Amino acid dipepetide frequency for Sulfurimonas hongkongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.991AlaAla: 3.991 ± 0.114
0.667AlaCys: 0.667 ± 0.038
3.375AlaAsp: 3.375 ± 0.074
3.167AlaGlu: 3.167 ± 0.069
3.026AlaPhe: 3.026 ± 0.069
3.932AlaGly: 3.932 ± 0.096
1.32AlaHis: 1.32 ± 0.051
6.167AlaIle: 6.167 ± 0.114
6.87AlaLys: 6.87 ± 0.109
7.561AlaLeu: 7.561 ± 0.131
2.023AlaMet: 2.023 ± 0.056
3.313AlaAsn: 3.313 ± 0.075
1.85AlaPro: 1.85 ± 0.054
2.549AlaGln: 2.549 ± 0.059
2.483AlaArg: 2.483 ± 0.07
5.146AlaSer: 5.146 ± 0.086
3.793AlaThr: 3.793 ± 0.079
3.742AlaVal: 3.742 ± 0.088
0.436AlaTrp: 0.436 ± 0.025
2.715AlaTyr: 2.715 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.637CysAla: 0.637 ± 0.033
0.066CysCys: 0.066 ± 0.011
0.623CysAsp: 0.623 ± 0.031
0.708CysGlu: 0.708 ± 0.038
0.337CysPhe: 0.337 ± 0.022
0.792CysGly: 0.792 ± 0.032
0.293CysHis: 0.293 ± 0.026
0.502CysIle: 0.502 ± 0.03
0.647CysLys: 0.647 ± 0.033
0.547CysLeu: 0.547 ± 0.03
0.189CysMet: 0.189 ± 0.019
0.406CysAsn: 0.406 ± 0.024
0.402CysPro: 0.402 ± 0.034
0.206CysGln: 0.206 ± 0.02
0.312CysArg: 0.312 ± 0.022
0.696CysSer: 0.696 ± 0.03
0.407CysThr: 0.407 ± 0.026
0.498CysVal: 0.498 ± 0.027
0.042CysTrp: 0.042 ± 0.008
0.289CysTyr: 0.289 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.191AspAla: 5.191 ± 0.096
0.395AspCys: 0.395 ± 0.025
3.413AspAsp: 3.413 ± 0.09
5.982AspGlu: 5.982 ± 0.107
3.322AspPhe: 3.322 ± 0.071
3.973AspGly: 3.973 ± 0.093
0.661AspHis: 0.661 ± 0.036
6.053AspIle: 6.053 ± 0.09
4.891AspLys: 4.891 ± 0.09
4.763AspLeu: 4.763 ± 0.084
1.619AspMet: 1.619 ± 0.045
2.56AspAsn: 2.56 ± 0.068
1.311AspPro: 1.311 ± 0.049
0.876AspGln: 0.876 ± 0.037
2.041AspArg: 2.041 ± 0.06
3.629AspSer: 3.629 ± 0.071
2.823AspThr: 2.823 ± 0.074
3.587AspVal: 3.587 ± 0.068
0.438AspTrp: 0.438 ± 0.027
2.135AspTyr: 2.135 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
4.951GluAla: 4.951 ± 0.096
0.633GluCys: 0.633 ± 0.03
4.183GluAsp: 4.183 ± 0.098
4.912GluGlu: 4.912 ± 0.119
3.794GluPhe: 3.794 ± 0.079
3.093GluGly: 3.093 ± 0.074
1.571GluHis: 1.571 ± 0.055
6.631GluIle: 6.631 ± 0.106
5.68GluLys: 5.68 ± 0.119
8.227GluLeu: 8.227 ± 0.135
2.144GluMet: 2.144 ± 0.053
3.399GluAsn: 3.399 ± 0.073
1.647GluPro: 1.647 ± 0.059
2.208GluGln: 2.208 ± 0.064
2.464GluArg: 2.464 ± 0.062
4.483GluSer: 4.483 ± 0.089
2.831GluThr: 2.831 ± 0.065
5.018GluVal: 5.018 ± 0.091
0.574GluTrp: 0.574 ± 0.03
2.928GluTyr: 2.928 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.329PheAla: 3.329 ± 0.074
0.523PheCys: 0.523 ± 0.03
3.222PheAsp: 3.222 ± 0.074
3.353PheGlu: 3.353 ± 0.071
2.629PhePhe: 2.629 ± 0.072
3.155PheGly: 3.155 ± 0.072
0.722PheHis: 0.722 ± 0.032
4.176PheIle: 4.176 ± 0.094
3.839PheLys: 3.839 ± 0.073
4.73PheLeu: 4.73 ± 0.106
1.339PheMet: 1.339 ± 0.049
2.36PheAsn: 2.36 ± 0.059
1.025PhePro: 1.025 ± 0.039
0.846PheGln: 0.846 ± 0.035
1.497PheArg: 1.497 ± 0.05
3.872PheSer: 3.872 ± 0.072
2.559PheThr: 2.559 ± 0.062
3.282PheVal: 3.282 ± 0.074
0.419PheTrp: 0.419 ± 0.027
1.941PheTyr: 1.941 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.307GlyAla: 4.307 ± 0.099
0.688GlyCys: 0.688 ± 0.03
3.348GlyAsp: 3.348 ± 0.084
3.759GlyGlu: 3.759 ± 0.066
3.387GlyPhe: 3.387 ± 0.078
3.918GlyGly: 3.918 ± 0.098
1.148GlyHis: 1.148 ± 0.043
4.778GlyIle: 4.778 ± 0.095
3.793GlyLys: 3.793 ± 0.075
5.1GlyLeu: 5.1 ± 0.105
1.623GlyMet: 1.623 ± 0.053
2.073GlyAsn: 2.073 ± 0.057
0.902GlyPro: 0.902 ± 0.04
1.256GlyGln: 1.256 ± 0.048
2.037GlyArg: 2.037 ± 0.058
3.843GlySer: 3.843 ± 0.077
2.841GlyThr: 2.841 ± 0.082
4.771GlyVal: 4.771 ± 0.081
0.496GlyTrp: 0.496 ± 0.028
2.611GlyTyr: 2.611 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.062HisAla: 1.062 ± 0.037
0.164HisCys: 0.164 ± 0.015
0.945HisAsp: 0.945 ± 0.039
1.169HisGlu: 1.169 ± 0.048
1.04HisPhe: 1.04 ± 0.043
1.093HisGly: 1.093 ± 0.044
0.467HisHis: 0.467 ± 0.028
1.688HisIle: 1.688 ± 0.046
1.592HisLys: 1.592 ± 0.052
1.831HisLeu: 1.831 ± 0.05
0.458HisMet: 0.458 ± 0.024
1.007HisAsn: 1.007 ± 0.035
0.85HisPro: 0.85 ± 0.035
0.599HisGln: 0.599 ± 0.029
0.702HisArg: 0.702 ± 0.034
1.282HisSer: 1.282 ± 0.045
1.026HisThr: 1.026 ± 0.039
0.777HisVal: 0.777 ± 0.036
0.148HisTrp: 0.148 ± 0.016
0.773HisTyr: 0.773 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.226IleAla: 6.226 ± 0.103
0.636IleCys: 0.636 ± 0.032
5.748IleAsp: 5.748 ± 0.094
6.609IleGlu: 6.609 ± 0.097
4.003IlePhe: 4.003 ± 0.083
4.819IleGly: 4.819 ± 0.111
1.26IleHis: 1.26 ± 0.04
6.753IleIle: 6.753 ± 0.121
7.701IleLys: 7.701 ± 0.122
7.688IleLeu: 7.688 ± 0.129
1.757IleMet: 1.757 ± 0.058
4.249IleAsn: 4.249 ± 0.093
2.505IlePro: 2.505 ± 0.066
2.088IleGln: 2.088 ± 0.057
2.648IleArg: 2.648 ± 0.063
6.856IleSer: 6.856 ± 0.098
4.375IleThr: 4.375 ± 0.089
5.8IleVal: 5.8 ± 0.1
0.488IleTrp: 0.488 ± 0.026
3.363IleTyr: 3.363 ± 0.081
0.0IleXaa: 0.0 ± 0.0
Lys
5.332LysAla: 5.332 ± 0.113
0.588LysCys: 0.588 ± 0.034
5.501LysAsp: 5.501 ± 0.094
8.617LysGlu: 8.617 ± 0.137
2.887LysPhe: 2.887 ± 0.073
3.728LysGly: 3.728 ± 0.077
1.678LysHis: 1.678 ± 0.049
7.264LysIle: 7.264 ± 0.114
8.54LysLys: 8.54 ± 0.148
7.592LysLeu: 7.592 ± 0.12
2.291LysMet: 2.291 ± 0.056
5.614LysAsn: 5.614 ± 0.098
2.378LysPro: 2.378 ± 0.075
2.497LysGln: 2.497 ± 0.058
3.509LysArg: 3.509 ± 0.073
5.692LysSer: 5.692 ± 0.113
4.371LysThr: 4.371 ± 0.068
4.701LysVal: 4.701 ± 0.083
0.499LysTrp: 0.499 ± 0.032
3.147LysTyr: 3.147 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
6.597LeuAla: 6.597 ± 0.118
0.832LeuCys: 0.832 ± 0.039
5.827LeuAsp: 5.827 ± 0.108
7.158LeuGlu: 7.158 ± 0.122
4.887LeuPhe: 4.887 ± 0.101
5.542LeuGly: 5.542 ± 0.096
1.836LeuHis: 1.836 ± 0.052
7.048LeuIle: 7.048 ± 0.112
8.752LeuLys: 8.752 ± 0.137
9.405LeuLeu: 9.405 ± 0.155
2.398LeuMet: 2.398 ± 0.061
5.131LeuAsn: 5.131 ± 0.09
2.947LeuPro: 2.947 ± 0.067
3.066LeuGln: 3.066 ± 0.068
3.563LeuArg: 3.563 ± 0.078
8.103LeuSer: 8.103 ± 0.134
4.426LeuThr: 4.426 ± 0.079
5.678LeuVal: 5.678 ± 0.102
0.646LeuTrp: 0.646 ± 0.032
3.598LeuTyr: 3.598 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.895MetAla: 1.895 ± 0.061
0.219MetCys: 0.219 ± 0.019
1.324MetAsp: 1.324 ± 0.05
1.194MetGlu: 1.194 ± 0.041
1.158MetPhe: 1.158 ± 0.039
1.643MetGly: 1.643 ± 0.053
0.488MetHis: 0.488 ± 0.025
2.212MetIle: 2.212 ± 0.063
2.294MetLys: 2.294 ± 0.062
2.701MetLeu: 2.701 ± 0.069
0.808MetMet: 0.808 ± 0.037
1.27MetAsn: 1.27 ± 0.045
1.007MetPro: 1.007 ± 0.036
1.346MetGln: 1.346 ± 0.041
1.001MetArg: 1.001 ± 0.038
2.115MetSer: 2.115 ± 0.052
1.184MetThr: 1.184 ± 0.038
1.487MetVal: 1.487 ± 0.051
0.179MetTrp: 0.179 ± 0.016
0.702MetTyr: 0.702 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.264AsnAla: 3.264 ± 0.077
0.348AsnCys: 0.348 ± 0.02
2.576AsnAsp: 2.576 ± 0.064
3.465AsnGlu: 3.465 ± 0.071
2.514AsnPhe: 2.514 ± 0.058
2.484AsnGly: 2.484 ± 0.075
0.868AsnHis: 0.868 ± 0.038
5.477AsnIle: 5.477 ± 0.095
4.036AsnLys: 4.036 ± 0.085
4.764AsnLeu: 4.764 ± 0.088
1.155AsnMet: 1.155 ± 0.04
2.467AsnAsn: 2.467 ± 0.073
1.929AsnPro: 1.929 ± 0.052
1.296AsnGln: 1.296 ± 0.046
1.851AsnArg: 1.851 ± 0.053
3.843AsnSer: 3.843 ± 0.078
2.462AsnThr: 2.462 ± 0.065
2.548AsnVal: 2.548 ± 0.076
0.31AsnTrp: 0.31 ± 0.025
2.05AsnTyr: 2.05 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
1.496ProAla: 1.496 ± 0.046
0.25ProCys: 0.25 ± 0.021
1.511ProAsp: 1.511 ± 0.042
1.686ProGlu: 1.686 ± 0.063
1.602ProPhe: 1.602 ± 0.048
1.097ProGly: 1.097 ± 0.042
0.668ProHis: 0.668 ± 0.032
2.503ProIle: 2.503 ± 0.064
2.584ProLys: 2.584 ± 0.078
2.925ProLeu: 2.925 ± 0.067
0.753ProMet: 0.753 ± 0.038
1.494ProAsn: 1.494 ± 0.044
0.729ProPro: 0.729 ± 0.035
1.008ProGln: 1.008 ± 0.037
0.895ProArg: 0.895 ± 0.042
2.003ProSer: 2.003 ± 0.061
1.754ProThr: 1.754 ± 0.055
1.588ProVal: 1.588 ± 0.051
0.219ProTrp: 0.219 ± 0.018
1.327ProTyr: 1.327 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
1.819GlnAla: 1.819 ± 0.053
0.171GlnCys: 0.171 ± 0.015
1.868GlnAsp: 1.868 ± 0.06
2.491GlnGlu: 2.491 ± 0.061
0.868GlnPhe: 0.868 ± 0.035
1.39GlnGly: 1.39 ± 0.05
0.447GlnHis: 0.447 ± 0.023
2.142GlnIle: 2.142 ± 0.069
3.402GlnLys: 3.402 ± 0.075
2.185GlnLeu: 2.185 ± 0.057
0.842GlnMet: 0.842 ± 0.035
2.249GlnAsn: 2.249 ± 0.052
0.63GlnPro: 0.63 ± 0.028
0.781GlnGln: 0.781 ± 0.036
1.442GlnArg: 1.442 ± 0.043
1.829GlnSer: 1.829 ± 0.055
1.724GlnThr: 1.724 ± 0.048
1.531GlnVal: 1.531 ± 0.045
0.18GlnTrp: 0.18 ± 0.018
0.87GlnTyr: 0.87 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.635ArgAla: 2.635 ± 0.07
0.354ArgCys: 0.354 ± 0.022
2.574ArgAsp: 2.574 ± 0.062
2.988ArgGlu: 2.988 ± 0.069
1.85ArgPhe: 1.85 ± 0.053
2.184ArgGly: 2.184 ± 0.064
0.718ArgHis: 0.718 ± 0.031
2.445ArgIle: 2.445 ± 0.065
2.245ArgLys: 2.245 ± 0.058
3.544ArgLeu: 3.544 ± 0.077
0.883ArgMet: 0.883 ± 0.033
1.42ArgAsn: 1.42 ± 0.04
0.904ArgPro: 0.904 ± 0.038
0.907ArgGln: 0.907 ± 0.037
1.331ArgArg: 1.331 ± 0.044
2.03ArgSer: 2.03 ± 0.053
1.456ArgThr: 1.456 ± 0.044
3.271ArgVal: 3.271 ± 0.067
0.252ArgTrp: 0.252 ± 0.019
1.613ArgTyr: 1.613 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.544SerAla: 4.544 ± 0.074
0.698SerCys: 0.698 ± 0.034
4.042SerAsp: 4.042 ± 0.078
4.021SerGlu: 4.021 ± 0.087
3.977SerPhe: 3.977 ± 0.086
4.397SerGly: 4.397 ± 0.084
1.442SerHis: 1.442 ± 0.044
6.428SerIle: 6.428 ± 0.124
6.208SerLys: 6.208 ± 0.106
7.587SerLeu: 7.587 ± 0.127
1.91SerMet: 1.91 ± 0.058
3.257SerAsn: 3.257 ± 0.067
1.781SerPro: 1.781 ± 0.053
2.535SerGln: 2.535 ± 0.05
2.417SerArg: 2.417 ± 0.06
5.703SerSer: 5.703 ± 0.094
3.44SerThr: 3.44 ± 0.069
4.447SerVal: 4.447 ± 0.085
0.565SerTrp: 0.565 ± 0.024
2.965SerTyr: 2.965 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
3.141ThrAla: 3.141 ± 0.085
0.378ThrCys: 0.378 ± 0.024
2.335ThrAsp: 2.335 ± 0.068
2.053ThrGlu: 2.053 ± 0.061
2.305ThrPhe: 2.305 ± 0.053
2.717ThrGly: 2.717 ± 0.069
1.119ThrHis: 1.119 ± 0.04
4.593ThrIle: 4.593 ± 0.087
4.572ThrLys: 4.572 ± 0.08
5.981ThrLeu: 5.981 ± 0.094
1.173ThrMet: 1.173 ± 0.042
2.503ThrAsn: 2.503 ± 0.065
2.274ThrPro: 2.274 ± 0.074
1.92ThrGln: 1.92 ± 0.051
1.527ThrArg: 1.527 ± 0.044
3.444ThrSer: 3.444 ± 0.07
2.945ThrThr: 2.945 ± 0.082
2.479ThrVal: 2.479 ± 0.08
0.259ThrTrp: 0.259 ± 0.023
1.908ThrTyr: 1.908 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.689ValAla: 4.689 ± 0.101
0.622ValCys: 0.622 ± 0.035
4.261ValAsp: 4.261 ± 0.089
4.524ValGlu: 4.524 ± 0.076
2.691ValPhe: 2.691 ± 0.069
4.025ValGly: 4.025 ± 0.083
1.045ValHis: 1.045 ± 0.041
5.026ValIle: 5.026 ± 0.078
4.837ValLys: 4.837 ± 0.09
5.875ValLeu: 5.875 ± 0.103
1.692ValMet: 1.692 ± 0.055
2.66ValAsn: 2.66 ± 0.068
1.674ValPro: 1.674 ± 0.055
1.61ValGln: 1.61 ± 0.053
2.081ValArg: 2.081 ± 0.054
4.541ValSer: 4.541 ± 0.07
2.986ValThr: 2.986 ± 0.067
4.854ValVal: 4.854 ± 0.098
0.436ValTrp: 0.436 ± 0.03
2.151ValTyr: 2.151 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.45TrpAla: 0.45 ± 0.027
0.08TrpCys: 0.08 ± 0.009
0.405TrpAsp: 0.405 ± 0.021
0.376TrpGlu: 0.376 ± 0.025
0.383TrpPhe: 0.383 ± 0.025
0.52TrpGly: 0.52 ± 0.03
0.179TrpHis: 0.179 ± 0.019
0.64TrpIle: 0.64 ± 0.031
0.334TrpLys: 0.334 ± 0.025
0.79TrpLeu: 0.79 ± 0.03
0.261TrpMet: 0.261 ± 0.022
0.293TrpAsn: 0.293 ± 0.02
0.131TrpPro: 0.131 ± 0.014
0.296TrpGln: 0.296 ± 0.021
0.271TrpArg: 0.271 ± 0.021
0.488TrpSer: 0.488 ± 0.03
0.257TrpThr: 0.257 ± 0.021
0.45TrpVal: 0.45 ± 0.026
0.063TrpTrp: 0.063 ± 0.011
0.274TrpTyr: 0.274 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.569TyrAla: 2.569 ± 0.061
0.29TyrCys: 0.29 ± 0.021
2.58TyrAsp: 2.58 ± 0.068
3.14TyrGlu: 3.14 ± 0.071
2.159TyrPhe: 2.159 ± 0.062
2.175TyrGly: 2.175 ± 0.058
0.742TyrHis: 0.742 ± 0.035
3.048TyrIle: 3.048 ± 0.063
3.608TyrLys: 3.608 ± 0.088
3.642TyrLeu: 3.642 ± 0.077
0.908TyrMet: 0.908 ± 0.038
1.982TyrAsn: 1.982 ± 0.05
1.218TyrPro: 1.218 ± 0.042
0.971TyrGln: 0.971 ± 0.035
1.53TyrArg: 1.53 ± 0.056
2.765TyrSer: 2.765 ± 0.069
1.967TyrThr: 1.967 ± 0.058
1.775TyrVal: 1.775 ± 0.047
0.29TyrTrp: 0.29 ± 0.021
1.579TyrTyr: 1.579 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2290 proteins (709285 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski