Amino acid dipepetide frequency for Corynebacterium sp. sy039

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.585AlaAla: 12.585 ± 0.207
0.91AlaCys: 0.91 ± 0.041
5.979AlaAsp: 5.979 ± 0.094
6.34AlaGlu: 6.34 ± 0.127
3.481AlaPhe: 3.481 ± 0.086
8.316AlaGly: 8.316 ± 0.119
3.296AlaHis: 3.296 ± 0.082
6.22AlaIle: 6.22 ± 0.114
4.243AlaLys: 4.243 ± 0.091
11.552AlaLeu: 11.552 ± 0.18
2.459AlaMet: 2.459 ± 0.062
2.515AlaAsn: 2.515 ± 0.071
4.602AlaPro: 4.602 ± 0.119
7.088AlaGln: 7.088 ± 0.125
5.951AlaArg: 5.951 ± 0.109
5.333AlaSer: 5.333 ± 0.087
6.378AlaThr: 6.378 ± 0.115
7.863AlaVal: 7.863 ± 0.127
1.38AlaTrp: 1.38 ± 0.048
2.502AlaTyr: 2.502 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.32CysAla: 1.32 ± 0.047
0.115CysCys: 0.115 ± 0.013
0.566CysAsp: 0.566 ± 0.029
0.468CysGlu: 0.468 ± 0.03
0.372CysPhe: 0.372 ± 0.022
0.855CysGly: 0.855 ± 0.039
0.188CysHis: 0.188 ± 0.016
0.538CysIle: 0.538 ± 0.031
0.148CysLys: 0.148 ± 0.015
0.737CysLeu: 0.737 ± 0.034
0.17CysMet: 0.17 ± 0.016
0.226CysAsn: 0.226 ± 0.018
0.411CysPro: 0.411 ± 0.024
0.32CysGln: 0.32 ± 0.021
0.31CysArg: 0.31 ± 0.02
0.694CysSer: 0.694 ± 0.029
0.496CysThr: 0.496 ± 0.025
0.763CysVal: 0.763 ± 0.04
0.095CysTrp: 0.095 ± 0.012
0.211CysTyr: 0.211 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
5.416AspAla: 5.416 ± 0.092
0.45AspCys: 0.45 ± 0.029
3.113AspAsp: 3.113 ± 0.073
3.796AspGlu: 3.796 ± 0.087
1.99AspPhe: 1.99 ± 0.052
3.905AspGly: 3.905 ± 0.096
1.227AspHis: 1.227 ± 0.049
3.841AspIle: 3.841 ± 0.078
2.305AspLys: 2.305 ± 0.059
4.715AspLeu: 4.715 ± 0.089
1.214AspMet: 1.214 ± 0.043
2.117AspAsn: 2.117 ± 0.064
3.059AspPro: 3.059 ± 0.081
1.785AspGln: 1.785 ± 0.056
2.727AspArg: 2.727 ± 0.078
3.576AspSer: 3.576 ± 0.074
3.431AspThr: 3.431 ± 0.091
4.156AspVal: 4.156 ± 0.095
0.655AspTrp: 0.655 ± 0.035
1.653AspTyr: 1.653 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.245GluAla: 5.245 ± 0.109
0.416GluCys: 0.416 ± 0.026
2.955GluAsp: 2.955 ± 0.071
4.286GluGlu: 4.286 ± 0.142
1.863GluPhe: 1.863 ± 0.051
3.233GluGly: 3.233 ± 0.079
1.822GluHis: 1.822 ± 0.061
3.723GluIle: 3.723 ± 0.09
3.55GluLys: 3.55 ± 0.081
6.822GluLeu: 6.822 ± 0.127
1.124GluMet: 1.124 ± 0.043
2.417GluAsn: 2.417 ± 0.062
2.58GluPro: 2.58 ± 0.091
3.796GluGln: 3.796 ± 0.095
3.308GluArg: 3.308 ± 0.088
3.414GluSer: 3.414 ± 0.094
3.1GluThr: 3.1 ± 0.069
4.403GluVal: 4.403 ± 0.088
0.636GluTrp: 0.636 ± 0.031
1.594GluTyr: 1.594 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.834PheAla: 3.834 ± 0.08
0.376PheCys: 0.376 ± 0.026
2.219PheAsp: 2.219 ± 0.054
1.504PheGlu: 1.504 ± 0.056
1.698PhePhe: 1.698 ± 0.064
3.213PheGly: 3.213 ± 0.082
0.884PheHis: 0.884 ± 0.041
2.285PheIle: 2.285 ± 0.075
0.682PheLys: 0.682 ± 0.039
3.535PheLeu: 3.535 ± 0.097
0.737PheMet: 0.737 ± 0.037
1.075PheAsn: 1.075 ± 0.037
1.462PhePro: 1.462 ± 0.051
0.996PheGln: 0.996 ± 0.033
1.481PheArg: 1.481 ± 0.053
2.987PheSer: 2.987 ± 0.076
1.812PheThr: 1.812 ± 0.059
2.525PheVal: 2.525 ± 0.063
0.41PheTrp: 0.41 ± 0.028
0.965PheTyr: 0.965 ± 0.038
0.0PheXaa: 0.0 ± 0.0
Gly
8.001GlyAla: 8.001 ± 0.134
0.757GlyCys: 0.757 ± 0.038
3.715GlyAsp: 3.715 ± 0.091
4.333GlyGlu: 4.333 ± 0.111
2.986GlyPhe: 2.986 ± 0.07
5.635GlyGly: 5.635 ± 0.129
1.767GlyHis: 1.767 ± 0.052
5.384GlyIle: 5.384 ± 0.097
3.464GlyLys: 3.464 ± 0.075
7.241GlyLeu: 7.241 ± 0.115
1.907GlyMet: 1.907 ± 0.052
2.368GlyAsn: 2.368 ± 0.06
2.147GlyPro: 2.147 ± 0.063
2.801GlyGln: 2.801 ± 0.066
3.697GlyArg: 3.697 ± 0.085
4.902GlySer: 4.902 ± 0.085
4.833GlyThr: 4.833 ± 0.096
6.38GlyVal: 6.38 ± 0.128
1.074GlyTrp: 1.074 ± 0.039
2.186GlyTyr: 2.186 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.415HisAla: 2.415 ± 0.071
0.245HisCys: 0.245 ± 0.02
1.536HisAsp: 1.536 ± 0.053
1.364HisGlu: 1.364 ± 0.057
0.763HisPhe: 0.763 ± 0.036
1.909HisGly: 1.909 ± 0.055
0.705HisHis: 0.705 ± 0.037
1.838HisIle: 1.838 ± 0.054
0.899HisLys: 0.899 ± 0.039
1.996HisLeu: 1.996 ± 0.061
0.586HisMet: 0.586 ± 0.03
1.132HisAsn: 1.132 ± 0.043
1.375HisPro: 1.375 ± 0.048
0.841HisGln: 0.841 ± 0.032
1.337HisArg: 1.337 ± 0.045
1.817HisSer: 1.817 ± 0.059
1.773HisThr: 1.773 ± 0.05
1.484HisVal: 1.484 ± 0.048
0.295HisTrp: 0.295 ± 0.023
0.748HisTyr: 0.748 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
8.07IleAla: 8.07 ± 0.132
0.684IleCys: 0.684 ± 0.032
4.042IleAsp: 4.042 ± 0.083
3.478IleGlu: 3.478 ± 0.084
2.29IlePhe: 2.29 ± 0.079
4.879IleGly: 4.879 ± 0.094
1.311IleHis: 1.311 ± 0.045
4.159IleIle: 4.159 ± 0.094
1.993IleLys: 1.993 ± 0.061
5.018IleLeu: 5.018 ± 0.097
1.331IleMet: 1.331 ± 0.043
2.074IleAsn: 2.074 ± 0.068
3.244IlePro: 3.244 ± 0.073
1.511IleGln: 1.511 ± 0.054
3.148IleArg: 3.148 ± 0.068
4.231IleSer: 4.231 ± 0.092
4.012IleThr: 4.012 ± 0.082
5.067IleVal: 5.067 ± 0.101
0.595IleTrp: 0.595 ± 0.033
1.269IleTyr: 1.269 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
3.949LysAla: 3.949 ± 0.096
0.2LysCys: 0.2 ± 0.018
2.253LysAsp: 2.253 ± 0.059
2.84LysGlu: 2.84 ± 0.071
0.951LysPhe: 0.951 ± 0.038
2.143LysGly: 2.143 ± 0.067
0.939LysHis: 0.939 ± 0.038
2.614LysIle: 2.614 ± 0.067
2.64LysLys: 2.64 ± 0.076
3.181LysLeu: 3.181 ± 0.069
0.883LysMet: 0.883 ± 0.041
1.76LysAsn: 1.76 ± 0.048
2.083LysPro: 2.083 ± 0.108
1.719LysGln: 1.719 ± 0.051
2.181LysArg: 2.181 ± 0.061
1.848LysSer: 1.848 ± 0.055
2.518LysThr: 2.518 ± 0.058
2.749LysVal: 2.749 ± 0.074
0.414LysTrp: 0.414 ± 0.028
0.951LysTyr: 0.951 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
11.569LeuAla: 11.569 ± 0.154
1.178LeuCys: 1.178 ± 0.052
5.514LeuAsp: 5.514 ± 0.107
5.177LeuGlu: 5.177 ± 0.108
3.163LeuPhe: 3.163 ± 0.09
8.221LeuGly: 8.221 ± 0.148
2.039LeuHis: 2.039 ± 0.05
6.092LeuIle: 6.092 ± 0.132
3.201LeuLys: 3.201 ± 0.086
9.428LeuLeu: 9.428 ± 0.16
1.967LeuMet: 1.967 ± 0.062
2.822LeuAsn: 2.822 ± 0.067
4.641LeuPro: 4.641 ± 0.097
2.518LeuGln: 2.518 ± 0.068
5.448LeuArg: 5.448 ± 0.093
7.771LeuSer: 7.771 ± 0.13
5.173LeuThr: 5.173 ± 0.093
7.065LeuVal: 7.065 ± 0.12
1.169LeuTrp: 1.169 ± 0.044
2.137LeuTyr: 2.137 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.225MetAla: 2.225 ± 0.067
0.213MetCys: 0.213 ± 0.017
0.982MetAsp: 0.982 ± 0.041
0.951MetGlu: 0.951 ± 0.04
0.635MetPhe: 0.635 ± 0.033
1.562MetGly: 1.562 ± 0.05
0.525MetHis: 0.525 ± 0.031
1.295MetIle: 1.295 ± 0.046
0.795MetLys: 0.795 ± 0.036
2.169MetLeu: 2.169 ± 0.065
0.517MetMet: 0.517 ± 0.031
0.873MetAsn: 0.873 ± 0.039
1.172MetPro: 1.172 ± 0.04
0.74MetGln: 0.74 ± 0.036
1.413MetArg: 1.413 ± 0.051
1.909MetSer: 1.909 ± 0.057
1.458MetThr: 1.458 ± 0.048
1.539MetVal: 1.539 ± 0.051
0.295MetTrp: 0.295 ± 0.024
0.402MetTyr: 0.402 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.305AsnAla: 3.305 ± 0.081
0.245AsnCys: 0.245 ± 0.019
1.67AsnAsp: 1.67 ± 0.055
1.76AsnGlu: 1.76 ± 0.057
1.112AsnPhe: 1.112 ± 0.046
2.146AsnGly: 2.146 ± 0.065
0.697AsnHis: 0.697 ± 0.032
1.944AsnIle: 1.944 ± 0.054
1.343AsnLys: 1.343 ± 0.044
2.591AsnLeu: 2.591 ± 0.059
0.705AsnMet: 0.705 ± 0.035
1.309AsnAsn: 1.309 ± 0.05
2.117AsnPro: 2.117 ± 0.054
1.126AsnGln: 1.126 ± 0.043
1.543AsnArg: 1.543 ± 0.05
2.088AsnSer: 2.088 ± 0.066
2.178AsnThr: 2.178 ± 0.063
2.29AsnVal: 2.29 ± 0.058
0.375AsnTrp: 0.375 ± 0.023
0.896AsnTyr: 0.896 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
4.919ProAla: 4.919 ± 0.124
0.269ProCys: 0.269 ± 0.022
2.765ProAsp: 2.765 ± 0.065
3.822ProGlu: 3.822 ± 0.082
1.51ProPhe: 1.51 ± 0.051
3.908ProGly: 3.908 ± 0.117
1.407ProHis: 1.407 ± 0.043
2.556ProIle: 2.556 ± 0.061
1.485ProLys: 1.485 ± 0.055
4.108ProLeu: 4.108 ± 0.085
0.912ProMet: 0.912 ± 0.039
1.152ProAsn: 1.152 ± 0.046
1.563ProPro: 1.563 ± 0.049
2.467ProGln: 2.467 ± 0.07
2.244ProArg: 2.244 ± 0.063
2.784ProSer: 2.784 ± 0.085
3.016ProThr: 3.016 ± 0.078
3.984ProVal: 3.984 ± 0.104
0.6ProTrp: 0.6 ± 0.032
1.063ProTyr: 1.063 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.835GlnAla: 4.835 ± 0.106
0.324GlnCys: 0.324 ± 0.023
1.716GlnAsp: 1.716 ± 0.059
3.061GlnGlu: 3.061 ± 0.075
1.113GlnPhe: 1.113 ± 0.041
2.95GlnGly: 2.95 ± 0.071
1.211GlnHis: 1.211 ± 0.042
2.08GlnIle: 2.08 ± 0.063
1.768GlnLys: 1.768 ± 0.061
4.771GlnLeu: 4.771 ± 0.112
0.771GlnMet: 0.771 ± 0.032
1.042GlnAsn: 1.042 ± 0.04
2.187GlnPro: 2.187 ± 0.07
2.473GlnGln: 2.473 ± 0.08
2.97GlnArg: 2.97 ± 0.089
2.239GlnSer: 2.239 ± 0.063
1.786GlnThr: 1.786 ± 0.055
2.778GlnVal: 2.778 ± 0.078
0.788GlnTrp: 0.788 ± 0.04
0.85GlnTyr: 0.85 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
5.275ArgAla: 5.275 ± 0.104
0.424ArgCys: 0.424 ± 0.026
2.779ArgAsp: 2.779 ± 0.069
3.428ArgGlu: 3.428 ± 0.079
1.964ArgPhe: 1.964 ± 0.064
3.767ArgGly: 3.767 ± 0.081
1.216ArgHis: 1.216 ± 0.039
3.457ArgIle: 3.457 ± 0.079
2.31ArgLys: 2.31 ± 0.075
4.913ArgLeu: 4.913 ± 0.098
1.323ArgMet: 1.323 ± 0.047
1.866ArgAsn: 1.866 ± 0.056
2.219ArgPro: 2.219 ± 0.066
2.199ArgGln: 2.199 ± 0.07
3.838ArgArg: 3.838 ± 0.099
3.475ArgSer: 3.475 ± 0.083
3.194ArgThr: 3.194 ± 0.073
3.928ArgVal: 3.928 ± 0.08
0.749ArgTrp: 0.749 ± 0.035
1.611ArgTyr: 1.611 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
7.481SerAla: 7.481 ± 0.123
0.526SerCys: 0.526 ± 0.034
3.556SerAsp: 3.556 ± 0.077
3.652SerGlu: 3.652 ± 0.105
2.589SerPhe: 2.589 ± 0.067
5.59SerGly: 5.59 ± 0.098
1.543SerHis: 1.543 ± 0.045
3.822SerIle: 3.822 ± 0.076
2.057SerLys: 2.057 ± 0.061
6.017SerLeu: 6.017 ± 0.108
1.522SerMet: 1.522 ± 0.05
1.678SerAsn: 1.678 ± 0.051
2.793SerPro: 2.793 ± 0.072
2.53SerGln: 2.53 ± 0.067
3.194SerArg: 3.194 ± 0.072
4.63SerSer: 4.63 ± 0.116
4.134SerThr: 4.134 ± 0.09
5.047SerVal: 5.047 ± 0.104
0.915SerTrp: 0.915 ± 0.039
1.728SerTyr: 1.728 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
6.045ThrAla: 6.045 ± 0.097
0.532ThrCys: 0.532 ± 0.047
3.131ThrAsp: 3.131 ± 0.074
3.056ThrGlu: 3.056 ± 0.082
2.039ThrPhe: 2.039 ± 0.067
4.758ThrGly: 4.758 ± 0.088
1.656ThrHis: 1.656 ± 0.049
3.555ThrIle: 3.555 ± 0.079
2.121ThrLys: 2.121 ± 0.066
5.83ThrLeu: 5.83 ± 0.108
1.263ThrMet: 1.263 ± 0.042
1.803ThrAsn: 1.803 ± 0.057
3.596ThrPro: 3.596 ± 0.097
2.736ThrGln: 2.736 ± 0.073
2.885ThrArg: 2.885 ± 0.057
3.548ThrSer: 3.548 ± 0.082
4.15ThrThr: 4.15 ± 0.101
4.693ThrVal: 4.693 ± 0.104
0.797ThrTrp: 0.797 ± 0.036
1.525ThrTyr: 1.525 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
8.449ValAla: 8.449 ± 0.13
0.786ValCys: 0.786 ± 0.035
4.515ValAsp: 4.515 ± 0.101
4.845ValGlu: 4.845 ± 0.086
2.683ValPhe: 2.683 ± 0.076
5.541ValGly: 5.541 ± 0.115
1.721ValHis: 1.721 ± 0.062
4.963ValIle: 4.963 ± 0.082
2.554ValLys: 2.554 ± 0.093
7.741ValLeu: 7.741 ± 0.127
1.58ValMet: 1.58 ± 0.049
2.131ValAsn: 2.131 ± 0.052
3.61ValPro: 3.61 ± 0.083
2.319ValGln: 2.319 ± 0.056
3.891ValArg: 3.891 ± 0.085
5.275ValSer: 5.275 ± 0.087
4.329ValThr: 4.329 ± 0.09
6.678ValVal: 6.678 ± 0.126
0.846ValTrp: 0.846 ± 0.039
1.686ValTyr: 1.686 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
1.253TrpAla: 1.253 ± 0.045
0.128TrpCys: 0.128 ± 0.013
0.658TrpAsp: 0.658 ± 0.031
0.687TrpGlu: 0.687 ± 0.032
0.578TrpPhe: 0.578 ± 0.033
0.846TrpGly: 0.846 ± 0.042
0.335TrpHis: 0.335 ± 0.021
0.772TrpIle: 0.772 ± 0.036
0.499TrpLys: 0.499 ± 0.025
1.54TrpLeu: 1.54 ± 0.059
0.28TrpMet: 0.28 ± 0.02
0.379TrpAsn: 0.379 ± 0.026
0.34TrpPro: 0.34 ± 0.023
0.661TrpGln: 0.661 ± 0.037
0.797TrpArg: 0.797 ± 0.035
0.757TrpSer: 0.757 ± 0.032
0.606TrpThr: 0.606 ± 0.033
0.942TrpVal: 0.942 ± 0.042
0.251TrpTrp: 0.251 ± 0.019
0.333TrpTyr: 0.333 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.804TyrAla: 2.804 ± 0.073
0.226TyrCys: 0.226 ± 0.018
1.465TyrAsp: 1.465 ± 0.051
1.438TyrGlu: 1.438 ± 0.051
0.902TyrPhe: 0.902 ± 0.04
2.198TyrGly: 2.198 ± 0.06
0.569TyrHis: 0.569 ± 0.028
1.266TyrIle: 1.266 ± 0.049
0.759TyrLys: 0.759 ± 0.036
2.386TyrLeu: 2.386 ± 0.053
0.418TyrMet: 0.418 ± 0.027
0.702TyrAsn: 0.702 ± 0.03
1.332TyrPro: 1.332 ± 0.044
1.089TyrGln: 1.089 ± 0.038
1.571TyrArg: 1.571 ± 0.055
1.728TyrSer: 1.728 ± 0.054
1.344TyrThr: 1.344 ± 0.042
1.809TyrVal: 1.809 ± 0.058
0.304TyrTrp: 0.304 ± 0.024
0.644TyrTyr: 0.644 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1918 proteins (653807 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski