Amino acid dipepetide frequency for bacterium LRH843

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.788AlaAla: 6.788 ± 0.101	0.741AlaCys: 0.741 ± 0.024	3.69AlaAsp: 3.69 ± 0.052	5.325AlaGlu: 5.325 ± 0.073	3.29AlaPhe: 3.29 ± 0.051	5.716AlaGly: 5.716 ± 0.07	1.425AlaHis: 1.425 ± 0.035	6.173AlaIle: 6.173 ± 0.077	4.866AlaLys: 4.866 ± 0.066	7.833AlaLeu: 7.833 ± 0.083	2.176AlaMet: 2.176 ± 0.042	3.045AlaAsn: 3.045 ± 0.049	2.407AlaPro: 2.407 ± 0.045	2.672AlaGln: 2.672 ± 0.046	3.211AlaArg: 3.211 ± 0.054	4.486AlaSer: 4.486 ± 0.066	4.161AlaThr: 4.161 ± 0.066	5.546AlaVal: 5.546 ± 0.066	0.676AlaTrp: 0.676 ± 0.025	2.313AlaTyr: 2.313 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.563CysAla: 0.563 ± 0.021	0.105CysCys: 0.105 ± 0.009	0.471CysAsp: 0.471 ± 0.018	0.488CysGlu: 0.488 ± 0.018	0.371CysPhe: 0.371 ± 0.017	0.764CysGly: 0.764 ± 0.024	0.218CysHis: 0.218 ± 0.013	0.549CysIle: 0.549 ± 0.019	0.377CysLys: 0.377 ± 0.016	0.773CysLeu: 0.773 ± 0.025	0.208CysMet: 0.208 ± 0.012	0.291CysAsn: 0.291 ± 0.014	0.365CysPro: 0.365 ± 0.02	0.273CysGln: 0.273 ± 0.013	0.351CysArg: 0.351 ± 0.016	0.527CysSer: 0.527 ± 0.022	0.42CysThr: 0.42 ± 0.017	0.481CysVal: 0.481 ± 0.02	0.08CysTrp: 0.08 ± 0.008	0.276CysTyr: 0.276 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.753AspAla: 3.753 ± 0.055	0.387AspCys: 0.387 ± 0.017	2.615AspAsp: 2.615 ± 0.047	4.368AspGlu: 4.368 ± 0.067	2.293AspPhe: 2.293 ± 0.05	3.525AspGly: 3.525 ± 0.055	1.266AspHis: 1.266 ± 0.028	3.911AspIle: 3.911 ± 0.057	2.798AspLys: 2.798 ± 0.047	5.207AspLeu: 5.207 ± 0.071	1.362AspMet: 1.362 ± 0.031	1.623AspAsn: 1.623 ± 0.041	2.12AspPro: 2.12 ± 0.046	2.17AspGln: 2.17 ± 0.04	2.461AspArg: 2.461 ± 0.046	2.566AspSer: 2.566 ± 0.048	2.363AspThr: 2.363 ± 0.04	4.09AspVal: 4.09 ± 0.054	0.609AspTrp: 0.609 ± 0.021	2.014AspTyr: 2.014 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.682GluAla: 5.682 ± 0.065	0.427GluCys: 0.427 ± 0.021	3.507GluAsp: 3.507 ± 0.053	6.631GluGlu: 6.631 ± 0.109	2.485GluPhe: 2.485 ± 0.051	4.358GluGly: 4.358 ± 0.056	1.588GluHis: 1.588 ± 0.033	5.215GluIle: 5.215 ± 0.071	5.86GluLys: 5.86 ± 0.075	7.238GluLeu: 7.238 ± 0.081	2.201GluMet: 2.201 ± 0.04	3.222GluAsn: 3.222 ± 0.051	2.017GluPro: 2.017 ± 0.04	3.815GluGln: 3.815 ± 0.051	3.987GluArg: 3.987 ± 0.057	3.65GluSer: 3.65 ± 0.053	3.844GluThr: 3.844 ± 0.062	5.023GluVal: 5.023 ± 0.07	0.814GluTrp: 0.814 ± 0.026	2.076GluTyr: 2.076 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.25PheAla: 3.25 ± 0.058	0.382PheCys: 0.382 ± 0.021	2.489PheAsp: 2.489 ± 0.042	2.784PheGlu: 2.784 ± 0.041	2.119PhePhe: 2.119 ± 0.053	3.302PheGly: 3.302 ± 0.048	0.961PheHis: 0.961 ± 0.029	3.587PheIle: 3.587 ± 0.058	2.281PheLys: 2.281 ± 0.045	4.278PheLeu: 4.278 ± 0.06	1.054PheMet: 1.054 ± 0.027	1.774PheAsn: 1.774 ± 0.034	1.555PhePro: 1.555 ± 0.036	1.532PheGln: 1.532 ± 0.03	1.557PheArg: 1.557 ± 0.033	3.092PheSer: 3.092 ± 0.05	2.372PheThr: 2.372 ± 0.047	2.999PheVal: 2.999 ± 0.051	0.482PheTrp: 0.482 ± 0.016	1.515PheTyr: 1.515 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.383GlyAla: 5.383 ± 0.069	0.686GlyCys: 0.686 ± 0.024	3.283GlyAsp: 3.283 ± 0.05	4.669GlyGlu: 4.669 ± 0.068	3.363GlyPhe: 3.363 ± 0.052	5.218GlyGly: 5.218 ± 0.088	1.562GlyHis: 1.562 ± 0.035	5.84GlyIle: 5.84 ± 0.077	4.554GlyLys: 4.554 ± 0.062	6.835GlyLeu: 6.835 ± 0.092	2.194GlyMet: 2.194 ± 0.047	2.651GlyAsn: 2.651 ± 0.05	1.918GlyPro: 1.918 ± 0.039	2.453GlyGln: 2.453 ± 0.046	2.933GlyArg: 2.933 ± 0.052	4.092GlySer: 4.092 ± 0.056	4.015GlyThr: 4.015 ± 0.052	5.21GlyVal: 5.21 ± 0.065	0.796GlyTrp: 0.796 ± 0.023	2.651GlyTyr: 2.651 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.571HisAla: 1.571 ± 0.036	0.235HisCys: 0.235 ± 0.014	1.123HisAsp: 1.123 ± 0.029	1.399HisGlu: 1.399 ± 0.032	1.055HisPhe: 1.055 ± 0.03	1.493HisGly: 1.493 ± 0.036	0.721HisHis: 0.721 ± 0.03	1.536HisIle: 1.536 ± 0.035	0.996HisLys: 0.996 ± 0.029	2.225HisLeu: 2.225 ± 0.042	0.508HisMet: 0.508 ± 0.022	0.771HisAsn: 0.771 ± 0.025	1.147HisPro: 1.147 ± 0.029	0.896HisGln: 0.896 ± 0.026	0.981HisArg: 0.981 ± 0.028	1.329HisSer: 1.329 ± 0.033	1.063HisThr: 1.063 ± 0.029	1.579HisVal: 1.579 ± 0.035	0.26HisTrp: 0.26 ± 0.014	0.869HisTyr: 0.869 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.298IleAla: 6.298 ± 0.073	0.674IleCys: 0.674 ± 0.022	4.521IleAsp: 4.521 ± 0.064	5.677IleGlu: 5.677 ± 0.068	2.886IlePhe: 2.886 ± 0.051	5.989IleGly: 5.989 ± 0.068	1.636IleHis: 1.636 ± 0.037	5.593IleIle: 5.593 ± 0.088	4.111IleLys: 4.111 ± 0.057	6.626IleLeu: 6.626 ± 0.089	1.671IleMet: 1.671 ± 0.038	3.115IleAsn: 3.115 ± 0.05	3.331IlePro: 3.331 ± 0.047	2.794IleGln: 2.794 ± 0.045	3.333IleArg: 3.333 ± 0.049	4.804IleSer: 4.804 ± 0.069	4.057IleThr: 4.057 ± 0.059	5.626IleVal: 5.626 ± 0.069	0.646IleTrp: 0.646 ± 0.02	2.239IleTyr: 2.239 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.632LysAla: 4.632 ± 0.064	0.345LysCys: 0.345 ± 0.021	3.287LysAsp: 3.287 ± 0.059	6.028LysGlu: 6.028 ± 0.062	1.772LysPhe: 1.772 ± 0.035	4.156LysGly: 4.156 ± 0.054	1.311LysHis: 1.311 ± 0.032	4.132LysIle: 4.132 ± 0.053	5.246LysLys: 5.246 ± 0.075	5.426LysLeu: 5.426 ± 0.065	1.988LysMet: 1.988 ± 0.042	2.866LysAsn: 2.866 ± 0.048	2.155LysPro: 2.155 ± 0.042	3.033LysGln: 3.033 ± 0.048	3.374LysArg: 3.374 ± 0.05	3.286LysSer: 3.286 ± 0.047	3.266LysThr: 3.266 ± 0.046	4.387LysVal: 4.387 ± 0.069	0.752LysTrp: 0.752 ± 0.022	1.834LysTyr: 1.834 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	7.996LeuAla: 7.996 ± 0.085	0.813LeuCys: 0.813 ± 0.024	5.013LeuAsp: 5.013 ± 0.062	6.617LeuGlu: 6.617 ± 0.084	4.667LeuPhe: 4.667 ± 0.074	6.668LeuGly: 6.668 ± 0.078	1.993LeuHis: 1.993 ± 0.042	7.068LeuIle: 7.068 ± 0.076	6.112LeuLys: 6.112 ± 0.066	9.924LeuLeu: 9.924 ± 0.098	2.494LeuMet: 2.494 ± 0.045	4.116LeuAsn: 4.116 ± 0.059	4.127LeuPro: 4.127 ± 0.06	3.601LeuGln: 3.601 ± 0.051	4.005LeuArg: 4.005 ± 0.059	6.823LeuSer: 6.823 ± 0.074	5.678LeuThr: 5.678 ± 0.074	6.472LeuVal: 6.472 ± 0.069	0.831LeuTrp: 0.831 ± 0.024	2.897LeuTyr: 2.897 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.115MetAla: 2.115 ± 0.052	0.163MetCys: 0.163 ± 0.01	1.358MetAsp: 1.358 ± 0.034	1.697MetGlu: 1.697 ± 0.032	1.034MetPhe: 1.034 ± 0.029	1.761MetGly: 1.761 ± 0.036	0.464MetHis: 0.464 ± 0.02	2.26MetIle: 2.26 ± 0.041	2.346MetLys: 2.346 ± 0.042	2.48MetLeu: 2.48 ± 0.05	0.895MetMet: 0.895 ± 0.028	1.546MetAsn: 1.546 ± 0.032	0.998MetPro: 0.998 ± 0.028	0.961MetGln: 0.961 ± 0.028	1.158MetArg: 1.158 ± 0.031	1.741MetSer: 1.741 ± 0.035	1.758MetThr: 1.758 ± 0.039	1.755MetVal: 1.755 ± 0.037	0.203MetTrp: 0.203 ± 0.01	0.721MetTyr: 0.721 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.808AsnAla: 2.808 ± 0.046	0.319AsnCys: 0.319 ± 0.015	2.166AsnAsp: 2.166 ± 0.049	3.496AsnGlu: 3.496 ± 0.045	1.546AsnPhe: 1.546 ± 0.035	3.146AsnGly: 3.146 ± 0.055	1.042AsnHis: 1.042 ± 0.027	3.153AsnIle: 3.153 ± 0.05	2.606AsnLys: 2.606 ± 0.045	3.665AsnLeu: 3.665 ± 0.052	1.129AsnMet: 1.129 ± 0.03	1.887AsnAsn: 1.887 ± 0.047	2.028AsnPro: 2.028 ± 0.044	1.821AsnGln: 1.821 ± 0.049	1.91AsnArg: 1.91 ± 0.044	2.201AsnSer: 2.201 ± 0.046	2.022AsnThr: 2.022 ± 0.041	3.006AsnVal: 3.006 ± 0.047	0.493AsnTrp: 0.493 ± 0.017	1.371AsnTyr: 1.371 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.652ProAla: 2.652 ± 0.046	0.231ProCys: 0.231 ± 0.013	2.041ProAsp: 2.041 ± 0.042	2.958ProGlu: 2.958 ± 0.045	1.94ProPhe: 1.94 ± 0.04	2.371ProGly: 2.371 ± 0.049	0.839ProHis: 0.839 ± 0.023	2.905ProIle: 2.905 ± 0.051	2.112ProLys: 2.112 ± 0.042	3.751ProLeu: 3.751 ± 0.048	0.894ProMet: 0.894 ± 0.026	1.808ProAsn: 1.808 ± 0.038	1.174ProPro: 1.174 ± 0.035	1.166ProGln: 1.166 ± 0.031	1.323ProArg: 1.323 ± 0.033	2.262ProSer: 2.262 ± 0.045	2.17ProThr: 2.17 ± 0.04	2.974ProVal: 2.974 ± 0.048	0.381ProTrp: 0.381 ± 0.015	1.359ProTyr: 1.359 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.216GlnAla: 3.216 ± 0.054	0.233GlnCys: 0.233 ± 0.013	1.675GlnAsp: 1.675 ± 0.034	2.704GlnGlu: 2.704 ± 0.043	1.665GlnPhe: 1.665 ± 0.035	2.303GlnGly: 2.303 ± 0.046	0.889GlnHis: 0.889 ± 0.023	2.754GlnIle: 2.754 ± 0.046	2.582GlnLys: 2.582 ± 0.047	4.374GlnLeu: 4.374 ± 0.052	1.222GlnMet: 1.222 ± 0.032	1.565GlnAsn: 1.565 ± 0.041	1.361GlnPro: 1.361 ± 0.031	2.044GlnGln: 2.044 ± 0.047	1.747GlnArg: 1.747 ± 0.035	2.3GlnSer: 2.3 ± 0.044	2.134GlnThr: 2.134 ± 0.036	2.733GlnVal: 2.733 ± 0.052	0.39GlnTrp: 0.39 ± 0.018	1.232GlnTyr: 1.232 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.131ArgAla: 3.131 ± 0.05	0.323ArgCys: 0.323 ± 0.014	2.369ArgAsp: 2.369 ± 0.038	3.344ArgGlu: 3.344 ± 0.055	1.998ArgPhe: 1.998 ± 0.04	2.779ArgGly: 2.779 ± 0.049	0.942ArgHis: 0.942 ± 0.024	3.242ArgIle: 3.242 ± 0.051	3.013ArgLys: 3.013 ± 0.049	4.486ArgLeu: 4.486 ± 0.065	1.326ArgMet: 1.326 ± 0.031	1.899ArgAsn: 1.899 ± 0.034	1.529ArgPro: 1.529 ± 0.034	1.782ArgGln: 1.782 ± 0.036	2.168ArgArg: 2.168 ± 0.041	2.474ArgSer: 2.474 ± 0.043	2.318ArgThr: 2.318 ± 0.039	2.936ArgVal: 2.936 ± 0.048	0.399ArgTrp: 0.399 ± 0.016	1.579ArgTyr: 1.579 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.167SerAla: 4.167 ± 0.058	0.439SerCys: 0.439 ± 0.018	2.865SerAsp: 2.865 ± 0.049	3.92SerGlu: 3.92 ± 0.056	3.203SerPhe: 3.203 ± 0.048	4.478SerGly: 4.478 ± 0.055	1.266SerHis: 1.266 ± 0.029	4.796SerIle: 4.796 ± 0.065	3.536SerLys: 3.536 ± 0.053	6.204SerLeu: 6.204 ± 0.067	1.689SerMet: 1.689 ± 0.034	2.455SerAsn: 2.455 ± 0.039	2.262SerPro: 2.262 ± 0.04	2.069SerGln: 2.069 ± 0.044	2.493SerArg: 2.493 ± 0.045	4.009SerSer: 4.009 ± 0.07	3.258SerThr: 3.258 ± 0.05	4.078SerVal: 4.078 ± 0.06	0.591SerTrp: 0.591 ± 0.024	2.226SerTyr: 2.226 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.117ThrAla: 4.117 ± 0.059	0.417ThrCys: 0.417 ± 0.016	2.836ThrAsp: 2.836 ± 0.052	3.49ThrGlu: 3.49 ± 0.051	2.63ThrPhe: 2.63 ± 0.048	4.349ThrGly: 4.349 ± 0.059	1.154ThrHis: 1.154 ± 0.03	4.389ThrIle: 4.389 ± 0.06	3.106ThrLys: 3.106 ± 0.048	5.345ThrLeu: 5.345 ± 0.069	1.376ThrMet: 1.376 ± 0.036	2.346ThrAsn: 2.346 ± 0.044	2.434ThrPro: 2.434 ± 0.044	1.609ThrGln: 1.609 ± 0.036	2.028ThrArg: 2.028 ± 0.042	3.23ThrSer: 3.23 ± 0.049	3.043ThrThr: 3.043 ± 0.049	4.169ThrVal: 4.169 ± 0.062	0.544ThrTrp: 0.544 ± 0.019	1.858ThrTyr: 1.858 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.543ValAla: 5.543 ± 0.069	0.629ValCys: 0.629 ± 0.024	3.834ValAsp: 3.834 ± 0.056	5.002ValGlu: 5.002 ± 0.072	2.9ValPhe: 2.9 ± 0.047	4.864ValGly: 4.864 ± 0.059	1.451ValHis: 1.451 ± 0.032	5.656ValIle: 5.656 ± 0.069	4.35ValLys: 4.35 ± 0.065	6.849ValLeu: 6.849 ± 0.067	1.97ValMet: 1.97 ± 0.044	2.986ValAsn: 2.986 ± 0.045	2.809ValPro: 2.809 ± 0.045	2.562ValGln: 2.562 ± 0.051	2.955ValArg: 2.955 ± 0.046	4.467ValSer: 4.467 ± 0.059	4.291ValThr: 4.291 ± 0.06	5.226ValVal: 5.226 ± 0.074	0.653ValTrp: 0.653 ± 0.021	2.144ValTyr: 2.144 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.643TrpAla: 0.643 ± 0.025	0.087TrpCys: 0.087 ± 0.008	0.503TrpAsp: 0.503 ± 0.021	0.604TrpGlu: 0.604 ± 0.023	0.479TrpPhe: 0.479 ± 0.02	0.626TrpGly: 0.626 ± 0.023	0.22TrpHis: 0.22 ± 0.013	0.771TrpIle: 0.771 ± 0.024	0.67TrpLys: 0.67 ± 0.021	1.183TrpLeu: 1.183 ± 0.035	0.314TrpMet: 0.314 ± 0.015	0.533TrpAsn: 0.533 ± 0.02	0.261TrpPro: 0.261 ± 0.013	0.447TrpGln: 0.447 ± 0.02	0.46TrpArg: 0.46 ± 0.018	0.67TrpSer: 0.67 ± 0.023	0.528TrpThr: 0.528 ± 0.02	0.633TrpVal: 0.633 ± 0.022	0.142TrpTrp: 0.142 ± 0.01	0.318TrpTyr: 0.318 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.232TyrAla: 2.232 ± 0.041	0.314TyrCys: 0.314 ± 0.016	1.855TyrAsp: 1.855 ± 0.04	2.438TyrGlu: 2.438 ± 0.042	1.667TyrPhe: 1.667 ± 0.039	2.439TyrGly: 2.439 ± 0.048	0.81TyrHis: 0.81 ± 0.023	2.098TyrIle: 2.098 ± 0.042	1.754TyrLys: 1.754 ± 0.035	3.213TyrLeu: 3.213 ± 0.05	0.74TyrMet: 0.74 ± 0.023	1.314TyrAsn: 1.314 ± 0.03	1.315TyrPro: 1.315 ± 0.033	1.424TyrGln: 1.424 ± 0.032	1.602TyrArg: 1.602 ± 0.032	1.995TyrSer: 1.995 ± 0.04	1.711TyrThr: 1.711 ± 0.036	2.218TyrVal: 2.218 ± 0.041	0.354TyrTrp: 0.354 ± 0.017	1.218TyrTyr: 1.218 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7593 proteins (1363251 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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