Amino acid dipepetide frequency for Tupaia chinensis (Chinese tree shrew)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.759AlaAla: 6.759 ± 0.046	1.577AlaCys: 1.577 ± 0.021	2.935AlaAsp: 2.935 ± 0.018	4.761AlaGlu: 4.761 ± 0.036	2.76AlaPhe: 2.76 ± 0.023	5.035AlaGly: 5.035 ± 0.031	1.678AlaHis: 1.678 ± 0.017	2.844AlaIle: 2.844 ± 0.022	3.482AlaLys: 3.482 ± 0.031	7.659AlaLeu: 7.659 ± 0.042	1.615AlaMet: 1.615 ± 0.014	1.945AlaAsn: 1.945 ± 0.021	4.405AlaPro: 4.405 ± 0.038	3.362AlaGln: 3.362 ± 0.026	3.932AlaArg: 3.932 ± 0.027	5.757AlaSer: 5.757 ± 0.031	3.668AlaThr: 3.668 ± 0.024	5.095AlaVal: 5.095 ± 0.032	0.861AlaTrp: 0.861 ± 0.011	1.57AlaTyr: 1.57 ± 0.014	0.012AlaXaa: 0.012 ± 0.001
Cys	1.464CysAla: 1.464 ± 0.016	0.667CysCys: 0.667 ± 0.014	1.016CysAsp: 1.016 ± 0.015	1.272CysGlu: 1.272 ± 0.016	0.869CysPhe: 0.869 ± 0.01	1.895CysGly: 1.895 ± 0.024	0.702CysHis: 0.702 ± 0.01	0.91CysIle: 0.91 ± 0.012	1.076CysLys: 1.076 ± 0.013	2.159CysLeu: 2.159 ± 0.02	0.449CysMet: 0.449 ± 0.007	0.759CysAsn: 0.759 ± 0.012	1.503CysPro: 1.503 ± 0.022	1.085CysGln: 1.085 ± 0.023	1.384CysArg: 1.384 ± 0.016	2.14CysSer: 2.14 ± 0.02	1.19CysThr: 1.19 ± 0.016	1.422CysVal: 1.422 ± 0.019	0.315CysTrp: 0.315 ± 0.007	0.593CysTyr: 0.593 ± 0.008	0.002CysXaa: 0.002 ± 0.0
Asp	2.894AspAla: 2.894 ± 0.019	1.018AspCys: 1.018 ± 0.012	2.501AspAsp: 2.501 ± 0.025	3.297AspGlu: 3.297 ± 0.026	1.999AspPhe: 1.999 ± 0.016	3.178AspGly: 3.178 ± 0.028	1.094AspHis: 1.094 ± 0.013	2.493AspIle: 2.493 ± 0.023	2.399AspLys: 2.399 ± 0.018	4.836AspLeu: 4.836 ± 0.032	1.119AspMet: 1.119 ± 0.012	1.547AspAsn: 1.547 ± 0.015	2.843AspPro: 2.843 ± 0.021	1.774AspGln: 1.774 ± 0.017	2.528AspArg: 2.528 ± 0.021	4.07AspSer: 4.07 ± 0.031	2.497AspThr: 2.497 ± 0.02	3.094AspVal: 3.094 ± 0.031	0.624AspTrp: 0.624 ± 0.009	1.338AspTyr: 1.338 ± 0.014	0.002AspXaa: 0.002 ± 0.0
Glu	5.244GluAla: 5.244 ± 0.041	1.356GluCys: 1.356 ± 0.024	4.355GluAsp: 4.355 ± 0.029	8.087GluGlu: 8.087 ± 0.114	1.929GluPhe: 1.929 ± 0.014	4.35GluGly: 4.35 ± 0.046	1.49GluHis: 1.49 ± 0.012	2.885GluIle: 2.885 ± 0.025	5.249GluLys: 5.249 ± 0.047	6.268GluLeu: 6.268 ± 0.044	1.597GluMet: 1.597 ± 0.021	2.846GluAsn: 2.846 ± 0.024	3.236GluPro: 3.236 ± 0.025	3.063GluGln: 3.063 ± 0.028	3.91GluArg: 3.91 ± 0.037	4.074GluSer: 4.074 ± 0.03	3.214GluThr: 3.214 ± 0.028	4.201GluVal: 4.201 ± 0.042	0.665GluTrp: 0.665 ± 0.01	1.447GluTyr: 1.447 ± 0.019	0.006GluXaa: 0.006 ± 0.001
Phe	1.997PheAla: 1.997 ± 0.017	1.056PheCys: 1.056 ± 0.012	1.597PheAsp: 1.597 ± 0.016	1.835PheGlu: 1.835 ± 0.017	1.7PhePhe: 1.7 ± 0.021	2.248PheGly: 2.248 ± 0.021	1.0PheHis: 1.0 ± 0.012	1.826PheIle: 1.826 ± 0.02	1.63PheLys: 1.63 ± 0.016	4.292PheLeu: 4.292 ± 0.031	0.79PheMet: 0.79 ± 0.01	1.228PheAsn: 1.228 ± 0.012	1.966PhePro: 1.966 ± 0.016	1.715PheGln: 1.715 ± 0.015	1.932PheArg: 1.932 ± 0.019	3.444PheSer: 3.444 ± 0.021	2.01PheThr: 2.01 ± 0.019	2.222PheVal: 2.222 ± 0.019	0.477PheTrp: 0.477 ± 0.009	1.23PheTyr: 1.23 ± 0.014	0.001PheXaa: 0.001 ± 0.0
Gly	4.759GlyAla: 4.759 ± 0.035	1.403GlyCys: 1.403 ± 0.016	3.141GlyAsp: 3.141 ± 0.024	4.182GlyGlu: 4.182 ± 0.033	2.422GlyPhe: 2.422 ± 0.025	5.104GlyGly: 5.104 ± 0.049	1.783GlyHis: 1.783 ± 0.02	2.678GlyIle: 2.678 ± 0.023	3.885GlyLys: 3.885 ± 0.045	6.212GlyLeu: 6.212 ± 0.036	1.309GlyMet: 1.309 ± 0.014	2.293GlyAsn: 2.293 ± 0.019	4.48GlyPro: 4.48 ± 0.053	2.88GlyGln: 2.88 ± 0.028	4.012GlyArg: 4.012 ± 0.026	5.81GlySer: 5.81 ± 0.035	3.801GlyThr: 3.801 ± 0.029	3.788GlyVal: 3.788 ± 0.026	0.824GlyTrp: 0.824 ± 0.011	1.663GlyTyr: 1.663 ± 0.019	0.012GlyXaa: 0.012 ± 0.001
His	1.412HisAla: 1.412 ± 0.014	0.727HisCys: 0.727 ± 0.011	0.847HisAsp: 0.847 ± 0.011	1.25HisGlu: 1.25 ± 0.014	1.133HisPhe: 1.133 ± 0.013	1.656HisGly: 1.656 ± 0.02	0.842HisHis: 0.842 ± 0.017	1.185HisIle: 1.185 ± 0.013	1.197HisLys: 1.197 ± 0.013	2.99HisLeu: 2.99 ± 0.022	0.587HisMet: 0.587 ± 0.01	0.779HisAsn: 0.779 ± 0.011	1.69HisPro: 1.69 ± 0.015	1.347HisGln: 1.347 ± 0.016	1.658HisArg: 1.658 ± 0.016	2.271HisSer: 2.271 ± 0.018	1.624HisThr: 1.624 ± 0.021	1.554HisVal: 1.554 ± 0.013	0.364HisTrp: 0.364 ± 0.007	0.809HisTyr: 0.809 ± 0.011	0.002HisXaa: 0.002 ± 0.0
Ile	2.53IleAla: 2.53 ± 0.019	1.118IleCys: 1.118 ± 0.013	1.877IleAsp: 1.877 ± 0.017	2.327IleGlu: 2.327 ± 0.021	1.849IlePhe: 1.849 ± 0.019	2.101IleGly: 2.101 ± 0.017	1.306IleHis: 1.306 ± 0.016	2.279IleIle: 2.279 ± 0.024	2.353IleLys: 2.353 ± 0.025	4.551IleLeu: 4.551 ± 0.035	0.984IleMet: 0.984 ± 0.011	1.664IleAsn: 1.664 ± 0.015	2.497IlePro: 2.497 ± 0.022	2.075IleGln: 2.075 ± 0.018	2.325IleArg: 2.325 ± 0.017	3.557IleSer: 3.557 ± 0.026	2.49IleThr: 2.49 ± 0.028	2.493IleVal: 2.493 ± 0.021	0.503IleTrp: 0.503 ± 0.018	1.409IleTyr: 1.409 ± 0.02	0.001IleXaa: 0.001 ± 0.0
Lys	4.234LysAla: 4.234 ± 0.032	1.049LysCys: 1.049 ± 0.014	2.966LysAsp: 2.966 ± 0.027	4.975LysGlu: 4.975 ± 0.058	1.646LysPhe: 1.646 ± 0.014	3.305LysGly: 3.305 ± 0.034	1.355LysHis: 1.355 ± 0.013	2.556LysIle: 2.556 ± 0.024	4.823LysLys: 4.823 ± 0.056	4.84LysLeu: 4.84 ± 0.034	1.447LysMet: 1.447 ± 0.017	2.14LysAsn: 2.14 ± 0.019	3.0LysPro: 3.0 ± 0.03	2.412LysGln: 2.412 ± 0.023	3.255LysArg: 3.255 ± 0.024	3.607LysSer: 3.607 ± 0.027	2.949LysThr: 2.949 ± 0.023	3.437LysVal: 3.437 ± 0.029	0.551LysTrp: 0.551 ± 0.008	1.466LysTyr: 1.466 ± 0.017	0.002LysXaa: 0.002 ± 0.0
Leu	7.303LeuAla: 7.303 ± 0.042	2.348LeuCys: 2.348 ± 0.021	4.562LeuAsp: 4.562 ± 0.03	6.794LeuGlu: 6.794 ± 0.049	3.409LeuPhe: 3.409 ± 0.027	6.31LeuGly: 6.31 ± 0.038	2.802LeuHis: 2.802 ± 0.02	3.803LeuIle: 3.803 ± 0.029	5.367LeuLys: 5.367 ± 0.037	11.099LeuLeu: 11.099 ± 0.064	2.014LeuMet: 2.014 ± 0.018	3.252LeuAsn: 3.252 ± 0.024	6.061LeuPro: 6.061 ± 0.037	5.604LeuGln: 5.604 ± 0.037	6.261LeuArg: 6.261 ± 0.039	8.256LeuSer: 8.256 ± 0.043	5.263LeuThr: 5.263 ± 0.033	5.921LeuVal: 5.921 ± 0.045	1.222LeuTrp: 1.222 ± 0.014	2.435LeuTyr: 2.435 ± 0.02	0.012LeuXaa: 0.012 ± 0.001
Met	2.043MetAla: 2.043 ± 0.018	0.405MetCys: 0.405 ± 0.007	1.185MetAsp: 1.185 ± 0.014	1.777MetGlu: 1.777 ± 0.022	0.72MetPhe: 0.72 ± 0.009	1.338MetGly: 1.338 ± 0.014	0.454MetHis: 0.454 ± 0.007	0.813MetIle: 0.813 ± 0.01	1.37MetLys: 1.37 ± 0.014	2.052MetLeu: 2.052 ± 0.019	0.54MetMet: 0.54 ± 0.01	0.829MetAsn: 0.829 ± 0.011	1.094MetPro: 1.094 ± 0.017	0.88MetGln: 0.88 ± 0.011	1.067MetArg: 1.067 ± 0.009	1.53MetSer: 1.53 ± 0.016	1.111MetThr: 1.111 ± 0.013	1.508MetVal: 1.508 ± 0.022	0.238MetTrp: 0.238 ± 0.005	0.715MetTyr: 0.715 ± 0.009	0.001MetXaa: 0.001 ± 0.0
Asn	1.971AsnAla: 1.971 ± 0.017	0.775AsnCys: 0.775 ± 0.012	1.417AsnAsp: 1.417 ± 0.014	2.02AsnGlu: 2.02 ± 0.02	1.352AsnPhe: 1.352 ± 0.013	2.272AsnGly: 2.272 ± 0.021	0.883AsnHis: 0.883 ± 0.014	1.896AsnIle: 1.896 ± 0.024	2.053AsnLys: 2.053 ± 0.018	3.469AsnLeu: 3.469 ± 0.025	0.824AsnMet: 0.824 ± 0.009	1.308AsnAsn: 1.308 ± 0.013	2.12AsnPro: 2.12 ± 0.018	1.481AsnGln: 1.481 ± 0.015	1.699AsnArg: 1.699 ± 0.014	2.781AsnSer: 2.781 ± 0.024	1.81AsnThr: 1.81 ± 0.019	2.134AsnVal: 2.134 ± 0.018	0.419AsnTrp: 0.419 ± 0.006	0.97AsnTyr: 0.97 ± 0.012	0.001AsnXaa: 0.001 ± 0.0
Pro	5.049ProAla: 5.049 ± 0.042	1.302ProCys: 1.302 ± 0.017	2.762ProAsp: 2.762 ± 0.029	4.414ProGlu: 4.414 ± 0.03	1.969ProPhe: 1.969 ± 0.017	5.343ProGly: 5.343 ± 0.057	1.475ProHis: 1.475 ± 0.017	1.766ProIle: 1.766 ± 0.017	2.794ProLys: 2.794 ± 0.035	5.424ProLeu: 5.424 ± 0.034	1.156ProMet: 1.156 ± 0.018	1.683ProAsn: 1.683 ± 0.016	5.795ProPro: 5.795 ± 0.114	2.77ProGln: 2.77 ± 0.029	3.577ProArg: 3.577 ± 0.028	5.572ProSer: 5.572 ± 0.038	3.069ProThr: 3.069 ± 0.027	3.852ProVal: 3.852 ± 0.028	0.764ProTrp: 0.764 ± 0.01	1.505ProTyr: 1.505 ± 0.026	0.013ProXaa: 0.013 ± 0.001
Gln	3.565GlnAla: 3.565 ± 0.033	0.962GlnCys: 0.962 ± 0.017	2.252GlnAsp: 2.252 ± 0.018	3.733GlnGlu: 3.733 ± 0.033	1.25GlnPhe: 1.25 ± 0.013	2.966GlnGly: 2.966 ± 0.023	1.275GlnHis: 1.275 ± 0.015	1.85GlnIle: 1.85 ± 0.016	2.811GlnLys: 2.811 ± 0.023	4.668GlnLeu: 4.668 ± 0.031	1.069GlnMet: 1.069 ± 0.013	1.676GlnAsn: 1.676 ± 0.016	2.707GlnPro: 2.707 ± 0.023	2.733GlnGln: 2.733 ± 0.036	2.974GlnArg: 2.974 ± 0.024	3.018GlnSer: 3.018 ± 0.026	2.254GlnThr: 2.254 ± 0.025	2.871GlnVal: 2.871 ± 0.019	0.52GlnTrp: 0.52 ± 0.007	1.096GlnTyr: 1.096 ± 0.015	0.003GlnXaa: 0.003 ± 0.001
Arg	4.273ArgAla: 4.273 ± 0.029	1.277ArgCys: 1.277 ± 0.018	2.722ArgAsp: 2.722 ± 0.023	3.977ArgGlu: 3.977 ± 0.032	1.832ArgPhe: 1.832 ± 0.016	3.845ArgGly: 3.845 ± 0.027	1.588ArgHis: 1.588 ± 0.015	2.36ArgIle: 2.36 ± 0.019	3.746ArgLys: 3.746 ± 0.031	5.481ArgLeu: 5.481 ± 0.038	1.168ArgMet: 1.168 ± 0.012	2.051ArgAsn: 2.051 ± 0.015	3.423ArgPro: 3.423 ± 0.028	2.616ArgGln: 2.616 ± 0.027	4.432ArgArg: 4.432 ± 0.034	4.163ArgSer: 4.163 ± 0.03	2.892ArgThr: 2.892 ± 0.02	3.413ArgVal: 3.413 ± 0.027	0.725ArgTrp: 0.725 ± 0.009	1.515ArgTyr: 1.515 ± 0.016	0.009ArgXaa: 0.009 ± 0.001
Ser	5.429SerAla: 5.429 ± 0.029	1.926SerCys: 1.926 ± 0.017	3.715SerAsp: 3.715 ± 0.033	5.06SerGlu: 5.06 ± 0.035	3.022SerPhe: 3.022 ± 0.022	5.643SerGly: 5.643 ± 0.045	2.182SerHis: 2.182 ± 0.018	3.016SerIle: 3.016 ± 0.022	3.778SerLys: 3.778 ± 0.025	8.141SerLeu: 8.141 ± 0.042	1.573SerMet: 1.573 ± 0.021	2.408SerAsn: 2.408 ± 0.022	5.851SerPro: 5.851 ± 0.045	3.686SerGln: 3.686 ± 0.027	4.539SerArg: 4.539 ± 0.028	8.838SerSer: 8.838 ± 0.075	4.384SerThr: 4.384 ± 0.043	5.001SerVal: 5.001 ± 0.028	1.116SerTrp: 1.116 ± 0.013	2.056SerTyr: 2.056 ± 0.018	0.006SerXaa: 0.006 ± 0.001
Thr	3.902ThrAla: 3.902 ± 0.023	1.423ThrCys: 1.423 ± 0.016	2.4ThrAsp: 2.4 ± 0.022	3.458ThrGlu: 3.458 ± 0.03	2.103ThrPhe: 2.103 ± 0.016	3.706ThrGly: 3.706 ± 0.027	1.37ThrHis: 1.37 ± 0.017	2.379ThrIle: 2.379 ± 0.025	2.543ThrLys: 2.543 ± 0.022	5.352ThrLeu: 5.352 ± 0.027	1.113ThrMet: 1.113 ± 0.013	1.6ThrAsn: 1.6 ± 0.016	3.598ThrPro: 3.598 ± 0.031	2.316ThrGln: 2.316 ± 0.018	2.566ThrArg: 2.566 ± 0.021	4.458ThrSer: 4.458 ± 0.059	3.004ThrThr: 3.004 ± 0.045	4.144ThrVal: 4.144 ± 0.029	0.733ThrTrp: 0.733 ± 0.011	1.4ThrTyr: 1.4 ± 0.014	0.005ThrXaa: 0.005 ± 0.001
Val	4.552ValAla: 4.552 ± 0.031	1.557ValCys: 1.557 ± 0.017	2.985ValAsp: 2.985 ± 0.028	3.797ValGlu: 3.797 ± 0.034	2.524ValPhe: 2.524 ± 0.02	3.659ValGly: 3.659 ± 0.031	1.602ValHis: 1.602 ± 0.016	2.979ValIle: 2.979 ± 0.027	3.293ValLys: 3.293 ± 0.029	6.72ValLeu: 6.72 ± 0.041	1.433ValMet: 1.433 ± 0.021	2.165ValAsn: 2.165 ± 0.016	3.925ValPro: 3.925 ± 0.03	2.763ValGln: 2.763 ± 0.019	3.181ValArg: 3.181 ± 0.022	4.961ValSer: 4.961 ± 0.028	4.128ValThr: 4.128 ± 0.04	4.41ValVal: 4.41 ± 0.044	0.746ValTrp: 0.746 ± 0.009	1.647ValTyr: 1.647 ± 0.017	0.003ValXaa: 0.003 ± 0.001
Trp	0.922TrpAla: 0.922 ± 0.011	0.244TrpCys: 0.244 ± 0.006	0.636TrpAsp: 0.636 ± 0.009	0.812TrpGlu: 0.812 ± 0.019	0.44TrpPhe: 0.44 ± 0.007	0.811TrpGly: 0.811 ± 0.012	0.312TrpHis: 0.312 ± 0.006	0.503TrpIle: 0.503 ± 0.008	0.783TrpLys: 0.783 ± 0.011	1.228TrpLeu: 1.228 ± 0.013	0.294TrpMet: 0.294 ± 0.005	0.493TrpAsn: 0.493 ± 0.008	0.569TrpPro: 0.569 ± 0.009	0.533TrpGln: 0.533 ± 0.008	0.747TrpArg: 0.747 ± 0.01	0.851TrpSer: 0.851 ± 0.011	0.687TrpThr: 0.687 ± 0.011	0.808TrpVal: 0.808 ± 0.011	0.193TrpTrp: 0.193 ± 0.005	0.328TrpTyr: 0.328 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.397TyrAla: 1.397 ± 0.012	0.676TyrCys: 0.676 ± 0.01	1.272TyrAsp: 1.272 ± 0.013	1.642TyrGlu: 1.642 ± 0.017	1.265TyrPhe: 1.265 ± 0.016	1.665TyrGly: 1.665 ± 0.019	0.732TyrHis: 0.732 ± 0.011	1.266TyrIle: 1.266 ± 0.016	1.379TyrLys: 1.379 ± 0.022	2.649TyrLeu: 2.649 ± 0.023	0.587TyrMet: 0.587 ± 0.008	0.986TyrAsn: 0.986 ± 0.011	1.277TyrPro: 1.277 ± 0.013	1.151TyrGln: 1.151 ± 0.013	1.521TyrArg: 1.521 ± 0.016	2.205TyrSer: 2.205 ± 0.024	1.53TyrThr: 1.53 ± 0.015	1.659TyrVal: 1.659 ± 0.015	0.336TyrTrp: 0.336 ± 0.007	0.871TyrTyr: 0.871 ± 0.012	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.009XaaAla: 0.009 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.005XaaGlu: 0.005 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.011XaaGly: 0.011 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.003XaaLys: 0.003 ± 0.0	0.008XaaLeu: 0.008 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.003XaaAsn: 0.003 ± 0.001	0.015XaaPro: 0.015 ± 0.001	0.004XaaGln: 0.004 ± 0.001	0.011XaaArg: 0.011 ± 0.001	0.007XaaSer: 0.007 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.004XaaVal: 0.004 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	4.361XaaXaa: 4.361 ± 0.367

Statistics based on 20824 proteins (9847371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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