21ThrArg: 3.21 ± 0.048	3.305ThrSer: 3.305 ± 0.059	2.914ThrThr: 2.914 ± 0.054	4.068ThrVal: 4.068 ± 0.052	0.712ThrTrp: 0.712 ± 0.024	1.372ThrTyr: 1.372 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.739ValAla: 7.739 ± 0.088	0.689ValCys: 0.689 ± 0.021	4.077ValAsp: 4.077 ± 0.06	4.333ValGlu: 4.333 ± 0.065	3.009ValPhe: 3.009 ± 0.048	5.428ValGly: 5.428 ± 0.071	1.367ValHis: 1.367 ± 0.034	4.504ValIle: 4.504 ± 0.079	2.482ValLys: 2.482 ± 0.045	7.026ValLeu: 7.026 ± 0.078	2.142ValMet: 2.142 ± 0.04	2.173ValAsn: 2.173 ± 0.045	3.325ValPro: 3.325 ± 0.051	2.236ValGln: 2.236 ± 0.049	3.788ValArg: 3.788 ± 0.055	4.478ValSer: 4.478 ± 0.063	4.517ValThr: 4.517 ± 0.067	5.142ValVal: 5.142 ± 0.083	0.902ValTrp: 0.902 ± 0.028	1.448ValTyr: 1.448 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.249TrpAla: 1.249 ± 0.035	0.146TrpCys: 0.146 ± 0.009	0.819TrpAsp: 0.819 ± 0.028	0.686TrpGlu: 0.686 ± 0.023	0.624TrpPhe: 0.624 ± 0.021	1.023TrpGly: 1.023 ± 0.029	0.358TrpHis: 0.358 ± 0.016	0.777TrpIle: 0.777 ± 0.024	0.506TrpLys: 0.506 ± 0.02	1.548TrpLeu: 1.548 ± 0.039	0.417TrpMet: 0.417 ± 0.017	0.458TrpAsn: 0.458 ± 0.02	0.626TrpPro: 0.626 ± 0.024	0.56TrpGln: 0.56 ± 0.022	0.969TrpArg: 0.969 ± 0.029	0.833TrpSer: 0.833 ± 0.028	0.714TrpThr: 0.714 ± 0.025	0.881TrpVal: 0.881 ± 0.03	0.225TrpTrp: 0.225 ± 0.013	0.292TrpTyr: 0.292 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.468TyrAla: 2.468 ± 0.047	0.265TyrCys: 0.265 ± 0.016	1.635TyrAsp: 1.635 ± 0.042	1.355TyrGlu: 1.355 ± 0.037	0.995TyrPhe: 0.995 ± 0.03	2.187TyrGly: 2.187 ± 0.038	0.535TyrHis: 0.535 ± 0.022	1.067TyrIle: 1.067 ± 0.03	0.769TyrLys: 0.769 ± 0.025	2.304TyrLeu: 2.304 ± 0.043	0.562TyrMet: 0.562 ± 0.022	0.694TyrAsn: 0.694 ± 0.022	1.07TyrPro: 1.07 ± 0.031	0.773TyrGln: 0.773 ± 0.026	1.415TyrArg: 1.415 ± 0.035	1.337TyrSer: 1.337 ± 0.037	1.259TyrThr: 1.259 ± 0.036	1.61TyrVal: 1.61 ± 0.04	0.385TyrTrp: 0.385 ± 0.017	0.586TyrTyr: 0.586 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4128 proteins (1233686 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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