Amino acid dipepetide frequency for Fibrobacter succinogenes (strain ATCC 19169 / S85)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.254AlaAla: 7.254 ± 0.126	1.23AlaCys: 1.23 ± 0.033	4.678AlaAsp: 4.678 ± 0.075	5.578AlaGlu: 5.578 ± 0.093	3.854AlaPhe: 3.854 ± 0.067	5.814AlaGly: 5.814 ± 0.104	1.329AlaHis: 1.329 ± 0.04	4.975AlaIle: 4.975 ± 0.088	5.849AlaLys: 5.849 ± 0.085	7.52AlaLeu: 7.52 ± 0.097	2.221AlaMet: 2.221 ± 0.054	3.491AlaAsn: 3.491 ± 0.066	2.972AlaPro: 2.972 ± 0.079	2.554AlaGln: 2.554 ± 0.055	3.308AlaArg: 3.308 ± 0.062	5.212AlaSer: 5.212 ± 0.08	4.176AlaThr: 4.176 ± 0.08	5.466AlaVal: 5.466 ± 0.084	0.849AlaTrp: 0.849 ± 0.028	2.762AlaTyr: 2.762 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.094CysAla: 1.094 ± 0.035	0.254CysCys: 0.254 ± 0.018	0.89CysAsp: 0.89 ± 0.036	0.859CysGlu: 0.859 ± 0.034	0.614CysPhe: 0.614 ± 0.027	1.306CysGly: 1.306 ± 0.039	0.289CysHis: 0.289 ± 0.015	0.806CysIle: 0.806 ± 0.031	0.885CysLys: 0.885 ± 0.03	1.082CysLeu: 1.082 ± 0.035	0.309CysMet: 0.309 ± 0.017	0.66CysAsn: 0.66 ± 0.031	0.644CysPro: 0.644 ± 0.035	0.301CysGln: 0.301 ± 0.017	0.592CysArg: 0.592 ± 0.024	1.032CysSer: 1.032 ± 0.033	0.713CysThr: 0.713 ± 0.024	0.985CysVal: 0.985 ± 0.031	0.141CysTrp: 0.141 ± 0.012	0.549CysTyr: 0.549 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.82AspAla: 4.82 ± 0.07	0.802AspCys: 0.802 ± 0.029	3.477AspAsp: 3.477 ± 0.073	4.402AspGlu: 4.402 ± 0.073	3.319AspPhe: 3.319 ± 0.064	4.658AspGly: 4.658 ± 0.093	0.954AspHis: 0.954 ± 0.032	3.773AspIle: 3.773 ± 0.067	3.739AspLys: 3.739 ± 0.066	4.958AspLeu: 4.958 ± 0.082	1.53AspMet: 1.53 ± 0.043	2.482AspAsn: 2.482 ± 0.046	2.227AspPro: 2.227 ± 0.061	1.213AspGln: 1.213 ± 0.036	2.41AspArg: 2.41 ± 0.059	4.654AspSer: 4.654 ± 0.09	2.855AspThr: 2.855 ± 0.063	4.145AspVal: 4.145 ± 0.077	0.858AspTrp: 0.858 ± 0.032	2.664AspTyr: 2.664 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.857GluAla: 4.857 ± 0.082	0.844GluCys: 0.844 ± 0.028	3.388GluAsp: 3.388 ± 0.069	4.27GluGlu: 4.27 ± 0.093	3.065GluPhe: 3.065 ± 0.055	3.891GluGly: 3.891 ± 0.058	1.234GluHis: 1.234 ± 0.034	4.529GluIle: 4.529 ± 0.072	5.66GluLys: 5.66 ± 0.089	5.576GluLeu: 5.576 ± 0.083	1.919GluMet: 1.919 ± 0.041	4.048GluAsn: 4.048 ± 0.071	2.034GluPro: 2.034 ± 0.049	2.08GluGln: 2.08 ± 0.054	3.235GluArg: 3.235 ± 0.068	4.112GluSer: 4.112 ± 0.089	3.48GluThr: 3.48 ± 0.059	3.91GluVal: 3.91 ± 0.068	0.967GluTrp: 0.967 ± 0.033	2.408GluTyr: 2.408 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	4.35PheAla: 4.35 ± 0.07	0.787PheCys: 0.787 ± 0.031	3.27PheAsp: 3.27 ± 0.052	3.049PheGlu: 3.049 ± 0.049	2.552PhePhe: 2.552 ± 0.068	3.571PheGly: 3.571 ± 0.066	0.85PheHis: 0.85 ± 0.03	2.779PheIle: 2.779 ± 0.063	2.979PheLys: 2.979 ± 0.062	4.039PheLeu: 4.039 ± 0.074	1.21PheMet: 1.21 ± 0.039	2.346PheAsn: 2.346 ± 0.056	1.755PhePro: 1.755 ± 0.037	1.162PheGln: 1.162 ± 0.036	2.043PheArg: 2.043 ± 0.043	3.31PheSer: 3.31 ± 0.064	2.638PheThr: 2.638 ± 0.059	3.575PheVal: 3.575 ± 0.065	0.687PheTrp: 0.687 ± 0.026	1.876PheTyr: 1.876 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.163GlyAla: 5.163 ± 0.098	1.113GlyCys: 1.113 ± 0.039	4.159GlyAsp: 4.159 ± 0.082	4.366GlyGlu: 4.366 ± 0.073	3.72GlyPhe: 3.72 ± 0.055	4.986GlyGly: 4.986 ± 0.11	1.308GlyHis: 1.308 ± 0.036	4.653GlyIle: 4.653 ± 0.072	5.459GlyLys: 5.459 ± 0.096	5.814GlyLeu: 5.814 ± 0.096	1.922GlyMet: 1.922 ± 0.048	3.443GlyAsn: 3.443 ± 0.074	1.595GlyPro: 1.595 ± 0.039	1.612GlyGln: 1.612 ± 0.044	3.018GlyArg: 3.018 ± 0.062	4.382GlySer: 4.382 ± 0.088	3.913GlyThr: 3.913 ± 0.082	5.107GlyVal: 5.107 ± 0.086	0.961GlyTrp: 0.961 ± 0.035	2.812GlyTyr: 2.812 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.253HisAla: 1.253 ± 0.04	0.313HisCys: 0.313 ± 0.018	1.02HisAsp: 1.02 ± 0.034	1.08HisGlu: 1.08 ± 0.031	1.039HisPhe: 1.039 ± 0.033	1.216HisGly: 1.216 ± 0.034	0.469HisHis: 0.469 ± 0.025	1.112HisIle: 1.112 ± 0.034	1.043HisLys: 1.043 ± 0.033	1.698HisLeu: 1.698 ± 0.036	0.354HisMet: 0.354 ± 0.02	0.765HisAsn: 0.765 ± 0.029	0.969HisPro: 0.969 ± 0.031	0.487HisGln: 0.487 ± 0.021	0.825HisArg: 0.825 ± 0.029	1.041HisSer: 1.041 ± 0.029	0.817HisThr: 0.817 ± 0.031	1.257HisVal: 1.257 ± 0.033	0.298HisTrp: 0.298 ± 0.018	0.807HisTyr: 0.807 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.751IleAla: 5.751 ± 0.081	0.964IleCys: 0.964 ± 0.032	3.981IleAsp: 3.981 ± 0.069	4.018IleGlu: 4.018 ± 0.075	2.714IlePhe: 2.714 ± 0.053	4.024IleGly: 4.024 ± 0.071	1.158IleHis: 1.158 ± 0.032	3.416IleIle: 3.416 ± 0.067	3.819IleLys: 3.819 ± 0.07	5.48IleLeu: 5.48 ± 0.085	1.22IleMet: 1.22 ± 0.037	2.478IleAsn: 2.478 ± 0.06	3.03IlePro: 3.03 ± 0.061	1.922IleGln: 1.922 ± 0.045	2.886IleArg: 2.886 ± 0.056	4.266IleSer: 4.266 ± 0.078	3.133IleThr: 3.133 ± 0.059	4.368IleVal: 4.368 ± 0.072	0.645IleTrp: 0.645 ± 0.026	2.129IleTyr: 2.129 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.379LysAla: 5.379 ± 0.094	0.792LysCys: 0.792 ± 0.032	4.406LysAsp: 4.406 ± 0.073	4.441LysGlu: 4.441 ± 0.085	3.076LysPhe: 3.076 ± 0.057	4.221LysGly: 4.221 ± 0.077	1.138LysHis: 1.138 ± 0.036	4.805LysIle: 4.805 ± 0.07	5.739LysLys: 5.739 ± 0.1	5.584LysLeu: 5.584 ± 0.088	2.159LysMet: 2.159 ± 0.048	4.149LysAsn: 4.149 ± 0.067	2.461LysPro: 2.461 ± 0.051	2.187LysGln: 2.187 ± 0.056	3.049LysArg: 3.049 ± 0.06	4.309LysSer: 4.309 ± 0.072	3.856LysThr: 3.856 ± 0.067	4.558LysVal: 4.558 ± 0.074	0.849LysTrp: 0.849 ± 0.038	2.449LysTyr: 2.449 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.301LeuAla: 7.301 ± 0.081	1.277LeuCys: 1.277 ± 0.041	5.371LeuAsp: 5.371 ± 0.073	5.491LeuGlu: 5.491 ± 0.085	4.224LeuPhe: 4.224 ± 0.079	5.92LeuGly: 5.92 ± 0.089	1.577LeuHis: 1.577 ± 0.045	4.334LeuIle: 4.334 ± 0.071	6.28LeuLys: 6.28 ± 0.075	7.707LeuLeu: 7.707 ± 0.125	2.092LeuMet: 2.092 ± 0.045	4.177LeuAsn: 4.177 ± 0.074	3.902LeuPro: 3.902 ± 0.052	2.813LeuGln: 2.813 ± 0.058	4.248LeuArg: 4.248 ± 0.078	6.164LeuSer: 6.164 ± 0.084	4.519LeuThr: 4.519 ± 0.073	5.752LeuVal: 5.752 ± 0.077	1.028LeuTrp: 1.028 ± 0.032	2.987LeuTyr: 2.987 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.252MetAla: 2.252 ± 0.047	0.246MetCys: 0.246 ± 0.015	1.55MetAsp: 1.55 ± 0.043	1.608MetGlu: 1.608 ± 0.044	1.279MetPhe: 1.279 ± 0.049	1.834MetGly: 1.834 ± 0.048	0.51MetHis: 0.51 ± 0.019	1.418MetIle: 1.418 ± 0.039	1.907MetLys: 1.907 ± 0.042	2.282MetLeu: 2.282 ± 0.044	0.71MetMet: 0.71 ± 0.027	1.441MetAsn: 1.441 ± 0.04	1.153MetPro: 1.153 ± 0.031	0.995MetGln: 0.995 ± 0.028	1.227MetArg: 1.227 ± 0.031	1.677MetSer: 1.677 ± 0.046	1.389MetThr: 1.389 ± 0.03	1.6MetVal: 1.6 ± 0.038	0.253MetTrp: 0.253 ± 0.015	0.679MetTyr: 0.679 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	4.009AsnAla: 4.009 ± 0.067	0.678AsnCys: 0.678 ± 0.027	2.761AsnAsp: 2.761 ± 0.055	2.988AsnGlu: 2.988 ± 0.054	2.397AsnPhe: 2.397 ± 0.052	4.203AsnGly: 4.203 ± 0.092	0.808AsnHis: 0.808 ± 0.029	3.066AsnIle: 3.066 ± 0.058	2.903AsnLys: 2.903 ± 0.058	4.131AsnLeu: 4.131 ± 0.061	1.264AsnMet: 1.264 ± 0.041	2.073AsnAsn: 2.073 ± 0.056	2.299AsnPro: 2.299 ± 0.047	1.221AsnGln: 1.221 ± 0.036	2.193AsnArg: 2.193 ± 0.049	2.872AsnSer: 2.872 ± 0.059	2.222AsnThr: 2.222 ± 0.047	3.583AsnVal: 3.583 ± 0.074	0.665AsnTrp: 0.665 ± 0.026	1.95AsnTyr: 1.95 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	3.163ProAla: 3.163 ± 0.073	0.447ProCys: 0.447 ± 0.021	2.393ProAsp: 2.393 ± 0.052	3.363ProGlu: 3.363 ± 0.064	1.82ProPhe: 1.82 ± 0.045	2.433ProGly: 2.433 ± 0.052	0.682ProHis: 0.682 ± 0.027	2.236ProIle: 2.236 ± 0.049	2.478ProLys: 2.478 ± 0.049	3.127ProLeu: 3.127 ± 0.059	0.943ProMet: 0.943 ± 0.029	1.803ProAsn: 1.803 ± 0.053	1.094ProPro: 1.094 ± 0.041	1.303ProGln: 1.303 ± 0.04	1.411ProArg: 1.411 ± 0.037	2.325ProSer: 2.325 ± 0.048	2.025ProThr: 2.025 ± 0.041	3.038ProVal: 3.038 ± 0.053	0.513ProTrp: 0.513 ± 0.023	1.388ProTyr: 1.388 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.268GlnAla: 2.268 ± 0.047	0.294GlnCys: 0.294 ± 0.018	1.491GlnAsp: 1.491 ± 0.042	1.854GlnGlu: 1.854 ± 0.053	1.374GlnPhe: 1.374 ± 0.031	1.857GlnGly: 1.857 ± 0.04	0.46GlnHis: 0.46 ± 0.02	2.036GlnIle: 2.036 ± 0.046	2.49GlnLys: 2.49 ± 0.051	2.347GlnLeu: 2.347 ± 0.056	0.986GlnMet: 0.986 ± 0.031	1.678GlnAsn: 1.678 ± 0.044	0.91GlnPro: 0.91 ± 0.029	0.944GlnGln: 0.944 ± 0.033	1.178GlnArg: 1.178 ± 0.035	1.763GlnSer: 1.763 ± 0.042	1.564GlnThr: 1.564 ± 0.038	1.98GlnVal: 1.98 ± 0.048	0.38GlnTrp: 0.38 ± 0.019	0.964GlnTyr: 0.964 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.028ArgAla: 3.028 ± 0.051	0.583ArgCys: 0.583 ± 0.024	2.78ArgAsp: 2.78 ± 0.049	3.368ArgGlu: 3.368 ± 0.071	2.3ArgPhe: 2.3 ± 0.05	2.704ArgGly: 2.704 ± 0.057	0.857ArgHis: 0.857 ± 0.028	3.079ArgIle: 3.079 ± 0.059	3.115ArgLys: 3.115 ± 0.061	4.24ArgLeu: 4.24 ± 0.066	1.323ArgMet: 1.323 ± 0.034	2.22ArgAsn: 2.22 ± 0.044	1.55ArgPro: 1.55 ± 0.044	1.21ArgGln: 1.21 ± 0.04	2.123ArgArg: 2.123 ± 0.055	2.485ArgSer: 2.485 ± 0.053	2.164ArgThr: 2.164 ± 0.046	3.027ArgVal: 3.027 ± 0.054	0.568ArgTrp: 0.568 ± 0.028	1.901ArgTyr: 1.901 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.459SerAla: 5.459 ± 0.09	0.936SerCys: 0.936 ± 0.033	3.752SerAsp: 3.752 ± 0.067	4.172SerGlu: 4.172 ± 0.08	3.337SerPhe: 3.337 ± 0.056	4.774SerGly: 4.774 ± 0.089	1.064SerHis: 1.064 ± 0.033	4.158SerIle: 4.158 ± 0.068	4.197SerLys: 4.197 ± 0.077	6.082SerLeu: 6.082 ± 0.091	1.597SerMet: 1.597 ± 0.042	2.772SerAsn: 2.772 ± 0.065	2.285SerPro: 2.285 ± 0.05	1.812SerGln: 1.812 ± 0.043	2.931SerArg: 2.931 ± 0.055	6.298SerSer: 6.298 ± 0.209	3.353SerThr: 3.353 ± 0.077	5.055SerVal: 5.055 ± 0.084	0.933SerTrp: 0.933 ± 0.032	2.366SerTyr: 2.366 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.139ThrAla: 4.139 ± 0.079	0.631ThrCys: 0.631 ± 0.026	3.143ThrAsp: 3.143 ± 0.067	3.125ThrGlu: 3.125 ± 0.052	2.519ThrPhe: 2.519 ± 0.054	4.014ThrGly: 4.014 ± 0.068	0.94ThrHis: 0.94 ± 0.029	3.464ThrIle: 3.464 ± 0.068	2.903ThrLys: 2.903 ± 0.057	5.235ThrLeu: 5.235 ± 0.078	1.211ThrMet: 1.211 ± 0.037	2.129ThrAsn: 2.129 ± 0.043	2.602ThrPro: 2.602 ± 0.048	1.494ThrGln: 1.494 ± 0.042	2.059ThrArg: 2.059 ± 0.043	3.29ThrSer: 3.29 ± 0.056	2.927ThrThr: 2.927 ± 0.059	3.914ThrVal: 3.914 ± 0.083	0.717ThrTrp: 0.717 ± 0.029	1.908ThrTyr: 1.908 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.869ValAla: 5.869 ± 0.086	1.091ValCys: 1.091 ± 0.036	4.182ValAsp: 4.182 ± 0.066	4.457ValGlu: 4.457 ± 0.07	3.217ValPhe: 3.217 ± 0.055	4.6ValGly: 4.6 ± 0.087	1.202ValHis: 1.202 ± 0.031	3.911ValIle: 3.911 ± 0.068	4.769ValLys: 4.769 ± 0.066	6.137ValLeu: 6.137 ± 0.085	1.703ValMet: 1.703 ± 0.044	3.375ValAsn: 3.375 ± 0.074	2.743ValPro: 2.743 ± 0.048	2.035ValGln: 2.035 ± 0.04	3.297ValArg: 3.297 ± 0.061	4.965ValSer: 4.965 ± 0.081	3.767ValThr: 3.767 ± 0.079	5.127ValVal: 5.127 ± 0.076	0.812ValTrp: 0.812 ± 0.024	2.438ValTyr: 2.438 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.822TrpAla: 0.822 ± 0.028	0.169TrpCys: 0.169 ± 0.013	0.818TrpAsp: 0.818 ± 0.032	0.677TrpGlu: 0.677 ± 0.031	0.604TrpPhe: 0.604 ± 0.024	0.825TrpGly: 0.825 ± 0.032	0.309TrpHis: 0.309 ± 0.017	0.8TrpIle: 0.8 ± 0.031	0.946TrpLys: 0.946 ± 0.034	1.096TrpLeu: 1.096 ± 0.036	0.441TrpMet: 0.441 ± 0.024	0.947TrpAsn: 0.947 ± 0.045	0.371TrpPro: 0.371 ± 0.021	0.432TrpGln: 0.432 ± 0.02	0.576TrpArg: 0.576 ± 0.027	0.774TrpSer: 0.774 ± 0.03	0.767TrpThr: 0.767 ± 0.03	0.797TrpVal: 0.797 ± 0.027	0.166TrpTrp: 0.166 ± 0.014	0.485TrpTyr: 0.485 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.861TyrAla: 2.861 ± 0.06	0.554TyrCys: 0.554 ± 0.024	2.429TyrAsp: 2.429 ± 0.053	2.343TyrGlu: 2.343 ± 0.051	1.805TyrPhe: 1.805 ± 0.042	2.654TyrGly: 2.654 ± 0.061	0.726TyrHis: 0.726 ± 0.024	2.052TyrIle: 2.052 ± 0.041	2.449TyrLys: 2.449 ± 0.051	3.03TyrLeu: 3.03 ± 0.06	0.895TyrMet: 0.895 ± 0.029	1.807TyrAsn: 1.807 ± 0.043	1.391TyrPro: 1.391 ± 0.038	1.042TyrGln: 1.042 ± 0.03	2.014TyrArg: 2.014 ± 0.049	2.398TyrSer: 2.398 ± 0.048	2.087TyrThr: 2.087 ± 0.055	2.451TyrVal: 2.451 ± 0.053	0.534TyrTrp: 0.534 ± 0.026	1.626TyrTyr: 1.626 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2871 proteins (1073633 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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