Amino acid dipepetide frequency for Arthrobacter sp. SRS-W-1-2016

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.699AlaAla: 19.699 ± 0.207	0.822AlaCys: 0.822 ± 0.027	6.695AlaAsp: 6.695 ± 0.075	7.654AlaGlu: 7.654 ± 0.101	3.824AlaPhe: 3.824 ± 0.061	12.794AlaGly: 12.794 ± 0.111	2.277AlaHis: 2.277 ± 0.046	5.456AlaIle: 5.456 ± 0.071	3.965AlaLys: 3.965 ± 0.062	12.879AlaLeu: 12.879 ± 0.125	2.871AlaMet: 2.871 ± 0.051	2.893AlaAsn: 2.893 ± 0.052	5.922AlaPro: 5.922 ± 0.098	3.811AlaGln: 3.811 ± 0.063	7.487AlaArg: 7.487 ± 0.088	7.662AlaSer: 7.662 ± 0.091	6.636AlaThr: 6.636 ± 0.068	11.416AlaVal: 11.416 ± 0.118	1.679AlaTrp: 1.679 ± 0.036	2.292AlaTyr: 2.292 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.724CysAla: 0.724 ± 0.025	0.07CysCys: 0.07 ± 0.007	0.372CysAsp: 0.372 ± 0.018	0.302CysGlu: 0.302 ± 0.017	0.205CysPhe: 0.205 ± 0.014	0.733CysGly: 0.733 ± 0.024	0.131CysHis: 0.131 ± 0.01	0.267CysIle: 0.267 ± 0.016	0.112CysLys: 0.112 ± 0.009	0.591CysLeu: 0.591 ± 0.021	0.107CysMet: 0.107 ± 0.009	0.165CysAsn: 0.165 ± 0.012	0.351CysPro: 0.351 ± 0.017	0.176CysGln: 0.176 ± 0.013	0.409CysArg: 0.409 ± 0.018	0.432CysSer: 0.432 ± 0.017	0.419CysThr: 0.419 ± 0.019	0.481CysVal: 0.481 ± 0.018	0.112CysTrp: 0.112 ± 0.01	0.144CysTyr: 0.144 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.316AspAla: 7.316 ± 0.079	0.308AspCys: 0.308 ± 0.018	3.013AspAsp: 3.013 ± 0.058	3.243AspGlu: 3.243 ± 0.052	1.918AspPhe: 1.918 ± 0.038	5.711AspGly: 5.711 ± 0.074	1.197AspHis: 1.197 ± 0.036	2.457AspIle: 2.457 ± 0.047	1.481AspLys: 1.481 ± 0.036	5.224AspLeu: 5.224 ± 0.077	0.993AspMet: 0.993 ± 0.029	1.199AspAsn: 1.199 ± 0.031	3.546AspPro: 3.546 ± 0.051	1.538AspGln: 1.538 ± 0.031	3.308AspArg: 3.308 ± 0.059	3.002AspSer: 3.002 ± 0.051	2.672AspThr: 2.672 ± 0.048	4.867AspVal: 4.867 ± 0.058	0.86AspTrp: 0.86 ± 0.026	1.257AspTyr: 1.257 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.051GluAla: 7.051 ± 0.089	0.315GluCys: 0.315 ± 0.018	2.884GluAsp: 2.884 ± 0.048	3.285GluGlu: 3.285 ± 0.061	1.737GluPhe: 1.737 ± 0.04	3.796GluGly: 3.796 ± 0.058	1.453GluHis: 1.453 ± 0.034	2.653GluIle: 2.653 ± 0.049	1.689GluLys: 1.689 ± 0.039	6.963GluLeu: 6.963 ± 0.086	0.967GluMet: 0.967 ± 0.031	1.442GluAsn: 1.442 ± 0.037	2.809GluPro: 2.809 ± 0.049	2.264GluGln: 2.264 ± 0.043	4.091GluArg: 4.091 ± 0.066	3.139GluSer: 3.139 ± 0.05	2.907GluThr: 2.907 ± 0.052	3.877GluVal: 3.877 ± 0.065	0.791GluTrp: 0.791 ± 0.027	1.09GluTyr: 1.09 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.085PheAla: 4.085 ± 0.065	0.237PheCys: 0.237 ± 0.014	2.167PheAsp: 2.167 ± 0.04	1.75PheGlu: 1.75 ± 0.038	1.205PhePhe: 1.205 ± 0.034	3.547PheGly: 3.547 ± 0.06	0.678PheHis: 0.678 ± 0.024	1.425PheIle: 1.425 ± 0.034	0.868PheLys: 0.868 ± 0.026	3.104PheLeu: 3.104 ± 0.064	0.648PheMet: 0.648 ± 0.021	0.921PheAsn: 0.921 ± 0.028	1.52PhePro: 1.52 ± 0.037	0.911PheGln: 0.911 ± 0.026	1.833PheArg: 1.833 ± 0.036	2.03PheSer: 2.03 ± 0.035	2.137PheThr: 2.137 ± 0.044	2.635PheVal: 2.635 ± 0.045	0.493PheTrp: 0.493 ± 0.022	0.717PheTyr: 0.717 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.919GlyAla: 9.919 ± 0.095	0.627GlyCys: 0.627 ± 0.024	4.178GlyAsp: 4.178 ± 0.062	4.396GlyGlu: 4.396 ± 0.06	3.364GlyPhe: 3.364 ± 0.053	7.628GlyGly: 7.628 ± 0.097	2.069GlyHis: 2.069 ± 0.044	5.0GlyIle: 5.0 ± 0.072	3.236GlyLys: 3.236 ± 0.052	9.417GlyLeu: 9.417 ± 0.106	2.079GlyMet: 2.079 ± 0.038	2.444GlyAsn: 2.444 ± 0.047	4.076GlyPro: 4.076 ± 0.06	3.036GlyGln: 3.036 ± 0.05	5.708GlyArg: 5.708 ± 0.067	6.152GlySer: 6.152 ± 0.068	6.167GlyThr: 6.167 ± 0.082	7.297GlyVal: 7.297 ± 0.078	1.606GlyTrp: 1.606 ± 0.039	2.368GlyTyr: 2.368 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.29HisAla: 2.29 ± 0.046	0.173HisCys: 0.173 ± 0.012	1.226HisAsp: 1.226 ± 0.032	1.239HisGlu: 1.239 ± 0.034	0.669HisPhe: 0.669 ± 0.027	2.079HisGly: 2.079 ± 0.04	0.661HisHis: 0.661 ± 0.025	0.884HisIle: 0.884 ± 0.024	0.481HisLys: 0.481 ± 0.02	2.023HisLeu: 2.023 ± 0.038	0.391HisMet: 0.391 ± 0.016	0.483HisAsn: 0.483 ± 0.019	1.476HisPro: 1.476 ± 0.033	0.655HisGln: 0.655 ± 0.021	1.475HisArg: 1.475 ± 0.039	1.262HisSer: 1.262 ± 0.032	1.067HisThr: 1.067 ± 0.031	1.586HisVal: 1.586 ± 0.038	0.309HisTrp: 0.309 ± 0.017	0.452HisTyr: 0.452 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.211IleAla: 6.211 ± 0.077	0.349IleCys: 0.349 ± 0.016	2.836IleAsp: 2.836 ± 0.051	2.503IleGlu: 2.503 ± 0.047	1.457IlePhe: 1.457 ± 0.038	4.362IleGly: 4.362 ± 0.069	0.927IleHis: 0.927 ± 0.024	2.03IleIle: 2.03 ± 0.047	1.237IleLys: 1.237 ± 0.029	4.112IleLeu: 4.112 ± 0.072	0.81IleMet: 0.81 ± 0.027	1.333IleAsn: 1.333 ± 0.036	2.497IlePro: 2.497 ± 0.046	1.267IleGln: 1.267 ± 0.03	2.771IleArg: 2.771 ± 0.044	2.845IleSer: 2.845 ± 0.05	2.811IleThr: 2.811 ± 0.051	3.959IleVal: 3.959 ± 0.063	0.509IleTrp: 0.509 ± 0.019	0.855IleTyr: 0.855 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.803LysAla: 3.803 ± 0.06	0.114LysCys: 0.114 ± 0.009	1.809LysAsp: 1.809 ± 0.043	1.511LysGlu: 1.511 ± 0.034	0.82LysPhe: 0.82 ± 0.025	2.203LysGly: 2.203 ± 0.04	0.654LysHis: 0.654 ± 0.022	1.426LysIle: 1.426 ± 0.038	1.03LysLys: 1.03 ± 0.029	2.887LysLeu: 2.887 ± 0.046	0.672LysMet: 0.672 ± 0.021	0.831LysAsn: 0.831 ± 0.029	1.73LysPro: 1.73 ± 0.045	0.942LysGln: 0.942 ± 0.027	1.815LysArg: 1.815 ± 0.042	1.765LysSer: 1.765 ± 0.04	1.762LysThr: 1.762 ± 0.043	2.425LysVal: 2.425 ± 0.046	0.362LysTrp: 0.362 ± 0.016	0.698LysTyr: 0.698 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.146LeuAla: 14.146 ± 0.147	0.681LeuCys: 0.681 ± 0.024	6.21LeuAsp: 6.21 ± 0.073	5.531LeuGlu: 5.531 ± 0.076	3.028LeuPhe: 3.028 ± 0.063	9.422LeuGly: 9.422 ± 0.091	2.059LeuHis: 2.059 ± 0.045	4.472LeuIle: 4.472 ± 0.075	2.863LeuLys: 2.863 ± 0.057	10.609LeuLeu: 10.609 ± 0.124	1.974LeuMet: 1.974 ± 0.041	2.597LeuAsn: 2.597 ± 0.045	5.638LeuPro: 5.638 ± 0.068	2.863LeuGln: 2.863 ± 0.05	6.709LeuArg: 6.709 ± 0.08	6.246LeuSer: 6.246 ± 0.068	5.852LeuThr: 5.852 ± 0.075	8.532LeuVal: 8.532 ± 0.087	1.283LeuTrp: 1.283 ± 0.036	1.74LeuTyr: 1.74 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.676MetAla: 2.676 ± 0.048	0.13MetCys: 0.13 ± 0.01	1.073MetAsp: 1.073 ± 0.03	0.934MetGlu: 0.934 ± 0.028	0.613MetPhe: 0.613 ± 0.021	1.651MetGly: 1.651 ± 0.038	0.349MetHis: 0.349 ± 0.017	0.922MetIle: 0.922 ± 0.032	0.633MetLys: 0.633 ± 0.022	2.004MetLeu: 2.004 ± 0.04	0.393MetMet: 0.393 ± 0.022	0.619MetAsn: 0.619 ± 0.021	1.13MetPro: 1.13 ± 0.027	0.568MetGln: 0.568 ± 0.02	1.208MetArg: 1.208 ± 0.03	1.599MetSer: 1.599 ± 0.031	1.678MetThr: 1.678 ± 0.035	1.632MetVal: 1.632 ± 0.041	0.226MetTrp: 0.226 ± 0.014	0.334MetTyr: 0.334 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.994AsnAla: 2.994 ± 0.056	0.17AsnCys: 0.17 ± 0.011	1.355AsnAsp: 1.355 ± 0.03	1.224AsnGlu: 1.224 ± 0.031	0.866AsnPhe: 0.866 ± 0.025	2.518AsnGly: 2.518 ± 0.059	0.499AsnHis: 0.499 ± 0.019	1.141AsnIle: 1.141 ± 0.028	0.744AsnLys: 0.744 ± 0.028	2.353AsnLeu: 2.353 ± 0.04	0.477AsnMet: 0.477 ± 0.018	0.764AsnAsn: 0.764 ± 0.026	1.939AsnPro: 1.939 ± 0.038	0.814AsnGln: 0.814 ± 0.025	1.555AsnArg: 1.555 ± 0.035	1.501AsnSer: 1.501 ± 0.037	1.441AsnThr: 1.441 ± 0.036	2.004AsnVal: 2.004 ± 0.041	0.396AsnTrp: 0.396 ± 0.018	0.626AsnTyr: 0.626 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.549ProAla: 7.549 ± 0.104	0.237ProCys: 0.237 ± 0.013	3.528ProAsp: 3.528 ± 0.061	3.86ProGlu: 3.86 ± 0.058	1.718ProPhe: 1.718 ± 0.034	5.556ProGly: 5.556 ± 0.067	1.087ProHis: 1.087 ± 0.031	1.83ProIle: 1.83 ± 0.04	1.444ProLys: 1.444 ± 0.037	4.822ProLeu: 4.822 ± 0.07	1.049ProMet: 1.049 ± 0.027	1.196ProAsn: 1.196 ± 0.03	2.207ProPro: 2.207 ± 0.064	1.667ProGln: 1.667 ± 0.035	2.846ProArg: 2.846 ± 0.051	3.482ProSer: 3.482 ± 0.062	2.779ProThr: 2.779 ± 0.063	4.737ProVal: 4.737 ± 0.056	0.81ProTrp: 0.81 ± 0.023	1.058ProTyr: 1.058 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.964GlnAla: 3.964 ± 0.061	0.169GlnCys: 0.169 ± 0.012	1.552GlnAsp: 1.552 ± 0.033	1.613GlnGlu: 1.613 ± 0.035	0.923GlnPhe: 0.923 ± 0.025	2.454GlnGly: 2.454 ± 0.041	0.719GlnHis: 0.719 ± 0.025	1.536GlnIle: 1.536 ± 0.033	0.898GlnLys: 0.898 ± 0.026	3.807GlnLeu: 3.807 ± 0.059	0.604GlnMet: 0.604 ± 0.022	0.776GlnAsn: 0.776 ± 0.03	1.723GlnPro: 1.723 ± 0.043	1.362GlnGln: 1.362 ± 0.037	2.283GlnArg: 2.283 ± 0.049	1.794GlnSer: 1.794 ± 0.035	1.579GlnThr: 1.579 ± 0.037	2.258GlnVal: 2.258 ± 0.044	0.5GlnTrp: 0.5 ± 0.017	0.664GlnTyr: 0.664 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.68ArgAla: 6.68 ± 0.083	0.351ArgCys: 0.351 ± 0.019	3.317ArgAsp: 3.317 ± 0.049	3.806ArgGlu: 3.806 ± 0.064	2.188ArgPhe: 2.188 ± 0.044	4.647ArgGly: 4.647 ± 0.065	1.482ArgHis: 1.482 ± 0.042	3.396ArgIle: 3.396 ± 0.058	2.032ArgLys: 2.032 ± 0.044	6.759ArgLeu: 6.759 ± 0.082	1.428ArgMet: 1.428 ± 0.037	1.717ArgAsn: 1.717 ± 0.039	3.301ArgPro: 3.301 ± 0.051	2.276ArgGln: 2.276 ± 0.047	5.342ArgArg: 5.342 ± 0.08	3.972ArgSer: 3.972 ± 0.056	3.748ArgThr: 3.748 ± 0.059	4.496ArgVal: 4.496 ± 0.066	1.089ArgTrp: 1.089 ± 0.027	1.437ArgTyr: 1.437 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	7.597SerAla: 7.597 ± 0.078	0.393SerCys: 0.393 ± 0.019	3.012SerAsp: 3.012 ± 0.052	3.083SerGlu: 3.083 ± 0.045	2.151SerPhe: 2.151 ± 0.044	6.478SerGly: 6.478 ± 0.079	1.19SerHis: 1.19 ± 0.031	2.685SerIle: 2.685 ± 0.049	1.819SerLys: 1.819 ± 0.038	6.051SerLeu: 6.051 ± 0.078	1.421SerMet: 1.421 ± 0.028	1.61SerAsn: 1.61 ± 0.038	3.433SerPro: 3.433 ± 0.054	1.833SerGln: 1.833 ± 0.039	3.875SerArg: 3.875 ± 0.067	4.051SerSer: 4.051 ± 0.068	3.82SerThr: 3.82 ± 0.057	4.9SerVal: 4.9 ± 0.066	1.007SerTrp: 1.007 ± 0.03	1.465SerTyr: 1.465 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.88ThrAla: 7.88 ± 0.094	0.298ThrCys: 0.298 ± 0.015	3.04ThrAsp: 3.04 ± 0.056	2.858ThrGlu: 2.858 ± 0.045	1.983ThrPhe: 1.983 ± 0.04	5.677ThrGly: 5.677 ± 0.083	1.077ThrHis: 1.077 ± 0.031	2.646ThrIle: 2.646 ± 0.049	1.58ThrLys: 1.58 ± 0.04	5.626ThrLeu: 5.626 ± 0.059	1.143ThrMet: 1.143 ± 0.027	1.309ThrAsn: 1.309 ± 0.038	3.702ThrPro: 3.702 ± 0.062	1.589ThrGln: 1.589 ± 0.04	3.072ThrArg: 3.072 ± 0.054	3.66ThrSer: 3.66 ± 0.059	3.695ThrThr: 3.695 ± 0.069	5.612ThrVal: 5.612 ± 0.071	0.768ThrTrp: 0.768 ± 0.025	1.101ThrTyr: 1.101 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	10.337ValAla: 10.337 ± 0.09	0.581ValCys: 0.581 ± 0.02	4.896ValAsp: 4.896 ± 0.067	4.66ValGlu: 4.66 ± 0.072	2.828ValPhe: 2.828 ± 0.049	6.473ValGly: 6.473 ± 0.07	1.731ValHis: 1.731 ± 0.034	3.958ValIle: 3.958 ± 0.06	2.176ValLys: 2.176 ± 0.044	9.196ValLeu: 9.196 ± 0.106	1.632ValMet: 1.632 ± 0.036	2.066ValAsn: 2.066 ± 0.041	4.686ValPro: 4.686 ± 0.056	2.35ValGln: 2.35 ± 0.04	5.15ValArg: 5.15 ± 0.064	5.102ValSer: 5.102 ± 0.059	5.08ValThr: 5.08 ± 0.075	8.179ValVal: 8.179 ± 0.08	0.998ValTrp: 0.998 ± 0.032	1.491ValTyr: 1.491 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.515TrpAla: 1.515 ± 0.033	0.117TrpCys: 0.117 ± 0.009	0.752TrpAsp: 0.752 ± 0.023	0.659TrpGlu: 0.659 ± 0.024	0.569TrpPhe: 0.569 ± 0.023	1.034TrpGly: 1.034 ± 0.03	0.323TrpHis: 0.323 ± 0.016	0.761TrpIle: 0.761 ± 0.025	0.435TrpLys: 0.435 ± 0.018	1.806TrpLeu: 1.806 ± 0.039	0.356TrpMet: 0.356 ± 0.018	0.467TrpAsn: 0.467 ± 0.018	0.687TrpPro: 0.687 ± 0.025	0.546TrpGln: 0.546 ± 0.021	1.001TrpArg: 1.001 ± 0.029	0.847TrpSer: 0.847 ± 0.029	0.92TrpThr: 0.92 ± 0.032	1.053TrpVal: 1.053 ± 0.027	0.318TrpTrp: 0.318 ± 0.017	0.291TrpTyr: 0.291 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.302TyrAla: 2.302 ± 0.044	0.163TyrCys: 0.163 ± 0.011	1.189TyrAsp: 1.189 ± 0.034	1.091TyrGlu: 1.091 ± 0.031	0.843TyrPhe: 0.843 ± 0.023	2.004TyrGly: 2.004 ± 0.042	0.319TyrHis: 0.319 ± 0.016	0.736TyrIle: 0.736 ± 0.025	0.536TyrLys: 0.536 ± 0.022	2.223TyrLeu: 2.223 ± 0.044	0.36TyrMet: 0.36 ± 0.016	0.551TyrAsn: 0.551 ± 0.022	1.088TyrPro: 1.088 ± 0.031	0.71TyrGln: 0.71 ± 0.026	1.52TyrArg: 1.52 ± 0.04	1.329TyrSer: 1.329 ± 0.029	1.149TyrThr: 1.149 ± 0.032	1.622TyrVal: 1.622 ± 0.036	0.343TyrTrp: 0.343 ± 0.017	0.537TyrTyr: 0.537 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4129 proteins (1309132 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---