Amino acid dipepetide frequency for Tepidibacter thalassicus DSM 15285

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.091AlaAla: 3.091 ± 0.1
0.628AlaCys: 0.628 ± 0.031
2.366AlaAsp: 2.366 ± 0.069
2.61AlaGlu: 2.61 ± 0.078
2.192AlaPhe: 2.192 ± 0.064
3.468AlaGly: 3.468 ± 0.093
0.764AlaHis: 0.764 ± 0.036
5.241AlaIle: 5.241 ± 0.11
4.733AlaLys: 4.733 ± 0.096
5.088AlaLeu: 5.088 ± 0.105
1.652AlaMet: 1.652 ± 0.058
2.491AlaAsn: 2.491 ± 0.067
1.281AlaPro: 1.281 ± 0.053
1.519AlaGln: 1.519 ± 0.06
1.825AlaArg: 1.825 ± 0.051
2.934AlaSer: 2.934 ± 0.068
2.348AlaThr: 2.348 ± 0.063
3.801AlaVal: 3.801 ± 0.094
0.276AlaTrp: 0.276 ± 0.02
1.879AlaTyr: 1.879 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.524CysAla: 0.524 ± 0.03
0.134CysCys: 0.134 ± 0.016
0.56CysAsp: 0.56 ± 0.028
0.806CysGlu: 0.806 ± 0.036
0.443CysPhe: 0.443 ± 0.027
0.955CysGly: 0.955 ± 0.049
0.179CysHis: 0.179 ± 0.015
1.085CysIle: 1.085 ± 0.04
1.04CysLys: 1.04 ± 0.043
0.739CysLeu: 0.739 ± 0.033
0.26CysMet: 0.26 ± 0.017
0.61CysAsn: 0.61 ± 0.029
0.495CysPro: 0.495 ± 0.036
0.19CysGln: 0.19 ± 0.017
0.37CysArg: 0.37 ± 0.023
0.716CysSer: 0.716 ± 0.033
0.466CysThr: 0.466 ± 0.029
0.667CysVal: 0.667 ± 0.037
0.054CysTrp: 0.054 ± 0.009
0.403CysTyr: 0.403 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.306AspAla: 2.306 ± 0.063
0.534AspCys: 0.534 ± 0.029
2.734AspAsp: 2.734 ± 0.075
5.086AspGlu: 5.086 ± 0.106
2.779AspPhe: 2.779 ± 0.07
3.01AspGly: 3.01 ± 0.088
0.493AspHis: 0.493 ± 0.027
7.356AspIle: 7.356 ± 0.119
5.865AspLys: 5.865 ± 0.125
5.064AspLeu: 5.064 ± 0.085
1.476AspMet: 1.476 ± 0.052
3.136AspAsn: 3.136 ± 0.076
1.307AspPro: 1.307 ± 0.044
0.676AspGln: 0.676 ± 0.036
1.8AspArg: 1.8 ± 0.054
2.585AspSer: 2.585 ± 0.061
2.191AspThr: 2.191 ± 0.061
3.934AspVal: 3.934 ± 0.08
0.343AspTrp: 0.343 ± 0.022
2.748AspTyr: 2.748 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
3.48GluAla: 3.48 ± 0.078
0.64GluCys: 0.64 ± 0.031
4.515GluAsp: 4.515 ± 0.096
7.238GluGlu: 7.238 ± 0.126
3.385GluPhe: 3.385 ± 0.075
4.256GluGly: 4.256 ± 0.082
0.851GluHis: 0.851 ± 0.037
8.646GluIle: 8.646 ± 0.133
8.901GluLys: 8.901 ± 0.123
6.523GluLeu: 6.523 ± 0.102
1.98GluMet: 1.98 ± 0.05
6.292GluAsn: 6.292 ± 0.122
1.313GluPro: 1.313 ± 0.046
1.595GluGln: 1.595 ± 0.058
2.536GluArg: 2.536 ± 0.072
3.207GluSer: 3.207 ± 0.075
2.522GluThr: 2.522 ± 0.064
5.116GluVal: 5.116 ± 0.093
0.369GluTrp: 0.369 ± 0.023
3.492GluTyr: 3.492 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.057PheAla: 2.057 ± 0.062
0.484PheCys: 0.484 ± 0.026
2.486PheAsp: 2.486 ± 0.06
3.248PheGlu: 3.248 ± 0.072
1.957PhePhe: 1.957 ± 0.07
2.636PheGly: 2.636 ± 0.068
0.458PheHis: 0.458 ± 0.025
4.852PheIle: 4.852 ± 0.106
4.339PheLys: 4.339 ± 0.078
4.298PheLeu: 4.298 ± 0.084
1.145PheMet: 1.145 ± 0.041
2.886PheAsn: 2.886 ± 0.064
1.095PhePro: 1.095 ± 0.045
0.775PheGln: 0.775 ± 0.036
1.324PheArg: 1.324 ± 0.049
2.751PheSer: 2.751 ± 0.074
2.076PheThr: 2.076 ± 0.051
2.877PheVal: 2.877 ± 0.07
0.285PheTrp: 0.285 ± 0.021
1.757PheTyr: 1.757 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
3.789GlyAla: 3.789 ± 0.102
0.827GlyCys: 0.827 ± 0.046
3.067GlyAsp: 3.067 ± 0.079
4.264GlyGlu: 4.264 ± 0.077
3.004GlyPhe: 3.004 ± 0.074
4.052GlyGly: 4.052 ± 0.095
0.978GlyHis: 0.978 ± 0.04
7.125GlyIle: 7.125 ± 0.104
5.913GlyLys: 5.913 ± 0.117
5.138GlyLeu: 5.138 ± 0.101
1.767GlyMet: 1.767 ± 0.059
3.079GlyAsn: 3.079 ± 0.08
1.321GlyPro: 1.321 ± 0.045
1.342GlyGln: 1.342 ± 0.044
2.17GlyArg: 2.17 ± 0.059
3.23GlySer: 3.23 ± 0.069
2.973GlyThr: 2.973 ± 0.079
4.615GlyVal: 4.615 ± 0.084
0.436GlyTrp: 0.436 ± 0.025
3.086GlyTyr: 3.086 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
0.657HisAla: 0.657 ± 0.035
0.172HisCys: 0.172 ± 0.016
0.613HisAsp: 0.613 ± 0.033
0.821HisGlu: 0.821 ± 0.03
0.601HisPhe: 0.601 ± 0.03
0.921HisGly: 0.921 ± 0.045
0.273HisHis: 0.273 ± 0.023
1.367HisIle: 1.367 ± 0.049
1.072HisLys: 1.072 ± 0.046
1.082HisLeu: 1.082 ± 0.042
0.307HisMet: 0.307 ± 0.021
0.664HisAsn: 0.664 ± 0.031
0.664HisPro: 0.664 ± 0.036
0.273HisGln: 0.273 ± 0.023
0.51HisArg: 0.51 ± 0.03
0.822HisSer: 0.822 ± 0.037
0.649HisThr: 0.649 ± 0.034
0.739HisVal: 0.739 ± 0.038
0.087HisTrp: 0.087 ± 0.013
0.53HisTyr: 0.53 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.489IleAla: 5.489 ± 0.112
1.206IleCys: 1.206 ± 0.043
6.731IleAsp: 6.731 ± 0.111
8.258IleGlu: 8.258 ± 0.119
4.258IlePhe: 4.258 ± 0.098
6.546IleGly: 6.546 ± 0.111
1.331IleHis: 1.331 ± 0.052
10.262IleIle: 10.262 ± 0.165
11.162IleLys: 11.162 ± 0.138
9.871IleLeu: 9.871 ± 0.155
2.348IleMet: 2.348 ± 0.061
7.207IleAsn: 7.207 ± 0.124
3.645IlePro: 3.645 ± 0.081
2.431IleGln: 2.431 ± 0.065
3.212IleArg: 3.212 ± 0.068
7.182IleSer: 7.182 ± 0.114
4.71IleThr: 4.71 ± 0.079
6.777IleVal: 6.777 ± 0.118
0.516IleTrp: 0.516 ± 0.03
4.106IleTyr: 4.106 ± 0.095
0.0IleXaa: 0.0 ± 0.0
Lys
4.764LysAla: 4.764 ± 0.081
0.937LysCys: 0.937 ± 0.04
6.21LysAsp: 6.21 ± 0.109
10.144LysGlu: 10.144 ± 0.147
3.767LysPhe: 3.767 ± 0.083
5.753LysGly: 5.753 ± 0.102
1.179LysHis: 1.179 ± 0.044
10.714LysIle: 10.714 ± 0.147
10.508LysLys: 10.508 ± 0.144
8.576LysLeu: 8.576 ± 0.135
2.512LysMet: 2.512 ± 0.058
8.353LysAsn: 8.353 ± 0.13
2.1LysPro: 2.1 ± 0.057
2.249LysGln: 2.249 ± 0.06
3.443LysArg: 3.443 ± 0.076
5.258LysSer: 5.258 ± 0.088
4.145LysThr: 4.145 ± 0.078
6.224LysVal: 6.224 ± 0.117
0.606LysTrp: 0.606 ± 0.032
4.952LysTyr: 4.952 ± 0.087
0.0LysXaa: 0.0 ± 0.0
Leu
4.495LeuAla: 4.495 ± 0.101
0.884LeuCys: 0.884 ± 0.037
5.485LeuAsp: 5.485 ± 0.099
6.621LeuGlu: 6.621 ± 0.108
3.777LeuPhe: 3.777 ± 0.091
6.126LeuGly: 6.126 ± 0.107
1.006LeuHis: 1.006 ± 0.037
8.479LeuIle: 8.479 ± 0.149
9.958LeuLys: 9.958 ± 0.137
7.25LeuLeu: 7.25 ± 0.127
2.075LeuMet: 2.075 ± 0.059
6.768LeuAsn: 6.768 ± 0.111
2.373LeuPro: 2.373 ± 0.063
1.74LeuGln: 1.74 ± 0.055
3.131LeuArg: 3.131 ± 0.069
6.1LeuSer: 6.1 ± 0.088
4.109LeuThr: 4.109 ± 0.075
5.441LeuVal: 5.441 ± 0.095
0.439LeuTrp: 0.439 ± 0.028
3.137LeuTyr: 3.137 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.824MetAla: 1.824 ± 0.059
0.234MetCys: 0.234 ± 0.02
1.507MetAsp: 1.507 ± 0.048
1.707MetGlu: 1.707 ± 0.053
0.952MetPhe: 0.952 ± 0.043
1.875MetGly: 1.875 ± 0.057
0.284MetHis: 0.284 ± 0.022
2.237MetIle: 2.237 ± 0.056
2.561MetLys: 2.561 ± 0.063
2.058MetLeu: 2.058 ± 0.057
0.664MetMet: 0.664 ± 0.034
1.715MetAsn: 1.715 ± 0.048
0.794MetPro: 0.794 ± 0.036
0.564MetGln: 0.564 ± 0.031
0.933MetArg: 0.933 ± 0.039
1.578MetSer: 1.578 ± 0.05
1.016MetThr: 1.016 ± 0.038
1.482MetVal: 1.482 ± 0.059
0.113MetTrp: 0.113 ± 0.012
0.889MetTyr: 0.889 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.742AsnAla: 2.742 ± 0.058
0.74AsnCys: 0.74 ± 0.037
2.818AsnAsp: 2.818 ± 0.06
4.736AsnGlu: 4.736 ± 0.087
2.83AsnPhe: 2.83 ± 0.07
3.318AsnGly: 3.318 ± 0.076
0.791AsnHis: 0.791 ± 0.035
8.619AsnIle: 8.619 ± 0.132
7.056AsnLys: 7.056 ± 0.126
6.506AsnLeu: 6.506 ± 0.103
1.719AsnMet: 1.719 ± 0.055
4.456AsnAsn: 4.456 ± 0.106
2.272AsnPro: 2.272 ± 0.072
1.392AsnGln: 1.392 ± 0.047
2.045AsnArg: 2.045 ± 0.052
3.742AsnSer: 3.742 ± 0.085
2.877AsnThr: 2.877 ± 0.072
4.009AsnVal: 4.009 ± 0.083
0.44AsnTrp: 0.44 ± 0.027
2.946AsnTyr: 2.946 ± 0.076
0.0AsnXaa: 0.0 ± 0.0
Pro
1.263ProAla: 1.263 ± 0.048
0.303ProCys: 0.303 ± 0.024
1.461ProAsp: 1.461 ± 0.049
1.954ProGlu: 1.954 ± 0.059
1.386ProPhe: 1.386 ± 0.047
1.706ProGly: 1.706 ± 0.059
0.473ProHis: 0.473 ± 0.026
2.794ProIle: 2.794 ± 0.072
2.534ProLys: 2.534 ± 0.059
2.383ProLeu: 2.383 ± 0.068
0.609ProMet: 0.609 ± 0.039
1.618ProAsn: 1.618 ± 0.053
0.639ProPro: 0.639 ± 0.034
0.721ProGln: 0.721 ± 0.034
0.906ProArg: 0.906 ± 0.043
1.595ProSer: 1.595 ± 0.056
1.389ProThr: 1.389 ± 0.047
2.098ProVal: 2.098 ± 0.058
0.239ProTrp: 0.239 ± 0.019
1.215ProTyr: 1.215 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.222GlnAla: 1.222 ± 0.048
0.19GlnCys: 0.19 ± 0.019
1.028GlnAsp: 1.028 ± 0.04
1.507GlnGlu: 1.507 ± 0.05
0.876GlnPhe: 0.876 ± 0.041
1.33GlnGly: 1.33 ± 0.046
0.267GlnHis: 0.267 ± 0.019
2.386GlnIle: 2.386 ± 0.058
2.366GlnLys: 2.366 ± 0.075
1.713GlnLeu: 1.713 ± 0.056
0.606GlnMet: 0.606 ± 0.033
1.488GlnAsn: 1.488 ± 0.047
0.534GlnPro: 0.534 ± 0.031
0.581GlnGln: 0.581 ± 0.034
1.004GlnArg: 1.004 ± 0.039
1.157GlnSer: 1.157 ± 0.04
0.998GlnThr: 0.998 ± 0.043
1.361GlnVal: 1.361 ± 0.044
0.158GlnTrp: 0.158 ± 0.015
0.869GlnTyr: 0.869 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
1.769ArgAla: 1.769 ± 0.05
0.373ArgCys: 0.373 ± 0.025
1.934ArgAsp: 1.934 ± 0.056
3.254ArgGlu: 3.254 ± 0.068
1.383ArgPhe: 1.383 ± 0.043
2.291ArgGly: 2.291 ± 0.065
0.475ArgHis: 0.475 ± 0.031
3.255ArgIle: 3.255 ± 0.073
3.352ArgLys: 3.352 ± 0.073
2.783ArgLeu: 2.783 ± 0.069
0.903ArgMet: 0.903 ± 0.039
2.033ArgAsn: 2.033 ± 0.05
0.912ArgPro: 0.912 ± 0.039
0.845ArgGln: 0.845 ± 0.039
1.442ArgArg: 1.442 ± 0.058
1.437ArgSer: 1.437 ± 0.047
1.386ArgThr: 1.386 ± 0.046
2.322ArgVal: 2.322 ± 0.066
0.222ArgTrp: 0.222 ± 0.019
1.412ArgTyr: 1.412 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
2.731SerAla: 2.731 ± 0.07
0.575SerCys: 0.575 ± 0.036
2.704SerAsp: 2.704 ± 0.063
3.743SerGlu: 3.743 ± 0.077
2.83SerPhe: 2.83 ± 0.062
3.634SerGly: 3.634 ± 0.09
0.807SerHis: 0.807 ± 0.036
6.707SerIle: 6.707 ± 0.118
6.012SerLys: 6.012 ± 0.095
5.598SerLeu: 5.598 ± 0.096
1.34SerMet: 1.34 ± 0.044
3.573SerAsn: 3.573 ± 0.073
1.485SerPro: 1.485 ± 0.046
1.497SerGln: 1.497 ± 0.05
2.013SerArg: 2.013 ± 0.055
3.642SerSer: 3.642 ± 0.09
2.6SerThr: 2.6 ± 0.062
3.519SerVal: 3.519 ± 0.08
0.385SerTrp: 0.385 ± 0.025
2.194SerTyr: 2.194 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
2.412ThrAla: 2.412 ± 0.059
0.497ThrCys: 0.497 ± 0.028
2.203ThrAsp: 2.203 ± 0.057
2.46ThrGlu: 2.46 ± 0.061
1.973ThrPhe: 1.973 ± 0.059
3.215ThrGly: 3.215 ± 0.076
0.724ThrHis: 0.724 ± 0.027
4.561ThrIle: 4.561 ± 0.084
3.683ThrLys: 3.683 ± 0.081
4.277ThrLeu: 4.277 ± 0.091
0.93ThrMet: 0.93 ± 0.039
2.533ThrAsn: 2.533 ± 0.072
1.685ThrPro: 1.685 ± 0.055
1.112ThrGln: 1.112 ± 0.046
1.454ThrArg: 1.454 ± 0.045
2.761ThrSer: 2.761 ± 0.066
2.234ThrThr: 2.234 ± 0.063
3.124ThrVal: 3.124 ± 0.078
0.309ThrTrp: 0.309 ± 0.022
1.713ThrTyr: 1.713 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
3.524ValAla: 3.524 ± 0.097
0.779ValCys: 0.779 ± 0.036
4.28ValAsp: 4.28 ± 0.089
4.903ValGlu: 4.903 ± 0.085
3.177ValPhe: 3.177 ± 0.077
4.176ValGly: 4.176 ± 0.087
0.827ValHis: 0.827 ± 0.033
6.356ValIle: 6.356 ± 0.109
6.44ValLys: 6.44 ± 0.112
6.062ValLeu: 6.062 ± 0.107
1.466ValMet: 1.466 ± 0.044
3.928ValAsn: 3.928 ± 0.08
1.894ValPro: 1.894 ± 0.057
1.212ValGln: 1.212 ± 0.042
2.024ValArg: 2.024 ± 0.059
3.901ValSer: 3.901 ± 0.079
2.94ValThr: 2.94 ± 0.071
5.031ValVal: 5.031 ± 0.107
0.34ValTrp: 0.34 ± 0.022
2.563ValTyr: 2.563 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.36TrpAla: 0.36 ± 0.024
0.061TrpCys: 0.061 ± 0.01
0.379TrpAsp: 0.379 ± 0.024
0.409TrpGlu: 0.409 ± 0.023
0.272TrpPhe: 0.272 ± 0.022
0.446TrpGly: 0.446 ± 0.03
0.082TrpHis: 0.082 ± 0.01
0.579TrpIle: 0.579 ± 0.033
0.549TrpLys: 0.549 ± 0.033
0.46TrpLeu: 0.46 ± 0.028
0.158TrpMet: 0.158 ± 0.017
0.394TrpAsn: 0.394 ± 0.027
0.13TrpPro: 0.13 ± 0.014
0.169TrpGln: 0.169 ± 0.016
0.19TrpArg: 0.19 ± 0.019
0.318TrpSer: 0.318 ± 0.024
0.275TrpThr: 0.275 ± 0.02
0.367TrpVal: 0.367 ± 0.023
0.081TrpTrp: 0.081 ± 0.012
0.254TrpTyr: 0.254 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.691TyrAla: 1.691 ± 0.047
0.498TyrCys: 0.498 ± 0.026
2.342TyrAsp: 2.342 ± 0.067
3.092TyrGlu: 3.092 ± 0.076
1.942TyrPhe: 1.942 ± 0.054
2.461TyrGly: 2.461 ± 0.059
0.584TyrHis: 0.584 ± 0.032
4.625TyrIle: 4.625 ± 0.089
4.35TyrLys: 4.35 ± 0.096
3.922TyrLeu: 3.922 ± 0.095
1.07TyrMet: 1.07 ± 0.038
2.828TyrAsn: 2.828 ± 0.07
1.348TyrPro: 1.348 ± 0.041
0.76TyrGln: 0.76 ± 0.037
1.452TyrArg: 1.452 ± 0.048
2.674TyrSer: 2.674 ± 0.066
1.954TyrThr: 1.954 ± 0.06
2.318TyrVal: 2.318 ± 0.056
0.233TyrTrp: 0.233 ± 0.02
1.916TyrTyr: 1.916 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2250 proteins (670041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski