Amino acid dipepetide frequency for Geodermatophilus sabuli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.345AlaAla: 24.345 ± 0.219	0.997AlaCys: 0.997 ± 0.027	9.057AlaAsp: 9.057 ± 0.072	9.039AlaGlu: 9.039 ± 0.082	3.481AlaPhe: 3.481 ± 0.046	14.991AlaGly: 14.991 ± 0.112	2.665AlaHis: 2.665 ± 0.042	3.751AlaIle: 3.751 ± 0.053	1.645AlaLys: 1.645 ± 0.037	15.024AlaLeu: 15.024 ± 0.127	2.591AlaMet: 2.591 ± 0.038	1.686AlaAsn: 1.686 ± 0.028	7.519AlaPro: 7.519 ± 0.095	3.664AlaGln: 3.664 ± 0.057	11.141AlaArg: 11.141 ± 0.1	5.471AlaSer: 5.471 ± 0.06	7.755AlaThr: 7.755 ± 0.079	14.319AlaVal: 14.319 ± 0.114	1.926AlaTrp: 1.926 ± 0.035	2.19AlaTyr: 2.19 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.912CysAla: 0.912 ± 0.022	0.089CysCys: 0.089 ± 0.008	0.429CysAsp: 0.429 ± 0.017	0.348CysGlu: 0.348 ± 0.015	0.189CysPhe: 0.189 ± 0.009	0.914CysGly: 0.914 ± 0.026	0.166CysHis: 0.166 ± 0.011	0.179CysIle: 0.179 ± 0.011	0.066CysLys: 0.066 ± 0.007	0.689CysLeu: 0.689 ± 0.02	0.095CysMet: 0.095 ± 0.008	0.104CysAsn: 0.104 ± 0.008	0.49CysPro: 0.49 ± 0.018	0.144CysGln: 0.144 ± 0.009	0.617CysArg: 0.617 ± 0.023	0.414CysSer: 0.414 ± 0.018	0.482CysThr: 0.482 ± 0.017	0.607CysVal: 0.607 ± 0.018	0.11CysTrp: 0.11 ± 0.009	0.131CysTyr: 0.131 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.307AspAla: 8.307 ± 0.069	0.359AspCys: 0.359 ± 0.015	4.251AspAsp: 4.251 ± 0.054	3.965AspGlu: 3.965 ± 0.051	1.406AspPhe: 1.406 ± 0.029	6.5AspGly: 6.5 ± 0.068	1.212AspHis: 1.212 ± 0.025	1.444AspIle: 1.444 ± 0.036	0.646AspLys: 0.646 ± 0.021	7.081AspLeu: 7.081 ± 0.069	0.74AspMet: 0.74 ± 0.022	0.722AspAsn: 0.722 ± 0.025	4.894AspPro: 4.894 ± 0.059	1.525AspGln: 1.525 ± 0.03	5.469AspArg: 5.469 ± 0.062	2.157AspSer: 2.157 ± 0.039	2.782AspThr: 2.782 ± 0.039	6.496AspVal: 6.496 ± 0.067	0.931AspTrp: 0.931 ± 0.022	0.979AspTyr: 0.979 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.135GluAla: 7.135 ± 0.074	0.312GluCys: 0.312 ± 0.015	3.047GluAsp: 3.047 ± 0.045	3.453GluGlu: 3.453 ± 0.049	1.469GluPhe: 1.469 ± 0.029	4.149GluGly: 4.149 ± 0.049	1.667GluHis: 1.667 ± 0.03	1.872GluIle: 1.872 ± 0.035	0.907GluLys: 0.907 ± 0.027	6.971GluLeu: 6.971 ± 0.075	0.846GluMet: 0.846 ± 0.024	0.787GluAsn: 0.787 ± 0.022	3.375GluPro: 3.375 ± 0.053	2.414GluGln: 2.414 ± 0.042	5.384GluArg: 5.384 ± 0.061	2.189GluSer: 2.189 ± 0.034	2.601GluThr: 2.601 ± 0.038	5.517GluVal: 5.517 ± 0.058	0.759GluTrp: 0.759 ± 0.023	1.007GluTyr: 1.007 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.641PheAla: 3.641 ± 0.049	0.252PheCys: 0.252 ± 0.011	1.925PheAsp: 1.925 ± 0.036	1.328PheGlu: 1.328 ± 0.027	0.842PhePhe: 0.842 ± 0.025	2.965PheGly: 2.965 ± 0.043	0.492PheHis: 0.492 ± 0.02	0.693PheIle: 0.693 ± 0.021	0.311PheLys: 0.311 ± 0.014	2.645PheLeu: 2.645 ± 0.043	0.336PheMet: 0.336 ± 0.014	0.448PheAsn: 0.448 ± 0.016	1.427PhePro: 1.427 ± 0.03	0.543PheGln: 0.543 ± 0.017	1.757PheArg: 1.757 ± 0.032	1.353PheSer: 1.353 ± 0.033	1.78PheThr: 1.78 ± 0.035	2.409PheVal: 2.409 ± 0.034	0.414PheTrp: 0.414 ± 0.016	0.545PheTyr: 0.545 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.934GlyAla: 11.934 ± 0.104	0.787GlyCys: 0.787 ± 0.022	5.42GlyAsp: 5.42 ± 0.065	5.252GlyGlu: 5.252 ± 0.061	2.785GlyPhe: 2.785 ± 0.04	9.097GlyGly: 9.097 ± 0.1	2.105GlyHis: 2.105 ± 0.036	3.308GlyIle: 3.308 ± 0.046	1.514GlyLys: 1.514 ± 0.036	10.146GlyLeu: 10.146 ± 0.092	1.999GlyMet: 1.999 ± 0.038	1.538GlyAsn: 1.538 ± 0.036	5.464GlyPro: 5.464 ± 0.068	2.825GlyGln: 2.825 ± 0.046	8.325GlyArg: 8.325 ± 0.089	5.263GlySer: 5.263 ± 0.063	6.116GlyThr: 6.116 ± 0.068	8.792GlyVal: 8.792 ± 0.09	1.799GlyTrp: 1.799 ± 0.038	2.123GlyTyr: 2.123 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.466HisAla: 2.466 ± 0.042	0.198HisCys: 0.198 ± 0.011	1.203HisAsp: 1.203 ± 0.028	1.115HisGlu: 1.115 ± 0.026	0.524HisPhe: 0.524 ± 0.018	2.199HisGly: 2.199 ± 0.032	0.587HisHis: 0.587 ± 0.022	0.475HisIle: 0.475 ± 0.018	0.203HisLys: 0.203 ± 0.012	2.39HisLeu: 2.39 ± 0.036	0.285HisMet: 0.285 ± 0.013	0.287HisAsn: 0.287 ± 0.014	1.748HisPro: 1.748 ± 0.034	0.542HisGln: 0.542 ± 0.018	2.01HisArg: 2.01 ± 0.041	0.837HisSer: 0.837 ± 0.024	1.035HisThr: 1.035 ± 0.025	1.978HisVal: 1.978 ± 0.036	0.312HisTrp: 0.312 ± 0.014	0.365HisTyr: 0.365 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.563IleAla: 4.563 ± 0.06	0.268IleCys: 0.268 ± 0.01	2.102IleAsp: 2.102 ± 0.034	1.783IleGlu: 1.783 ± 0.036	0.504IlePhe: 0.504 ± 0.021	3.493IleGly: 3.493 ± 0.048	0.41IleHis: 0.41 ± 0.016	0.699IleIle: 0.699 ± 0.028	0.405IleLys: 0.405 ± 0.017	1.844IleLeu: 1.844 ± 0.035	0.347IleMet: 0.347 ± 0.015	0.574IleAsn: 0.574 ± 0.021	1.585IlePro: 1.585 ± 0.037	0.581IleGln: 0.581 ± 0.02	2.045IleArg: 2.045 ± 0.037	1.48IleSer: 1.48 ± 0.03	1.899IleThr: 1.899 ± 0.032	2.588IleVal: 2.588 ± 0.045	0.343IleTrp: 0.343 ± 0.015	0.424IleTyr: 0.424 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	1.752LysAla: 1.752 ± 0.033	0.067LysCys: 0.067 ± 0.006	0.689LysAsp: 0.689 ± 0.023	0.672LysGlu: 0.672 ± 0.025	0.258LysPhe: 0.258 ± 0.013	1.05LysGly: 1.05 ± 0.031	0.287LysHis: 0.287 ± 0.013	0.431LysIle: 0.431 ± 0.018	0.368LysLys: 0.368 ± 0.019	1.267LysLeu: 1.267 ± 0.031	0.226LysMet: 0.226 ± 0.013	0.263LysAsn: 0.263 ± 0.014	0.795LysPro: 0.795 ± 0.024	0.444LysGln: 0.444 ± 0.018	1.027LysArg: 1.027 ± 0.031	0.654LysSer: 0.654 ± 0.02	0.798LysThr: 0.798 ± 0.026	1.184LysVal: 1.184 ± 0.03	0.167LysTrp: 0.167 ± 0.01	0.251LysTyr: 0.251 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.896LeuAla: 16.896 ± 0.137	0.72LeuCys: 0.72 ± 0.021	7.049LeuAsp: 7.049 ± 0.079	5.056LeuGlu: 5.056 ± 0.059	2.579LeuPhe: 2.579 ± 0.045	9.882LeuGly: 9.882 ± 0.093	2.068LeuHis: 2.068 ± 0.035	2.537LeuIle: 2.537 ± 0.045	1.128LeuLys: 1.128 ± 0.032	11.865LeuLeu: 11.865 ± 0.113	1.413LeuMet: 1.413 ± 0.029	1.297LeuAsn: 1.297 ± 0.03	6.828LeuPro: 6.828 ± 0.069	2.579LeuGln: 2.579 ± 0.045	8.701LeuArg: 8.701 ± 0.09	5.257LeuSer: 5.257 ± 0.064	6.89LeuThr: 6.89 ± 0.069	10.938LeuVal: 10.938 ± 0.099	1.209LeuTrp: 1.209 ± 0.026	1.535LeuTyr: 1.535 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.315MetAla: 2.315 ± 0.042	0.138MetCys: 0.138 ± 0.01	0.847MetAsp: 0.847 ± 0.025	0.657MetGlu: 0.657 ± 0.02	0.357MetPhe: 0.357 ± 0.016	1.295MetGly: 1.295 ± 0.03	0.335MetHis: 0.335 ± 0.014	0.493MetIle: 0.493 ± 0.017	0.281MetLys: 0.281 ± 0.014	1.483MetLeu: 1.483 ± 0.029	0.215MetMet: 0.215 ± 0.013	0.334MetAsn: 0.334 ± 0.014	1.042MetPro: 1.042 ± 0.028	0.45MetGln: 0.45 ± 0.016	1.327MetArg: 1.327 ± 0.029	1.322MetSer: 1.322 ± 0.027	1.717MetThr: 1.717 ± 0.033	1.404MetVal: 1.404 ± 0.031	0.182MetTrp: 0.182 ± 0.011	0.262MetTyr: 0.262 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.906AsnAla: 1.906 ± 0.038	0.134AsnCys: 0.134 ± 0.007	0.77AsnAsp: 0.77 ± 0.023	0.668AsnGlu: 0.668 ± 0.021	0.381AsnPhe: 0.381 ± 0.016	1.482AsnGly: 1.482 ± 0.033	0.29AsnHis: 0.29 ± 0.013	0.462AsnIle: 0.462 ± 0.017	0.206AsnLys: 0.206 ± 0.012	1.46AsnLeu: 1.46 ± 0.029	0.242AsnMet: 0.242 ± 0.013	0.304AsnAsn: 0.304 ± 0.015	1.177AsnPro: 1.177 ± 0.03	0.399AsnGln: 0.399 ± 0.015	1.12AsnArg: 1.12 ± 0.026	0.673AsnSer: 0.673 ± 0.024	0.826AsnThr: 0.826 ± 0.026	1.278AsnVal: 1.278 ± 0.026	0.242AsnTrp: 0.242 ± 0.013	0.316AsnTyr: 0.316 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.683ProAla: 9.683 ± 0.088	0.309ProCys: 0.309 ± 0.014	4.8ProAsp: 4.8 ± 0.052	4.292ProGlu: 4.292 ± 0.047	1.604ProPhe: 1.604 ± 0.035	7.026ProGly: 7.026 ± 0.072	1.231ProHis: 1.231 ± 0.026	1.395ProIle: 1.395 ± 0.032	0.673ProLys: 0.673 ± 0.022	5.572ProLeu: 5.572 ± 0.063	1.042ProMet: 1.042 ± 0.029	0.766ProAsn: 0.766 ± 0.021	4.138ProPro: 4.138 ± 0.075	1.555ProGln: 1.555 ± 0.037	4.332ProArg: 4.332 ± 0.054	3.059ProSer: 3.059 ± 0.046	3.468ProThr: 3.468 ± 0.046	6.269ProVal: 6.269 ± 0.062	0.95ProTrp: 0.95 ± 0.027	1.057ProTyr: 1.057 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.7GlnAla: 3.7 ± 0.058	0.148GlnCys: 0.148 ± 0.01	1.216GlnAsp: 1.216 ± 0.027	1.361GlnGlu: 1.361 ± 0.033	0.709GlnPhe: 0.709 ± 0.018	2.01GlnGly: 2.01 ± 0.036	0.646GlnHis: 0.646 ± 0.018	0.873GlnIle: 0.873 ± 0.023	0.392GlnLys: 0.392 ± 0.015	3.356GlnLeu: 3.356 ± 0.049	0.467GlnMet: 0.467 ± 0.017	0.394GlnAsn: 0.394 ± 0.015	1.757GlnPro: 1.757 ± 0.045	1.174GlnGln: 1.174 ± 0.028	2.505GlnArg: 2.505 ± 0.045	1.106GlnSer: 1.106 ± 0.028	1.299GlnThr: 1.299 ± 0.028	2.831GlnVal: 2.831 ± 0.039	0.405GlnTrp: 0.405 ± 0.015	0.506GlnTyr: 0.506 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.747ArgAla: 10.747 ± 0.101	0.59ArgCys: 0.59 ± 0.021	4.45ArgAsp: 4.45 ± 0.05	4.632ArgGlu: 4.632 ± 0.062	2.345ArgPhe: 2.345 ± 0.04	6.325ArgGly: 6.325 ± 0.062	1.868ArgHis: 1.868 ± 0.032	2.658ArgIle: 2.658 ± 0.044	1.011ArgLys: 1.011 ± 0.026	9.105ArgLeu: 9.105 ± 0.082	1.799ArgMet: 1.799 ± 0.033	1.144ArgAsn: 1.144 ± 0.03	5.538ArgPro: 5.538 ± 0.064	2.324ArgGln: 2.324 ± 0.044	8.534ArgArg: 8.534 ± 0.083	4.332ArgSer: 4.332 ± 0.051	5.107ArgThr: 5.107 ± 0.06	6.896ArgVal: 6.896 ± 0.075	1.528ArgTrp: 1.528 ± 0.032	1.748ArgTyr: 1.748 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.564SerAla: 6.564 ± 0.069	0.366SerCys: 0.366 ± 0.016	2.563SerAsp: 2.563 ± 0.043	2.076SerGlu: 2.076 ± 0.037	1.412SerPhe: 1.412 ± 0.027	5.381SerGly: 5.381 ± 0.065	0.822SerHis: 0.822 ± 0.021	1.527SerIle: 1.527 ± 0.03	0.599SerLys: 0.599 ± 0.02	4.548SerLeu: 4.548 ± 0.05	1.085SerMet: 1.085 ± 0.024	0.72SerAsn: 0.72 ± 0.021	3.229SerPro: 3.229 ± 0.042	1.034SerGln: 1.034 ± 0.028	3.774SerArg: 3.774 ± 0.05	2.798SerSer: 2.798 ± 0.052	3.054SerThr: 3.054 ± 0.044	4.202SerVal: 4.202 ± 0.05	0.845SerTrp: 0.845 ± 0.024	0.986SerTyr: 0.986 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.889ThrAla: 8.889 ± 0.078	0.427ThrCys: 0.427 ± 0.019	3.537ThrAsp: 3.537 ± 0.044	3.046ThrGlu: 3.046 ± 0.047	1.54ThrPhe: 1.54 ± 0.035	6.692ThrGly: 6.692 ± 0.069	1.056ThrHis: 1.056 ± 0.027	1.707ThrIle: 1.707 ± 0.038	0.708ThrLys: 0.708 ± 0.022	5.535ThrLeu: 5.535 ± 0.062	0.907ThrMet: 0.907 ± 0.025	0.892ThrAsn: 0.892 ± 0.023	4.216ThrPro: 4.216 ± 0.049	1.282ThrGln: 1.282 ± 0.027	4.019ThrArg: 4.019 ± 0.053	3.018ThrSer: 3.018 ± 0.048	4.017ThrThr: 4.017 ± 0.054	6.266ThrVal: 6.266 ± 0.065	0.901ThrTrp: 0.901 ± 0.025	1.055ThrTyr: 1.055 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	13.451ValAla: 13.451 ± 0.1	0.703ValCys: 0.703 ± 0.022	6.455ValAsp: 6.455 ± 0.064	5.425ValGlu: 5.425 ± 0.058	2.714ValPhe: 2.714 ± 0.043	8.108ValGly: 8.108 ± 0.075	2.165ValHis: 2.165 ± 0.035	2.623ValIle: 2.623 ± 0.047	1.145ValLys: 1.145 ± 0.031	11.711ValLeu: 11.711 ± 0.113	1.34ValMet: 1.34 ± 0.034	1.538ValAsn: 1.538 ± 0.032	6.262ValPro: 6.262 ± 0.064	2.346ValGln: 2.346 ± 0.037	7.575ValArg: 7.575 ± 0.067	4.416ValSer: 4.416 ± 0.051	6.149ValThr: 6.149 ± 0.062	11.292ValVal: 11.292 ± 0.116	1.141ValTrp: 1.141 ± 0.03	1.542ValTyr: 1.542 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.744TrpAla: 1.744 ± 0.032	0.145TrpCys: 0.145 ± 0.009	0.792TrpAsp: 0.792 ± 0.021	0.66TrpGlu: 0.66 ± 0.021	0.48TrpPhe: 0.48 ± 0.018	1.081TrpGly: 1.081 ± 0.031	0.354TrpHis: 0.354 ± 0.013	0.428TrpIle: 0.428 ± 0.015	0.188TrpLys: 0.188 ± 0.011	1.836TrpLeu: 1.836 ± 0.036	0.268TrpMet: 0.268 ± 0.013	0.288TrpAsn: 0.288 ± 0.013	0.844TrpPro: 0.844 ± 0.025	0.539TrpGln: 0.539 ± 0.018	1.381TrpArg: 1.381 ± 0.031	0.947TrpSer: 0.947 ± 0.026	0.978TrpThr: 0.978 ± 0.026	1.193TrpVal: 1.193 ± 0.027	0.321TrpTrp: 0.321 ± 0.015	0.293TrpTyr: 0.293 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.04	0.167TyrCys: 0.167 ± 0.01	1.265TyrAsp: 1.265 ± 0.025	1.034TyrGlu: 1.034 ± 0.026	0.528TyrPhe: 0.528 ± 0.021	1.95TyrGly: 1.95 ± 0.048	0.332TyrHis: 0.332 ± 0.014	0.383TyrIle: 0.383 ± 0.017	0.251TyrLys: 0.251 ± 0.013	1.899TyrLeu: 1.899 ± 0.034	0.209TyrMet: 0.209 ± 0.011	0.248TyrAsn: 0.248 ± 0.015	0.896TyrPro: 0.896 ± 0.022	0.493TyrGln: 0.493 ± 0.018	1.638TyrArg: 1.638 ± 0.031	0.837TyrSer: 0.837 ± 0.022	0.956TyrThr: 0.956 ± 0.026	1.642TyrVal: 1.642 ± 0.032	0.276TyrTrp: 0.276 ± 0.013	0.35TyrTyr: 0.35 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5204 proteins (1639597 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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