Amino acid dipepetide frequency for Oryzihumus leptocrescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.079AlaAla: 21.079 ± 0.202
1.062AlaCys: 1.062 ± 0.031
7.792AlaAsp: 7.792 ± 0.087
7.473AlaGlu: 7.473 ± 0.096
3.495AlaPhe: 3.495 ± 0.052
13.144AlaGly: 13.144 ± 0.116
2.987AlaHis: 2.987 ± 0.05
3.855AlaIle: 3.855 ± 0.059
2.549AlaLys: 2.549 ± 0.063
14.665AlaLeu: 14.665 ± 0.146
2.938AlaMet: 2.938 ± 0.046
2.047AlaAsn: 2.047 ± 0.048
7.011AlaPro: 7.011 ± 0.103
4.11AlaGln: 4.11 ± 0.061
10.462AlaArg: 10.462 ± 0.117
6.686AlaSer: 6.686 ± 0.085
8.282AlaThr: 8.282 ± 0.1
12.707AlaVal: 12.707 ± 0.127
2.165AlaTrp: 2.165 ± 0.042
2.536AlaTyr: 2.536 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.953CysAla: 0.953 ± 0.029
0.094CysCys: 0.094 ± 0.008
0.441CysAsp: 0.441 ± 0.02
0.34CysGlu: 0.34 ± 0.018
0.234CysPhe: 0.234 ± 0.013
0.902CysGly: 0.902 ± 0.026
0.205CysHis: 0.205 ± 0.013
0.178CysIle: 0.178 ± 0.013
0.083CysLys: 0.083 ± 0.007
0.674CysLeu: 0.674 ± 0.022
0.101CysMet: 0.101 ± 0.009
0.124CysAsn: 0.124 ± 0.013
0.474CysPro: 0.474 ± 0.019
0.164CysGln: 0.164 ± 0.012
0.562CysArg: 0.562 ± 0.02
0.437CysSer: 0.437 ± 0.02
0.482CysThr: 0.482 ± 0.021
0.633CysVal: 0.633 ± 0.023
0.113CysTrp: 0.113 ± 0.009
0.127CysTyr: 0.127 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.657AspAla: 7.657 ± 0.08
0.352AspCys: 0.352 ± 0.018
3.368AspAsp: 3.368 ± 0.059
3.723AspGlu: 3.723 ± 0.063
1.509AspPhe: 1.509 ± 0.037
5.897AspGly: 5.897 ± 0.085
1.487AspHis: 1.487 ± 0.035
1.695AspIle: 1.695 ± 0.039
1.066AspLys: 1.066 ± 0.034
6.887AspLeu: 6.887 ± 0.086
0.795AspMet: 0.795 ± 0.024
0.957AspAsn: 0.957 ± 0.032
4.443AspPro: 4.443 ± 0.077
1.71AspGln: 1.71 ± 0.041
4.51AspArg: 4.51 ± 0.066
2.267AspSer: 2.267 ± 0.043
2.866AspThr: 2.866 ± 0.05
5.587AspVal: 5.587 ± 0.073
0.95AspTrp: 0.95 ± 0.033
1.179AspTyr: 1.179 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
7.329GluAla: 7.329 ± 0.095
0.327GluCys: 0.327 ± 0.015
2.908GluAsp: 2.908 ± 0.056
3.08GluGlu: 3.08 ± 0.067
1.286GluPhe: 1.286 ± 0.036
4.292GluGly: 4.292 ± 0.068
1.661GluHis: 1.661 ± 0.038
1.699GluIle: 1.699 ± 0.041
1.085GluLys: 1.085 ± 0.04
5.968GluLeu: 5.968 ± 0.077
0.861GluMet: 0.861 ± 0.027
0.723GluAsn: 0.723 ± 0.026
3.002GluPro: 3.002 ± 0.059
2.357GluGln: 2.357 ± 0.045
5.025GluArg: 5.025 ± 0.081
2.343GluSer: 2.343 ± 0.043
2.47GluThr: 2.47 ± 0.05
5.436GluVal: 5.436 ± 0.075
0.731GluTrp: 0.731 ± 0.026
0.794GluTyr: 0.794 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.676PheAla: 3.676 ± 0.056
0.238PheCys: 0.238 ± 0.014
1.872PheAsp: 1.872 ± 0.038
1.443PheGlu: 1.443 ± 0.037
0.862PhePhe: 0.862 ± 0.029
2.905PheGly: 2.905 ± 0.056
0.601PheHis: 0.601 ± 0.023
0.802PheIle: 0.802 ± 0.027
0.43PheLys: 0.43 ± 0.017
2.434PheLeu: 2.434 ± 0.048
0.388PheMet: 0.388 ± 0.018
0.587PheAsn: 0.587 ± 0.024
1.256PhePro: 1.256 ± 0.031
0.612PheGln: 0.612 ± 0.021
1.642PheArg: 1.642 ± 0.038
1.441PheSer: 1.441 ± 0.039
1.904PheThr: 1.904 ± 0.044
2.524PheVal: 2.524 ± 0.051
0.411PheTrp: 0.411 ± 0.019
0.578PheTyr: 0.578 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
11.031GlyAla: 11.031 ± 0.116
0.783GlyCys: 0.783 ± 0.026
5.056GlyAsp: 5.056 ± 0.07
4.863GlyGlu: 4.863 ± 0.074
2.899GlyPhe: 2.899 ± 0.049
8.303GlyGly: 8.303 ± 0.121
2.481GlyHis: 2.481 ± 0.043
3.344GlyIle: 3.344 ± 0.058
2.069GlyLys: 2.069 ± 0.05
9.698GlyLeu: 9.698 ± 0.11
2.083GlyMet: 2.083 ± 0.043
1.762GlyAsn: 1.762 ± 0.065
5.016GlyPro: 5.016 ± 0.084
3.119GlyGln: 3.119 ± 0.055
7.342GlyArg: 7.342 ± 0.09
5.761GlySer: 5.761 ± 0.069
6.097GlyThr: 6.097 ± 0.078
8.179GlyVal: 8.179 ± 0.092
1.895GlyTrp: 1.895 ± 0.043
2.112GlyTyr: 2.112 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.806HisAla: 2.806 ± 0.063
0.184HisCys: 0.184 ± 0.013
1.552HisAsp: 1.552 ± 0.038
1.366HisGlu: 1.366 ± 0.032
0.595HisPhe: 0.595 ± 0.025
2.48HisGly: 2.48 ± 0.046
0.712HisHis: 0.712 ± 0.026
0.544HisIle: 0.544 ± 0.019
0.331HisLys: 0.331 ± 0.016
2.65HisLeu: 2.65 ± 0.05
0.332HisMet: 0.332 ± 0.018
0.378HisAsn: 0.378 ± 0.02
1.802HisPro: 1.802 ± 0.041
0.673HisGln: 0.673 ± 0.028
1.998HisArg: 1.998 ± 0.038
0.951HisSer: 0.951 ± 0.029
1.261HisThr: 1.261 ± 0.03
2.18HisVal: 2.18 ± 0.041
0.36HisTrp: 0.36 ± 0.017
0.448HisTyr: 0.448 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.418IleAla: 4.418 ± 0.066
0.273IleCys: 0.273 ± 0.015
2.134IleAsp: 2.134 ± 0.05
1.869IleGlu: 1.869 ± 0.041
0.694IlePhe: 0.694 ± 0.026
3.256IleGly: 3.256 ± 0.062
0.618IleHis: 0.618 ± 0.021
0.886IleIle: 0.886 ± 0.03
0.668IleLys: 0.668 ± 0.029
2.358IleLeu: 2.358 ± 0.048
0.366IleMet: 0.366 ± 0.017
0.636IleAsn: 0.636 ± 0.024
1.616IlePro: 1.616 ± 0.039
0.695IleGln: 0.695 ± 0.027
2.024IleArg: 2.024 ± 0.037
1.68IleSer: 1.68 ± 0.037
1.968IleThr: 1.968 ± 0.046
2.763IleVal: 2.763 ± 0.056
0.396IleTrp: 0.396 ± 0.018
0.532IleTyr: 0.532 ± 0.022
0.0IleXaa: 0.0 ± 0.0
Lys
2.758LysAla: 2.758 ± 0.067
0.075LysCys: 0.075 ± 0.008
1.219LysAsp: 1.219 ± 0.034
0.84LysGlu: 0.84 ± 0.034
0.452LysPhe: 0.452 ± 0.022
1.653LysGly: 1.653 ± 0.049
0.383LysHis: 0.383 ± 0.017
0.643LysIle: 0.643 ± 0.028
0.592LysLys: 0.592 ± 0.035
1.531LysLeu: 1.531 ± 0.041
0.297LysMet: 0.297 ± 0.017
0.413LysAsn: 0.413 ± 0.02
1.16LysPro: 1.16 ± 0.035
0.591LysGln: 0.591 ± 0.023
1.222LysArg: 1.222 ± 0.031
0.947LysSer: 0.947 ± 0.032
1.094LysThr: 1.094 ± 0.031
1.97LysVal: 1.97 ± 0.048
0.223LysTrp: 0.223 ± 0.013
0.357LysTyr: 0.357 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
15.925LeuAla: 15.925 ± 0.148
0.707LeuCys: 0.707 ± 0.025
6.56LeuAsp: 6.56 ± 0.079
5.196LeuGlu: 5.196 ± 0.078
2.41LeuPhe: 2.41 ± 0.048
9.758LeuGly: 9.758 ± 0.099
2.231LeuHis: 2.231 ± 0.042
2.659LeuIle: 2.659 ± 0.053
1.73LeuLys: 1.73 ± 0.048
10.891LeuLeu: 10.891 ± 0.133
1.636LeuMet: 1.636 ± 0.034
1.498LeuAsn: 1.498 ± 0.035
6.272LeuPro: 6.272 ± 0.079
2.495LeuGln: 2.495 ± 0.042
8.277LeuArg: 8.277 ± 0.092
5.383LeuSer: 5.383 ± 0.074
6.625LeuThr: 6.625 ± 0.09
10.62LeuVal: 10.62 ± 0.111
1.358LeuTrp: 1.358 ± 0.037
1.556LeuTyr: 1.556 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
2.38MetAla: 2.38 ± 0.046
0.127MetCys: 0.127 ± 0.011
0.888MetAsp: 0.888 ± 0.025
0.695MetGlu: 0.695 ± 0.022
0.47MetPhe: 0.47 ± 0.021
1.424MetGly: 1.424 ± 0.035
0.374MetHis: 0.374 ± 0.018
0.549MetIle: 0.549 ± 0.021
0.374MetLys: 0.374 ± 0.017
1.736MetLeu: 1.736 ± 0.041
0.295MetMet: 0.295 ± 0.015
0.371MetAsn: 0.371 ± 0.016
1.204MetPro: 1.204 ± 0.031
0.481MetGln: 0.481 ± 0.02
1.4MetArg: 1.4 ± 0.031
1.511MetSer: 1.511 ± 0.036
1.753MetThr: 1.753 ± 0.036
1.585MetVal: 1.585 ± 0.037
0.211MetTrp: 0.211 ± 0.012
0.279MetTyr: 0.279 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.199AsnAla: 2.199 ± 0.045
0.136AsnCys: 0.136 ± 0.01
0.928AsnAsp: 0.928 ± 0.026
0.673AsnGlu: 0.673 ± 0.021
0.425AsnPhe: 0.425 ± 0.021
1.753AsnGly: 1.753 ± 0.071
0.399AsnHis: 0.399 ± 0.018
0.568AsnIle: 0.568 ± 0.021
0.334AsnLys: 0.334 ± 0.018
1.789AsnLeu: 1.789 ± 0.046
0.252AsnMet: 0.252 ± 0.014
0.392AsnAsn: 0.392 ± 0.018
1.448AsnPro: 1.448 ± 0.037
0.462AsnGln: 0.462 ± 0.021
1.132AsnArg: 1.132 ± 0.032
0.746AsnSer: 0.746 ± 0.024
1.014AsnThr: 1.014 ± 0.026
1.485AsnVal: 1.485 ± 0.04
0.239AsnTrp: 0.239 ± 0.016
0.394AsnTyr: 0.394 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
8.537ProAla: 8.537 ± 0.099
0.327ProCys: 0.327 ± 0.017
4.05ProAsp: 4.05 ± 0.064
3.886ProGlu: 3.886 ± 0.055
1.444ProPhe: 1.444 ± 0.037
6.37ProGly: 6.37 ± 0.075
1.324ProHis: 1.324 ± 0.032
1.364ProIle: 1.364 ± 0.036
1.005ProLys: 1.005 ± 0.034
5.046ProLeu: 5.046 ± 0.066
1.103ProMet: 1.103 ± 0.026
0.847ProAsn: 0.847 ± 0.027
3.157ProPro: 3.157 ± 0.063
1.853ProGln: 1.853 ± 0.048
3.911ProArg: 3.911 ± 0.067
3.329ProSer: 3.329 ± 0.062
3.764ProThr: 3.764 ± 0.071
5.661ProVal: 5.661 ± 0.083
1.027ProTrp: 1.027 ± 0.027
1.052ProTyr: 1.052 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
4.068GlnAla: 4.068 ± 0.065
0.182GlnCys: 0.182 ± 0.012
1.429GlnAsp: 1.429 ± 0.034
1.46GlnGlu: 1.46 ± 0.039
0.7GlnPhe: 0.7 ± 0.023
2.452GlnGly: 2.452 ± 0.058
0.707GlnHis: 0.707 ± 0.026
0.921GlnIle: 0.921 ± 0.028
0.503GlnLys: 0.503 ± 0.025
3.186GlnLeu: 3.186 ± 0.06
0.6GlnMet: 0.6 ± 0.024
0.446GlnAsn: 0.446 ± 0.021
1.836GlnPro: 1.836 ± 0.038
1.259GlnGln: 1.259 ± 0.037
2.673GlnArg: 2.673 ± 0.051
1.289GlnSer: 1.289 ± 0.032
1.529GlnThr: 1.529 ± 0.033
3.275GlnVal: 3.275 ± 0.05
0.519GlnTrp: 0.519 ± 0.022
0.496GlnTyr: 0.496 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
9.672ArgAla: 9.672 ± 0.107
0.545ArgCys: 0.545 ± 0.021
4.463ArgAsp: 4.463 ± 0.057
4.647ArgGlu: 4.647 ± 0.07
2.234ArgPhe: 2.234 ± 0.042
5.924ArgGly: 5.924 ± 0.085
2.089ArgHis: 2.089 ± 0.04
2.562ArgIle: 2.562 ± 0.045
1.307ArgLys: 1.307 ± 0.038
8.522ArgLeu: 8.522 ± 0.107
1.717ArgMet: 1.717 ± 0.036
1.133ArgAsn: 1.133 ± 0.034
4.583ArgPro: 4.583 ± 0.065
2.445ArgGln: 2.445 ± 0.048
7.783ArgArg: 7.783 ± 0.088
4.171ArgSer: 4.171 ± 0.072
4.548ArgThr: 4.548 ± 0.061
6.797ArgVal: 6.797 ± 0.076
1.51ArgTrp: 1.51 ± 0.035
1.616ArgTyr: 1.616 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.937SerAla: 6.937 ± 0.083
0.391SerCys: 0.391 ± 0.018
2.595SerAsp: 2.595 ± 0.052
2.215SerGlu: 2.215 ± 0.041
1.571SerPhe: 1.571 ± 0.038
5.849SerGly: 5.849 ± 0.067
1.131SerHis: 1.131 ± 0.03
1.595SerIle: 1.595 ± 0.045
0.85SerLys: 0.85 ± 0.025
5.314SerLeu: 5.314 ± 0.071
1.171SerMet: 1.171 ± 0.028
0.916SerAsn: 0.916 ± 0.03
3.282SerPro: 3.282 ± 0.056
1.436SerGln: 1.436 ± 0.038
4.053SerArg: 4.053 ± 0.063
3.275SerSer: 3.275 ± 0.071
3.629SerThr: 3.629 ± 0.055
4.539SerVal: 4.539 ± 0.062
1.016SerTrp: 1.016 ± 0.032
1.142SerTyr: 1.142 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
8.125ThrAla: 8.125 ± 0.076
0.46ThrCys: 0.46 ± 0.022
3.474ThrAsp: 3.474 ± 0.051
2.625ThrGlu: 2.625 ± 0.048
1.862ThrPhe: 1.862 ± 0.04
6.482ThrGly: 6.482 ± 0.076
1.275ThrHis: 1.275 ± 0.031
1.957ThrIle: 1.957 ± 0.046
1.131ThrLys: 1.131 ± 0.041
5.893ThrLeu: 5.893 ± 0.073
1.059ThrMet: 1.059 ± 0.028
1.108ThrAsn: 1.108 ± 0.034
4.221ThrPro: 4.221 ± 0.065
1.483ThrGln: 1.483 ± 0.037
4.18ThrArg: 4.18 ± 0.066
3.665ThrSer: 3.665 ± 0.069
4.392ThrThr: 4.392 ± 0.084
6.043ThrVal: 6.043 ± 0.078
1.136ThrTrp: 1.136 ± 0.033
1.3ThrTyr: 1.3 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
12.993ValAla: 12.993 ± 0.123
0.741ValCys: 0.741 ± 0.026
5.932ValAsp: 5.932 ± 0.088
5.311ValGlu: 5.311 ± 0.082
2.368ValPhe: 2.368 ± 0.045
8.028ValGly: 8.028 ± 0.095
2.155ValHis: 2.155 ± 0.041
3.202ValIle: 3.202 ± 0.056
1.7ValLys: 1.7 ± 0.042
10.468ValLeu: 10.468 ± 0.112
1.618ValMet: 1.618 ± 0.04
1.74ValAsn: 1.74 ± 0.039
5.407ValPro: 5.407 ± 0.064
2.397ValGln: 2.397 ± 0.046
7.124ValArg: 7.124 ± 0.088
5.03ValSer: 5.03 ± 0.062
6.216ValThr: 6.216 ± 0.083
10.602ValVal: 10.602 ± 0.126
1.267ValTrp: 1.267 ± 0.032
1.457ValTyr: 1.457 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.817TrpAla: 1.817 ± 0.041
0.171TrpCys: 0.171 ± 0.013
0.828TrpAsp: 0.828 ± 0.026
0.688TrpGlu: 0.688 ± 0.023
0.559TrpPhe: 0.559 ± 0.022
1.208TrpGly: 1.208 ± 0.03
0.441TrpHis: 0.441 ± 0.017
0.415TrpIle: 0.415 ± 0.018
0.293TrpLys: 0.293 ± 0.015
2.01TrpLeu: 2.01 ± 0.053
0.29TrpMet: 0.29 ± 0.015
0.327TrpAsn: 0.327 ± 0.02
0.887TrpPro: 0.887 ± 0.029
0.629TrpGln: 0.629 ± 0.021
1.426TrpArg: 1.426 ± 0.035
1.088TrpSer: 1.088 ± 0.034
0.978TrpThr: 0.978 ± 0.029
1.481TrpVal: 1.481 ± 0.035
0.437TrpTrp: 0.437 ± 0.02
0.293TrpTyr: 0.293 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.686TyrAla: 2.686 ± 0.048
0.147TyrCys: 0.147 ± 0.01
1.415TyrAsp: 1.415 ± 0.043
0.983TyrGlu: 0.983 ± 0.029
0.537TyrPhe: 0.537 ± 0.021
1.813TyrGly: 1.813 ± 0.038
0.343TyrHis: 0.343 ± 0.018
0.411TyrIle: 0.411 ± 0.019
0.32TyrLys: 0.32 ± 0.019
2.065TyrLeu: 2.065 ± 0.041
0.205TyrMet: 0.205 ± 0.014
0.366TyrAsn: 0.366 ± 0.018
0.98TyrPro: 0.98 ± 0.031
0.559TyrGln: 0.559 ± 0.023
1.525TyrArg: 1.525 ± 0.033
0.906TyrSer: 0.906 ± 0.028
1.002TyrThr: 1.002 ± 0.036
1.689TyrVal: 1.689 ± 0.039
0.3TyrTrp: 0.3 ± 0.016
0.421TyrTyr: 0.421 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4026 proteins (1271052 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski