Amino acid dipepetide frequency for Penicillium vulpinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.218AlaAla: 8.218 ± 0.069	1.094AlaCys: 1.094 ± 0.015	4.137AlaAsp: 4.137 ± 0.029	4.938AlaGlu: 4.938 ± 0.052	3.152AlaPhe: 3.152 ± 0.03	5.527AlaGly: 5.527 ± 0.042	1.796AlaHis: 1.796 ± 0.02	4.532AlaIle: 4.532 ± 0.038	3.812AlaLys: 3.812 ± 0.032	7.685AlaLeu: 7.685 ± 0.049	2.031AlaMet: 2.031 ± 0.02	2.915AlaAsn: 2.915 ± 0.026	4.608AlaPro: 4.608 ± 0.045	3.343AlaGln: 3.343 ± 0.028	4.607AlaArg: 4.607 ± 0.031	7.039AlaSer: 7.039 ± 0.044	5.089AlaThr: 5.089 ± 0.034	5.247AlaVal: 5.247 ± 0.044	1.144AlaTrp: 1.144 ± 0.019	2.12AlaTyr: 2.12 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.97CysAla: 0.97 ± 0.016	0.249CysCys: 0.249 ± 0.009	0.688CysAsp: 0.688 ± 0.014	0.624CysGlu: 0.624 ± 0.012	0.569CysPhe: 0.569 ± 0.012	0.94CysGly: 0.94 ± 0.017	0.341CysHis: 0.341 ± 0.009	0.734CysIle: 0.734 ± 0.012	0.495CysLys: 0.495 ± 0.01	1.305CysLeu: 1.305 ± 0.017	0.281CysMet: 0.281 ± 0.007	0.451CysAsn: 0.451 ± 0.011	0.664CysPro: 0.664 ± 0.016	0.474CysGln: 0.474 ± 0.011	0.738CysArg: 0.738 ± 0.013	0.94CysSer: 0.94 ± 0.016	0.703CysThr: 0.703 ± 0.012	0.844CysVal: 0.844 ± 0.015	0.2CysTrp: 0.2 ± 0.007	0.359CysTyr: 0.359 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.366AspAla: 4.366 ± 0.036	0.631AspCys: 0.631 ± 0.013	3.835AspAsp: 3.835 ± 0.043	4.265AspGlu: 4.265 ± 0.047	2.199AspPhe: 2.199 ± 0.021	3.78AspGly: 3.78 ± 0.03	1.348AspHis: 1.348 ± 0.016	3.338AspIle: 3.338 ± 0.028	2.274AspLys: 2.274 ± 0.026	5.202AspLeu: 5.202 ± 0.032	1.322AspMet: 1.322 ± 0.016	1.942AspAsn: 1.942 ± 0.02	3.38AspPro: 3.38 ± 0.027	2.068AspGln: 2.068 ± 0.023	3.025AspArg: 3.025 ± 0.03	4.319AspSer: 4.319 ± 0.031	3.072AspThr: 3.072 ± 0.026	3.501AspVal: 3.501 ± 0.025	0.888AspTrp: 0.888 ± 0.014	1.617AspTyr: 1.617 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.11GluAla: 5.11 ± 0.047	0.65GluCys: 0.65 ± 0.012	4.09GluAsp: 4.09 ± 0.044	5.233GluGlu: 5.233 ± 0.057	2.042GluPhe: 2.042 ± 0.023	3.522GluGly: 3.522 ± 0.029	1.405GluHis: 1.405 ± 0.017	3.354GluIle: 3.354 ± 0.032	3.593GluLys: 3.593 ± 0.037	5.224GluLeu: 5.224 ± 0.036	1.529GluMet: 1.529 ± 0.017	2.475GluAsn: 2.475 ± 0.023	2.841GluPro: 2.841 ± 0.05	2.501GluGln: 2.501 ± 0.026	3.716GluArg: 3.716 ± 0.037	4.501GluSer: 4.501 ± 0.036	3.64GluThr: 3.64 ± 0.031	3.437GluVal: 3.437 ± 0.028	0.895GluTrp: 0.895 ± 0.014	1.746GluTyr: 1.746 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.061PheAla: 3.061 ± 0.028	0.581PheCys: 0.581 ± 0.011	2.381PheAsp: 2.381 ± 0.022	2.224PheGlu: 2.224 ± 0.022	1.717PhePhe: 1.717 ± 0.021	2.868PheGly: 2.868 ± 0.029	0.95PheHis: 0.95 ± 0.014	1.993PheIle: 1.993 ± 0.02	1.503PheLys: 1.503 ± 0.016	3.582PheLeu: 3.582 ± 0.029	0.846PheMet: 0.846 ± 0.014	1.549PheAsn: 1.549 ± 0.019	2.038PhePro: 2.038 ± 0.022	1.485PheGln: 1.485 ± 0.016	1.946PheArg: 1.946 ± 0.019	3.118PheSer: 3.118 ± 0.03	2.186PheThr: 2.186 ± 0.023	2.415PheVal: 2.415 ± 0.022	0.664PheTrp: 0.664 ± 0.012	1.154PheTyr: 1.154 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.144GlyAla: 5.144 ± 0.038	0.91GlyCys: 0.91 ± 0.016	3.524GlyAsp: 3.524 ± 0.028	3.44GlyGlu: 3.44 ± 0.024	2.853GlyPhe: 2.853 ± 0.029	5.203GlyGly: 5.203 ± 0.059	1.658GlyHis: 1.658 ± 0.022	3.668GlyIle: 3.668 ± 0.029	3.259GlyLys: 3.259 ± 0.026	6.114GlyLeu: 6.114 ± 0.044	1.62GlyMet: 1.62 ± 0.022	2.555GlyAsn: 2.555 ± 0.026	3.305GlyPro: 3.305 ± 0.029	2.529GlyGln: 2.529 ± 0.027	3.846GlyArg: 3.846 ± 0.03	5.699GlySer: 5.699 ± 0.041	3.883GlyThr: 3.883 ± 0.033	4.272GlyVal: 4.272 ± 0.033	1.138GlyTrp: 1.138 ± 0.017	2.159GlyTyr: 2.159 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.804HisAla: 1.804 ± 0.018	0.357HisCys: 0.357 ± 0.01	1.308HisAsp: 1.308 ± 0.017	1.361HisGlu: 1.361 ± 0.019	0.947HisPhe: 0.947 ± 0.015	1.754HisGly: 1.754 ± 0.023	0.809HisHis: 0.809 ± 0.016	1.298HisIle: 1.298 ± 0.019	0.896HisLys: 0.896 ± 0.013	2.263HisLeu: 2.263 ± 0.021	0.536HisMet: 0.536 ± 0.01	0.899HisAsn: 0.899 ± 0.013	1.654HisPro: 1.654 ± 0.019	1.019HisGln: 1.019 ± 0.016	1.541HisArg: 1.541 ± 0.018	1.954HisSer: 1.954 ± 0.023	1.353HisThr: 1.353 ± 0.018	1.427HisVal: 1.427 ± 0.018	0.363HisTrp: 0.363 ± 0.008	0.687HisTyr: 0.687 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.422IleAla: 4.422 ± 0.041	0.827IleCys: 0.827 ± 0.014	3.041IleAsp: 3.041 ± 0.024	3.102IleGlu: 3.102 ± 0.03	2.208IlePhe: 2.208 ± 0.022	3.434IleGly: 3.434 ± 0.033	1.296IleHis: 1.296 ± 0.016	2.806IleIle: 2.806 ± 0.03	2.252IleLys: 2.252 ± 0.022	4.905IleLeu: 4.905 ± 0.035	1.132IleMet: 1.132 ± 0.015	1.927IleAsn: 1.927 ± 0.02	3.362IlePro: 3.362 ± 0.026	2.121IleGln: 2.121 ± 0.021	2.856IleArg: 2.856 ± 0.024	4.311IleSer: 4.311 ± 0.029	2.985IleThr: 2.985 ± 0.026	3.282IleVal: 3.282 ± 0.026	0.769IleTrp: 0.769 ± 0.012	1.537IleTyr: 1.537 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.907LysAla: 3.907 ± 0.04	0.501LysCys: 0.501 ± 0.011	2.665LysAsp: 2.665 ± 0.026	3.207LysGlu: 3.207 ± 0.036	1.515LysPhe: 1.515 ± 0.017	2.79LysGly: 2.79 ± 0.025	1.073LysHis: 1.073 ± 0.016	2.41LysIle: 2.41 ± 0.024	3.038LysLys: 3.038 ± 0.044	3.989LysLeu: 3.989 ± 0.035	1.038LysMet: 1.038 ± 0.016	1.804LysAsn: 1.804 ± 0.022	2.614LysPro: 2.614 ± 0.028	1.858LysGln: 1.858 ± 0.02	3.203LysArg: 3.203 ± 0.032	3.548LysSer: 3.548 ± 0.033	2.791LysThr: 2.791 ± 0.025	2.687LysVal: 2.687 ± 0.025	0.668LysTrp: 0.668 ± 0.013	1.364LysTyr: 1.364 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.798LeuAla: 7.798 ± 0.044	1.254LeuCys: 1.254 ± 0.017	5.277LeuAsp: 5.277 ± 0.035	5.603LeuGlu: 5.603 ± 0.034	3.432LeuPhe: 3.432 ± 0.029	5.984LeuGly: 5.984 ± 0.041	2.304LeuHis: 2.304 ± 0.024	4.246LeuIle: 4.246 ± 0.037	4.09LeuLys: 4.09 ± 0.034	8.481LeuLeu: 8.481 ± 0.061	1.893LeuMet: 1.893 ± 0.02	3.361LeuAsn: 3.361 ± 0.026	5.487LeuPro: 5.487 ± 0.037	3.952LeuGln: 3.952 ± 0.03	5.652LeuArg: 5.652 ± 0.034	7.541LeuSer: 7.541 ± 0.043	4.857LeuThr: 4.857 ± 0.033	5.46LeuVal: 5.46 ± 0.04	1.207LeuTrp: 1.207 ± 0.016	2.374LeuTyr: 2.374 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.237MetAla: 2.237 ± 0.023	0.269MetCys: 0.269 ± 0.007	1.333MetAsp: 1.333 ± 0.016	1.369MetGlu: 1.369 ± 0.016	0.808MetPhe: 0.808 ± 0.013	1.577MetGly: 1.577 ± 0.021	0.521MetHis: 0.521 ± 0.009	1.138MetIle: 1.138 ± 0.016	1.031MetLys: 1.031 ± 0.013	1.904MetLeu: 1.904 ± 0.019	0.608MetMet: 0.608 ± 0.011	0.88MetAsn: 0.88 ± 0.014	1.29MetPro: 1.29 ± 0.015	0.91MetGln: 0.91 ± 0.015	1.257MetArg: 1.257 ± 0.016	2.004MetSer: 2.004 ± 0.019	1.373MetThr: 1.373 ± 0.018	1.385MetVal: 1.385 ± 0.018	0.278MetTrp: 0.278 ± 0.008	0.525MetTyr: 0.525 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.118AsnAla: 3.118 ± 0.029	0.488AsnCys: 0.488 ± 0.012	2.003AsnAsp: 2.003 ± 0.023	2.179AsnGlu: 2.179 ± 0.027	1.479AsnPhe: 1.479 ± 0.02	2.885AsnGly: 2.885 ± 0.027	0.89AsnHis: 0.89 ± 0.016	2.237AsnIle: 2.237 ± 0.02	1.557AsnLys: 1.557 ± 0.018	3.398AsnLeu: 3.398 ± 0.029	0.934AsnMet: 0.934 ± 0.013	1.528AsnAsn: 1.528 ± 0.023	2.646AsnPro: 2.646 ± 0.024	1.43AsnGln: 1.43 ± 0.019	1.989AsnArg: 1.989 ± 0.023	2.924AsnSer: 2.924 ± 0.024	2.31AsnThr: 2.31 ± 0.02	2.32AsnVal: 2.32 ± 0.021	0.593AsnTrp: 0.593 ± 0.011	1.117AsnTyr: 1.117 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.021ProAla: 5.021 ± 0.048	0.519ProCys: 0.519 ± 0.011	3.163ProAsp: 3.163 ± 0.026	3.954ProGlu: 3.954 ± 0.053	2.143ProPhe: 2.143 ± 0.025	3.836ProGly: 3.836 ± 0.034	1.34ProHis: 1.34 ± 0.017	2.776ProIle: 2.776 ± 0.023	2.626ProLys: 2.626 ± 0.028	4.776ProLeu: 4.776 ± 0.035	1.172ProMet: 1.172 ± 0.016	2.332ProAsn: 2.332 ± 0.028	4.581ProPro: 4.581 ± 0.055	2.441ProGln: 2.441 ± 0.032	3.365ProArg: 3.365 ± 0.035	6.011ProSer: 6.011 ± 0.05	4.046ProThr: 4.046 ± 0.035	3.656ProVal: 3.656 ± 0.033	0.778ProTrp: 0.778 ± 0.012	1.492ProTyr: 1.492 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.377GlnAla: 3.377 ± 0.029	0.463GlnCys: 0.463 ± 0.011	2.07GlnAsp: 2.07 ± 0.018	2.423GlnGlu: 2.423 ± 0.026	1.385GlnPhe: 1.385 ± 0.016	2.394GlnGly: 2.394 ± 0.024	1.057GlnHis: 1.057 ± 0.016	2.106GlnIle: 2.106 ± 0.021	2.036GlnLys: 2.036 ± 0.021	3.566GlnLeu: 3.566 ± 0.026	0.953GlnMet: 0.953 ± 0.014	1.667GlnAsn: 1.667 ± 0.022	2.549GlnPro: 2.549 ± 0.031	2.189GlnGln: 2.189 ± 0.043	2.548GlnArg: 2.548 ± 0.025	3.388GlnSer: 3.388 ± 0.035	2.426GlnThr: 2.426 ± 0.024	2.222GlnVal: 2.222 ± 0.025	0.615GlnTrp: 0.615 ± 0.011	1.222GlnTyr: 1.222 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.486ArgAla: 4.486 ± 0.03	0.69ArgCys: 0.69 ± 0.011	3.281ArgAsp: 3.281 ± 0.034	3.648ArgGlu: 3.648 ± 0.04	2.176ArgPhe: 2.176 ± 0.025	3.596ArgGly: 3.596 ± 0.034	1.498ArgHis: 1.498 ± 0.016	2.93ArgIle: 2.93 ± 0.023	3.207ArgLys: 3.207 ± 0.035	5.36ArgLeu: 5.36 ± 0.038	1.29ArgMet: 1.29 ± 0.017	2.242ArgAsn: 2.242 ± 0.023	3.346ArgPro: 3.346 ± 0.035	2.523ArgGln: 2.523 ± 0.027	4.66ArgArg: 4.66 ± 0.049	4.757ArgSer: 4.757 ± 0.045	3.17ArgThr: 3.17 ± 0.028	3.331ArgVal: 3.331 ± 0.023	0.927ArgTrp: 0.927 ± 0.013	1.648ArgTyr: 1.648 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.588SerAla: 6.588 ± 0.054	0.893SerCys: 0.893 ± 0.016	4.383SerAsp: 4.383 ± 0.035	4.386SerGlu: 4.386 ± 0.033	3.15SerPhe: 3.15 ± 0.024	5.541SerGly: 5.541 ± 0.044	2.087SerHis: 2.087 ± 0.022	4.328SerIle: 4.328 ± 0.032	3.741SerLys: 3.741 ± 0.032	7.518SerLeu: 7.518 ± 0.042	1.843SerMet: 1.843 ± 0.021	3.193SerAsn: 3.193 ± 0.025	5.596SerPro: 5.596 ± 0.046	3.463SerGln: 3.463 ± 0.037	4.913SerArg: 4.913 ± 0.048	8.774SerSer: 8.774 ± 0.068	5.681SerThr: 5.681 ± 0.046	4.809SerVal: 4.809 ± 0.037	1.19SerTrp: 1.19 ± 0.018	2.149SerTyr: 2.149 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.052ThrAla: 5.052 ± 0.037	0.739ThrCys: 0.739 ± 0.016	2.959ThrAsp: 2.959 ± 0.024	3.375ThrGlu: 3.375 ± 0.032	2.233ThrPhe: 2.233 ± 0.021	4.217ThrGly: 4.217 ± 0.033	1.304ThrHis: 1.304 ± 0.019	3.232ThrIle: 3.232 ± 0.03	2.616ThrLys: 2.616 ± 0.029	5.279ThrLeu: 5.279 ± 0.035	1.254ThrMet: 1.254 ± 0.016	2.171ThrAsn: 2.171 ± 0.023	4.321ThrPro: 4.321 ± 0.041	2.21ThrGln: 2.21 ± 0.021	3.105ThrArg: 3.105 ± 0.026	5.345ThrSer: 5.345 ± 0.041	4.196ThrThr: 4.196 ± 0.046	3.786ThrVal: 3.786 ± 0.032	0.848ThrTrp: 0.848 ± 0.013	1.609ThrTyr: 1.609 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	5.082ValAla: 5.082 ± 0.042	0.855ValCys: 0.855 ± 0.015	3.679ValAsp: 3.679 ± 0.032	3.758ValGlu: 3.758 ± 0.038	2.499ValPhe: 2.499 ± 0.024	3.916ValGly: 3.916 ± 0.033	1.424ValHis: 1.424 ± 0.018	3.154ValIle: 3.154 ± 0.028	2.718ValLys: 2.718 ± 0.025	5.603ValLeu: 5.603 ± 0.044	1.353ValMet: 1.353 ± 0.017	2.3ValAsn: 2.3 ± 0.022	3.608ValPro: 3.608 ± 0.032	2.411ValGln: 2.411 ± 0.023	3.255ValArg: 3.255 ± 0.024	4.813ValSer: 4.813 ± 0.03	3.53ValThr: 3.53 ± 0.028	4.136ValVal: 4.136 ± 0.043	0.846ValTrp: 0.846 ± 0.014	1.749ValTyr: 1.749 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.138TrpAla: 1.138 ± 0.017	0.192TrpCys: 0.192 ± 0.006	0.917TrpAsp: 0.917 ± 0.017	0.857TrpGlu: 0.857 ± 0.015	0.536TrpPhe: 0.536 ± 0.011	0.925TrpGly: 0.925 ± 0.014	0.352TrpHis: 0.352 ± 0.009	0.806TrpIle: 0.806 ± 0.013	0.823TrpLys: 0.823 ± 0.014	1.371TrpLeu: 1.371 ± 0.018	0.399TrpMet: 0.399 ± 0.009	0.672TrpAsn: 0.672 ± 0.012	0.594TrpPro: 0.594 ± 0.012	0.572TrpGln: 0.572 ± 0.01	0.93TrpArg: 0.93 ± 0.014	1.118TrpSer: 1.118 ± 0.016	0.915TrpThr: 0.915 ± 0.015	0.887TrpVal: 0.887 ± 0.014	0.287TrpTrp: 0.287 ± 0.007	0.46TrpTyr: 0.46 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.135TyrAla: 2.135 ± 0.026	0.41TyrCys: 0.41 ± 0.011	1.636TyrAsp: 1.636 ± 0.016	1.557TyrGlu: 1.557 ± 0.019	1.22TyrPhe: 1.22 ± 0.015	2.09TyrGly: 2.09 ± 0.026	0.777TyrHis: 0.777 ± 0.013	1.488TyrIle: 1.488 ± 0.018	1.102TyrLys: 1.102 ± 0.016	2.727TyrLeu: 2.727 ± 0.024	0.665TyrMet: 0.665 ± 0.012	1.164TyrAsn: 1.164 ± 0.016	1.542TyrPro: 1.542 ± 0.019	1.156TyrGln: 1.156 ± 0.016	1.612TyrArg: 1.612 ± 0.018	2.124TyrSer: 2.124 ± 0.022	1.647TyrThr: 1.647 ± 0.018	1.585TyrVal: 1.585 ± 0.018	0.454TyrTrp: 0.454 ± 0.01	0.962TyrTyr: 0.962 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.007

Statistics based on 10245 proteins (5054469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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