Amino acid dipepetide frequency for Amycolatopsis xylanica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.078AlaAla: 19.078 ± 0.128	1.068AlaCys: 1.068 ± 0.02	7.926AlaAsp: 7.926 ± 0.059	8.974AlaGlu: 8.974 ± 0.08	3.661AlaPhe: 3.661 ± 0.042	12.416AlaGly: 12.416 ± 0.082	2.446AlaHis: 2.446 ± 0.031	4.661AlaIle: 4.661 ± 0.047	4.064AlaLys: 4.064 ± 0.053	13.787AlaLeu: 13.787 ± 0.097	2.542AlaMet: 2.542 ± 0.03	2.613AlaAsn: 2.613 ± 0.036	5.882AlaPro: 5.882 ± 0.061	3.653AlaGln: 3.653 ± 0.042	8.647AlaArg: 8.647 ± 0.076	6.271AlaSer: 6.271 ± 0.052	7.007AlaThr: 7.007 ± 0.053	11.028AlaVal: 11.028 ± 0.076	1.811AlaTrp: 1.811 ± 0.027	2.438AlaTyr: 2.438 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.027CysAla: 1.027 ± 0.022	0.102CysCys: 0.102 ± 0.006	0.482CysAsp: 0.482 ± 0.013	0.415CysGlu: 0.415 ± 0.013	0.257CysPhe: 0.257 ± 0.011	0.9CysGly: 0.9 ± 0.02	0.184CysHis: 0.184 ± 0.007	0.155CysIle: 0.155 ± 0.008	0.146CysLys: 0.146 ± 0.007	0.751CysLeu: 0.751 ± 0.016	0.115CysMet: 0.115 ± 0.006	0.152CysAsn: 0.152 ± 0.008	0.445CysPro: 0.445 ± 0.012	0.2CysGln: 0.2 ± 0.009	0.516CysArg: 0.516 ± 0.014	0.484CysSer: 0.484 ± 0.012	0.459CysThr: 0.459 ± 0.015	0.679CysVal: 0.679 ± 0.016	0.127CysTrp: 0.127 ± 0.007	0.18CysTyr: 0.18 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.224AspAla: 7.224 ± 0.069	0.414AspCys: 0.414 ± 0.014	3.423AspAsp: 3.423 ± 0.039	3.911AspGlu: 3.911 ± 0.045	1.842AspPhe: 1.842 ± 0.028	6.301AspGly: 6.301 ± 0.053	1.337AspHis: 1.337 ± 0.023	2.103AspIle: 2.103 ± 0.023	1.498AspLys: 1.498 ± 0.028	6.341AspLeu: 6.341 ± 0.052	0.761AspMet: 0.761 ± 0.016	1.154AspAsn: 1.154 ± 0.024	4.23AspPro: 4.23 ± 0.044	1.742AspGln: 1.742 ± 0.025	4.382AspArg: 4.382 ± 0.049	2.594AspSer: 2.594 ± 0.035	2.983AspThr: 2.983 ± 0.033	4.851AspVal: 4.851 ± 0.045	0.995AspTrp: 0.995 ± 0.02	1.292AspTyr: 1.292 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.848GluAla: 6.848 ± 0.069	0.37GluCys: 0.37 ± 0.011	2.72GluAsp: 2.72 ± 0.036	2.903GluGlu: 2.903 ± 0.04	1.921GluPhe: 1.921 ± 0.026	3.564GluGly: 3.564 ± 0.039	1.621GluHis: 1.621 ± 0.026	2.665GluIle: 2.665 ± 0.033	1.57GluLys: 1.57 ± 0.024	7.459GluLeu: 7.459 ± 0.081	0.883GluMet: 0.883 ± 0.018	1.27GluAsn: 1.27 ± 0.024	3.408GluPro: 3.408 ± 0.046	2.222GluGln: 2.222 ± 0.031	4.886GluArg: 4.886 ± 0.063	2.749GluSer: 2.749 ± 0.035	3.024GluThr: 3.024 ± 0.036	4.664GluVal: 4.664 ± 0.049	0.803GluTrp: 0.803 ± 0.017	1.147GluTyr: 1.147 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	4.142PheAla: 4.142 ± 0.039	0.277PheCys: 0.277 ± 0.01	2.37PheAsp: 2.37 ± 0.032	1.642PheGlu: 1.642 ± 0.023	0.966PhePhe: 0.966 ± 0.019	3.52PheGly: 3.52 ± 0.043	0.648PheHis: 0.648 ± 0.015	0.888PheIle: 0.888 ± 0.019	0.618PheLys: 0.618 ± 0.015	2.778PheLeu: 2.778 ± 0.037	0.392PheMet: 0.392 ± 0.012	0.644PheAsn: 0.644 ± 0.016	1.507PhePro: 1.507 ± 0.022	0.774PheGln: 0.774 ± 0.019	1.863PheArg: 1.863 ± 0.028	1.808PheSer: 1.808 ± 0.03	2.218PheThr: 2.218 ± 0.031	2.593PheVal: 2.593 ± 0.032	0.458PheTrp: 0.458 ± 0.015	0.715PheTyr: 0.715 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	9.863GlyAla: 9.863 ± 0.067	0.818GlyCys: 0.818 ± 0.017	5.057GlyAsp: 5.057 ± 0.054	5.084GlyGlu: 5.084 ± 0.047	3.279GlyPhe: 3.279 ± 0.037	8.119GlyGly: 8.119 ± 0.068	2.126GlyHis: 2.126 ± 0.032	3.924GlyIle: 3.924 ± 0.038	3.252GlyLys: 3.252 ± 0.041	9.412GlyLeu: 9.412 ± 0.068	2.026GlyMet: 2.026 ± 0.029	2.048GlyAsn: 2.048 ± 0.034	4.398GlyPro: 4.398 ± 0.04	2.879GlyGln: 2.879 ± 0.039	6.212GlyArg: 6.212 ± 0.055	5.158GlySer: 5.158 ± 0.05	5.724GlyThr: 5.724 ± 0.057	7.689GlyVal: 7.689 ± 0.053	1.742GlyTrp: 1.742 ± 0.027	2.435GlyTyr: 2.435 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.56HisAla: 2.56 ± 0.031	0.207HisCys: 0.207 ± 0.008	1.31HisAsp: 1.31 ± 0.023	1.217HisGlu: 1.217 ± 0.023	0.685HisPhe: 0.685 ± 0.016	2.201HisGly: 2.201 ± 0.032	0.598HisHis: 0.598 ± 0.015	0.662HisIle: 0.662 ± 0.014	0.407HisLys: 0.407 ± 0.013	2.195HisLeu: 2.195 ± 0.026	0.287HisMet: 0.287 ± 0.01	0.445HisAsn: 0.445 ± 0.014	1.512HisPro: 1.512 ± 0.024	0.641HisGln: 0.641 ± 0.016	1.745HisArg: 1.745 ± 0.027	1.018HisSer: 1.018 ± 0.02	1.16HisThr: 1.16 ± 0.02	1.684HisVal: 1.684 ± 0.023	0.392HisTrp: 0.392 ± 0.012	0.509HisTyr: 0.509 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.629IleAla: 5.629 ± 0.048	0.288IleCys: 0.288 ± 0.009	2.584IleAsp: 2.584 ± 0.036	2.492IleGlu: 2.492 ± 0.031	0.909IlePhe: 0.909 ± 0.021	4.113IleGly: 4.113 ± 0.044	0.684IleHis: 0.684 ± 0.014	1.173IleIle: 1.173 ± 0.025	1.009IleLys: 1.009 ± 0.019	2.739IleLeu: 2.739 ± 0.034	0.527IleMet: 0.527 ± 0.012	0.881IleAsn: 0.881 ± 0.018	2.109IlePro: 2.109 ± 0.032	0.898IleGln: 0.898 ± 0.019	2.434IleArg: 2.434 ± 0.03	2.156IleSer: 2.156 ± 0.034	2.654IleThr: 2.654 ± 0.034	3.274IleVal: 3.274 ± 0.038	0.451IleTrp: 0.451 ± 0.014	0.663IleTyr: 0.663 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.502LysAla: 3.502 ± 0.047	0.152LysCys: 0.152 ± 0.007	1.39LysAsp: 1.39 ± 0.031	1.273LysGlu: 1.273 ± 0.025	0.753LysPhe: 0.753 ± 0.017	1.771LysGly: 1.771 ± 0.026	0.6LysHis: 0.6 ± 0.016	1.27LysIle: 1.27 ± 0.023	0.882LysLys: 0.882 ± 0.02	3.122LysLeu: 3.122 ± 0.034	0.479LysMet: 0.479 ± 0.015	0.653LysAsn: 0.653 ± 0.02	2.014LysPro: 2.014 ± 0.032	0.918LysGln: 0.918 ± 0.021	1.824LysArg: 1.824 ± 0.027	1.407LysSer: 1.407 ± 0.025	1.78LysThr: 1.78 ± 0.029	2.401LysVal: 2.401 ± 0.03	0.356LysTrp: 0.356 ± 0.011	0.614LysTyr: 0.614 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.542LeuAla: 15.542 ± 0.108	0.81LeuCys: 0.81 ± 0.018	6.895LeuAsp: 6.895 ± 0.063	4.866LeuGlu: 4.866 ± 0.047	2.871LeuPhe: 2.871 ± 0.037	9.724LeuGly: 9.724 ± 0.077	2.114LeuHis: 2.114 ± 0.03	3.85LeuIle: 3.85 ± 0.044	2.466LeuLys: 2.466 ± 0.031	11.143LeuLeu: 11.143 ± 0.105	1.495LeuMet: 1.495 ± 0.026	2.026LeuAsn: 2.026 ± 0.03	6.155LeuPro: 6.155 ± 0.048	2.141LeuGln: 2.141 ± 0.025	8.35LeuArg: 8.35 ± 0.084	5.887LeuSer: 5.887 ± 0.056	6.998LeuThr: 6.998 ± 0.053	9.049LeuVal: 9.049 ± 0.07	1.322LeuTrp: 1.322 ± 0.027	1.773LeuTyr: 1.773 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.117MetAla: 2.117 ± 0.029	0.112MetCys: 0.112 ± 0.007	0.851MetAsp: 0.851 ± 0.018	0.614MetGlu: 0.614 ± 0.017	0.523MetPhe: 0.523 ± 0.015	1.22MetGly: 1.22 ± 0.024	0.334MetHis: 0.334 ± 0.011	0.812MetIle: 0.812 ± 0.015	0.49MetLys: 0.49 ± 0.013	1.866MetLeu: 1.866 ± 0.031	0.282MetMet: 0.282 ± 0.011	0.474MetAsn: 0.474 ± 0.013	1.107MetPro: 1.107 ± 0.019	0.376MetGln: 0.376 ± 0.012	1.409MetArg: 1.409 ± 0.022	1.249MetSer: 1.249 ± 0.019	1.538MetThr: 1.538 ± 0.024	1.32MetVal: 1.32 ± 0.023	0.195MetTrp: 0.195 ± 0.008	0.272MetTyr: 0.272 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.661AsnAla: 2.661 ± 0.033	0.175AsnCys: 0.175 ± 0.008	1.139AsnAsp: 1.139 ± 0.02	0.995AsnGlu: 0.995 ± 0.018	0.634AsnPhe: 0.634 ± 0.016	2.312AsnGly: 2.312 ± 0.038	0.438AsnHis: 0.438 ± 0.012	0.748AsnIle: 0.748 ± 0.017	0.541AsnLys: 0.541 ± 0.016	2.093AsnLeu: 2.093 ± 0.031	0.313AsnMet: 0.313 ± 0.01	0.561AsnAsn: 0.561 ± 0.018	1.642AsnPro: 1.642 ± 0.031	0.658AsnGln: 0.658 ± 0.016	1.365AsnArg: 1.365 ± 0.022	1.129AsnSer: 1.129 ± 0.024	1.291AsnThr: 1.291 ± 0.026	1.668AsnVal: 1.668 ± 0.03	0.364AsnTrp: 0.364 ± 0.014	0.511AsnTyr: 0.511 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	7.662ProAla: 7.662 ± 0.06	0.341ProCys: 0.341 ± 0.012	4.15ProAsp: 4.15 ± 0.041	4.1ProGlu: 4.1 ± 0.045	1.615ProPhe: 1.615 ± 0.023	5.982ProGly: 5.982 ± 0.063	1.108ProHis: 1.108 ± 0.021	1.865ProIle: 1.865 ± 0.027	1.546ProLys: 1.546 ± 0.023	5.07ProLeu: 5.07 ± 0.049	1.0ProMet: 1.0 ± 0.017	1.188ProAsn: 1.188 ± 0.023	3.276ProPro: 3.276 ± 0.054	1.577ProGln: 1.577 ± 0.029	3.371ProArg: 3.371 ± 0.038	3.407ProSer: 3.407 ± 0.04	2.806ProThr: 2.806 ± 0.037	5.086ProVal: 5.086 ± 0.048	0.866ProTrp: 0.866 ± 0.018	1.136ProTyr: 1.136 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.931GlnAla: 3.931 ± 0.046	0.196GlnCys: 0.196 ± 0.009	1.291GlnAsp: 1.291 ± 0.022	1.233GlnGlu: 1.233 ± 0.023	0.838GlnPhe: 0.838 ± 0.018	2.145GlnGly: 2.145 ± 0.032	0.631GlnHis: 0.631 ± 0.014	1.203GlnIle: 1.203 ± 0.021	0.663GlnLys: 0.663 ± 0.019	3.33GlnLeu: 3.33 ± 0.034	0.446GlnMet: 0.446 ± 0.012	0.594GlnAsn: 0.594 ± 0.014	1.767GlnPro: 1.767 ± 0.032	1.231GlnGln: 1.231 ± 0.029	2.463GlnArg: 2.463 ± 0.032	1.321GlnSer: 1.321 ± 0.024	1.378GlnThr: 1.378 ± 0.024	2.6GlnVal: 2.6 ± 0.029	0.501GlnTrp: 0.501 ± 0.014	0.613GlnTyr: 0.613 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	8.544ArgAla: 8.544 ± 0.071	0.547ArgCys: 0.547 ± 0.016	4.054ArgAsp: 4.054 ± 0.041	4.493ArgGlu: 4.493 ± 0.047	2.538ArgPhe: 2.538 ± 0.03	5.211ArgGly: 5.211 ± 0.04	1.717ArgHis: 1.717 ± 0.027	3.023ArgIle: 3.023 ± 0.03	2.036ArgLys: 2.036 ± 0.027	8.17ArgLeu: 8.17 ± 0.08	1.584ArgMet: 1.584 ± 0.023	1.452ArgAsn: 1.452 ± 0.022	3.911ArgPro: 3.911 ± 0.044	2.225ArgGln: 2.225 ± 0.029	6.233ArgArg: 6.233 ± 0.067	3.557ArgSer: 3.557 ± 0.036	4.293ArgThr: 4.293 ± 0.04	5.688ArgVal: 5.688 ± 0.048	1.301ArgTrp: 1.301 ± 0.02	1.76ArgTyr: 1.76 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.965SerAla: 6.965 ± 0.056	0.436SerCys: 0.436 ± 0.015	2.802SerAsp: 2.802 ± 0.034	2.624SerGlu: 2.624 ± 0.033	1.703SerPhe: 1.703 ± 0.026	5.895SerGly: 5.895 ± 0.057	0.971SerHis: 0.971 ± 0.019	1.944SerIle: 1.944 ± 0.031	1.329SerLys: 1.329 ± 0.025	5.187SerLeu: 5.187 ± 0.052	1.239SerMet: 1.239 ± 0.021	1.07SerAsn: 1.07 ± 0.023	3.146SerPro: 3.146 ± 0.034	1.393SerGln: 1.393 ± 0.025	3.528SerArg: 3.528 ± 0.035	3.11SerSer: 3.11 ± 0.046	3.439SerThr: 3.439 ± 0.04	4.597SerVal: 4.597 ± 0.038	0.964SerTrp: 0.964 ± 0.019	1.237SerTyr: 1.237 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	7.906ThrAla: 7.906 ± 0.061	0.458ThrCys: 0.458 ± 0.014	3.356ThrAsp: 3.356 ± 0.04	3.416ThrGlu: 3.416 ± 0.034	1.846ThrPhe: 1.846 ± 0.028	6.412ThrGly: 6.412 ± 0.056	1.137ThrHis: 1.137 ± 0.021	2.293ThrIle: 2.293 ± 0.032	1.625ThrLys: 1.625 ± 0.026	5.832ThrLeu: 5.832 ± 0.047	1.009ThrMet: 1.009 ± 0.019	1.209ThrAsn: 1.209 ± 0.027	3.755ThrPro: 3.755 ± 0.039	1.458ThrGln: 1.458 ± 0.022	3.661ThrArg: 3.661 ± 0.038	3.349ThrSer: 3.349 ± 0.043	3.924ThrThr: 3.924 ± 0.044	5.83ThrVal: 5.83 ± 0.054	0.98ThrTrp: 0.98 ± 0.018	1.26ThrTyr: 1.26 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	10.748ValAla: 10.748 ± 0.073	0.678ValCys: 0.678 ± 0.016	5.382ValAsp: 5.382 ± 0.047	4.677ValGlu: 4.677 ± 0.044	2.707ValPhe: 2.707 ± 0.036	6.361ValGly: 6.361 ± 0.054	1.874ValHis: 1.874 ± 0.022	3.325ValIle: 3.325 ± 0.038	2.18ValLys: 2.18 ± 0.036	9.929ValLeu: 9.929 ± 0.083	1.26ValMet: 1.26 ± 0.022	1.887ValAsn: 1.887 ± 0.026	4.856ValPro: 4.856 ± 0.039	2.021ValGln: 2.021 ± 0.023	6.335ValArg: 6.335 ± 0.049	4.809ValSer: 4.809 ± 0.05	5.767ValThr: 5.767 ± 0.056	7.965ValVal: 7.965 ± 0.068	1.057ValTrp: 1.057 ± 0.018	1.595ValTyr: 1.595 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.601TrpAla: 1.601 ± 0.026	0.147TrpCys: 0.147 ± 0.006	0.818TrpAsp: 0.818 ± 0.019	0.687TrpGlu: 0.687 ± 0.016	0.55TrpPhe: 0.55 ± 0.013	1.036TrpGly: 1.036 ± 0.021	0.386TrpHis: 0.386 ± 0.013	0.592TrpIle: 0.592 ± 0.014	0.404TrpLys: 0.404 ± 0.01	1.887TrpLeu: 1.887 ± 0.025	0.296TrpMet: 0.296 ± 0.01	0.439TrpAsn: 0.439 ± 0.015	0.821TrpPro: 0.821 ± 0.017	0.649TrpGln: 0.649 ± 0.017	1.314TrpArg: 1.314 ± 0.024	0.958TrpSer: 0.958 ± 0.017	1.047TrpThr: 1.047 ± 0.022	1.097TrpVal: 1.097 ± 0.021	0.35TrpTrp: 0.35 ± 0.013	0.342TrpTyr: 0.342 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.423TyrAla: 2.423 ± 0.028	0.178TyrCys: 0.178 ± 0.01	1.379TyrAsp: 1.379 ± 0.031	1.081TyrGlu: 1.081 ± 0.019	0.723TyrPhe: 0.723 ± 0.017	2.04TyrGly: 2.04 ± 0.027	0.48TyrHis: 0.48 ± 0.014	0.513TyrIle: 0.513 ± 0.014	0.434TyrLys: 0.434 ± 0.012	2.385TyrLeu: 2.385 ± 0.032	0.223TyrMet: 0.223 ± 0.01	0.479TyrAsn: 0.479 ± 0.016	1.208TyrPro: 1.208 ± 0.027	0.72TyrGln: 0.72 ± 0.018	1.801TyrArg: 1.801 ± 0.024	1.158TyrSer: 1.158 ± 0.025	1.224TyrThr: 1.224 ± 0.022	1.653TyrVal: 1.653 ± 0.03	0.388TyrTrp: 0.388 ± 0.011	0.485TyrTyr: 0.485 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8491 proteins (2874613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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