Amino acid dipepetide frequency for Rhodococcus kyotonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.866AlaAla: 17.866 ± 0.186	0.839AlaCys: 0.839 ± 0.025	8.282AlaAsp: 8.282 ± 0.093	7.367AlaGlu: 7.367 ± 0.082	3.648AlaPhe: 3.648 ± 0.044	10.784AlaGly: 10.784 ± 0.101	2.456AlaHis: 2.456 ± 0.044	5.166AlaIle: 5.166 ± 0.057	2.871AlaLys: 2.871 ± 0.054	12.88AlaLeu: 12.88 ± 0.123	2.675AlaMet: 2.675 ± 0.044	2.241AlaAsn: 2.241 ± 0.038	5.621AlaPro: 5.621 ± 0.075	3.595AlaGln: 3.595 ± 0.047	8.137AlaArg: 8.137 ± 0.081	7.59AlaSer: 7.59 ± 0.08	7.183AlaThr: 7.183 ± 0.074	12.034AlaVal: 12.034 ± 0.107	1.517AlaTrp: 1.517 ± 0.032	2.245AlaTyr: 2.245 ± 0.041	0.002AlaXaa: 0.002 ± 0.001
Cys	0.896CysAla: 0.896 ± 0.025	0.079CysCys: 0.079 ± 0.008	0.427CysAsp: 0.427 ± 0.018	0.332CysGlu: 0.332 ± 0.016	0.196CysPhe: 0.196 ± 0.012	0.754CysGly: 0.754 ± 0.024	0.16CysHis: 0.16 ± 0.01	0.293CysIle: 0.293 ± 0.012	0.1CysLys: 0.1 ± 0.008	0.54CysLeu: 0.54 ± 0.02	0.112CysMet: 0.112 ± 0.009	0.125CysAsn: 0.125 ± 0.009	0.372CysPro: 0.372 ± 0.016	0.139CysGln: 0.139 ± 0.01	0.475CysArg: 0.475 ± 0.018	0.511CysSer: 0.511 ± 0.017	0.466CysThr: 0.466 ± 0.016	0.552CysVal: 0.552 ± 0.02	0.097CysTrp: 0.097 ± 0.008	0.134CysTyr: 0.134 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.951AspAla: 8.951 ± 0.092	0.36AspCys: 0.36 ± 0.018	4.851AspAsp: 4.851 ± 0.06	4.247AspGlu: 4.247 ± 0.059	1.79AspPhe: 1.79 ± 0.037	6.308AspGly: 6.308 ± 0.076	1.366AspHis: 1.366 ± 0.03	2.919AspIle: 2.919 ± 0.038	1.393AspLys: 1.393 ± 0.032	6.466AspLeu: 6.466 ± 0.074	0.992AspMet: 0.992 ± 0.022	1.25AspAsn: 1.25 ± 0.027	4.178AspPro: 4.178 ± 0.053	1.543AspGln: 1.543 ± 0.032	4.837AspArg: 4.837 ± 0.068	3.525AspSer: 3.525 ± 0.047	3.639AspThr: 3.639 ± 0.043	6.33AspVal: 6.33 ± 0.082	0.848AspTrp: 0.848 ± 0.025	1.375AspTyr: 1.375 ± 0.032	0.001AspXaa: 0.001 ± 0.001
Glu	5.839GluAla: 5.839 ± 0.084	0.325GluCys: 0.325 ± 0.015	2.587GluAsp: 2.587 ± 0.044	2.621GluGlu: 2.621 ± 0.043	1.94GluPhe: 1.94 ± 0.036	3.412GluGly: 3.412 ± 0.052	1.516GluHis: 1.516 ± 0.032	2.789GluIle: 2.789 ± 0.036	1.739GluLys: 1.739 ± 0.035	6.598GluLeu: 6.598 ± 0.068	1.075GluMet: 1.075 ± 0.029	1.536GluAsn: 1.536 ± 0.032	2.947GluPro: 2.947 ± 0.053	2.207GluGln: 2.207 ± 0.043	4.521GluArg: 4.521 ± 0.059	3.402GluSer: 3.402 ± 0.053	2.955GluThr: 2.955 ± 0.042	4.287GluVal: 4.287 ± 0.058	0.874GluTrp: 0.874 ± 0.025	1.192GluTyr: 1.192 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.107PheAla: 4.107 ± 0.052	0.267PheCys: 0.267 ± 0.013	2.822PheAsp: 2.822 ± 0.048	1.753PheGlu: 1.753 ± 0.041	1.069PhePhe: 1.069 ± 0.029	3.517PheGly: 3.517 ± 0.052	0.644PheHis: 0.644 ± 0.022	0.906PheIle: 0.906 ± 0.03	0.502PheLys: 0.502 ± 0.021	2.671PheLeu: 2.671 ± 0.046	0.491PheMet: 0.491 ± 0.018	0.582PheAsn: 0.582 ± 0.022	1.346PhePro: 1.346 ± 0.03	0.724PheGln: 0.724 ± 0.024	1.662PheArg: 1.662 ± 0.032	1.775PheSer: 1.775 ± 0.033	2.002PheThr: 2.002 ± 0.04	3.201PheVal: 3.201 ± 0.052	0.415PheTrp: 0.415 ± 0.018	0.668PheTyr: 0.668 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.513GlyAla: 9.513 ± 0.094	0.676GlyCys: 0.676 ± 0.022	5.126GlyAsp: 5.126 ± 0.06	4.41GlyGlu: 4.41 ± 0.053	3.084GlyPhe: 3.084 ± 0.046	7.414GlyGly: 7.414 ± 0.088	2.01GlyHis: 2.01 ± 0.042	4.488GlyIle: 4.488 ± 0.063	2.523GlyLys: 2.523 ± 0.05	8.401GlyLeu: 8.401 ± 0.087	1.954GlyMet: 1.954 ± 0.035	1.923GlyAsn: 1.923 ± 0.038	4.023GlyPro: 4.023 ± 0.05	2.421GlyGln: 2.421 ± 0.046	6.17GlyArg: 6.17 ± 0.075	5.825GlySer: 5.825 ± 0.054	5.643GlyThr: 5.643 ± 0.067	7.907GlyVal: 7.907 ± 0.075	1.479GlyTrp: 1.479 ± 0.03	2.209GlyTyr: 2.209 ± 0.037	0.002GlyXaa: 0.002 ± 0.001
His	2.429HisAla: 2.429 ± 0.045	0.183HisCys: 0.183 ± 0.011	1.442HisAsp: 1.442 ± 0.032	1.123HisGlu: 1.123 ± 0.026	0.658HisPhe: 0.658 ± 0.022	2.052HisGly: 2.052 ± 0.044	0.635HisHis: 0.635 ± 0.028	0.827HisIle: 0.827 ± 0.022	0.347HisLys: 0.347 ± 0.014	2.025HisLeu: 2.025 ± 0.039	0.364HisMet: 0.364 ± 0.016	0.415HisAsn: 0.415 ± 0.018	1.473HisPro: 1.473 ± 0.032	0.528HisGln: 0.528 ± 0.019	1.745HisArg: 1.745 ± 0.035	1.179HisSer: 1.179 ± 0.026	1.103HisThr: 1.103 ± 0.026	1.779HisVal: 1.779 ± 0.038	0.29HisTrp: 0.29 ± 0.014	0.448HisTyr: 0.448 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.529IleAla: 6.529 ± 0.062	0.336IleCys: 0.336 ± 0.015	3.822IleAsp: 3.822 ± 0.05	2.792IleGlu: 2.792 ± 0.046	1.086IlePhe: 1.086 ± 0.029	4.604IleGly: 4.604 ± 0.053	0.756IleHis: 0.756 ± 0.021	1.334IleIle: 1.334 ± 0.038	0.815IleLys: 0.815 ± 0.026	3.459IleLeu: 3.459 ± 0.052	0.667IleMet: 0.667 ± 0.021	0.912IleAsn: 0.912 ± 0.022	2.349IlePro: 2.349 ± 0.035	0.853IleGln: 0.853 ± 0.019	2.542IleArg: 2.542 ± 0.037	2.481IleSer: 2.481 ± 0.04	2.727IleThr: 2.727 ± 0.039	4.286IleVal: 4.286 ± 0.056	0.432IleTrp: 0.432 ± 0.019	0.753IleTyr: 0.753 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.847LysAla: 2.847 ± 0.052	0.108LysCys: 0.108 ± 0.008	1.236LysAsp: 1.236 ± 0.035	1.093LysGlu: 1.093 ± 0.032	0.736LysPhe: 0.736 ± 0.026	1.624LysGly: 1.624 ± 0.034	0.508LysHis: 0.508 ± 0.018	1.199LysIle: 1.199 ± 0.033	0.925LysLys: 0.925 ± 0.034	2.258LysLeu: 2.258 ± 0.046	0.501LysMet: 0.501 ± 0.016	0.642LysAsn: 0.642 ± 0.02	1.356LysPro: 1.356 ± 0.032	0.727LysGln: 0.727 ± 0.024	1.543LysArg: 1.543 ± 0.032	1.462LysSer: 1.462 ± 0.038	1.528LysThr: 1.528 ± 0.033	1.988LysVal: 1.988 ± 0.039	0.321LysTrp: 0.321 ± 0.013	0.59LysTyr: 0.59 ± 0.021	0.001LysXaa: 0.001 ± 0.001
Leu	13.117LeuAla: 13.117 ± 0.11	0.719LeuCys: 0.719 ± 0.023	7.247LeuAsp: 7.247 ± 0.089	4.713LeuGlu: 4.713 ± 0.049	2.939LeuPhe: 2.939 ± 0.052	9.013LeuGly: 9.013 ± 0.082	1.958LeuHis: 1.958 ± 0.04	3.856LeuIle: 3.856 ± 0.056	1.822LeuLys: 1.822 ± 0.042	9.319LeuLeu: 9.319 ± 0.095	1.72LeuMet: 1.72 ± 0.04	1.888LeuAsn: 1.888 ± 0.042	5.316LeuPro: 5.316 ± 0.074	2.472LeuGln: 2.472 ± 0.041	6.972LeuArg: 6.972 ± 0.073	6.048LeuSer: 6.048 ± 0.063	6.358LeuThr: 6.358 ± 0.061	9.217LeuVal: 9.217 ± 0.089	1.149LeuTrp: 1.149 ± 0.029	1.686LeuTyr: 1.686 ± 0.028	0.002LeuXaa: 0.002 ± 0.001
Met	2.232MetAla: 2.232 ± 0.038	0.163MetCys: 0.163 ± 0.01	0.927MetAsp: 0.927 ± 0.026	0.694MetGlu: 0.694 ± 0.022	0.645MetPhe: 0.645 ± 0.02	1.387MetGly: 1.387 ± 0.034	0.423MetHis: 0.423 ± 0.015	0.961MetIle: 0.961 ± 0.027	0.535MetLys: 0.535 ± 0.021	1.963MetLeu: 1.963 ± 0.034	0.387MetMet: 0.387 ± 0.015	0.587MetAsn: 0.587 ± 0.019	1.093MetPro: 1.093 ± 0.027	0.562MetGln: 0.562 ± 0.02	1.369MetArg: 1.369 ± 0.03	1.666MetSer: 1.666 ± 0.031	1.838MetThr: 1.838 ± 0.034	1.601MetVal: 1.601 ± 0.032	0.266MetTrp: 0.266 ± 0.015	0.378MetTyr: 0.378 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	2.549AsnAla: 2.549 ± 0.041	0.148AsnCys: 0.148 ± 0.008	1.273AsnAsp: 1.273 ± 0.029	1.014AsnGlu: 1.014 ± 0.025	0.688AsnPhe: 0.688 ± 0.022	1.962AsnGly: 1.962 ± 0.037	0.437AsnHis: 0.437 ± 0.016	1.012AsnIle: 1.012 ± 0.026	0.519AsnLys: 0.519 ± 0.018	2.0AsnLeu: 2.0 ± 0.036	0.405AsnMet: 0.405 ± 0.017	0.532AsnAsn: 0.532 ± 0.018	1.554AsnPro: 1.554 ± 0.035	0.578AsnGln: 0.578 ± 0.016	1.384AsnArg: 1.384 ± 0.033	1.273AsnSer: 1.273 ± 0.029	1.362AsnThr: 1.362 ± 0.032	1.74AsnVal: 1.74 ± 0.036	0.331AsnTrp: 0.331 ± 0.016	0.526AsnTyr: 0.526 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.071ProAla: 6.071 ± 0.078	0.237ProCys: 0.237 ± 0.013	4.213ProAsp: 4.213 ± 0.054	3.625ProGlu: 3.625 ± 0.058	1.555ProPhe: 1.555 ± 0.032	4.754ProGly: 4.754 ± 0.058	1.055ProHis: 1.055 ± 0.026	2.256ProIle: 2.256 ± 0.04	1.308ProLys: 1.308 ± 0.032	4.563ProLeu: 4.563 ± 0.059	0.99ProMet: 0.99 ± 0.026	1.187ProAsn: 1.187 ± 0.031	2.473ProPro: 2.473 ± 0.052	1.453ProGln: 1.453 ± 0.037	3.077ProArg: 3.077 ± 0.046	3.504ProSer: 3.504 ± 0.054	3.598ProThr: 3.598 ± 0.056	4.911ProVal: 4.911 ± 0.058	0.724ProTrp: 0.724 ± 0.025	1.057ProTyr: 1.057 ± 0.029	0.001ProXaa: 0.001 ± 0.001
Gln	3.149GlnAla: 3.149 ± 0.047	0.173GlnCys: 0.173 ± 0.011	1.278GlnAsp: 1.278 ± 0.028	1.174GlnGlu: 1.174 ± 0.028	0.97GlnPhe: 0.97 ± 0.025	1.961GlnGly: 1.961 ± 0.037	0.626GlnHis: 0.626 ± 0.02	1.427GlnIle: 1.427 ± 0.027	0.734GlnLys: 0.734 ± 0.021	3.106GlnLeu: 3.106 ± 0.055	0.611GlnMet: 0.611 ± 0.023	0.758GlnAsn: 0.758 ± 0.024	1.413GlnPro: 1.413 ± 0.034	1.169GlnGln: 1.169 ± 0.036	2.146GlnArg: 2.146 ± 0.041	1.614GlnSer: 1.614 ± 0.03	1.385GlnThr: 1.385 ± 0.028	2.403GlnVal: 2.403 ± 0.046	0.516GlnTrp: 0.516 ± 0.019	0.665GlnTyr: 0.665 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.752ArgAla: 7.752 ± 0.081	0.461ArgCys: 0.461 ± 0.017	4.137ArgAsp: 4.137 ± 0.056	3.894ArgGlu: 3.894 ± 0.06	2.239ArgPhe: 2.239 ± 0.038	5.05ArgGly: 5.05 ± 0.056	1.547ArgHis: 1.547 ± 0.033	3.506ArgIle: 3.506 ± 0.046	1.707ArgLys: 1.707 ± 0.035	6.509ArgLeu: 6.509 ± 0.062	1.709ArgMet: 1.709 ± 0.031	1.503ArgAsn: 1.503 ± 0.031	3.421ArgPro: 3.421 ± 0.054	1.939ArgGln: 1.939 ± 0.038	6.114ArgArg: 6.114 ± 0.078	4.482ArgSer: 4.482 ± 0.058	4.823ArgThr: 4.823 ± 0.061	5.618ArgVal: 5.618 ± 0.065	1.195ArgTrp: 1.195 ± 0.028	1.648ArgTyr: 1.648 ± 0.034	0.002ArgXaa: 0.002 ± 0.002
Ser	7.545SerAla: 7.545 ± 0.072	0.35SerCys: 0.35 ± 0.016	4.111SerAsp: 4.111 ± 0.051	3.17SerGlu: 3.17 ± 0.052	1.882SerPhe: 1.882 ± 0.039	6.11SerGly: 6.11 ± 0.06	1.072SerHis: 1.072 ± 0.025	2.964SerIle: 2.964 ± 0.045	1.457SerLys: 1.457 ± 0.032	5.551SerLeu: 5.551 ± 0.066	1.551SerMet: 1.551 ± 0.032	1.352SerAsn: 1.352 ± 0.029	3.153SerPro: 3.153 ± 0.041	1.512SerGln: 1.512 ± 0.03	3.994SerArg: 3.994 ± 0.05	4.109SerSer: 4.109 ± 0.055	4.351SerThr: 4.351 ± 0.054	5.559SerVal: 5.559 ± 0.066	0.931SerTrp: 0.931 ± 0.025	1.327SerTyr: 1.327 ± 0.026	0.001SerXaa: 0.001 ± 0.001
Thr	7.936ThrAla: 7.936 ± 0.072	0.382ThrCys: 0.382 ± 0.018	4.094ThrAsp: 4.094 ± 0.048	3.475ThrGlu: 3.475 ± 0.043	1.967ThrPhe: 1.967 ± 0.034	5.8ThrGly: 5.8 ± 0.066	1.254ThrHis: 1.254 ± 0.032	2.643ThrIle: 2.643 ± 0.046	1.35ThrLys: 1.35 ± 0.033	5.92ThrLeu: 5.92 ± 0.058	1.216ThrMet: 1.216 ± 0.032	1.202ThrAsn: 1.202 ± 0.029	3.829ThrPro: 3.829 ± 0.052	1.508ThrGln: 1.508 ± 0.03	3.757ThrArg: 3.757 ± 0.045	3.986ThrSer: 3.986 ± 0.054	4.467ThrThr: 4.467 ± 0.059	6.622ThrVal: 6.622 ± 0.065	0.837ThrTrp: 0.837 ± 0.022	1.292ThrTyr: 1.292 ± 0.031	0.002ThrXaa: 0.002 ± 0.001
Val	11.856ValAla: 11.856 ± 0.115	0.674ValCys: 0.674 ± 0.019	7.101ValAsp: 7.101 ± 0.068	5.126ValGlu: 5.126 ± 0.067	2.777ValPhe: 2.777 ± 0.047	7.741ValGly: 7.741 ± 0.078	1.959ValHis: 1.959 ± 0.035	3.557ValIle: 3.557 ± 0.052	1.812ValLys: 1.812 ± 0.038	9.673ValLeu: 9.673 ± 0.095	1.599ValMet: 1.599 ± 0.032	1.775ValAsn: 1.775 ± 0.032	4.903ValPro: 4.903 ± 0.066	2.253ValGln: 2.253 ± 0.036	6.074ValArg: 6.074 ± 0.068	5.392ValSer: 5.392 ± 0.063	5.947ValThr: 5.947 ± 0.07	10.219ValVal: 10.219 ± 0.09	1.05ValTrp: 1.05 ± 0.024	1.524ValTyr: 1.524 ± 0.028	0.001ValXaa: 0.001 ± 0.001
Trp	1.499TrpAla: 1.499 ± 0.028	0.117TrpCys: 0.117 ± 0.008	0.738TrpAsp: 0.738 ± 0.026	0.609TrpGlu: 0.609 ± 0.021	0.518TrpPhe: 0.518 ± 0.02	0.943TrpGly: 0.943 ± 0.024	0.294TrpHis: 0.294 ± 0.014	0.722TrpIle: 0.722 ± 0.021	0.372TrpLys: 0.372 ± 0.016	1.453TrpLeu: 1.453 ± 0.032	0.342TrpMet: 0.342 ± 0.016	0.448TrpAsn: 0.448 ± 0.018	0.679TrpPro: 0.679 ± 0.023	0.537TrpGln: 0.537 ± 0.017	1.082TrpArg: 1.082 ± 0.028	0.943TrpSer: 0.943 ± 0.019	0.967TrpThr: 0.967 ± 0.025	1.055TrpVal: 1.055 ± 0.027	0.321TrpTrp: 0.321 ± 0.015	0.274TrpTyr: 0.274 ± 0.014	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.315TyrAla: 2.315 ± 0.039	0.161TyrCys: 0.161 ± 0.01	1.457TyrAsp: 1.457 ± 0.035	1.129TyrGlu: 1.129 ± 0.027	0.735TyrPhe: 0.735 ± 0.023	2.009TyrGly: 2.009 ± 0.035	0.37TyrHis: 0.37 ± 0.016	0.711TyrIle: 0.711 ± 0.022	0.362TyrLys: 0.362 ± 0.016	2.178TyrLeu: 2.178 ± 0.038	0.313TyrMet: 0.313 ± 0.016	0.43TyrAsn: 0.43 ± 0.018	1.11TyrPro: 1.11 ± 0.028	0.558TyrGln: 0.558 ± 0.017	1.649TyrArg: 1.649 ± 0.036	1.284TyrSer: 1.284 ± 0.029	1.196TyrThr: 1.196 ± 0.028	1.702TyrVal: 1.702 ± 0.033	0.322TyrTrp: 0.322 ± 0.014	0.451TyrTyr: 0.451 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4877 proteins (1626480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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