Amino acid dipepetide frequency for Lysobacter dokdonensis DS-58

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.619AlaAla: 16.619 ± 0.18	1.378AlaCys: 1.378 ± 0.036	7.24AlaAsp: 7.24 ± 0.095	6.264AlaGlu: 6.264 ± 0.098	4.569AlaPhe: 4.569 ± 0.075	10.47AlaGly: 10.47 ± 0.118	2.999AlaHis: 2.999 ± 0.069	5.888AlaIle: 5.888 ± 0.083	4.242AlaLys: 4.242 ± 0.083	15.174AlaLeu: 15.174 ± 0.145	3.775AlaMet: 3.775 ± 0.065	3.292AlaAsn: 3.292 ± 0.062	6.628AlaPro: 6.628 ± 0.086	5.414AlaGln: 5.414 ± 0.09	10.169AlaArg: 10.169 ± 0.13	6.571AlaSer: 6.571 ± 0.082	6.905AlaThr: 6.905 ± 0.103	8.615AlaVal: 8.615 ± 0.107	2.416AlaTrp: 2.416 ± 0.059	2.716AlaTyr: 2.716 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.147CysAla: 1.147 ± 0.037	0.125CysCys: 0.125 ± 0.012	0.55CysAsp: 0.55 ± 0.027	0.453CysGlu: 0.453 ± 0.019	0.319CysPhe: 0.319 ± 0.018	0.899CysGly: 0.899 ± 0.037	0.233CysHis: 0.233 ± 0.015	0.36CysIle: 0.36 ± 0.019	0.249CysLys: 0.249 ± 0.015	0.697CysLeu: 0.697 ± 0.026	0.158CysMet: 0.158 ± 0.013	0.228CysAsn: 0.228 ± 0.015	0.442CysPro: 0.442 ± 0.026	0.181CysGln: 0.181 ± 0.013	0.554CysArg: 0.554 ± 0.026	0.381CysSer: 0.381 ± 0.023	0.497CysThr: 0.497 ± 0.023	0.743CysVal: 0.743 ± 0.027	0.131CysTrp: 0.131 ± 0.011	0.179CysTyr: 0.179 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	10.028AspAla: 10.028 ± 0.125	0.443AspCys: 0.443 ± 0.021	4.004AspAsp: 4.004 ± 0.081	3.387AspGlu: 3.387 ± 0.072	2.226AspPhe: 2.226 ± 0.058	6.001AspGly: 6.001 ± 0.098	1.176AspHis: 1.176 ± 0.036	2.614AspIle: 2.614 ± 0.063	1.819AspLys: 1.819 ± 0.051	5.585AspLeu: 5.585 ± 0.071	1.22AspMet: 1.22 ± 0.034	1.384AspAsn: 1.384 ± 0.04	3.544AspPro: 3.544 ± 0.06	1.584AspGln: 1.584 ± 0.042	4.262AspArg: 4.262 ± 0.068	2.44AspSer: 2.44 ± 0.056	3.19AspThr: 3.19 ± 0.064	4.903AspVal: 4.903 ± 0.071	1.127AspTrp: 1.127 ± 0.035	1.636AspTyr: 1.636 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.686GluAla: 6.686 ± 0.102	0.395GluCys: 0.395 ± 0.02	2.657GluAsp: 2.657 ± 0.055	2.433GluGlu: 2.433 ± 0.06	1.863GluPhe: 1.863 ± 0.046	4.111GluGly: 4.111 ± 0.059	1.421GluHis: 1.421 ± 0.041	2.412GluIle: 2.412 ± 0.05	1.643GluLys: 1.643 ± 0.053	5.417GluLeu: 5.417 ± 0.084	1.236GluMet: 1.236 ± 0.038	1.244GluAsn: 1.244 ± 0.043	2.336GluPro: 2.336 ± 0.05	2.161GluGln: 2.161 ± 0.051	5.124GluArg: 5.124 ± 0.088	2.738GluSer: 2.738 ± 0.055	2.706GluThr: 2.706 ± 0.049	3.665GluVal: 3.665 ± 0.065	0.755GluTrp: 0.755 ± 0.027	1.135GluTyr: 1.135 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.974PheAla: 4.974 ± 0.081	0.332PheCys: 0.332 ± 0.018	3.128PheAsp: 3.128 ± 0.056	2.122PheGlu: 2.122 ± 0.043	1.266PhePhe: 1.266 ± 0.045	3.523PheGly: 3.523 ± 0.06	0.758PheHis: 0.758 ± 0.025	1.239PheIle: 1.239 ± 0.04	0.915PheLys: 0.915 ± 0.037	3.121PheLeu: 3.121 ± 0.059	0.61PheMet: 0.61 ± 0.025	1.018PheAsn: 1.018 ± 0.032	1.436PhePro: 1.436 ± 0.039	0.88PheGln: 0.88 ± 0.031	2.283PheArg: 2.283 ± 0.055	1.777PheSer: 1.777 ± 0.046	1.784PheThr: 1.784 ± 0.045	2.907PheVal: 2.907 ± 0.061	0.519PheTrp: 0.519 ± 0.022	0.8PheTyr: 0.8 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.591GlyAla: 9.591 ± 0.108	0.803GlyCys: 0.803 ± 0.029	5.333GlyAsp: 5.333 ± 0.099	4.645GlyGlu: 4.645 ± 0.065	3.396GlyPhe: 3.396 ± 0.063	7.118GlyGly: 7.118 ± 0.123	1.957GlyHis: 1.957 ± 0.048	3.893GlyIle: 3.893 ± 0.074	3.352GlyLys: 3.352 ± 0.07	8.175GlyLeu: 8.175 ± 0.111	2.302GlyMet: 2.302 ± 0.054	2.437GlyAsn: 2.437 ± 0.064	3.159GlyPro: 3.159 ± 0.055	2.785GlyGln: 2.785 ± 0.052	5.972GlyArg: 5.972 ± 0.08	3.991GlySer: 3.991 ± 0.065	4.813GlyThr: 4.813 ± 0.091	6.479GlyVal: 6.479 ± 0.083	1.575GlyTrp: 1.575 ± 0.039	2.337GlyTyr: 2.337 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	3.519HisAla: 3.519 ± 0.075	0.26HisCys: 0.26 ± 0.017	1.5HisAsp: 1.5 ± 0.036	1.125HisGlu: 1.125 ± 0.036	0.842HisPhe: 0.842 ± 0.031	2.347HisGly: 2.347 ± 0.05	0.61HisHis: 0.61 ± 0.025	0.731HisIle: 0.731 ± 0.027	0.491HisLys: 0.491 ± 0.024	2.137HisLeu: 2.137 ± 0.051	0.439HisMet: 0.439 ± 0.021	0.473HisAsn: 0.473 ± 0.021	1.426HisPro: 1.426 ± 0.041	0.568HisGln: 0.568 ± 0.025	1.793HisArg: 1.793 ± 0.041	0.905HisSer: 0.905 ± 0.034	0.939HisThr: 0.939 ± 0.03	1.84HisVal: 1.84 ± 0.044	0.455HisTrp: 0.455 ± 0.021	0.571HisTyr: 0.571 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.28IleAla: 7.28 ± 0.092	0.297IleCys: 0.297 ± 0.016	3.677IleAsp: 3.677 ± 0.068	3.05IleGlu: 3.05 ± 0.054	1.104IlePhe: 1.104 ± 0.038	4.31IleGly: 4.31 ± 0.079	0.743IleHis: 0.743 ± 0.028	1.202IleIle: 1.202 ± 0.04	1.033IleLys: 1.033 ± 0.037	2.912IleLeu: 2.912 ± 0.053	0.489IleMet: 0.489 ± 0.023	1.086IleAsn: 1.086 ± 0.032	2.134IlePro: 2.134 ± 0.048	0.984IleGln: 0.984 ± 0.035	2.714IleArg: 2.714 ± 0.051	1.849IleSer: 1.849 ± 0.047	2.188IleThr: 2.188 ± 0.051	3.838IleVal: 3.838 ± 0.067	0.412IleTrp: 0.412 ± 0.021	0.74IleTyr: 0.74 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.676LysAla: 3.676 ± 0.077	0.183LysCys: 0.183 ± 0.014	1.768LysAsp: 1.768 ± 0.054	1.337LysGlu: 1.337 ± 0.045	0.923LysPhe: 0.923 ± 0.031	2.213LysGly: 2.213 ± 0.054	0.744LysHis: 0.744 ± 0.025	1.264LysIle: 1.264 ± 0.041	1.231LysLys: 1.231 ± 0.061	3.114LysLeu: 3.114 ± 0.066	0.703LysMet: 0.703 ± 0.026	0.736LysAsn: 0.736 ± 0.03	2.121LysPro: 2.121 ± 0.056	1.266LysGln: 1.266 ± 0.036	2.476LysArg: 2.476 ± 0.049	1.601LysSer: 1.601 ± 0.045	1.653LysThr: 1.653 ± 0.049	2.187LysVal: 2.187 ± 0.05	0.411LysTrp: 0.411 ± 0.018	0.696LysTyr: 0.696 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	14.032LeuAla: 14.032 ± 0.158	0.918LeuCys: 0.918 ± 0.032	6.743LeuAsp: 6.743 ± 0.097	4.985LeuGlu: 4.985 ± 0.087	3.407LeuPhe: 3.407 ± 0.069	8.044LeuGly: 8.044 ± 0.114	2.516LeuHis: 2.516 ± 0.052	3.576LeuIle: 3.576 ± 0.057	2.799LeuLys: 2.799 ± 0.059	10.294LeuLeu: 10.294 ± 0.152	2.002LeuMet: 2.002 ± 0.051	2.123LeuAsn: 2.123 ± 0.047	5.838LeuPro: 5.838 ± 0.08	3.51LeuGln: 3.51 ± 0.063	8.906LeuArg: 8.906 ± 0.098	5.499LeuSer: 5.499 ± 0.072	4.57LeuThr: 4.57 ± 0.081	7.822LeuVal: 7.822 ± 0.104	1.339LeuTrp: 1.339 ± 0.048	2.072LeuTyr: 2.072 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.757MetAla: 2.757 ± 0.054	0.152MetCys: 0.152 ± 0.013	1.218MetAsp: 1.218 ± 0.038	1.052MetGlu: 1.052 ± 0.036	0.69MetPhe: 0.69 ± 0.029	1.619MetGly: 1.619 ± 0.04	0.626MetHis: 0.626 ± 0.025	0.885MetIle: 0.885 ± 0.038	0.826MetLys: 0.826 ± 0.026	2.368MetLeu: 2.368 ± 0.049	0.462MetMet: 0.462 ± 0.025	0.682MetAsn: 0.682 ± 0.026	1.567MetPro: 1.567 ± 0.041	1.054MetGln: 1.054 ± 0.035	2.167MetArg: 2.167 ± 0.044	1.399MetSer: 1.399 ± 0.038	1.442MetThr: 1.442 ± 0.037	1.543MetVal: 1.543 ± 0.041	0.232MetTrp: 0.232 ± 0.015	0.4MetTyr: 0.4 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.723AsnAla: 3.723 ± 0.073	0.223AsnCys: 0.223 ± 0.016	1.576AsnAsp: 1.576 ± 0.039	1.201AsnGlu: 1.201 ± 0.034	0.88AsnPhe: 0.88 ± 0.034	2.57AsnGly: 2.57 ± 0.068	0.479AsnHis: 0.479 ± 0.024	1.058AsnIle: 1.058 ± 0.035	0.681AsnLys: 0.681 ± 0.027	2.324AsnLeu: 2.324 ± 0.053	0.413AsnMet: 0.413 ± 0.019	0.71AsnAsn: 0.71 ± 0.032	1.689AsnPro: 1.689 ± 0.042	0.663AsnGln: 0.663 ± 0.026	1.673AsnArg: 1.673 ± 0.04	1.059AsnSer: 1.059 ± 0.033	1.434AsnThr: 1.434 ± 0.046	2.038AsnVal: 2.038 ± 0.047	0.393AsnTrp: 0.393 ± 0.021	0.611AsnTyr: 0.611 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.892ProAla: 6.892 ± 0.099	0.34ProCys: 0.34 ± 0.022	3.653ProAsp: 3.653 ± 0.068	3.238ProGlu: 3.238 ± 0.063	1.727ProPhe: 1.727 ± 0.041	4.503ProGly: 4.503 ± 0.066	1.134ProHis: 1.134 ± 0.03	2.199ProIle: 2.199 ± 0.042	1.697ProLys: 1.697 ± 0.051	4.807ProLeu: 4.807 ± 0.071	1.437ProMet: 1.437 ± 0.039	1.44ProAsn: 1.44 ± 0.039	2.948ProPro: 2.948 ± 0.078	1.915ProGln: 1.915 ± 0.043	3.572ProArg: 3.572 ± 0.065	2.579ProSer: 2.579 ± 0.051	2.616ProThr: 2.616 ± 0.052	4.194ProVal: 4.194 ± 0.066	0.866ProTrp: 0.866 ± 0.031	1.141ProTyr: 1.141 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.712GlnAla: 4.712 ± 0.072	0.241GlnCys: 0.241 ± 0.017	1.534GlnAsp: 1.534 ± 0.044	1.256GlnGlu: 1.256 ± 0.033	1.199GlnPhe: 1.199 ± 0.036	2.597GlnGly: 2.597 ± 0.053	0.81GlnHis: 0.81 ± 0.03	1.389GlnIle: 1.389 ± 0.041	0.972GlnLys: 0.972 ± 0.034	3.612GlnLeu: 3.612 ± 0.058	0.86GlnMet: 0.86 ± 0.03	0.685GlnAsn: 0.685 ± 0.029	2.017GlnPro: 2.017 ± 0.05	1.549GlnGln: 1.549 ± 0.05	3.333GlnArg: 3.333 ± 0.067	1.789GlnSer: 1.789 ± 0.044	1.52GlnThr: 1.52 ± 0.04	2.848GlnVal: 2.848 ± 0.058	0.62GlnTrp: 0.62 ± 0.022	0.798GlnTyr: 0.798 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	9.551ArgAla: 9.551 ± 0.123	0.578ArgCys: 0.578 ± 0.024	5.092ArgAsp: 5.092 ± 0.08	4.789ArgGlu: 4.789 ± 0.067	3.06ArgPhe: 3.06 ± 0.053	5.458ArgGly: 5.458 ± 0.077	1.791ArgHis: 1.791 ± 0.047	4.08ArgIle: 4.08 ± 0.064	2.425ArgLys: 2.425 ± 0.054	7.71ArgLeu: 7.71 ± 0.103	2.305ArgMet: 2.305 ± 0.045	2.227ArgAsn: 2.227 ± 0.048	3.215ArgPro: 3.215 ± 0.062	2.415ArgGln: 2.415 ± 0.05	5.823ArgArg: 5.823 ± 0.099	3.334ArgSer: 3.334 ± 0.062	4.164ArgThr: 4.164 ± 0.068	5.919ArgVal: 5.919 ± 0.085	1.465ArgTrp: 1.465 ± 0.038	2.056ArgTyr: 2.056 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.776SerAla: 5.776 ± 0.078	0.371SerCys: 0.371 ± 0.022	2.836SerAsp: 2.836 ± 0.054	2.457SerGlu: 2.457 ± 0.048	1.739SerPhe: 1.739 ± 0.049	4.61SerGly: 4.61 ± 0.077	1.122SerHis: 1.122 ± 0.037	2.159SerIle: 2.159 ± 0.048	1.554SerLys: 1.554 ± 0.041	4.924SerLeu: 4.924 ± 0.075	1.149SerMet: 1.149 ± 0.037	1.412SerAsn: 1.412 ± 0.038	2.737SerPro: 2.737 ± 0.057	1.646SerGln: 1.646 ± 0.044	3.428SerArg: 3.428 ± 0.064	2.373SerSer: 2.373 ± 0.054	2.793SerThr: 2.793 ± 0.053	3.699SerVal: 3.699 ± 0.062	0.681SerTrp: 0.681 ± 0.027	1.161SerTyr: 1.161 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.884ThrAla: 5.884 ± 0.099	0.461ThrCys: 0.461 ± 0.021	2.803ThrAsp: 2.803 ± 0.053	2.098ThrGlu: 2.098 ± 0.048	1.867ThrPhe: 1.867 ± 0.054	4.716ThrGly: 4.716 ± 0.097	1.225ThrHis: 1.225 ± 0.035	2.365ThrIle: 2.365 ± 0.055	1.24ThrLys: 1.24 ± 0.044	6.169ThrLeu: 6.169 ± 0.078	1.154ThrMet: 1.154 ± 0.033	1.276ThrAsn: 1.276 ± 0.052	3.596ThrPro: 3.596 ± 0.059	1.89ThrGln: 1.89 ± 0.044	3.632ThrArg: 3.632 ± 0.061	2.464ThrSer: 2.464 ± 0.052	2.987ThrThr: 2.987 ± 0.071	4.123ThrVal: 4.123 ± 0.073	0.902ThrTrp: 0.902 ± 0.032	1.251ThrTyr: 1.251 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.138ValAla: 10.138 ± 0.103	0.688ValCys: 0.688 ± 0.028	5.039ValAsp: 5.039 ± 0.081	4.508ValGlu: 4.508 ± 0.065	2.756ValPhe: 2.756 ± 0.056	5.898ValGly: 5.898 ± 0.088	1.798ValHis: 1.798 ± 0.049	3.153ValIle: 3.153 ± 0.062	2.022ValLys: 2.022 ± 0.058	8.137ValLeu: 8.137 ± 0.113	1.541ValMet: 1.541 ± 0.047	1.847ValAsn: 1.847 ± 0.047	4.107ValPro: 4.107 ± 0.072	2.518ValGln: 2.518 ± 0.049	6.026ValArg: 6.026 ± 0.078	3.848ValSer: 3.848 ± 0.057	3.716ValThr: 3.716 ± 0.071	6.606ValVal: 6.606 ± 0.093	0.929ValTrp: 0.929 ± 0.031	1.559ValTyr: 1.559 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.38TrpAla: 1.38 ± 0.043	0.161TrpCys: 0.161 ± 0.011	0.736TrpAsp: 0.736 ± 0.032	0.581TrpGlu: 0.581 ± 0.023	0.65TrpPhe: 0.65 ± 0.026	0.952TrpGly: 0.952 ± 0.031	0.399TrpHis: 0.399 ± 0.022	0.816TrpIle: 0.816 ± 0.031	0.528TrpLys: 0.528 ± 0.026	2.092TrpLeu: 2.092 ± 0.052	0.489TrpMet: 0.489 ± 0.022	0.52TrpAsn: 0.52 ± 0.025	0.859TrpPro: 0.859 ± 0.029	0.644TrpGln: 0.644 ± 0.025	1.59TrpArg: 1.59 ± 0.049	0.916TrpSer: 0.916 ± 0.03	0.919TrpThr: 0.919 ± 0.03	1.039TrpVal: 1.039 ± 0.033	0.378TrpTrp: 0.378 ± 0.022	0.365TrpTyr: 0.365 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.977TyrAla: 2.977 ± 0.066	0.175TyrCys: 0.175 ± 0.012	1.484TyrAsp: 1.484 ± 0.048	1.158TyrGlu: 1.158 ± 0.035	0.91TyrPhe: 0.91 ± 0.033	2.152TyrGly: 2.152 ± 0.063	0.432TyrHis: 0.432 ± 0.022	0.76TyrIle: 0.76 ± 0.028	0.584TyrLys: 0.584 ± 0.023	2.224TyrLeu: 2.224 ± 0.043	0.399TyrMet: 0.399 ± 0.018	0.58TyrAsn: 0.58 ± 0.029	1.099TyrPro: 1.099 ± 0.033	0.715TyrGln: 0.715 ± 0.027	1.96TyrArg: 1.96 ± 0.046	1.117TyrSer: 1.117 ± 0.037	1.265TyrThr: 1.265 ± 0.044	1.825TyrVal: 1.825 ± 0.043	0.409TyrTrp: 0.409 ± 0.02	0.569TyrTyr: 0.569 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3154 proteins (998534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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