Amino acid dipepetide frequency for Streptococcus satellite phage Javan176

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.886AlaAla: 1.886 ± 0.763
1.509AlaCys: 1.509 ± 0.731
3.395AlaAsp: 3.395 ± 1.015
4.527AlaGlu: 4.527 ± 1.618
2.641AlaPhe: 2.641 ± 1.02
1.509AlaGly: 1.509 ± 1.006
1.509AlaHis: 1.509 ± 0.568
4.149AlaIle: 4.149 ± 0.884
5.658AlaLys: 5.658 ± 1.272
6.79AlaLeu: 6.79 ± 1.044
1.132AlaMet: 1.132 ± 0.449
4.149AlaAsn: 4.149 ± 1.021
1.132AlaPro: 1.132 ± 0.715
4.527AlaGln: 4.527 ± 1.894
4.904AlaArg: 4.904 ± 1.521
5.281AlaSer: 5.281 ± 1.354
3.772AlaThr: 3.772 ± 0.9
5.658AlaVal: 5.658 ± 1.129
1.132AlaTrp: 1.132 ± 0.723
3.395AlaTyr: 3.395 ± 0.952
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.754CysGlu: 0.754 ± 0.604
0.0CysPhe: 0.0 ± 0.0
0.377CysGly: 0.377 ± 0.354
0.0CysHis: 0.0 ± 0.0
0.377CysIle: 0.377 ± 0.354
0.377CysLys: 0.377 ± 0.403
0.0CysLeu: 0.0 ± 0.0
0.377CysMet: 0.377 ± 0.331
0.0CysAsn: 0.0 ± 0.0
1.132CysPro: 1.132 ± 0.798
0.0CysGln: 0.0 ± 0.0
0.754CysArg: 0.754 ± 0.436
0.377CysSer: 0.377 ± 0.331
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.377CysTyr: 0.377 ± 0.341
0.0CysXaa: 0.0 ± 0.0
Asp
1.886AspAla: 1.886 ± 1.018
0.377AspCys: 0.377 ± 0.354
2.641AspAsp: 2.641 ± 0.782
4.149AspGlu: 4.149 ± 1.185
2.641AspPhe: 2.641 ± 1.176
3.018AspGly: 3.018 ± 1.45
0.377AspHis: 0.377 ± 0.403
6.035AspIle: 6.035 ± 1.276
4.904AspLys: 4.904 ± 1.492
6.035AspLeu: 6.035 ± 1.406
2.263AspMet: 2.263 ± 0.777
1.509AspAsn: 1.509 ± 1.137
2.641AspPro: 2.641 ± 1.375
0.754AspGln: 0.754 ± 0.513
2.641AspArg: 2.641 ± 0.851
3.395AspSer: 3.395 ± 1.053
5.658AspThr: 5.658 ± 1.407
3.018AspVal: 3.018 ± 0.725
0.377AspTrp: 0.377 ± 0.395
4.904AspTyr: 4.904 ± 1.017
0.0AspXaa: 0.0 ± 0.0
Glu
6.79GluAla: 6.79 ± 1.106
0.0GluCys: 0.0 ± 0.0
3.772GluAsp: 3.772 ± 1.478
4.527GluGlu: 4.527 ± 1.308
4.149GluPhe: 4.149 ± 1.399
4.527GluGly: 4.527 ± 1.185
1.132GluHis: 1.132 ± 0.647
6.413GluIle: 6.413 ± 1.553
5.281GluLys: 5.281 ± 1.517
10.562GluLeu: 10.562 ± 2.296
4.149GluMet: 4.149 ± 1.123
4.527GluAsn: 4.527 ± 1.322
1.132GluPro: 1.132 ± 0.474
7.167GluGln: 7.167 ± 1.195
6.413GluArg: 6.413 ± 1.626
3.395GluSer: 3.395 ± 1.036
4.527GluThr: 4.527 ± 0.955
6.035GluVal: 6.035 ± 2.074
1.132GluTrp: 1.132 ± 0.464
2.641GluTyr: 2.641 ± 1.018
0.0GluXaa: 0.0 ± 0.0
Phe
2.641PheAla: 2.641 ± 1.026
0.377PheCys: 0.377 ± 0.38
5.658PheAsp: 5.658 ± 1.258
2.641PheGlu: 2.641 ± 0.904
1.886PhePhe: 1.886 ± 0.716
2.263PheGly: 2.263 ± 0.688
0.377PheHis: 0.377 ± 0.331
1.132PheIle: 1.132 ± 0.487
3.018PheLys: 3.018 ± 1.218
4.904PheLeu: 4.904 ± 1.637
0.754PheMet: 0.754 ± 0.537
0.754PheAsn: 0.754 ± 0.575
0.0PhePro: 0.0 ± 0.0
1.132PheGln: 1.132 ± 0.549
2.641PheArg: 2.641 ± 0.845
3.018PheSer: 3.018 ± 0.94
2.263PheThr: 2.263 ± 0.568
2.263PheVal: 2.263 ± 0.764
0.377PheTrp: 0.377 ± 0.354
0.377PheTyr: 0.377 ± 0.458
0.0PheXaa: 0.0 ± 0.0
Gly
1.886GlyAla: 1.886 ± 0.878
0.377GlyCys: 0.377 ± 0.331
2.641GlyAsp: 2.641 ± 0.781
3.772GlyGlu: 3.772 ± 1.296
1.509GlyPhe: 1.509 ± 0.742
2.263GlyGly: 2.263 ± 0.799
0.754GlyHis: 0.754 ± 0.663
4.527GlyIle: 4.527 ± 1.227
3.772GlyLys: 3.772 ± 1.205
4.527GlyLeu: 4.527 ± 1.375
1.132GlyMet: 1.132 ± 0.575
1.886GlyAsn: 1.886 ± 0.753
0.0GlyPro: 0.0 ± 0.0
1.886GlyGln: 1.886 ± 0.896
2.641GlyArg: 2.641 ± 0.462
0.754GlySer: 0.754 ± 0.506
2.641GlyThr: 2.641 ± 0.83
4.149GlyVal: 4.149 ± 1.826
0.377GlyTrp: 0.377 ± 0.38
2.263GlyTyr: 2.263 ± 0.918
0.0GlyXaa: 0.0 ± 0.0
His
1.132HisAla: 1.132 ± 0.994
0.0HisCys: 0.0 ± 0.0
0.754HisAsp: 0.754 ± 0.57
1.509HisGlu: 1.509 ± 0.732
0.377HisPhe: 0.377 ± 0.331
0.377HisGly: 0.377 ± 0.331
0.377HisHis: 0.377 ± 0.331
0.754HisIle: 0.754 ± 0.466
2.263HisLys: 2.263 ± 0.767
1.132HisLeu: 1.132 ± 0.67
0.0HisMet: 0.0 ± 0.0
0.377HisAsn: 0.377 ± 0.331
0.754HisPro: 0.754 ± 0.475
0.0HisGln: 0.0 ± 0.0
0.754HisArg: 0.754 ± 0.6
1.509HisSer: 1.509 ± 0.435
0.754HisThr: 0.754 ± 0.663
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.377HisTyr: 0.377 ± 0.403
0.0HisXaa: 0.0 ± 0.0
Ile
3.395IleAla: 3.395 ± 1.01
0.0IleCys: 0.0 ± 0.0
4.527IleAsp: 4.527 ± 0.975
4.904IleGlu: 4.904 ± 1.061
4.904IlePhe: 4.904 ± 0.911
2.641IleGly: 2.641 ± 1.098
1.132IleHis: 1.132 ± 0.603
2.263IleIle: 2.263 ± 0.914
4.904IleLys: 4.904 ± 0.834
3.395IleLeu: 3.395 ± 0.728
1.132IleMet: 1.132 ± 0.581
3.018IleAsn: 3.018 ± 1.226
2.641IlePro: 2.641 ± 1.068
2.641IleGln: 2.641 ± 0.955
1.132IleArg: 1.132 ± 0.554
5.658IleSer: 5.658 ± 1.408
3.018IleThr: 3.018 ± 0.978
3.395IleVal: 3.395 ± 1.395
0.754IleTrp: 0.754 ± 0.44
3.018IleTyr: 3.018 ± 0.772
0.0IleXaa: 0.0 ± 0.0
Lys
8.676LysAla: 8.676 ± 1.722
0.377LysCys: 0.377 ± 0.354
4.527LysAsp: 4.527 ± 1.246
7.544LysGlu: 7.544 ± 2.163
3.395LysPhe: 3.395 ± 0.975
4.149LysGly: 4.149 ± 1.142
0.754LysHis: 0.754 ± 0.482
3.772LysIle: 3.772 ± 0.793
6.79LysLys: 6.79 ± 1.808
8.676LysLeu: 8.676 ± 1.741
0.754LysMet: 0.754 ± 0.624
3.772LysAsn: 3.772 ± 0.882
2.641LysPro: 2.641 ± 0.764
3.018LysGln: 3.018 ± 0.801
4.904LysArg: 4.904 ± 2.014
7.167LysSer: 7.167 ± 2.225
4.527LysThr: 4.527 ± 0.925
3.018LysVal: 3.018 ± 0.8
1.132LysTrp: 1.132 ± 0.438
2.263LysTyr: 2.263 ± 0.735
0.0LysXaa: 0.0 ± 0.0
Leu
7.922LeuAla: 7.922 ± 1.237
0.377LeuCys: 0.377 ± 0.38
9.808LeuAsp: 9.808 ± 1.486
10.185LeuGlu: 10.185 ± 1.61
1.509LeuPhe: 1.509 ± 0.587
4.527LeuGly: 4.527 ± 1.471
0.377LeuHis: 0.377 ± 0.331
5.658LeuIle: 5.658 ± 1.178
8.676LeuLys: 8.676 ± 1.638
6.79LeuLeu: 6.79 ± 1.482
2.263LeuMet: 2.263 ± 0.876
6.035LeuAsn: 6.035 ± 1.479
2.263LeuPro: 2.263 ± 0.587
5.658LeuGln: 5.658 ± 1.303
5.658LeuArg: 5.658 ± 1.35
8.676LeuSer: 8.676 ± 2.302
4.904LeuThr: 4.904 ± 1.058
4.149LeuVal: 4.149 ± 0.832
0.377LeuTrp: 0.377 ± 0.331
3.395LeuTyr: 3.395 ± 0.834
0.0LeuXaa: 0.0 ± 0.0
Met
4.527MetAla: 4.527 ± 1.636
0.0MetCys: 0.0 ± 0.0
1.132MetAsp: 1.132 ± 0.572
1.886MetGlu: 1.886 ± 0.692
0.377MetPhe: 0.377 ± 0.403
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.886MetLys: 1.886 ± 1.071
4.527MetLeu: 4.527 ± 1.309
0.754MetMet: 0.754 ± 0.503
1.509MetAsn: 1.509 ± 0.768
0.377MetPro: 0.377 ± 0.458
1.132MetGln: 1.132 ± 0.495
0.0MetArg: 0.0 ± 0.0
3.018MetSer: 3.018 ± 0.978
3.018MetThr: 3.018 ± 0.824
1.132MetVal: 1.132 ± 0.734
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.527AsnAla: 4.527 ± 0.902
0.377AsnCys: 0.377 ± 0.331
1.886AsnAsp: 1.886 ± 1.091
3.018AsnGlu: 3.018 ± 0.886
1.132AsnPhe: 1.132 ± 0.566
2.641AsnGly: 2.641 ± 1.215
1.509AsnHis: 1.509 ± 0.593
4.149AsnIle: 4.149 ± 1.416
1.132AsnLys: 1.132 ± 0.723
3.395AsnLeu: 3.395 ± 0.804
1.132AsnMet: 1.132 ± 0.557
1.132AsnAsn: 1.132 ± 0.604
1.509AsnPro: 1.509 ± 0.885
4.527AsnGln: 4.527 ± 1.743
3.772AsnArg: 3.772 ± 1.199
2.263AsnSer: 2.263 ± 0.61
1.886AsnThr: 1.886 ± 0.601
2.263AsnVal: 2.263 ± 0.927
0.754AsnTrp: 0.754 ± 0.506
1.886AsnTyr: 1.886 ± 0.739
0.0AsnXaa: 0.0 ± 0.0
Pro
1.132ProAla: 1.132 ± 0.681
0.754ProCys: 0.754 ± 0.543
1.886ProAsp: 1.886 ± 0.68
1.886ProGlu: 1.886 ± 0.699
1.132ProPhe: 1.132 ± 0.626
1.132ProGly: 1.132 ± 0.522
0.377ProHis: 0.377 ± 0.331
1.132ProIle: 1.132 ± 0.761
3.395ProLys: 3.395 ± 0.857
1.886ProLeu: 1.886 ± 0.866
0.377ProMet: 0.377 ± 0.354
0.377ProAsn: 0.377 ± 0.331
1.132ProPro: 1.132 ± 0.582
2.263ProGln: 2.263 ± 0.877
1.509ProArg: 1.509 ± 0.674
3.018ProSer: 3.018 ± 0.741
2.263ProThr: 2.263 ± 1.024
1.886ProVal: 1.886 ± 0.845
0.0ProTrp: 0.0 ± 0.0
1.132ProTyr: 1.132 ± 0.691
0.0ProXaa: 0.0 ± 0.0
Gln
5.281GlnAla: 5.281 ± 1.412
0.0GlnCys: 0.0 ± 0.0
1.509GlnAsp: 1.509 ± 0.603
7.922GlnGlu: 7.922 ± 1.682
1.132GlnPhe: 1.132 ± 0.743
2.263GlnGly: 2.263 ± 0.603
0.377GlnHis: 0.377 ± 0.427
2.263GlnIle: 2.263 ± 0.737
4.149GlnLys: 4.149 ± 1.207
6.79GlnLeu: 6.79 ± 1.888
0.377GlnMet: 0.377 ± 0.331
2.641GlnAsn: 2.641 ± 0.736
1.886GlnPro: 1.886 ± 0.871
6.79GlnGln: 6.79 ± 1.429
4.149GlnArg: 4.149 ± 1.462
4.149GlnSer: 4.149 ± 1.133
3.018GlnThr: 3.018 ± 1.591
2.263GlnVal: 2.263 ± 0.851
0.0GlnTrp: 0.0 ± 0.0
1.886GlnTyr: 1.886 ± 1.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.281ArgAla: 5.281 ± 1.431
0.0ArgCys: 0.0 ± 0.0
2.263ArgAsp: 2.263 ± 1.152
6.79ArgGlu: 6.79 ± 1.17
1.886ArgPhe: 1.886 ± 1.048
2.263ArgGly: 2.263 ± 1.139
0.754ArgHis: 0.754 ± 0.454
4.527ArgIle: 4.527 ± 1.069
4.149ArgLys: 4.149 ± 0.821
6.79ArgLeu: 6.79 ± 0.984
1.132ArgMet: 1.132 ± 0.583
3.018ArgAsn: 3.018 ± 0.998
0.754ArgPro: 0.754 ± 0.707
3.018ArgGln: 3.018 ± 1.1
1.886ArgArg: 1.886 ± 0.779
3.018ArgSer: 3.018 ± 1.02
1.886ArgThr: 1.886 ± 0.881
2.263ArgVal: 2.263 ± 0.812
0.754ArgTrp: 0.754 ± 0.447
2.263ArgTyr: 2.263 ± 0.91
0.0ArgXaa: 0.0 ± 0.0
Ser
1.886SerAla: 1.886 ± 0.812
0.0SerCys: 0.0 ± 0.0
6.035SerAsp: 6.035 ± 1.28
6.79SerGlu: 6.79 ± 1.469
3.772SerPhe: 3.772 ± 0.612
1.509SerGly: 1.509 ± 0.642
1.132SerHis: 1.132 ± 0.637
2.641SerIle: 2.641 ± 0.881
5.658SerLys: 5.658 ± 1.724
6.79SerLeu: 6.79 ± 1.614
0.754SerMet: 0.754 ± 0.489
3.772SerAsn: 3.772 ± 1.152
2.641SerPro: 2.641 ± 1.042
6.035SerGln: 6.035 ± 1.784
3.772SerArg: 3.772 ± 0.981
2.641SerSer: 2.641 ± 0.854
1.132SerThr: 1.132 ± 0.497
3.395SerVal: 3.395 ± 1.254
1.132SerTrp: 1.132 ± 0.739
5.658SerTyr: 5.658 ± 1.193
0.0SerXaa: 0.0 ± 0.0
Thr
1.886ThrAla: 1.886 ± 1.065
0.0ThrCys: 0.0 ± 0.0
3.018ThrAsp: 3.018 ± 1.106
5.658ThrGlu: 5.658 ± 1.356
2.263ThrPhe: 2.263 ± 0.722
3.018ThrGly: 3.018 ± 1.035
1.132ThrHis: 1.132 ± 0.552
3.018ThrIle: 3.018 ± 1.135
4.527ThrLys: 4.527 ± 1.472
4.527ThrLeu: 4.527 ± 1.283
2.641ThrMet: 2.641 ± 1.034
2.263ThrAsn: 2.263 ± 0.741
2.641ThrPro: 2.641 ± 1.157
2.641ThrGln: 2.641 ± 0.799
0.754ThrArg: 0.754 ± 0.663
2.263ThrSer: 2.263 ± 0.884
4.904ThrThr: 4.904 ± 1.206
4.904ThrVal: 4.904 ± 1.187
0.377ThrTrp: 0.377 ± 0.331
4.149ThrTyr: 4.149 ± 1.285
0.0ThrXaa: 0.0 ± 0.0
Val
3.772ValAla: 3.772 ± 0.977
0.377ValCys: 0.377 ± 0.38
1.509ValAsp: 1.509 ± 0.614
4.527ValGlu: 4.527 ± 1.393
2.263ValPhe: 2.263 ± 0.768
1.886ValGly: 1.886 ± 0.669
0.754ValHis: 0.754 ± 0.467
3.772ValIle: 3.772 ± 1.114
4.149ValLys: 4.149 ± 1.514
5.281ValLeu: 5.281 ± 1.577
2.263ValMet: 2.263 ± 1.363
2.641ValAsn: 2.641 ± 1.079
2.263ValPro: 2.263 ± 0.621
1.886ValGln: 1.886 ± 0.855
3.395ValArg: 3.395 ± 1.133
3.772ValSer: 3.772 ± 0.778
4.149ValThr: 4.149 ± 1.086
1.886ValVal: 1.886 ± 1.069
0.0ValTrp: 0.0 ± 0.0
3.018ValTyr: 3.018 ± 1.001
0.0ValXaa: 0.0 ± 0.0
Trp
0.754TrpAla: 0.754 ± 0.393
0.0TrpCys: 0.0 ± 0.0
0.754TrpAsp: 0.754 ± 0.663
1.509TrpGlu: 1.509 ± 0.854
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.754TrpLys: 0.754 ± 0.454
1.509TrpLeu: 1.509 ± 1.009
0.0TrpMet: 0.0 ± 0.0
1.132TrpAsn: 1.132 ± 0.543
0.0TrpPro: 0.0 ± 0.0
0.754TrpGln: 0.754 ± 0.393
0.377TrpArg: 0.377 ± 0.426
0.377TrpSer: 0.377 ± 0.331
0.0TrpThr: 0.0 ± 0.0
0.754TrpVal: 0.754 ± 0.497
0.377TrpTrp: 0.377 ± 0.331
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.395TyrAla: 3.395 ± 1.256
0.0TyrCys: 0.0 ± 0.0
1.509TyrAsp: 1.509 ± 0.714
4.149TyrGlu: 4.149 ± 1.108
1.509TyrPhe: 1.509 ± 1.139
3.395TyrGly: 3.395 ± 1.192
0.377TyrHis: 0.377 ± 0.331
1.886TyrIle: 1.886 ± 0.916
6.413TyrLys: 6.413 ± 1.11
4.904TyrLeu: 4.904 ± 1.246
1.509TyrMet: 1.509 ± 0.853
0.377TyrAsn: 0.377 ± 0.351
1.132TyrPro: 1.132 ± 0.731
3.018TyrGln: 3.018 ± 1.14
2.641TyrArg: 2.641 ± 1.09
3.395TyrSer: 3.395 ± 1.271
2.263TyrThr: 2.263 ± 1.113
1.132TyrVal: 1.132 ± 0.674
0.0TyrTrp: 0.0 ± 0.0
2.263TyrTyr: 2.263 ± 0.797
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 16 proteins (2652 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski