Amino acid dipepetide frequency for Marisediminitalea aggregata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.501AlaAla: 8.501 ± 0.098	1.042AlaCys: 1.042 ± 0.027	5.284AlaAsp: 5.284 ± 0.061	5.888AlaGlu: 5.888 ± 0.074	3.854AlaPhe: 3.854 ± 0.051	6.771AlaGly: 6.771 ± 0.076	1.739AlaHis: 1.739 ± 0.037	5.892AlaIle: 5.892 ± 0.063	4.539AlaLys: 4.539 ± 0.063	10.693AlaLeu: 10.693 ± 0.1	2.825AlaMet: 2.825 ± 0.048	3.916AlaAsn: 3.916 ± 0.053	3.334AlaPro: 3.334 ± 0.047	4.136AlaGln: 4.136 ± 0.058	4.146AlaArg: 4.146 ± 0.057	6.216AlaSer: 6.216 ± 0.061	5.038AlaThr: 5.038 ± 0.063	6.661AlaVal: 6.661 ± 0.075	1.021AlaTrp: 1.021 ± 0.032	2.652AlaTyr: 2.652 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.863CysAla: 0.863 ± 0.026	0.169CysCys: 0.169 ± 0.01	0.591CysAsp: 0.591 ± 0.019	0.648CysGlu: 0.648 ± 0.021	0.448CysPhe: 0.448 ± 0.019	0.772CysGly: 0.772 ± 0.023	0.284CysHis: 0.284 ± 0.013	0.537CysIle: 0.537 ± 0.019	0.408CysLys: 0.408 ± 0.017	0.97CysLeu: 0.97 ± 0.026	0.217CysMet: 0.217 ± 0.01	0.374CysAsn: 0.374 ± 0.016	0.418CysPro: 0.418 ± 0.021	0.462CysGln: 0.462 ± 0.017	0.453CysArg: 0.453 ± 0.019	0.665CysSer: 0.665 ± 0.024	0.468CysThr: 0.468 ± 0.016	0.684CysVal: 0.684 ± 0.021	0.131CysTrp: 0.131 ± 0.009	0.34CysTyr: 0.34 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.534AspAla: 5.534 ± 0.063	0.565AspCys: 0.565 ± 0.024	3.693AspAsp: 3.693 ± 0.066	3.736AspGlu: 3.736 ± 0.056	2.615AspPhe: 2.615 ± 0.046	4.092AspGly: 4.092 ± 0.07	1.022AspHis: 1.022 ± 0.026	4.171AspIle: 4.171 ± 0.056	2.854AspLys: 2.854 ± 0.046	4.853AspLeu: 4.853 ± 0.056	1.58AspMet: 1.58 ± 0.037	2.741AspAsn: 2.741 ± 0.042	2.213AspPro: 2.213 ± 0.041	1.753AspGln: 1.753 ± 0.035	2.205AspArg: 2.205 ± 0.039	3.356AspSer: 3.356 ± 0.053	3.467AspThr: 3.467 ± 0.061	4.335AspVal: 4.335 ± 0.051	1.015AspTrp: 1.015 ± 0.028	2.211AspTyr: 2.211 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.619GluAla: 5.619 ± 0.068	0.436GluCys: 0.436 ± 0.019	2.968GluAsp: 2.968 ± 0.05	3.333GluGlu: 3.333 ± 0.063	2.346GluPhe: 2.346 ± 0.045	3.529GluGly: 3.529 ± 0.052	1.607GluHis: 1.607 ± 0.034	3.235GluIle: 3.235 ± 0.047	3.027GluLys: 3.027 ± 0.052	6.116GluLeu: 6.116 ± 0.074	1.498GluMet: 1.498 ± 0.04	2.449GluAsn: 2.449 ± 0.041	2.209GluPro: 2.209 ± 0.053	4.119GluGln: 4.119 ± 0.059	3.135GluArg: 3.135 ± 0.049	3.776GluSer: 3.776 ± 0.054	3.084GluThr: 3.084 ± 0.054	3.945GluVal: 3.945 ± 0.056	0.749GluTrp: 0.749 ± 0.025	1.833GluTyr: 1.833 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.943PheAla: 3.943 ± 0.048	0.49PheCys: 0.49 ± 0.018	2.904PheAsp: 2.904 ± 0.05	2.484PheGlu: 2.484 ± 0.04	1.711PhePhe: 1.711 ± 0.038	3.153PheGly: 3.153 ± 0.046	0.83PheHis: 0.83 ± 0.026	2.512PheIle: 2.512 ± 0.042	1.783PheLys: 1.783 ± 0.033	3.186PheLeu: 3.186 ± 0.051	0.99PheMet: 0.99 ± 0.023	2.009PheAsn: 2.009 ± 0.037	1.44PhePro: 1.44 ± 0.027	1.236PheGln: 1.236 ± 0.032	1.696PheArg: 1.696 ± 0.034	3.384PheSer: 3.384 ± 0.049	2.667PheThr: 2.667 ± 0.037	2.915PheVal: 2.915 ± 0.05	0.589PheTrp: 0.589 ± 0.023	1.458PheTyr: 1.458 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.473GlyAla: 5.473 ± 0.068	0.811GlyCys: 0.811 ± 0.023	3.969GlyAsp: 3.969 ± 0.06	4.402GlyGlu: 4.402 ± 0.061	3.367GlyPhe: 3.367 ± 0.046	4.801GlyGly: 4.801 ± 0.074	1.524GlyHis: 1.524 ± 0.035	4.567GlyIle: 4.567 ± 0.066	3.792GlyLys: 3.792 ± 0.056	6.902GlyLeu: 6.902 ± 0.087	2.026GlyMet: 2.026 ± 0.044	2.932GlyAsn: 2.932 ± 0.051	1.907GlyPro: 1.907 ± 0.045	2.813GlyGln: 2.813 ± 0.047	2.932GlyArg: 2.932 ± 0.052	4.023GlySer: 4.023 ± 0.064	3.713GlyThr: 3.713 ± 0.063	5.276GlyVal: 5.276 ± 0.058	1.078GlyTrp: 1.078 ± 0.029	2.643GlyTyr: 2.643 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.862HisAla: 1.862 ± 0.037	0.338HisCys: 0.338 ± 0.017	1.144HisAsp: 1.144 ± 0.028	1.136HisGlu: 1.136 ± 0.026	1.059HisPhe: 1.059 ± 0.028	1.574HisGly: 1.574 ± 0.032	0.673HisHis: 0.673 ± 0.025	1.398HisIle: 1.398 ± 0.035	0.927HisLys: 0.927 ± 0.027	2.109HisLeu: 2.109 ± 0.042	0.516HisMet: 0.516 ± 0.019	0.923HisAsn: 0.923 ± 0.028	1.204HisPro: 1.204 ± 0.031	1.062HisGln: 1.062 ± 0.028	1.084HisArg: 1.084 ± 0.028	1.357HisSer: 1.357 ± 0.034	1.209HisThr: 1.209 ± 0.031	1.352HisVal: 1.352 ± 0.035	0.401HisTrp: 0.401 ± 0.018	0.959HisTyr: 0.959 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.342IleAla: 6.342 ± 0.057	0.589IleCys: 0.589 ± 0.02	4.014IleAsp: 4.014 ± 0.053	3.998IleGlu: 3.998 ± 0.056	1.892IlePhe: 1.892 ± 0.035	4.27IleGly: 4.27 ± 0.061	1.217IleHis: 1.217 ± 0.032	2.919IleIle: 2.919 ± 0.051	2.625IleLys: 2.625 ± 0.049	4.604IleLeu: 4.604 ± 0.07	1.174IleMet: 1.174 ± 0.029	2.848IleAsn: 2.848 ± 0.043	2.494IlePro: 2.494 ± 0.046	2.265IleGln: 2.265 ± 0.041	2.718IleArg: 2.718 ± 0.049	4.065IleSer: 4.065 ± 0.058	3.592IleThr: 3.592 ± 0.051	3.996IleVal: 3.996 ± 0.057	0.626IleTrp: 0.626 ± 0.023	1.643IleTyr: 1.643 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.779LysAla: 4.779 ± 0.071	0.282LysCys: 0.282 ± 0.016	2.302LysAsp: 2.302 ± 0.04	2.338LysGlu: 2.338 ± 0.051	1.343LysPhe: 1.343 ± 0.028	2.893LysGly: 2.893 ± 0.049	1.172LysHis: 1.172 ± 0.029	2.247LysIle: 2.247 ± 0.042	2.074LysLys: 2.074 ± 0.04	4.566LysLeu: 4.566 ± 0.061	1.101LysMet: 1.101 ± 0.028	1.612LysAsn: 1.612 ± 0.033	2.245LysPro: 2.245 ± 0.043	2.89LysGln: 2.89 ± 0.047	2.705LysArg: 2.705 ± 0.05	2.68LysSer: 2.68 ± 0.046	2.582LysThr: 2.582 ± 0.04	3.305LysVal: 3.305 ± 0.041	0.525LysTrp: 0.525 ± 0.019	1.209LysTyr: 1.209 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	10.31LeuAla: 10.31 ± 0.1	1.092LeuCys: 1.092 ± 0.031	5.641LeuAsp: 5.641 ± 0.072	5.197LeuGlu: 5.197 ± 0.069	4.219LeuPhe: 4.219 ± 0.062	6.538LeuGly: 6.538 ± 0.07	2.134LeuHis: 2.134 ± 0.038	5.766LeuIle: 5.766 ± 0.07	4.493LeuLys: 4.493 ± 0.067	10.513LeuLeu: 10.513 ± 0.129	2.511LeuMet: 2.511 ± 0.043	4.454LeuAsn: 4.454 ± 0.056	4.947LeuPro: 4.947 ± 0.057	4.103LeuGln: 4.103 ± 0.064	4.363LeuArg: 4.363 ± 0.053	7.914LeuSer: 7.914 ± 0.089	6.415LeuThr: 6.415 ± 0.063	6.888LeuVal: 6.888 ± 0.074	1.097LeuTrp: 1.097 ± 0.031	2.782LeuTyr: 2.782 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.52MetAla: 2.52 ± 0.048	0.197MetCys: 0.197 ± 0.011	1.221MetAsp: 1.221 ± 0.029	1.195MetGlu: 1.195 ± 0.028	0.849MetPhe: 0.849 ± 0.029	1.666MetGly: 1.666 ± 0.033	0.527MetHis: 0.527 ± 0.021	1.191MetIle: 1.191 ± 0.029	1.244MetLys: 1.244 ± 0.027	2.741MetLeu: 2.741 ± 0.055	0.69MetMet: 0.69 ± 0.024	0.997MetAsn: 0.997 ± 0.028	1.284MetPro: 1.284 ± 0.03	1.361MetGln: 1.361 ± 0.034	1.244MetArg: 1.244 ± 0.031	1.803MetSer: 1.803 ± 0.029	1.687MetThr: 1.687 ± 0.034	1.679MetVal: 1.679 ± 0.036	0.258MetTrp: 0.258 ± 0.014	0.574MetTyr: 0.574 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.974AsnAla: 3.974 ± 0.052	0.382AsnCys: 0.382 ± 0.016	2.52AsnAsp: 2.52 ± 0.05	2.43AsnGlu: 2.43 ± 0.038	1.465AsnPhe: 1.465 ± 0.028	3.096AsnGly: 3.096 ± 0.054	0.855AsnHis: 0.855 ± 0.021	2.525AsnIle: 2.525 ± 0.04	1.872AsnLys: 1.872 ± 0.038	3.745AsnLeu: 3.745 ± 0.051	0.931AsnMet: 0.931 ± 0.024	1.927AsnAsn: 1.927 ± 0.047	2.102AsnPro: 2.102 ± 0.04	2.045AsnGln: 2.045 ± 0.039	2.026AsnArg: 2.026 ± 0.034	2.445AsnSer: 2.445 ± 0.044	2.603AsnThr: 2.603 ± 0.046	2.909AsnVal: 2.909 ± 0.05	0.673AsnTrp: 0.673 ± 0.022	1.325AsnTyr: 1.325 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.023ProAla: 4.023 ± 0.055	0.298ProCys: 0.298 ± 0.013	3.071ProAsp: 3.071 ± 0.052	3.299ProGlu: 3.299 ± 0.062	1.831ProPhe: 1.831 ± 0.035	3.001ProGly: 3.001 ± 0.05	0.866ProHis: 0.866 ± 0.027	2.105ProIle: 2.105 ± 0.04	1.643ProLys: 1.643 ± 0.037	4.079ProLeu: 4.079 ± 0.053	0.948ProMet: 0.948 ± 0.026	1.641ProAsn: 1.641 ± 0.038	1.391ProPro: 1.391 ± 0.03	1.73ProGln: 1.73 ± 0.036	1.433ProArg: 1.433 ± 0.032	2.392ProSer: 2.392 ± 0.043	2.281ProThr: 2.281 ± 0.042	3.765ProVal: 3.765 ± 0.054	0.521ProTrp: 0.521 ± 0.019	1.268ProTyr: 1.268 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.808GlnAla: 4.808 ± 0.067	0.431GlnCys: 0.431 ± 0.018	2.102GlnAsp: 2.102 ± 0.039	2.116GlnGlu: 2.116 ± 0.044	1.969GlnPhe: 1.969 ± 0.038	2.922GlnGly: 2.922 ± 0.048	1.432GlnHis: 1.432 ± 0.035	2.388GlnIle: 2.388 ± 0.045	1.768GlnLys: 1.768 ± 0.04	5.14GlnLeu: 5.14 ± 0.073	1.036GlnMet: 1.036 ± 0.027	1.549GlnAsn: 1.549 ± 0.036	2.077GlnPro: 2.077 ± 0.039	3.65GlnGln: 3.65 ± 0.078	2.686GlnArg: 2.686 ± 0.046	3.05GlnSer: 3.05 ± 0.051	2.515GlnThr: 2.515 ± 0.049	3.187GlnVal: 3.187 ± 0.057	0.755GlnTrp: 0.755 ± 0.023	1.587GlnTyr: 1.587 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.752ArgAla: 3.752 ± 0.053	0.444ArgCys: 0.444 ± 0.017	2.609ArgAsp: 2.609 ± 0.044	2.963ArgGlu: 2.963 ± 0.051	2.273ArgPhe: 2.273 ± 0.039	2.657ArgGly: 2.657 ± 0.044	1.161ArgHis: 1.161 ± 0.028	2.962ArgIle: 2.962 ± 0.04	2.146ArgLys: 2.146 ± 0.042	5.019ArgLeu: 5.019 ± 0.065	1.193ArgMet: 1.193 ± 0.03	1.887ArgAsn: 1.887 ± 0.038	1.655ArgPro: 1.655 ± 0.034	2.439ArgGln: 2.439 ± 0.04	2.358ArgArg: 2.358 ± 0.042	2.485ArgSer: 2.485 ± 0.045	2.214ArgThr: 2.214 ± 0.038	3.316ArgVal: 3.316 ± 0.048	0.73ArgTrp: 0.73 ± 0.02	1.987ArgTyr: 1.987 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.19SerAla: 6.19 ± 0.079	0.569SerCys: 0.569 ± 0.023	3.935SerAsp: 3.935 ± 0.058	3.94SerGlu: 3.94 ± 0.06	2.658SerPhe: 2.658 ± 0.046	5.113SerGly: 5.113 ± 0.07	1.438SerHis: 1.438 ± 0.031	3.534SerIle: 3.534 ± 0.051	2.641SerLys: 2.641 ± 0.046	7.14SerLeu: 7.14 ± 0.075	1.666SerMet: 1.666 ± 0.035	2.513SerAsn: 2.513 ± 0.05	2.691SerPro: 2.691 ± 0.045	3.08SerGln: 3.08 ± 0.047	2.999SerArg: 2.999 ± 0.038	4.177SerSer: 4.177 ± 0.063	3.446SerThr: 3.446 ± 0.05	5.172SerVal: 5.172 ± 0.067	0.869SerTrp: 0.869 ± 0.029	1.997SerTyr: 1.997 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.305ThrAla: 5.305 ± 0.068	0.491ThrCys: 0.491 ± 0.02	3.344ThrAsp: 3.344 ± 0.05	3.256ThrGlu: 3.256 ± 0.048	2.296ThrPhe: 2.296 ± 0.043	4.414ThrGly: 4.414 ± 0.053	1.336ThrHis: 1.336 ± 0.028	3.191ThrIle: 3.191 ± 0.048	1.885ThrLys: 1.885 ± 0.035	6.827ThrLeu: 6.827 ± 0.071	1.146ThrMet: 1.146 ± 0.029	2.053ThrAsn: 2.053 ± 0.039	3.109ThrPro: 3.109 ± 0.046	2.673ThrGln: 2.673 ± 0.045	2.512ThrArg: 2.512 ± 0.045	3.561ThrSer: 3.561 ± 0.051	3.195ThrThr: 3.195 ± 0.059	4.348ThrVal: 4.348 ± 0.079	0.653ThrTrp: 0.653 ± 0.021	1.694ThrTyr: 1.694 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.717ValAla: 6.717 ± 0.077	0.763ValCys: 0.763 ± 0.024	4.215ValAsp: 4.215 ± 0.061	4.289ValGlu: 4.289 ± 0.056	3.007ValPhe: 3.007 ± 0.042	4.628ValGly: 4.628 ± 0.067	1.269ValHis: 1.269 ± 0.031	4.558ValIle: 4.558 ± 0.063	3.468ValLys: 3.468 ± 0.055	7.01ValLeu: 7.01 ± 0.078	1.914ValMet: 1.914 ± 0.042	3.393ValAsn: 3.393 ± 0.057	2.868ValPro: 2.868 ± 0.045	2.361ValGln: 2.361 ± 0.039	2.93ValArg: 2.93 ± 0.048	5.551ValSer: 5.551 ± 0.071	4.832ValThr: 4.832 ± 0.073	5.63ValVal: 5.63 ± 0.08	0.836ValTrp: 0.836 ± 0.025	2.049ValTyr: 2.049 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.908TrpAla: 0.908 ± 0.031	0.15TrpCys: 0.15 ± 0.01	0.644TrpAsp: 0.644 ± 0.023	0.614TrpGlu: 0.614 ± 0.025	0.637TrpPhe: 0.637 ± 0.018	0.847TrpGly: 0.847 ± 0.025	0.395TrpHis: 0.395 ± 0.015	0.659TrpIle: 0.659 ± 0.022	0.418TrpLys: 0.418 ± 0.017	1.883TrpLeu: 1.883 ± 0.042	0.368TrpMet: 0.368 ± 0.018	0.41TrpAsn: 0.41 ± 0.015	0.52TrpPro: 0.52 ± 0.019	1.184TrpGln: 1.184 ± 0.032	0.75TrpArg: 0.75 ± 0.025	0.767TrpSer: 0.767 ± 0.024	0.52TrpThr: 0.52 ± 0.022	0.957TrpVal: 0.957 ± 0.028	0.212TrpTrp: 0.212 ± 0.011	0.429TrpTyr: 0.429 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.725TyrAla: 2.725 ± 0.045	0.362TyrCys: 0.362 ± 0.015	1.839TyrAsp: 1.839 ± 0.038	1.753TyrGlu: 1.753 ± 0.04	1.541TyrPhe: 1.541 ± 0.037	2.213TyrGly: 2.213 ± 0.044	0.804TyrHis: 0.804 ± 0.025	1.534TyrIle: 1.534 ± 0.033	1.243TyrLys: 1.243 ± 0.03	3.28TyrLeu: 3.28 ± 0.047	0.599TyrMet: 0.599 ± 0.019	1.222TyrAsn: 1.222 ± 0.036	1.478TyrPro: 1.478 ± 0.033	1.805TyrGln: 1.805 ± 0.045	1.878TyrArg: 1.878 ± 0.036	2.098TyrSer: 2.098 ± 0.042	1.761TyrThr: 1.761 ± 0.041	1.968TyrVal: 1.968 ± 0.038	0.535TyrTrp: 0.535 ± 0.019	1.149TyrTyr: 1.149 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4313 proteins (1469709 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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