Amino acid dipepetide frequency for Alteribacillus iranensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.993AlaAla: 6.993 ± 0.116
0.651AlaCys: 0.651 ± 0.028
3.742AlaAsp: 3.742 ± 0.078
5.299AlaGlu: 5.299 ± 0.083
3.325AlaPhe: 3.325 ± 0.068
5.96AlaGly: 5.96 ± 0.082
1.411AlaHis: 1.411 ± 0.04
5.394AlaIle: 5.394 ± 0.093
4.039AlaLys: 4.039 ± 0.07
7.198AlaLeu: 7.198 ± 0.103
2.115AlaMet: 2.115 ± 0.05
2.522AlaAsn: 2.522 ± 0.055
2.296AlaPro: 2.296 ± 0.048
2.158AlaGln: 2.158 ± 0.045
2.951AlaArg: 2.951 ± 0.052
4.582AlaSer: 4.582 ± 0.076
3.467AlaThr: 3.467 ± 0.072
5.853AlaVal: 5.853 ± 0.095
0.649AlaTrp: 0.649 ± 0.033
2.292AlaTyr: 2.292 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.024
0.08CysCys: 0.08 ± 0.01
0.372CysAsp: 0.372 ± 0.02
0.394CysGlu: 0.394 ± 0.024
0.292CysPhe: 0.292 ± 0.018
0.691CysGly: 0.691 ± 0.025
0.178CysHis: 0.178 ± 0.014
0.442CysIle: 0.442 ± 0.018
0.292CysLys: 0.292 ± 0.018
0.655CysLeu: 0.655 ± 0.026
0.174CysMet: 0.174 ± 0.015
0.227CysAsn: 0.227 ± 0.016
0.377CysPro: 0.377 ± 0.02
0.246CysGln: 0.246 ± 0.017
0.32CysArg: 0.32 ± 0.018
0.473CysSer: 0.473 ± 0.024
0.406CysThr: 0.406 ± 0.023
0.411CysVal: 0.411 ± 0.022
0.072CysTrp: 0.072 ± 0.009
0.235CysTyr: 0.235 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.305AspAla: 3.305 ± 0.075
0.326AspCys: 0.326 ± 0.02
2.68AspAsp: 2.68 ± 0.075
4.478AspGlu: 4.478 ± 0.089
2.202AspPhe: 2.202 ± 0.057
3.41AspGly: 3.41 ± 0.075
1.387AspHis: 1.387 ± 0.04
4.481AspIle: 4.481 ± 0.081
3.011AspLys: 3.011 ± 0.057
4.709AspLeu: 4.709 ± 0.072
1.615AspMet: 1.615 ± 0.043
1.965AspAsn: 1.965 ± 0.051
2.204AspPro: 2.204 ± 0.052
2.023AspGln: 2.023 ± 0.051
2.386AspArg: 2.386 ± 0.05
2.678AspSer: 2.678 ± 0.061
2.953AspThr: 2.953 ± 0.055
4.087AspVal: 4.087 ± 0.079
0.661AspTrp: 0.661 ± 0.032
1.998AspTyr: 1.998 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.493GluAla: 6.493 ± 0.096
0.411GluCys: 0.411 ± 0.02
4.73GluAsp: 4.73 ± 0.1
9.713GluGlu: 9.713 ± 0.147
2.293GluPhe: 2.293 ± 0.059
5.147GluGly: 5.147 ± 0.082
1.693GluHis: 1.693 ± 0.043
5.054GluIle: 5.054 ± 0.074
6.839GluLys: 6.839 ± 0.104
6.838GluLeu: 6.838 ± 0.1
2.467GluMet: 2.467 ± 0.051
3.893GluAsn: 3.893 ± 0.074
2.189GluPro: 2.189 ± 0.06
3.417GluGln: 3.417 ± 0.063
4.216GluArg: 4.216 ± 0.072
3.903GluSer: 3.903 ± 0.07
4.604GluThr: 4.604 ± 0.062
5.486GluVal: 5.486 ± 0.1
1.034GluTrp: 1.034 ± 0.032
2.314GluTyr: 2.314 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
2.857PheAla: 2.857 ± 0.054
0.318PheCys: 0.318 ± 0.018
2.13PheAsp: 2.13 ± 0.053
2.656PheGlu: 2.656 ± 0.062
2.31PhePhe: 2.31 ± 0.06
3.16PheGly: 3.16 ± 0.069
1.097PheHis: 1.097 ± 0.036
3.543PheIle: 3.543 ± 0.066
1.705PheLys: 1.705 ± 0.046
4.59PheLeu: 4.59 ± 0.091
1.173PheMet: 1.173 ± 0.036
1.416PheAsn: 1.416 ± 0.04
1.742PhePro: 1.742 ± 0.048
1.641PheGln: 1.641 ± 0.038
1.639PheArg: 1.639 ± 0.046
3.107PheSer: 3.107 ± 0.058
2.574PheThr: 2.574 ± 0.056
2.969PheVal: 2.969 ± 0.07
0.446PheTrp: 0.446 ± 0.023
1.59PheTyr: 1.59 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.326GlyAla: 5.326 ± 0.082
0.595GlyCys: 0.595 ± 0.028
3.408GlyAsp: 3.408 ± 0.067
5.13GlyGlu: 5.13 ± 0.077
3.176GlyPhe: 3.176 ± 0.06
5.307GlyGly: 5.307 ± 0.09
1.47GlyHis: 1.47 ± 0.042
5.646GlyIle: 5.646 ± 0.098
4.698GlyLys: 4.698 ± 0.074
6.445GlyLeu: 6.445 ± 0.113
2.327GlyMet: 2.327 ± 0.055
2.694GlyAsn: 2.694 ± 0.055
2.024GlyPro: 2.024 ± 0.046
2.18GlyGln: 2.18 ± 0.049
3.011GlyArg: 3.011 ± 0.055
4.308GlySer: 4.308 ± 0.074
4.208GlyThr: 4.208 ± 0.071
5.281GlyVal: 5.281 ± 0.076
0.838GlyTrp: 0.838 ± 0.031
2.683GlyTyr: 2.683 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.506HisAla: 1.506 ± 0.045
0.194HisCys: 0.194 ± 0.014
1.048HisAsp: 1.048 ± 0.039
1.515HisGlu: 1.515 ± 0.04
1.073HisPhe: 1.073 ± 0.033
1.592HisGly: 1.592 ± 0.04
0.806HisHis: 0.806 ± 0.031
1.661HisIle: 1.661 ± 0.048
0.956HisLys: 0.956 ± 0.035
2.242HisLeu: 2.242 ± 0.059
0.64HisMet: 0.64 ± 0.026
0.717HisAsn: 0.717 ± 0.027
1.296HisPro: 1.296 ± 0.042
0.985HisGln: 0.985 ± 0.036
1.055HisArg: 1.055 ± 0.038
1.501HisSer: 1.501 ± 0.041
1.248HisThr: 1.248 ± 0.037
1.676HisVal: 1.676 ± 0.044
0.275HisTrp: 0.275 ± 0.018
0.939HisTyr: 0.939 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.652IleAla: 5.652 ± 0.1
0.541IleCys: 0.541 ± 0.025
3.921IleAsp: 3.921 ± 0.06
5.486IleGlu: 5.486 ± 0.081
2.944IlePhe: 2.944 ± 0.084
5.729IleGly: 5.729 ± 0.102
1.807IleHis: 1.807 ± 0.048
5.34IleIle: 5.34 ± 0.109
3.623IleLys: 3.623 ± 0.07
6.467IleLeu: 6.467 ± 0.104
1.707IleMet: 1.707 ± 0.047
2.812IleAsn: 2.812 ± 0.06
3.426IlePro: 3.426 ± 0.069
2.852IleGln: 2.852 ± 0.061
3.101IleArg: 3.101 ± 0.06
4.636IleSer: 4.636 ± 0.081
4.388IleThr: 4.388 ± 0.068
5.174IleVal: 5.174 ± 0.086
0.658IleTrp: 0.658 ± 0.028
2.177IleTyr: 2.177 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
4.27LysAla: 4.27 ± 0.071
0.231LysCys: 0.231 ± 0.015
3.499LysAsp: 3.499 ± 0.073
7.178LysGlu: 7.178 ± 0.096
1.406LysPhe: 1.406 ± 0.044
3.995LysGly: 3.995 ± 0.081
1.348LysHis: 1.348 ± 0.042
3.487LysIle: 3.487 ± 0.069
5.613LysLys: 5.613 ± 0.084
4.558LysLeu: 4.558 ± 0.069
1.926LysMet: 1.926 ± 0.045
2.838LysAsn: 2.838 ± 0.056
1.998LysPro: 1.998 ± 0.047
2.774LysGln: 2.774 ± 0.065
3.381LysArg: 3.381 ± 0.07
3.035LysSer: 3.035 ± 0.059
3.273LysThr: 3.273 ± 0.063
4.169LysVal: 4.169 ± 0.072
0.757LysTrp: 0.757 ± 0.031
1.718LysTyr: 1.718 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
7.084LeuAla: 7.084 ± 0.106
0.629LeuCys: 0.629 ± 0.025
4.692LeuAsp: 4.692 ± 0.071
6.95LeuGlu: 6.95 ± 0.102
4.667LeuPhe: 4.667 ± 0.09
6.5LeuGly: 6.5 ± 0.108
2.297LeuHis: 2.297 ± 0.057
6.58LeuIle: 6.58 ± 0.129
5.252LeuLys: 5.252 ± 0.086
9.918LeuLeu: 9.918 ± 0.151
2.423LeuMet: 2.423 ± 0.058
3.417LeuAsn: 3.417 ± 0.056
4.244LeuPro: 4.244 ± 0.079
3.711LeuGln: 3.711 ± 0.061
4.111LeuArg: 4.111 ± 0.074
6.598LeuSer: 6.598 ± 0.091
5.443LeuThr: 5.443 ± 0.083
5.945LeuVal: 5.945 ± 0.074
0.799LeuTrp: 0.799 ± 0.031
3.018LeuTyr: 3.018 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.232MetAla: 2.232 ± 0.044
0.133MetCys: 0.133 ± 0.013
1.61MetAsp: 1.61 ± 0.038
2.433MetGlu: 2.433 ± 0.044
1.091MetPhe: 1.091 ± 0.033
1.928MetGly: 1.928 ± 0.048
0.453MetHis: 0.453 ± 0.024
2.05MetIle: 2.05 ± 0.053
2.369MetLys: 2.369 ± 0.05
2.567MetLeu: 2.567 ± 0.055
0.909MetMet: 0.909 ± 0.035
1.531MetAsn: 1.531 ± 0.04
1.047MetPro: 1.047 ± 0.034
0.841MetGln: 0.841 ± 0.032
1.246MetArg: 1.246 ± 0.039
1.795MetSer: 1.795 ± 0.042
1.766MetThr: 1.766 ± 0.045
1.816MetVal: 1.816 ± 0.047
0.234MetTrp: 0.234 ± 0.016
0.764MetTyr: 0.764 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.495AsnAla: 2.495 ± 0.053
0.255AsnCys: 0.255 ± 0.019
2.156AsnAsp: 2.156 ± 0.048
3.435AsnGlu: 3.435 ± 0.075
1.32AsnPhe: 1.32 ± 0.039
2.89AsnGly: 2.89 ± 0.066
0.987AsnHis: 0.987 ± 0.031
3.215AsnIle: 3.215 ± 0.059
2.611AsnLys: 2.611 ± 0.056
2.985AsnLeu: 2.985 ± 0.053
1.215AsnMet: 1.215 ± 0.037
1.844AsnAsn: 1.844 ± 0.057
1.859AsnPro: 1.859 ± 0.045
1.677AsnGln: 1.677 ± 0.043
2.007AsnArg: 2.007 ± 0.05
1.906AsnSer: 1.906 ± 0.049
2.157AsnThr: 2.157 ± 0.05
2.939AsnVal: 2.939 ± 0.059
0.466AsnTrp: 0.466 ± 0.024
1.259AsnTyr: 1.259 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.67ProAla: 2.67 ± 0.055
0.222ProCys: 0.222 ± 0.017
2.367ProAsp: 2.367 ± 0.062
3.523ProGlu: 3.523 ± 0.071
1.94ProPhe: 1.94 ± 0.047
2.721ProGly: 2.721 ± 0.056
0.993ProHis: 0.993 ± 0.036
2.709ProIle: 2.709 ± 0.06
1.807ProLys: 1.807 ± 0.04
3.812ProLeu: 3.812 ± 0.065
0.881ProMet: 0.881 ± 0.032
1.425ProAsn: 1.425 ± 0.042
1.355ProPro: 1.355 ± 0.04
1.137ProGln: 1.137 ± 0.035
1.348ProArg: 1.348 ± 0.044
2.682ProSer: 2.682 ± 0.054
1.884ProThr: 1.884 ± 0.044
3.197ProVal: 3.197 ± 0.062
0.431ProTrp: 0.431 ± 0.022
1.438ProTyr: 1.438 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
2.97GlnAla: 2.97 ± 0.061
0.189GlnCys: 0.189 ± 0.013
1.742GlnAsp: 1.742 ± 0.045
3.402GlnGlu: 3.402 ± 0.066
1.479GlnPhe: 1.479 ± 0.043
2.186GlnGly: 2.186 ± 0.048
0.842GlnHis: 0.842 ± 0.036
2.189GlnIle: 2.189 ± 0.045
2.348GlnLys: 2.348 ± 0.049
3.826GlnLeu: 3.826 ± 0.08
1.159GlnMet: 1.159 ± 0.034
1.349GlnAsn: 1.349 ± 0.038
1.366GlnPro: 1.366 ± 0.04
1.746GlnGln: 1.746 ± 0.059
1.682GlnArg: 1.682 ± 0.043
2.238GlnSer: 2.238 ± 0.054
2.088GlnThr: 2.088 ± 0.054
2.448GlnVal: 2.448 ± 0.049
0.492GlnTrp: 0.492 ± 0.023
1.134GlnTyr: 1.134 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.843ArgAla: 2.843 ± 0.053
0.275ArgCys: 0.275 ± 0.018
2.404ArgAsp: 2.404 ± 0.055
4.101ArgGlu: 4.101 ± 0.08
1.953ArgPhe: 1.953 ± 0.052
2.592ArgGly: 2.592 ± 0.063
1.007ArgHis: 1.007 ± 0.028
2.999ArgIle: 2.999 ± 0.059
3.449ArgLys: 3.449 ± 0.064
4.305ArgLeu: 4.305 ± 0.07
1.446ArgMet: 1.446 ± 0.041
1.851ArgAsn: 1.851 ± 0.046
1.587ArgPro: 1.587 ± 0.043
1.69ArgGln: 1.69 ± 0.047
2.276ArgArg: 2.276 ± 0.055
2.563ArgSer: 2.563 ± 0.052
2.268ArgThr: 2.268 ± 0.048
2.874ArgVal: 2.874 ± 0.057
0.465ArgTrp: 0.465 ± 0.022
1.613ArgTyr: 1.613 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.935SerAla: 3.935 ± 0.072
0.375SerCys: 0.375 ± 0.024
3.036SerAsp: 3.036 ± 0.065
4.237SerGlu: 4.237 ± 0.073
3.255SerPhe: 3.255 ± 0.059
4.535SerGly: 4.535 ± 0.068
1.413SerHis: 1.413 ± 0.036
4.704SerIle: 4.704 ± 0.086
3.068SerLys: 3.068 ± 0.057
6.384SerLeu: 6.384 ± 0.101
1.897SerMet: 1.897 ± 0.048
2.254SerAsn: 2.254 ± 0.048
2.385SerPro: 2.385 ± 0.055
2.156SerGln: 2.156 ± 0.048
2.616SerArg: 2.616 ± 0.054
4.215SerSer: 4.215 ± 0.08
3.24SerThr: 3.24 ± 0.065
4.373SerVal: 4.373 ± 0.065
0.71SerTrp: 0.71 ± 0.027
2.203SerTyr: 2.203 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.475ThrAla: 4.475 ± 0.08
0.391ThrCys: 0.391 ± 0.022
2.93ThrAsp: 2.93 ± 0.059
4.092ThrGlu: 4.092 ± 0.074
2.732ThrPhe: 2.732 ± 0.054
4.599ThrGly: 4.599 ± 0.068
1.074ThrHis: 1.074 ± 0.037
4.192ThrIle: 4.192 ± 0.07
2.967ThrLys: 2.967 ± 0.053
5.371ThrLeu: 5.371 ± 0.079
1.509ThrMet: 1.509 ± 0.037
2.233ThrAsn: 2.233 ± 0.048
2.497ThrPro: 2.497 ± 0.057
1.456ThrGln: 1.456 ± 0.04
2.098ThrArg: 2.098 ± 0.05
3.398ThrSer: 3.398 ± 0.056
3.042ThrThr: 3.042 ± 0.064
4.284ThrVal: 4.284 ± 0.062
0.594ThrTrp: 0.594 ± 0.025
2.024ThrTyr: 2.024 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.736ValAla: 4.736 ± 0.082
0.614ValCys: 0.614 ± 0.027
3.682ValAsp: 3.682 ± 0.064
5.174ValGlu: 5.174 ± 0.094
3.093ValPhe: 3.093 ± 0.064
4.636ValGly: 4.636 ± 0.085
1.504ValHis: 1.504 ± 0.039
5.745ValIle: 5.745 ± 0.089
4.269ValLys: 4.269 ± 0.07
7.075ValLeu: 7.075 ± 0.085
2.016ValMet: 2.016 ± 0.045
2.886ValAsn: 2.886 ± 0.055
2.894ValPro: 2.894 ± 0.053
2.392ValGln: 2.392 ± 0.057
2.993ValArg: 2.993 ± 0.062
4.774ValSer: 4.774 ± 0.074
4.575ValThr: 4.575 ± 0.068
5.16ValVal: 5.16 ± 0.076
0.671ValTrp: 0.671 ± 0.028
2.222ValTyr: 2.222 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.637TrpAla: 0.637 ± 0.028
0.076TrpCys: 0.076 ± 0.009
0.523TrpAsp: 0.523 ± 0.024
0.841TrpGlu: 0.841 ± 0.03
0.505TrpPhe: 0.505 ± 0.029
0.728TrpGly: 0.728 ± 0.034
0.216TrpHis: 0.216 ± 0.016
0.748TrpIle: 0.748 ± 0.029
0.819TrpLys: 0.819 ± 0.031
1.227TrpLeu: 1.227 ± 0.04
0.39TrpMet: 0.39 ± 0.022
0.513TrpAsn: 0.513 ± 0.02
0.31TrpPro: 0.31 ± 0.019
0.391TrpGln: 0.391 ± 0.02
0.452TrpArg: 0.452 ± 0.023
0.667TrpSer: 0.667 ± 0.03
0.578TrpThr: 0.578 ± 0.025
0.695TrpVal: 0.695 ± 0.03
0.134TrpTrp: 0.134 ± 0.014
0.317TrpTyr: 0.317 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.005TyrAla: 2.005 ± 0.051
0.245TyrCys: 0.245 ± 0.017
1.89TyrAsp: 1.89 ± 0.052
2.697TyrGlu: 2.697 ± 0.053
1.608TyrPhe: 1.608 ± 0.042
2.45TyrGly: 2.45 ± 0.052
0.942TyrHis: 0.942 ± 0.036
2.26TyrIle: 2.26 ± 0.047
1.72TyrLys: 1.72 ± 0.042
3.107TyrLeu: 3.107 ± 0.053
0.823TyrMet: 0.823 ± 0.028
1.293TyrAsn: 1.293 ± 0.043
1.442TyrPro: 1.442 ± 0.04
1.402TyrGln: 1.402 ± 0.043
1.674TyrArg: 1.674 ± 0.046
1.929TyrSer: 1.929 ± 0.046
1.796TyrThr: 1.796 ± 0.042
2.275TyrVal: 2.275 ± 0.05
0.38TyrTrp: 0.38 ± 0.019
1.313TyrTyr: 1.313 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3218 proteins (934243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski