Amino acid dipepetide frequency for Enterococcus thailandicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.297AlaAla: 5.297 ± 0.109	0.461AlaCys: 0.461 ± 0.027	3.852AlaAsp: 3.852 ± 0.138	5.038AlaGlu: 5.038 ± 0.105	3.234AlaPhe: 3.234 ± 0.076	5.168AlaGly: 5.168 ± 0.094	1.186AlaHis: 1.186 ± 0.037	5.99AlaIle: 5.99 ± 0.098	5.149AlaLys: 5.149 ± 0.085	6.778AlaLeu: 6.778 ± 0.117	1.964AlaMet: 1.964 ± 0.058	3.177AlaAsn: 3.177 ± 0.068	2.11AlaPro: 2.11 ± 0.058	3.056AlaGln: 3.056 ± 0.068	2.507AlaArg: 2.507 ± 0.062	4.042AlaSer: 4.042 ± 0.074	4.453AlaThr: 4.453 ± 0.087	4.97AlaVal: 4.97 ± 0.083	0.625AlaTrp: 0.625 ± 0.03	2.474AlaTyr: 2.474 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.352CysAla: 0.352 ± 0.022	0.06CysCys: 0.06 ± 0.009	0.277CysAsp: 0.277 ± 0.018	0.322CysGlu: 0.322 ± 0.023	0.298CysPhe: 0.298 ± 0.018	0.55CysGly: 0.55 ± 0.03	0.143CysHis: 0.143 ± 0.015	0.345CysIle: 0.345 ± 0.025	0.211CysLys: 0.211 ± 0.02	0.619CysLeu: 0.619 ± 0.028	0.145CysMet: 0.145 ± 0.014	0.191CysAsn: 0.191 ± 0.016	0.234CysPro: 0.234 ± 0.02	0.265CysGln: 0.265 ± 0.019	0.191CysArg: 0.191 ± 0.018	0.358CysSer: 0.358 ± 0.021	0.266CysThr: 0.266 ± 0.019	0.361CysVal: 0.361 ± 0.024	0.065CysTrp: 0.065 ± 0.008	0.273CysTyr: 0.273 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.576AspAla: 3.576 ± 0.144	0.285AspCys: 0.285 ± 0.021	2.453AspAsp: 2.453 ± 0.073	4.497AspGlu: 4.497 ± 0.084	2.706AspPhe: 2.706 ± 0.074	3.507AspGly: 3.507 ± 0.081	1.032AspHis: 1.032 ± 0.037	3.472AspIle: 3.472 ± 0.075	2.998AspLys: 2.998 ± 0.065	5.089AspLeu: 5.089 ± 0.083	1.148AspMet: 1.148 ± 0.041	1.988AspAsn: 1.988 ± 0.063	1.874AspPro: 1.874 ± 0.051	2.318AspGln: 2.318 ± 0.051	1.865AspArg: 1.865 ± 0.054	2.905AspSer: 2.905 ± 0.07	2.671AspThr: 2.671 ± 0.065	3.56AspVal: 3.56 ± 0.07	0.636AspTrp: 0.636 ± 0.028	2.452AspTyr: 2.452 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	5.418GluAla: 5.418 ± 0.097	0.302GluCys: 0.302 ± 0.023	3.526GluAsp: 3.526 ± 0.071	6.723GluGlu: 6.723 ± 0.104	2.73GluPhe: 2.73 ± 0.066	3.791GluGly: 3.791 ± 0.075	1.278GluHis: 1.278 ± 0.049	5.714GluIle: 5.714 ± 0.089	7.022GluLys: 7.022 ± 0.114	7.84GluLeu: 7.84 ± 0.127	2.387GluMet: 2.387 ± 0.059	4.123GluAsn: 4.123 ± 0.078	2.003GluPro: 2.003 ± 0.051	3.964GluGln: 3.964 ± 0.083	3.054GluArg: 3.054 ± 0.074	3.522GluSer: 3.522 ± 0.073	4.675GluThr: 4.675 ± 0.089	5.117GluVal: 5.117 ± 0.099	0.748GluTrp: 0.748 ± 0.031	2.221GluTyr: 2.221 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.299PheAla: 3.299 ± 0.075	0.348PheCys: 0.348 ± 0.022	2.782PheAsp: 2.782 ± 0.063	3.074PheGlu: 3.074 ± 0.069	2.736PhePhe: 2.736 ± 0.068	3.422PheGly: 3.422 ± 0.073	0.935PheHis: 0.935 ± 0.033	3.458PheIle: 3.458 ± 0.073	2.135PheLys: 2.135 ± 0.053	4.932PheLeu: 4.932 ± 0.112	1.122PheMet: 1.122 ± 0.042	1.889PheAsn: 1.889 ± 0.047	1.697PhePro: 1.697 ± 0.048	1.73PheGln: 1.73 ± 0.048	1.513PheArg: 1.513 ± 0.046	3.545PheSer: 3.545 ± 0.085	2.735PheThr: 2.735 ± 0.064	3.339PheVal: 3.339 ± 0.077	0.523PheTrp: 0.523 ± 0.031	1.976PheTyr: 1.976 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.521GlyAla: 4.521 ± 0.091	0.414GlyCys: 0.414 ± 0.026	3.001GlyAsp: 3.001 ± 0.076	4.399GlyGlu: 4.399 ± 0.084	3.311GlyPhe: 3.311 ± 0.075	4.395GlyGly: 4.395 ± 0.103	1.179GlyHis: 1.179 ± 0.041	5.876GlyIle: 5.876 ± 0.108	4.755GlyLys: 4.755 ± 0.072	6.408GlyLeu: 6.408 ± 0.098	1.922GlyMet: 1.922 ± 0.055	2.833GlyAsn: 2.833 ± 0.075	1.423GlyPro: 1.423 ± 0.04	2.407GlyGln: 2.407 ± 0.06	2.44GlyArg: 2.44 ± 0.064	3.796GlySer: 3.796 ± 0.071	4.148GlyThr: 4.148 ± 0.081	4.765GlyVal: 4.765 ± 0.086	0.733GlyTrp: 0.733 ± 0.03	2.694GlyTyr: 2.694 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.175HisAla: 1.175 ± 0.035	0.145HisCys: 0.145 ± 0.016	0.905HisAsp: 0.905 ± 0.038	1.34HisGlu: 1.34 ± 0.05	1.075HisPhe: 1.075 ± 0.038	1.235HisGly: 1.235 ± 0.043	0.467HisHis: 0.467 ± 0.025	1.051HisIle: 1.051 ± 0.039	0.74HisLys: 0.74 ± 0.036	2.048HisLeu: 2.048 ± 0.059	0.372HisMet: 0.372 ± 0.022	0.63HisAsn: 0.63 ± 0.031	0.935HisPro: 0.935 ± 0.041	0.956HisGln: 0.956 ± 0.032	0.722HisArg: 0.722 ± 0.034	1.104HisSer: 1.104 ± 0.04	0.959HisThr: 0.959 ± 0.038	1.158HisVal: 1.158 ± 0.042	0.233HisTrp: 0.233 ± 0.02	0.832HisTyr: 0.832 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.744IleAla: 5.744 ± 0.1	0.576IleCys: 0.576 ± 0.028	4.407IleAsp: 4.407 ± 0.074	5.319IleGlu: 5.319 ± 0.089	3.527IlePhe: 3.527 ± 0.073	5.412IleGly: 5.412 ± 0.106	1.452IleHis: 1.452 ± 0.047	5.165IleIle: 5.165 ± 0.108	4.196IleLys: 4.196 ± 0.081	7.101IleLeu: 7.101 ± 0.125	1.613IleMet: 1.613 ± 0.049	3.215IleAsn: 3.215 ± 0.061	3.128IlePro: 3.128 ± 0.063	3.324IleGln: 3.324 ± 0.071	2.936IleArg: 2.936 ± 0.058	4.786IleSer: 4.786 ± 0.09	4.248IleThr: 4.248 ± 0.081	5.268IleVal: 5.268 ± 0.101	0.63IleTrp: 0.63 ± 0.035	2.552IleTyr: 2.552 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	4.337LysAla: 4.337 ± 0.089	0.191LysCys: 0.191 ± 0.016	3.404LysAsp: 3.404 ± 0.076	7.005LysGlu: 7.005 ± 0.105	2.06LysPhe: 2.06 ± 0.056	3.687LysGly: 3.687 ± 0.067	1.059LysHis: 1.059 ± 0.037	5.331LysIle: 5.331 ± 0.092	6.621LysLys: 6.621 ± 0.123	5.462LysLeu: 5.462 ± 0.087	2.29LysMet: 2.29 ± 0.052	3.908LysAsn: 3.908 ± 0.077	1.799LysPro: 1.799 ± 0.049	3.317LysGln: 3.317 ± 0.077	2.939LysArg: 2.939 ± 0.068	3.079LysSer: 3.079 ± 0.068	3.784LysThr: 3.784 ± 0.072	4.439LysVal: 4.439 ± 0.08	0.621LysTrp: 0.621 ± 0.027	2.156LysTyr: 2.156 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	8.585LeuAla: 8.585 ± 0.128	0.536LeuCys: 0.536 ± 0.025	4.981LeuAsp: 4.981 ± 0.097	6.367LeuGlu: 6.367 ± 0.108	5.051LeuPhe: 5.051 ± 0.124	6.505LeuGly: 6.505 ± 0.105	1.557LeuHis: 1.557 ± 0.043	7.0LeuIle: 7.0 ± 0.124	6.07LeuLys: 6.07 ± 0.092	10.566LeuLeu: 10.566 ± 0.178	2.445LeuMet: 2.445 ± 0.063	4.537LeuAsn: 4.537 ± 0.084	4.252LeuPro: 4.252 ± 0.086	3.516LeuGln: 3.516 ± 0.069	3.441LeuArg: 3.441 ± 0.076	6.873LeuSer: 6.873 ± 0.106	6.839LeuThr: 6.839 ± 0.106	6.819LeuVal: 6.819 ± 0.097	0.761LeuTrp: 0.761 ± 0.033	2.951LeuTyr: 2.951 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.93MetAla: 1.93 ± 0.059	0.114MetCys: 0.114 ± 0.011	1.342MetAsp: 1.342 ± 0.04	1.766MetGlu: 1.766 ± 0.054	0.925MetPhe: 0.925 ± 0.038	1.682MetGly: 1.682 ± 0.052	0.349MetHis: 0.349 ± 0.02	2.336MetIle: 2.336 ± 0.053	2.24MetLys: 2.24 ± 0.051	2.265MetLeu: 2.265 ± 0.054	0.794MetMet: 0.794 ± 0.037	1.584MetAsn: 1.584 ± 0.051	0.93MetPro: 0.93 ± 0.033	0.917MetGln: 0.917 ± 0.038	0.948MetArg: 0.948 ± 0.034	1.481MetSer: 1.481 ± 0.045	1.762MetThr: 1.762 ± 0.056	1.757MetVal: 1.757 ± 0.046	0.138MetTrp: 0.138 ± 0.011	0.733MetTyr: 0.733 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.745AsnAla: 2.745 ± 0.072	0.275AsnCys: 0.275 ± 0.021	2.327AsnAsp: 2.327 ± 0.07	3.742AsnGlu: 3.742 ± 0.074	1.969AsnPhe: 1.969 ± 0.05	3.34AsnGly: 3.34 ± 0.07	1.102AsnHis: 1.102 ± 0.04	2.95AsnIle: 2.95 ± 0.064	2.663AsnLys: 2.663 ± 0.07	4.057AsnLeu: 4.057 ± 0.076	1.013AsnMet: 1.013 ± 0.035	2.083AsnAsn: 2.083 ± 0.071	1.97AsnPro: 1.97 ± 0.055	3.157AsnGln: 3.157 ± 0.083	1.934AsnArg: 1.934 ± 0.046	2.375AsnSer: 2.375 ± 0.072	2.231AsnThr: 2.231 ± 0.064	2.837AsnVal: 2.837 ± 0.07	0.575AsnTrp: 0.575 ± 0.028	2.137AsnTyr: 2.137 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.428ProAla: 2.428 ± 0.059	0.139ProCys: 0.139 ± 0.015	1.945ProAsp: 1.945 ± 0.055	3.447ProGlu: 3.447 ± 0.075	1.877ProPhe: 1.877 ± 0.054	1.904ProGly: 1.904 ± 0.059	0.6ProHis: 0.6 ± 0.03	2.61ProIle: 2.61 ± 0.059	2.211ProLys: 2.211 ± 0.052	3.33ProLeu: 3.33 ± 0.071	0.833ProMet: 0.833 ± 0.036	1.612ProAsn: 1.612 ± 0.053	0.669ProPro: 0.669 ± 0.03	1.282ProGln: 1.282 ± 0.042	1.008ProArg: 1.008 ± 0.034	1.888ProSer: 1.888 ± 0.051	2.311ProThr: 2.311 ± 0.059	2.756ProVal: 2.756 ± 0.065	0.348ProTrp: 0.348 ± 0.021	1.356ProTyr: 1.356 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.647GlnAla: 3.647 ± 0.083	0.134GlnCys: 0.134 ± 0.014	1.726GlnAsp: 1.726 ± 0.051	3.741GlnGlu: 3.741 ± 0.087	1.873GlnPhe: 1.873 ± 0.06	2.425GlnGly: 2.425 ± 0.054	0.711GlnHis: 0.711 ± 0.036	3.004GlnIle: 3.004 ± 0.06	3.628GlnLys: 3.628 ± 0.074	5.245GlnLeu: 5.245 ± 0.102	1.275GlnMet: 1.275 ± 0.042	1.822GlnAsn: 1.822 ± 0.053	1.451GlnPro: 1.451 ± 0.047	2.52GlnGln: 2.52 ± 0.073	1.819GlnArg: 1.819 ± 0.052	2.253GlnSer: 2.253 ± 0.054	2.937GlnThr: 2.937 ± 0.064	3.044GlnVal: 3.044 ± 0.062	0.463GlnTrp: 0.463 ± 0.025	1.259GlnTyr: 1.259 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.185ArgAla: 2.185 ± 0.06	0.204ArgCys: 0.204 ± 0.018	1.609ArgAsp: 1.609 ± 0.051	3.1ArgGlu: 3.1 ± 0.066	1.901ArgPhe: 1.901 ± 0.05	2.177ArgGly: 2.177 ± 0.069	0.706ArgHis: 0.706 ± 0.031	2.787ArgIle: 2.787 ± 0.062	2.946ArgLys: 2.946 ± 0.071	4.026ArgLeu: 4.026 ± 0.074	1.083ArgMet: 1.083 ± 0.04	1.686ArgAsn: 1.686 ± 0.051	1.29ArgPro: 1.29 ± 0.046	1.803ArgGln: 1.803 ± 0.047	1.718ArgArg: 1.718 ± 0.052	1.997ArgSer: 1.997 ± 0.055	1.95ArgThr: 1.95 ± 0.052	2.536ArgVal: 2.536 ± 0.058	0.375ArgTrp: 0.375 ± 0.022	1.609ArgTyr: 1.609 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.908SerAla: 3.908 ± 0.071	0.298SerCys: 0.298 ± 0.021	2.883SerAsp: 2.883 ± 0.067	4.169SerGlu: 4.169 ± 0.079	3.236SerPhe: 3.236 ± 0.073	4.413SerGly: 4.413 ± 0.067	1.021SerHis: 1.021 ± 0.035	4.282SerIle: 4.282 ± 0.079	3.569SerLys: 3.569 ± 0.069	6.007SerLeu: 6.007 ± 0.113	1.438SerMet: 1.438 ± 0.044	2.451SerAsn: 2.451 ± 0.062	1.81SerPro: 1.81 ± 0.052	2.456SerGln: 2.456 ± 0.06	2.142SerArg: 2.142 ± 0.052	3.83SerSer: 3.83 ± 0.094	3.505SerThr: 3.505 ± 0.087	4.029SerVal: 4.029 ± 0.079	0.645SerTrp: 0.645 ± 0.032	2.433SerTyr: 2.433 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.245ThrAla: 4.245 ± 0.065	0.318ThrCys: 0.318 ± 0.023	3.32ThrAsp: 3.32 ± 0.071	4.118ThrGlu: 4.118 ± 0.081	2.866ThrPhe: 2.866 ± 0.064	4.195ThrGly: 4.195 ± 0.085	1.075ThrHis: 1.075 ± 0.034	5.168ThrIle: 5.168 ± 0.095	4.044ThrLys: 4.044 ± 0.076	5.665ThrLeu: 5.665 ± 0.083	1.358ThrMet: 1.358 ± 0.047	2.96ThrAsn: 2.96 ± 0.068	2.509ThrPro: 2.509 ± 0.065	2.234ThrGln: 2.234 ± 0.057	1.937ThrArg: 1.937 ± 0.046	3.484ThrSer: 3.484 ± 0.089	4.006ThrThr: 4.006 ± 0.092	4.398ThrVal: 4.398 ± 0.086	0.554ThrTrp: 0.554 ± 0.027	2.241ThrTyr: 2.241 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	5.385ValAla: 5.385 ± 0.099	0.415ValCys: 0.415 ± 0.026	3.821ValAsp: 3.821 ± 0.077	4.812ValGlu: 4.812 ± 0.076	3.194ValPhe: 3.194 ± 0.072	4.555ValGly: 4.555 ± 0.092	1.187ValHis: 1.187 ± 0.038	5.347ValIle: 5.347 ± 0.094	4.253ValLys: 4.253 ± 0.093	6.579ValLeu: 6.579 ± 0.091	1.768ValMet: 1.768 ± 0.061	2.885ValAsn: 2.885 ± 0.066	2.747ValPro: 2.747 ± 0.066	2.513ValGln: 2.513 ± 0.061	2.465ValArg: 2.465 ± 0.059	4.422ValSer: 4.422 ± 0.078	4.675ValThr: 4.675 ± 0.082	5.044ValVal: 5.044 ± 0.096	0.6ValTrp: 0.6 ± 0.03	2.284ValTyr: 2.284 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.537TrpAla: 0.537 ± 0.027	0.069TrpCys: 0.069 ± 0.01	0.464TrpAsp: 0.464 ± 0.027	0.646TrpGlu: 0.646 ± 0.031	0.522TrpPhe: 0.522 ± 0.029	0.659TrpGly: 0.659 ± 0.033	0.204TrpHis: 0.204 ± 0.017	0.664TrpIle: 0.664 ± 0.032	0.559TrpLys: 0.559 ± 0.028	1.246TrpLeu: 1.246 ± 0.043	0.264TrpMet: 0.264 ± 0.02	0.525TrpAsn: 0.525 ± 0.036	0.237TrpPro: 0.237 ± 0.016	0.6TrpGln: 0.6 ± 0.026	0.434TrpArg: 0.434 ± 0.026	0.592TrpSer: 0.592 ± 0.026	0.573TrpThr: 0.573 ± 0.03	0.533TrpVal: 0.533 ± 0.027	0.142TrpTrp: 0.142 ± 0.016	0.36TrpTyr: 0.36 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.215TyrAla: 2.215 ± 0.061	0.245TyrCys: 0.245 ± 0.018	2.008TyrAsp: 2.008 ± 0.059	2.53TyrGlu: 2.53 ± 0.064	2.098TyrPhe: 2.098 ± 0.063	2.398TyrGly: 2.398 ± 0.054	0.834TyrHis: 0.834 ± 0.037	2.053TyrIle: 2.053 ± 0.051	1.48TyrLys: 1.48 ± 0.047	4.387TyrLeu: 4.387 ± 0.089	0.757TyrMet: 0.757 ± 0.032	1.384TyrAsn: 1.384 ± 0.045	1.488TyrPro: 1.488 ± 0.044	2.641TyrGln: 2.641 ± 0.064	1.678TyrArg: 1.678 ± 0.05	2.192TyrSer: 2.192 ± 0.066	1.964TyrThr: 1.964 ± 0.052	2.225TyrVal: 2.225 ± 0.056	0.415TyrTrp: 0.415 ± 0.021	1.636TyrTyr: 1.636 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2368 proteins (739427 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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