Amino acid dipepetide frequency for Planctomicrobium piriforme

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.759AlaAla: 12.759 ± 0.123	1.259AlaCys: 1.259 ± 0.034	5.55AlaAsp: 5.55 ± 0.066	6.273AlaGlu: 6.273 ± 0.075	3.418AlaPhe: 3.418 ± 0.051	8.154AlaGly: 8.154 ± 0.089	1.719AlaHis: 1.719 ± 0.033	5.078AlaIle: 5.078 ± 0.058	3.678AlaLys: 3.678 ± 0.054	9.233AlaLeu: 9.233 ± 0.079	2.328AlaMet: 2.328 ± 0.046	3.038AlaAsn: 3.038 ± 0.055	4.683AlaPro: 4.683 ± 0.069	3.76AlaGln: 3.76 ± 0.055	5.786AlaArg: 5.786 ± 0.062	5.684AlaSer: 5.684 ± 0.07	5.44AlaThr: 5.44 ± 0.07	7.58AlaVal: 7.58 ± 0.081	1.463AlaTrp: 1.463 ± 0.03	2.157AlaTyr: 2.157 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.891CysAla: 0.891 ± 0.03	0.249CysCys: 0.249 ± 0.014	0.68CysAsp: 0.68 ± 0.022	0.684CysGlu: 0.684 ± 0.02	0.439CysPhe: 0.439 ± 0.018	1.149CysGly: 1.149 ± 0.029	0.389CysHis: 0.389 ± 0.018	0.485CysIle: 0.485 ± 0.015	0.341CysLys: 0.341 ± 0.016	1.361CysLeu: 1.361 ± 0.035	0.193CysMet: 0.193 ± 0.011	0.301CysAsn: 0.301 ± 0.012	0.692CysPro: 0.692 ± 0.021	0.483CysGln: 0.483 ± 0.016	0.877CysArg: 0.877 ± 0.024	0.677CysSer: 0.677 ± 0.02	0.554CysThr: 0.554 ± 0.018	0.846CysVal: 0.846 ± 0.025	0.213CysTrp: 0.213 ± 0.01	0.297CysTyr: 0.297 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.609AspAla: 5.609 ± 0.071	0.547AspCys: 0.547 ± 0.017	3.124AspAsp: 3.124 ± 0.05	3.601AspGlu: 3.601 ± 0.054	2.259AspPhe: 2.259 ± 0.045	4.958AspGly: 4.958 ± 0.088	1.254AspHis: 1.254 ± 0.028	2.316AspIle: 2.316 ± 0.039	1.639AspLys: 1.639 ± 0.038	5.778AspLeu: 5.778 ± 0.064	0.944AspMet: 0.944 ± 0.025	1.383AspAsn: 1.383 ± 0.029	3.408AspPro: 3.408 ± 0.05	2.343AspGln: 2.343 ± 0.039	3.754AspArg: 3.754 ± 0.048	3.099AspSer: 3.099 ± 0.064	2.067AspThr: 2.067 ± 0.049	4.212AspVal: 4.212 ± 0.048	1.063AspTrp: 1.063 ± 0.026	1.464AspTyr: 1.464 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.325GluAla: 5.325 ± 0.066	0.539GluCys: 0.539 ± 0.018	2.5GluAsp: 2.5 ± 0.039	3.475GluGlu: 3.475 ± 0.06	2.624GluPhe: 2.624 ± 0.046	3.419GluGly: 3.419 ± 0.044	1.34GluHis: 1.34 ± 0.027	3.508GluIle: 3.508 ± 0.047	2.69GluLys: 2.69 ± 0.054	6.88GluLeu: 6.88 ± 0.08	1.534GluMet: 1.534 ± 0.03	1.869GluAsn: 1.869 ± 0.038	2.754GluPro: 2.754 ± 0.04	3.222GluGln: 3.222 ± 0.053	4.178GluArg: 4.178 ± 0.067	3.51GluSer: 3.51 ± 0.048	3.524GluThr: 3.524 ± 0.056	3.948GluVal: 3.948 ± 0.046	0.83GluTrp: 0.83 ± 0.024	1.396GluTyr: 1.396 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.725PheAla: 3.725 ± 0.048	0.526PheCys: 0.526 ± 0.018	2.595PheAsp: 2.595 ± 0.044	2.279PheGlu: 2.279 ± 0.041	1.394PhePhe: 1.394 ± 0.031	3.186PheGly: 3.186 ± 0.05	0.863PheHis: 0.863 ± 0.022	1.52PheIle: 1.52 ± 0.03	1.098PheLys: 1.098 ± 0.026	3.794PheLeu: 3.794 ± 0.054	0.694PheMet: 0.694 ± 0.019	1.305PheAsn: 1.305 ± 0.035	1.903PhePro: 1.903 ± 0.039	1.577PheGln: 1.577 ± 0.032	2.425PheArg: 2.425 ± 0.044	2.609PheSer: 2.609 ± 0.043	2.126PheThr: 2.126 ± 0.052	2.843PheVal: 2.843 ± 0.044	0.606PheTrp: 0.606 ± 0.019	0.968PheTyr: 0.968 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	6.107GlyAla: 6.107 ± 0.081	1.012GlyCys: 1.012 ± 0.027	4.205GlyAsp: 4.205 ± 0.065	4.564GlyGlu: 4.564 ± 0.058	3.048GlyPhe: 3.048 ± 0.044	6.43GlyGly: 6.43 ± 0.105	1.661GlyHis: 1.661 ± 0.036	4.029GlyIle: 4.029 ± 0.055	3.531GlyLys: 3.531 ± 0.059	7.46GlyLeu: 7.46 ± 0.07	1.951GlyMet: 1.951 ± 0.04	2.851GlyAsn: 2.851 ± 0.076	3.291GlyPro: 3.291 ± 0.054	3.48GlyGln: 3.48 ± 0.052	4.871GlyArg: 4.871 ± 0.053	4.984GlySer: 4.984 ± 0.089	4.953GlyThr: 4.953 ± 0.12	5.54GlyVal: 5.54 ± 0.06	1.39GlyTrp: 1.39 ± 0.034	2.166GlyTyr: 2.166 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.996HisAla: 1.996 ± 0.04	0.322HisCys: 0.322 ± 0.014	1.203HisAsp: 1.203 ± 0.029	1.21HisGlu: 1.21 ± 0.026	0.944HisPhe: 0.944 ± 0.025	1.841HisGly: 1.841 ± 0.038	0.619HisHis: 0.619 ± 0.02	0.847HisIle: 0.847 ± 0.024	0.568HisLys: 0.568 ± 0.02	2.249HisLeu: 2.249 ± 0.044	0.389HisMet: 0.389 ± 0.017	0.602HisAsn: 0.602 ± 0.02	1.512HisPro: 1.512 ± 0.032	0.879HisGln: 0.879 ± 0.02	1.514HisArg: 1.514 ± 0.029	1.241HisSer: 1.241 ± 0.03	0.884HisThr: 0.884 ± 0.025	1.542HisVal: 1.542 ± 0.032	0.412HisTrp: 0.412 ± 0.016	0.588HisTyr: 0.588 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.432IleAla: 5.432 ± 0.053	0.693IleCys: 0.693 ± 0.023	3.412IleAsp: 3.412 ± 0.046	3.379IleGlu: 3.379 ± 0.049	1.545IlePhe: 1.545 ± 0.036	4.026IleGly: 4.026 ± 0.061	1.018IleHis: 1.018 ± 0.023	1.919IleIle: 1.919 ± 0.04	1.385IleLys: 1.385 ± 0.03	4.413IleLeu: 4.413 ± 0.057	0.715IleMet: 0.715 ± 0.02	1.51IleAsn: 1.51 ± 0.038	2.824IlePro: 2.824 ± 0.041	1.883IleGln: 1.883 ± 0.031	3.316IleArg: 3.316 ± 0.049	3.154IleSer: 3.154 ± 0.044	2.645IleThr: 2.645 ± 0.054	3.865IleVal: 3.865 ± 0.056	0.675IleTrp: 0.675 ± 0.021	1.141IleTyr: 1.141 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.225LysAla: 3.225 ± 0.056	0.329LysCys: 0.329 ± 0.016	1.852LysAsp: 1.852 ± 0.041	2.166LysGlu: 2.166 ± 0.047	1.324LysPhe: 1.324 ± 0.032	2.207LysGly: 2.207 ± 0.039	0.751LysHis: 0.751 ± 0.021	1.931LysIle: 1.931 ± 0.033	1.829LysLys: 1.829 ± 0.05	3.862LysLeu: 3.862 ± 0.052	0.991LysMet: 0.991 ± 0.027	1.289LysAsn: 1.289 ± 0.025	2.283LysPro: 2.283 ± 0.047	1.777LysGln: 1.777 ± 0.033	2.146LysArg: 2.146 ± 0.043	2.471LysSer: 2.471 ± 0.039	2.3LysThr: 2.3 ± 0.046	2.51LysVal: 2.51 ± 0.045	0.558LysTrp: 0.558 ± 0.017	0.924LysTyr: 0.924 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.86LeuAla: 10.86 ± 0.099	1.313LeuCys: 1.313 ± 0.033	5.535LeuAsp: 5.535 ± 0.066	5.639LeuGlu: 5.639 ± 0.066	3.724LeuPhe: 3.724 ± 0.05	7.311LeuGly: 7.311 ± 0.068	2.102LeuHis: 2.102 ± 0.043	4.971LeuIle: 4.971 ± 0.056	4.442LeuLys: 4.442 ± 0.064	11.373LeuLeu: 11.373 ± 0.113	2.057LeuMet: 2.057 ± 0.037	3.393LeuAsn: 3.393 ± 0.051	5.997LeuPro: 5.997 ± 0.065	4.623LeuGln: 4.623 ± 0.054	6.55LeuArg: 6.55 ± 0.066	6.838LeuSer: 6.838 ± 0.071	6.406LeuThr: 6.406 ± 0.097	6.879LeuVal: 6.879 ± 0.075	1.389LeuTrp: 1.389 ± 0.035	2.049LeuTyr: 2.049 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.107MetAla: 2.107 ± 0.039	0.235MetCys: 0.235 ± 0.013	0.944MetAsp: 0.944 ± 0.023	1.042MetGlu: 1.042 ± 0.024	0.741MetPhe: 0.741 ± 0.021	1.403MetGly: 1.403 ± 0.031	0.458MetHis: 0.458 ± 0.018	1.082MetIle: 1.082 ± 0.028	0.881MetLys: 0.881 ± 0.026	2.345MetLeu: 2.345 ± 0.039	0.491MetMet: 0.491 ± 0.016	0.825MetAsn: 0.825 ± 0.021	1.375MetPro: 1.375 ± 0.026	1.055MetGln: 1.055 ± 0.025	1.337MetArg: 1.337 ± 0.028	1.586MetSer: 1.586 ± 0.029	1.547MetThr: 1.547 ± 0.03	1.297MetVal: 1.297 ± 0.028	0.229MetTrp: 0.229 ± 0.011	0.367MetTyr: 0.367 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.048AsnAla: 3.048 ± 0.053	0.396AsnCys: 0.396 ± 0.015	1.828AsnAsp: 1.828 ± 0.055	1.636AsnGlu: 1.636 ± 0.03	1.261AsnPhe: 1.261 ± 0.029	3.054AsnGly: 3.054 ± 0.076	0.682AsnHis: 0.682 ± 0.02	1.374AsnIle: 1.374 ± 0.033	0.872AsnLys: 0.872 ± 0.019	3.065AsnLeu: 3.065 ± 0.051	0.599AsnMet: 0.599 ± 0.017	1.09AsnAsn: 1.09 ± 0.036	2.116AsnPro: 2.116 ± 0.038	1.317AsnGln: 1.317 ± 0.029	2.106AsnArg: 2.106 ± 0.037	2.059AsnSer: 2.059 ± 0.051	1.608AsnThr: 1.608 ± 0.04	2.39AsnVal: 2.39 ± 0.04	0.667AsnTrp: 0.667 ± 0.02	0.926AsnTyr: 0.926 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.203ProAla: 6.203 ± 0.075	0.461ProCys: 0.461 ± 0.019	3.384ProAsp: 3.384 ± 0.049	4.09ProGlu: 4.09 ± 0.057	1.978ProPhe: 1.978 ± 0.032	4.497ProGly: 4.497 ± 0.07	1.174ProHis: 1.174 ± 0.03	2.412ProIle: 2.412 ± 0.036	1.929ProLys: 1.929 ± 0.041	5.063ProLeu: 5.063 ± 0.054	1.038ProMet: 1.038 ± 0.027	1.763ProAsn: 1.763 ± 0.035	3.213ProPro: 3.213 ± 0.058	2.36ProGln: 2.36 ± 0.039	2.908ProArg: 2.908 ± 0.04	3.172ProSer: 3.172 ± 0.047	3.025ProThr: 3.025 ± 0.04	4.606ProVal: 4.606 ± 0.06	0.737ProTrp: 0.737 ± 0.021	1.208ProTyr: 1.208 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.702GlnAla: 4.702 ± 0.066	0.44GlnCys: 0.44 ± 0.017	1.717GlnAsp: 1.717 ± 0.034	2.037GlnGlu: 2.037 ± 0.036	1.753GlnPhe: 1.753 ± 0.032	2.923GlnGly: 2.923 ± 0.047	1.008GlnHis: 1.008 ± 0.023	2.355GlnIle: 2.355 ± 0.041	1.698GlnLys: 1.698 ± 0.039	5.035GlnLeu: 5.035 ± 0.058	1.052GlnMet: 1.052 ± 0.026	1.374GlnAsn: 1.374 ± 0.031	2.537GlnPro: 2.537 ± 0.042	2.75GlnGln: 2.75 ± 0.071	3.179GlnArg: 3.179 ± 0.055	2.792GlnSer: 2.792 ± 0.049	2.577GlnThr: 2.577 ± 0.048	3.021GlnVal: 3.021 ± 0.043	0.561GlnTrp: 0.561 ± 0.018	0.955GlnTyr: 0.955 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.901ArgAla: 4.901 ± 0.069	0.773ArgCys: 0.773 ± 0.024	3.533ArgAsp: 3.533 ± 0.052	4.098ArgGlu: 4.098 ± 0.065	2.755ArgPhe: 2.755 ± 0.042	4.09ArgGly: 4.09 ± 0.052	1.549ArgHis: 1.549 ± 0.031	3.564ArgIle: 3.564 ± 0.041	2.48ArgLys: 2.48 ± 0.042	7.177ArgLeu: 7.177 ± 0.082	1.682ArgMet: 1.682 ± 0.031	2.025ArgAsn: 2.025 ± 0.039	3.232ArgPro: 3.232 ± 0.05	3.265ArgGln: 3.265 ± 0.051	4.971ArgArg: 4.971 ± 0.07	3.902ArgSer: 3.902 ± 0.05	3.483ArgThr: 3.483 ± 0.044	4.306ArgVal: 4.306 ± 0.051	1.139ArgTrp: 1.139 ± 0.029	1.701ArgTyr: 1.701 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.905SerAla: 5.905 ± 0.067	0.586SerCys: 0.586 ± 0.019	3.36SerAsp: 3.36 ± 0.052	3.474SerGlu: 3.474 ± 0.042	2.304SerPhe: 2.304 ± 0.049	5.632SerGly: 5.632 ± 0.096	1.331SerHis: 1.331 ± 0.031	2.987SerIle: 2.987 ± 0.046	2.0SerLys: 2.0 ± 0.035	6.595SerLeu: 6.595 ± 0.073	1.313SerMet: 1.313 ± 0.033	2.036SerAsn: 2.036 ± 0.052	3.85SerPro: 3.85 ± 0.047	2.818SerGln: 2.818 ± 0.046	3.993SerArg: 3.993 ± 0.058	4.357SerSer: 4.357 ± 0.092	3.64SerThr: 3.64 ± 0.057	4.311SerVal: 4.311 ± 0.062	0.896SerTrp: 0.896 ± 0.023	1.43SerTyr: 1.43 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.046ThrAla: 6.046 ± 0.077	0.563ThrCys: 0.563 ± 0.023	3.076ThrAsp: 3.076 ± 0.06	2.837ThrGlu: 2.837 ± 0.042	2.282ThrPhe: 2.282 ± 0.049	5.214ThrGly: 5.214 ± 0.086	1.027ThrHis: 1.027 ± 0.024	2.947ThrIle: 2.947 ± 0.059	1.754ThrLys: 1.754 ± 0.031	6.04ThrLeu: 6.04 ± 0.087	1.071ThrMet: 1.071 ± 0.025	1.672ThrAsn: 1.672 ± 0.037	3.701ThrPro: 3.701 ± 0.052	2.072ThrGln: 2.072 ± 0.035	3.108ThrArg: 3.108 ± 0.043	3.49ThrSer: 3.49 ± 0.06	3.287ThrThr: 3.287 ± 0.067	4.488ThrVal: 4.488 ± 0.088	0.852ThrTrp: 0.852 ± 0.024	1.412ThrTyr: 1.412 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	6.999ValAla: 6.999 ± 0.072	1.007ValCys: 1.007 ± 0.025	4.08ValAsp: 4.08 ± 0.055	4.433ValGlu: 4.433 ± 0.053	2.592ValPhe: 2.592 ± 0.047	4.922ValGly: 4.922 ± 0.061	1.421ValHis: 1.421 ± 0.03	3.946ValIle: 3.946 ± 0.049	2.48ValLys: 2.48 ± 0.045	7.389ValLeu: 7.389 ± 0.069	1.502ValMet: 1.502 ± 0.032	2.409ValAsn: 2.409 ± 0.055	3.912ValPro: 3.912 ± 0.052	2.861ValGln: 2.861 ± 0.042	4.738ValArg: 4.738 ± 0.059	4.662ValSer: 4.662 ± 0.068	4.732ValThr: 4.732 ± 0.088	5.633ValVal: 5.633 ± 0.07	1.067ValTrp: 1.067 ± 0.026	1.62ValTyr: 1.62 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.096TrpAla: 1.096 ± 0.026	0.213TrpCys: 0.213 ± 0.011	0.706TrpAsp: 0.706 ± 0.024	0.784TrpGlu: 0.784 ± 0.025	0.583TrpPhe: 0.583 ± 0.019	1.043TrpGly: 1.043 ± 0.028	0.389TrpHis: 0.389 ± 0.014	0.882TrpIle: 0.882 ± 0.025	0.755TrpLys: 0.755 ± 0.021	1.864TrpLeu: 1.864 ± 0.037	0.426TrpMet: 0.426 ± 0.017	0.648TrpAsn: 0.648 ± 0.02	0.722TrpPro: 0.722 ± 0.021	0.83TrpGln: 0.83 ± 0.02	0.97TrpArg: 0.97 ± 0.024	1.006TrpSer: 1.006 ± 0.024	0.966TrpThr: 0.966 ± 0.03	0.901TrpVal: 0.901 ± 0.026	0.273TrpTrp: 0.273 ± 0.014	0.378TrpTyr: 0.378 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.102TyrAla: 2.102 ± 0.035	0.339TyrCys: 0.339 ± 0.014	1.538TyrAsp: 1.538 ± 0.047	1.363TyrGlu: 1.363 ± 0.027	1.065TyrPhe: 1.065 ± 0.028	2.064TyrGly: 2.064 ± 0.043	0.608TyrHis: 0.608 ± 0.02	0.795TyrIle: 0.795 ± 0.022	0.676TyrLys: 0.676 ± 0.018	2.475TyrLeu: 2.475 ± 0.043	0.376TyrMet: 0.376 ± 0.016	0.714TyrAsn: 0.714 ± 0.023	1.218TyrPro: 1.218 ± 0.032	1.11TyrGln: 1.11 ± 0.023	1.901TyrArg: 1.901 ± 0.034	1.53TyrSer: 1.53 ± 0.036	1.174TyrThr: 1.174 ± 0.034	1.684TyrVal: 1.684 ± 0.027	0.413TyrTrp: 0.413 ± 0.015	0.729TyrTyr: 0.729 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5057 proteins (1801768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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