Amino acid dipepetide frequency for Candidatus Fokinia solitaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.929AlaAla: 4.929 ± 0.173
0.9AlaCys: 0.9 ± 0.075
2.895AlaAsp: 2.895 ± 0.119
4.114AlaGlu: 4.114 ± 0.186
3.254AlaPhe: 3.254 ± 0.099
3.121AlaGly: 3.121 ± 0.128
1.215AlaHis: 1.215 ± 0.071
6.645AlaIle: 6.645 ± 0.185
5.046AlaLys: 5.046 ± 0.159
7.295AlaLeu: 7.295 ± 0.177
1.841AlaMet: 1.841 ± 0.085
2.878AlaAsn: 2.878 ± 0.115
1.647AlaPro: 1.647 ± 0.088
2.382AlaGln: 2.382 ± 0.124
2.559AlaArg: 2.559 ± 0.11
4.711AlaSer: 4.711 ± 0.142
3.484AlaThr: 3.484 ± 0.133
4.748AlaVal: 4.748 ± 0.149
0.396AlaTrp: 0.396 ± 0.039
2.103AlaTyr: 2.103 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
1.07CysAla: 1.07 ± 0.066
0.335CysCys: 0.335 ± 0.046
0.888CysAsp: 0.888 ± 0.065
0.856CysGlu: 0.856 ± 0.069
0.836CysPhe: 0.836 ± 0.06
1.122CysGly: 1.122 ± 0.073
0.258CysHis: 0.258 ± 0.031
1.583CysIle: 1.583 ± 0.095
1.05CysLys: 1.05 ± 0.072
0.904CysLeu: 0.904 ± 0.067
0.424CysMet: 0.424 ± 0.043
1.058CysAsn: 1.058 ± 0.07
0.347CysPro: 0.347 ± 0.042
0.359CysGln: 0.359 ± 0.04
0.549CysArg: 0.549 ± 0.049
1.142CysSer: 1.142 ± 0.073
1.013CysThr: 1.013 ± 0.07
0.977CysVal: 0.977 ± 0.074
0.101CysTrp: 0.101 ± 0.021
0.618CysTyr: 0.618 ± 0.054
0.0CysXaa: 0.0 ± 0.0
Asp
3.876AspAla: 3.876 ± 0.201
0.666AspCys: 0.666 ± 0.05
2.955AspAsp: 2.955 ± 0.131
3.649AspGlu: 3.649 ± 0.153
2.459AspPhe: 2.459 ± 0.1
2.818AspGly: 2.818 ± 0.127
0.723AspHis: 0.723 ± 0.058
5.692AspIle: 5.692 ± 0.169
3.629AspLys: 3.629 ± 0.132
3.609AspLeu: 3.609 ± 0.141
1.247AspMet: 1.247 ± 0.071
2.604AspAsn: 2.604 ± 0.107
0.985AspPro: 0.985 ± 0.064
0.949AspGln: 0.949 ± 0.068
1.724AspArg: 1.724 ± 0.085
3.976AspSer: 3.976 ± 0.147
2.886AspThr: 2.886 ± 0.122
4.457AspVal: 4.457 ± 0.147
0.299AspTrp: 0.299 ± 0.031
1.829AspTyr: 1.829 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
4.053GluAla: 4.053 ± 0.167
1.106GluCys: 1.106 ± 0.079
3.032GluAsp: 3.032 ± 0.143
5.712GluGlu: 5.712 ± 0.381
2.58GluPhe: 2.58 ± 0.14
2.705GluGly: 2.705 ± 0.128
1.433GluHis: 1.433 ± 0.093
6.245GluIle: 6.245 ± 0.171
6.649GluLys: 6.649 ± 0.264
5.854GluLeu: 5.854 ± 0.218
2.103GluMet: 2.103 ± 0.108
3.859GluAsn: 3.859 ± 0.219
0.997GluPro: 0.997 ± 0.059
2.35GluGln: 2.35 ± 0.16
3.278GluArg: 3.278 ± 0.159
4.223GluSer: 4.223 ± 0.174
2.164GluThr: 2.164 ± 0.099
4.38GluVal: 4.38 ± 0.134
0.44GluTrp: 0.44 ± 0.043
2.862GluTyr: 2.862 ± 0.112
0.0GluXaa: 0.0 ± 0.0
Phe
2.636PheAla: 2.636 ± 0.099
0.892PheCys: 0.892 ± 0.069
2.555PheAsp: 2.555 ± 0.102
2.378PheGlu: 2.378 ± 0.124
2.285PhePhe: 2.285 ± 0.112
2.555PheGly: 2.555 ± 0.129
1.187PheHis: 1.187 ± 0.074
4.037PheIle: 4.037 ± 0.14
2.41PheLys: 2.41 ± 0.104
4.675PheLeu: 4.675 ± 0.157
1.183PheMet: 1.183 ± 0.065
1.926PheAsn: 1.926 ± 0.098
1.28PhePro: 1.28 ± 0.08
1.421PheGln: 1.421 ± 0.081
1.583PheArg: 1.583 ± 0.083
4.509PheSer: 4.509 ± 0.157
2.483PheThr: 2.483 ± 0.097
2.733PheVal: 2.733 ± 0.126
0.408PheTrp: 0.408 ± 0.039
1.841PheTyr: 1.841 ± 0.12
0.0PheXaa: 0.0 ± 0.0
Gly
3.722GlyAla: 3.722 ± 0.153
0.945GlyCys: 0.945 ± 0.067
2.612GlyAsp: 2.612 ± 0.119
3.383GlyGlu: 3.383 ± 0.137
2.438GlyPhe: 2.438 ± 0.115
3.549GlyGly: 3.549 ± 0.153
0.864GlyHis: 0.864 ± 0.061
5.345GlyIle: 5.345 ± 0.209
4.299GlyLys: 4.299 ± 0.133
4.178GlyLeu: 4.178 ± 0.173
1.675GlyMet: 1.675 ± 0.086
2.608GlyAsn: 2.608 ± 0.104
0.763GlyPro: 0.763 ± 0.066
1.288GlyGln: 1.288 ± 0.069
2.224GlyArg: 2.224 ± 0.096
3.064GlySer: 3.064 ± 0.115
3.347GlyThr: 3.347 ± 0.112
4.186GlyVal: 4.186 ± 0.129
0.468GlyTrp: 0.468 ± 0.049
2.285GlyTyr: 2.285 ± 0.104
0.0GlyXaa: 0.0 ± 0.0
His
1.26HisAla: 1.26 ± 0.082
0.351HisCys: 0.351 ± 0.035
1.381HisAsp: 1.381 ± 0.075
1.36HisGlu: 1.36 ± 0.094
1.074HisPhe: 1.074 ± 0.068
1.256HisGly: 1.256 ± 0.073
0.731HisHis: 0.731 ± 0.057
1.974HisIle: 1.974 ± 0.104
1.49HisLys: 1.49 ± 0.076
1.748HisLeu: 1.748 ± 0.091
0.597HisMet: 0.597 ± 0.051
1.381HisAsn: 1.381 ± 0.076
0.759HisPro: 0.759 ± 0.061
0.658HisGln: 0.658 ± 0.064
0.985HisArg: 0.985 ± 0.074
1.845HisSer: 1.845 ± 0.096
1.207HisThr: 1.207 ± 0.076
1.377HisVal: 1.377 ± 0.072
0.109HisTrp: 0.109 ± 0.02
0.937HisTyr: 0.937 ± 0.065
0.0HisXaa: 0.0 ± 0.0
Ile
7.674IleAla: 7.674 ± 0.18
1.409IleCys: 1.409 ± 0.093
4.404IleAsp: 4.404 ± 0.142
5.942IleGlu: 5.942 ± 0.159
3.799IlePhe: 3.799 ± 0.159
5.777IleGly: 5.777 ± 0.202
1.663IleHis: 1.663 ± 0.084
6.883IleIle: 6.883 ± 0.214
6.148IleLys: 6.148 ± 0.173
8.377IleLeu: 8.377 ± 0.225
2.115IleMet: 2.115 ± 0.086
3.742IleAsn: 3.742 ± 0.119
3.238IlePro: 3.238 ± 0.131
2.741IleGln: 2.741 ± 0.134
3.516IleArg: 3.516 ± 0.122
8.304IleSer: 8.304 ± 0.192
5.486IleThr: 5.486 ± 0.173
6.031IleVal: 6.031 ± 0.171
0.436IleTrp: 0.436 ± 0.043
2.475IleTyr: 2.475 ± 0.131
0.0IleXaa: 0.0 ± 0.0
Lys
4.881LysAla: 4.881 ± 0.155
1.046LysCys: 1.046 ± 0.069
3.811LysAsp: 3.811 ± 0.193
5.793LysGlu: 5.793 ± 0.285
3.209LysPhe: 3.209 ± 0.123
3.27LysGly: 3.27 ± 0.114
1.837LysHis: 1.837 ± 0.089
7.214LysIle: 7.214 ± 0.199
6.923LysLys: 6.923 ± 0.238
6.657LysLeu: 6.657 ± 0.226
2.438LysMet: 2.438 ± 0.095
4.695LysAsn: 4.695 ± 0.139
1.336LysPro: 1.336 ± 0.076
2.398LysGln: 2.398 ± 0.132
3.67LysArg: 3.67 ± 0.134
4.957LysSer: 4.957 ± 0.154
3.286LysThr: 3.286 ± 0.117
4.723LysVal: 4.723 ± 0.158
0.452LysTrp: 0.452 ± 0.043
3.056LysTyr: 3.056 ± 0.117
0.0LysXaa: 0.0 ± 0.0
Leu
5.393LeuAla: 5.393 ± 0.16
1.692LeuCys: 1.692 ± 0.104
4.356LeuAsp: 4.356 ± 0.142
5.624LeuGlu: 5.624 ± 0.245
4.368LeuPhe: 4.368 ± 0.152
4.869LeuGly: 4.869 ± 0.167
2.588LeuHis: 2.588 ± 0.104
6.556LeuIle: 6.556 ± 0.158
6.677LeuLys: 6.677 ± 0.219
10.391LeuLeu: 10.391 ± 0.253
2.208LeuMet: 2.208 ± 0.1
4.55LeuAsn: 4.55 ± 0.134
3.314LeuPro: 3.314 ± 0.13
4.336LeuGln: 4.336 ± 0.239
4.174LeuArg: 4.174 ± 0.113
9.067LeuSer: 9.067 ± 0.213
3.831LeuThr: 3.831 ± 0.135
4.227LeuVal: 4.227 ± 0.153
0.638LeuTrp: 0.638 ± 0.055
3.698LeuTyr: 3.698 ± 0.136
0.0LeuXaa: 0.0 ± 0.0
Met
1.207MetAla: 1.207 ± 0.063
0.468MetCys: 0.468 ± 0.042
1.05MetAsp: 1.05 ± 0.069
1.546MetGlu: 1.546 ± 0.083
0.924MetPhe: 0.924 ± 0.061
0.957MetGly: 0.957 ± 0.066
0.957MetHis: 0.957 ± 0.057
2.333MetIle: 2.333 ± 0.089
2.543MetLys: 2.543 ± 0.108
3.31MetLeu: 3.31 ± 0.13
0.953MetMet: 0.953 ± 0.059
1.461MetAsn: 1.461 ± 0.08
1.013MetPro: 1.013 ± 0.071
1.574MetGln: 1.574 ± 0.107
1.461MetArg: 1.461 ± 0.079
2.091MetSer: 2.091 ± 0.103
1.142MetThr: 1.142 ± 0.075
1.195MetVal: 1.195 ± 0.082
0.178MetTrp: 0.178 ± 0.022
0.965MetTyr: 0.965 ± 0.07
0.0MetXaa: 0.0 ± 0.0
Asn
4.166AsnAla: 4.166 ± 0.147
0.573AsnCys: 0.573 ± 0.059
2.963AsnAsp: 2.963 ± 0.128
3.326AsnGlu: 3.326 ± 0.14
2.455AsnPhe: 2.455 ± 0.103
3.234AsnGly: 3.234 ± 0.133
0.937AsnHis: 0.937 ± 0.069
5.079AsnIle: 5.079 ± 0.141
3.31AsnLys: 3.31 ± 0.133
4.037AsnLeu: 4.037 ± 0.139
1.32AsnMet: 1.32 ± 0.068
2.79AsnAsn: 2.79 ± 0.123
1.409AsnPro: 1.409 ± 0.068
1.219AsnGln: 1.219 ± 0.088
1.792AsnArg: 1.792 ± 0.099
4.178AsnSer: 4.178 ± 0.14
2.975AsnThr: 2.975 ± 0.118
3.98AsnVal: 3.98 ± 0.158
0.311AsnTrp: 0.311 ± 0.042
1.671AsnTyr: 1.671 ± 0.094
0.0AsnXaa: 0.0 ± 0.0
Pro
1.292ProAla: 1.292 ± 0.083
0.379ProCys: 0.379 ± 0.046
1.025ProAsp: 1.025 ± 0.077
1.474ProGlu: 1.474 ± 0.095
1.449ProPhe: 1.449 ± 0.079
1.219ProGly: 1.219 ± 0.083
0.86ProHis: 0.86 ± 0.077
2.495ProIle: 2.495 ± 0.128
1.692ProLys: 1.692 ± 0.095
2.842ProLeu: 2.842 ± 0.106
0.541ProMet: 0.541 ± 0.054
1.159ProAsn: 1.159 ± 0.069
0.82ProPro: 0.82 ± 0.08
1.114ProGln: 1.114 ± 0.07
0.981ProArg: 0.981 ± 0.075
2.535ProSer: 2.535 ± 0.107
1.449ProThr: 1.449 ± 0.082
1.74ProVal: 1.74 ± 0.104
0.194ProTrp: 0.194 ± 0.027
1.167ProTyr: 1.167 ± 0.069
0.0ProXaa: 0.0 ± 0.0
Gln
1.671GlnAla: 1.671 ± 0.08
0.493GlnCys: 0.493 ± 0.045
1.72GlnAsp: 1.72 ± 0.113
2.656GlnGlu: 2.656 ± 0.195
1.316GlnPhe: 1.316 ± 0.07
1.118GlnGly: 1.118 ± 0.066
1.054GlnHis: 1.054 ± 0.065
2.713GlnIle: 2.713 ± 0.109
3.339GlnLys: 3.339 ± 0.24
3.016GlnLeu: 3.016 ± 0.16
0.953GlnMet: 0.953 ± 0.061
2.616GlnAsn: 2.616 ± 0.123
0.702GlnPro: 0.702 ± 0.055
1.954GlnGln: 1.954 ± 0.207
1.49GlnArg: 1.49 ± 0.115
2.656GlnSer: 2.656 ± 0.151
1.243GlnThr: 1.243 ± 0.081
1.546GlnVal: 1.546 ± 0.088
0.194GlnTrp: 0.194 ± 0.027
1.893GlnTyr: 1.893 ± 0.098
0.0GlnXaa: 0.0 ± 0.0
Arg
2.442ArgAla: 2.442 ± 0.103
0.517ArgCys: 0.517 ± 0.048
2.333ArgAsp: 2.333 ± 0.105
3.294ArgGlu: 3.294 ± 0.143
1.841ArgPhe: 1.841 ± 0.084
2.329ArgGly: 2.329 ± 0.118
0.723ArgHis: 0.723 ± 0.06
3.625ArgIle: 3.625 ± 0.129
3.714ArgLys: 3.714 ± 0.129
3.117ArgLeu: 3.117 ± 0.125
1.268ArgMet: 1.268 ± 0.076
2.523ArgAsn: 2.523 ± 0.091
0.836ArgPro: 0.836 ± 0.061
1.142ArgGln: 1.142 ± 0.086
1.829ArgArg: 1.829 ± 0.093
2.543ArgSer: 2.543 ± 0.114
1.954ArgThr: 1.954 ± 0.091
2.741ArgVal: 2.741 ± 0.115
0.335ArgTrp: 0.335 ± 0.037
1.982ArgTyr: 1.982 ± 0.091
0.0ArgXaa: 0.0 ± 0.0
Ser
5.365SerAla: 5.365 ± 0.175
1.175SerCys: 1.175 ± 0.088
4.618SerAsp: 4.618 ± 0.165
5.075SerGlu: 5.075 ± 0.213
3.674SerPhe: 3.674 ± 0.129
4.509SerGly: 4.509 ± 0.19
1.861SerHis: 1.861 ± 0.101
7.569SerIle: 7.569 ± 0.221
5.406SerLys: 5.406 ± 0.183
6.693SerLeu: 6.693 ± 0.168
2.079SerMet: 2.079 ± 0.094
4.178SerAsn: 4.178 ± 0.167
2.099SerPro: 2.099 ± 0.102
2.64SerGln: 2.64 ± 0.123
2.697SerArg: 2.697 ± 0.121
6.722SerSer: 6.722 ± 0.293
4.8SerThr: 4.8 ± 0.214
4.949SerVal: 4.949 ± 0.135
0.488SerTrp: 0.488 ± 0.049
3.044SerTyr: 3.044 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
3.678ThrAla: 3.678 ± 0.143
0.646ThrCys: 0.646 ± 0.061
2.539ThrAsp: 2.539 ± 0.091
3.121ThrGlu: 3.121 ± 0.139
2.418ThrPhe: 2.418 ± 0.105
2.656ThrGly: 2.656 ± 0.125
1.086ThrHis: 1.086 ± 0.069
4.651ThrIle: 4.651 ± 0.164
3.367ThrLys: 3.367 ± 0.131
5.474ThrLeu: 5.474 ± 0.156
1.114ThrMet: 1.114 ± 0.063
2.329ThrAsn: 2.329 ± 0.106
1.865ThrPro: 1.865 ± 0.111
1.817ThrGln: 1.817 ± 0.087
1.76ThrArg: 1.76 ± 0.087
4.069ThrSer: 4.069 ± 0.181
3.31ThrThr: 3.31 ± 0.15
3.734ThrVal: 3.734 ± 0.138
0.323ThrTrp: 0.323 ± 0.032
1.853ThrTyr: 1.853 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
4.348ValAla: 4.348 ± 0.13
1.05ValCys: 1.05 ± 0.064
3.201ValAsp: 3.201 ± 0.113
4.085ValGlu: 4.085 ± 0.14
2.664ValPhe: 2.664 ± 0.094
3.536ValGly: 3.536 ± 0.13
1.389ValHis: 1.389 ± 0.087
5.898ValIle: 5.898 ± 0.167
4.683ValLys: 4.683 ± 0.152
6.754ValLeu: 6.754 ± 0.18
2.035ValMet: 2.035 ± 0.092
2.777ValAsn: 2.777 ± 0.107
1.938ValPro: 1.938 ± 0.134
2.293ValGln: 2.293 ± 0.091
2.745ValArg: 2.745 ± 0.12
5.119ValSer: 5.119 ± 0.16
3.577ValThr: 3.577 ± 0.143
5.212ValVal: 5.212 ± 0.19
0.347ValTrp: 0.347 ± 0.04
1.865ValTyr: 1.865 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.279TrpAla: 0.279 ± 0.036
0.141TrpCys: 0.141 ± 0.028
0.246TrpAsp: 0.246 ± 0.033
0.287TrpGlu: 0.287 ± 0.037
0.222TrpPhe: 0.222 ± 0.03
0.311TrpGly: 0.311 ± 0.039
0.161TrpHis: 0.161 ± 0.031
0.529TrpIle: 0.529 ± 0.051
0.634TrpLys: 0.634 ± 0.052
0.702TrpLeu: 0.702 ± 0.059
0.242TrpMet: 0.242 ± 0.033
0.448TrpAsn: 0.448 ± 0.041
0.145TrpPro: 0.145 ± 0.026
0.347TrpGln: 0.347 ± 0.042
0.371TrpArg: 0.371 ± 0.034
0.505TrpSer: 0.505 ± 0.051
0.246TrpThr: 0.246 ± 0.032
0.222TrpVal: 0.222 ± 0.028
0.089TrpTrp: 0.089 ± 0.018
0.339TrpTyr: 0.339 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.22TyrAla: 2.22 ± 0.095
0.706TyrCys: 0.706 ± 0.05
2.446TyrAsp: 2.446 ± 0.097
2.35TyrGlu: 2.35 ± 0.085
1.712TyrPhe: 1.712 ± 0.096
2.333TyrGly: 2.333 ± 0.112
0.953TyrHis: 0.953 ± 0.062
3.096TyrIle: 3.096 ± 0.123
2.644TyrLys: 2.644 ± 0.095
2.923TyrLeu: 2.923 ± 0.114
0.989TyrMet: 0.989 ± 0.066
2.144TyrAsn: 2.144 ± 0.094
0.933TyrPro: 0.933 ± 0.067
1.36TyrGln: 1.36 ± 0.104
1.7TyrArg: 1.7 ± 0.084
3.423TyrSer: 3.423 ± 0.134
1.926TyrThr: 1.926 ± 0.081
2.362TyrVal: 2.362 ± 0.104
0.262TyrTrp: 0.262 ± 0.036
1.385TyrTyr: 1.385 ± 0.076
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 720 proteins (247709 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski