Amino acid dipepetide frequency for Mangrovimonas yunxiaonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.89AlaAla: 4.89 ± 0.107
0.779AlaCys: 0.779 ± 0.038
3.516AlaAsp: 3.516 ± 0.118
4.255AlaGlu: 4.255 ± 0.107
4.154AlaPhe: 4.154 ± 0.064
4.116AlaGly: 4.116 ± 0.09
1.521AlaHis: 1.521 ± 0.05
5.767AlaIle: 5.767 ± 0.1
5.198AlaLys: 5.198 ± 0.097
7.936AlaLeu: 7.936 ± 0.117
1.657AlaMet: 1.657 ± 0.052
3.906AlaAsn: 3.906 ± 0.08
2.285AlaPro: 2.285 ± 0.067
2.811AlaGln: 2.811 ± 0.062
2.132AlaArg: 2.132 ± 0.06
4.269AlaSer: 4.269 ± 0.076
4.146AlaThr: 4.146 ± 0.105
4.589AlaVal: 4.589 ± 0.085
0.679AlaTrp: 0.679 ± 0.038
2.996AlaTyr: 2.996 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.575CysAla: 0.575 ± 0.044
0.116CysCys: 0.116 ± 0.011
0.502CysAsp: 0.502 ± 0.049
0.478CysGlu: 0.478 ± 0.03
0.405CysPhe: 0.405 ± 0.025
0.72CysGly: 0.72 ± 0.04
0.209CysHis: 0.209 ± 0.018
0.542CysIle: 0.542 ± 0.031
0.487CysLys: 0.487 ± 0.025
0.724CysLeu: 0.724 ± 0.033
0.167CysMet: 0.167 ± 0.021
0.491CysAsn: 0.491 ± 0.034
0.389CysPro: 0.389 ± 0.044
0.254CysGln: 0.254 ± 0.02
0.182CysArg: 0.182 ± 0.014
0.546CysSer: 0.546 ± 0.038
0.383CysThr: 0.383 ± 0.027
0.451CysVal: 0.451 ± 0.025
0.066CysTrp: 0.066 ± 0.011
0.322CysTyr: 0.322 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.083AspAla: 4.083 ± 0.112
0.515AspCys: 0.515 ± 0.059
3.14AspAsp: 3.14 ± 0.096
3.476AspGlu: 3.476 ± 0.071
3.348AspPhe: 3.348 ± 0.072
3.533AspGly: 3.533 ± 0.147
1.055AspHis: 1.055 ± 0.045
4.329AspIle: 4.329 ± 0.089
3.884AspLys: 3.884 ± 0.069
5.154AspLeu: 5.154 ± 0.09
1.241AspMet: 1.241 ± 0.042
3.114AspAsn: 3.114 ± 0.083
1.606AspPro: 1.606 ± 0.054
1.583AspGln: 1.583 ± 0.049
1.832AspArg: 1.832 ± 0.047
2.852AspSer: 2.852 ± 0.077
2.914AspThr: 2.914 ± 0.069
4.097AspVal: 4.097 ± 0.096
0.666AspTrp: 0.666 ± 0.032
2.886AspTyr: 2.886 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
5.486GluAla: 5.486 ± 0.119
0.336GluCys: 0.336 ± 0.024
3.565GluAsp: 3.565 ± 0.067
4.182GluGlu: 4.182 ± 0.091
2.745GluPhe: 2.745 ± 0.056
3.614GluGly: 3.614 ± 0.069
1.423GluHis: 1.423 ± 0.04
4.588GluIle: 4.588 ± 0.078
5.092GluLys: 5.092 ± 0.108
5.68GluLeu: 5.68 ± 0.096
1.357GluMet: 1.357 ± 0.044
4.185GluAsn: 4.185 ± 0.088
1.435GluPro: 1.435 ± 0.049
2.502GluGln: 2.502 ± 0.074
2.462GluArg: 2.462 ± 0.061
2.882GluSer: 2.882 ± 0.061
4.222GluThr: 4.222 ± 0.082
4.372GluVal: 4.372 ± 0.077
0.509GluTrp: 0.509 ± 0.028
2.053GluTyr: 2.053 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
2.919PheAla: 2.919 ± 0.079
0.421PheCys: 0.421 ± 0.022
2.999PheAsp: 2.999 ± 0.071
3.263PheGlu: 3.263 ± 0.065
2.598PhePhe: 2.598 ± 0.065
3.623PheGly: 3.623 ± 0.082
0.834PheHis: 0.834 ± 0.033
3.587PheIle: 3.587 ± 0.082
4.133PheLys: 4.133 ± 0.083
4.581PheLeu: 4.581 ± 0.104
1.145PheMet: 1.145 ± 0.037
3.67PheAsn: 3.67 ± 0.079
1.653PhePro: 1.653 ± 0.048
1.442PheGln: 1.442 ± 0.048
1.394PheArg: 1.394 ± 0.048
3.742PheSer: 3.742 ± 0.082
2.999PheThr: 2.999 ± 0.08
3.123PheVal: 3.123 ± 0.077
0.531PheTrp: 0.531 ± 0.027
2.048PheTyr: 2.048 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.575GlyAla: 4.575 ± 0.093
0.652GlyCys: 0.652 ± 0.046
3.513GlyAsp: 3.513 ± 0.093
3.551GlyGlu: 3.551 ± 0.072
3.537GlyPhe: 3.537 ± 0.072
4.372GlyGly: 4.372 ± 0.111
1.394GlyHis: 1.394 ± 0.047
4.907GlyIle: 4.907 ± 0.082
4.635GlyLys: 4.635 ± 0.084
5.956GlyLeu: 5.956 ± 0.093
1.606GlyMet: 1.606 ± 0.055
3.401GlyAsn: 3.401 ± 0.077
1.331GlyPro: 1.331 ± 0.05
2.145GlyGln: 2.145 ± 0.065
2.012GlyArg: 2.012 ± 0.062
3.692GlySer: 3.692 ± 0.085
3.985GlyThr: 3.985 ± 0.103
4.549GlyVal: 4.549 ± 0.086
0.651GlyTrp: 0.651 ± 0.033
2.768GlyTyr: 2.768 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.267HisAla: 1.267 ± 0.036
0.199HisCys: 0.199 ± 0.016
0.945HisAsp: 0.945 ± 0.035
1.054HisGlu: 1.054 ± 0.036
1.224HisPhe: 1.224 ± 0.041
1.129HisGly: 1.129 ± 0.04
0.56HisHis: 0.56 ± 0.031
1.694HisIle: 1.694 ± 0.049
1.415HisLys: 1.415 ± 0.047
2.099HisLeu: 2.099 ± 0.056
0.431HisMet: 0.431 ± 0.022
1.181HisAsn: 1.181 ± 0.05
0.955HisPro: 0.955 ± 0.04
0.788HisGln: 0.788 ± 0.031
0.675HisArg: 0.675 ± 0.032
1.024HisSer: 1.024 ± 0.037
1.215HisThr: 1.215 ± 0.043
1.311HisVal: 1.311 ± 0.048
0.252HisTrp: 0.252 ± 0.018
0.988HisTyr: 0.988 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.761IleAla: 5.761 ± 0.097
0.611IleCys: 0.611 ± 0.042
4.731IleAsp: 4.731 ± 0.078
5.012IleGlu: 5.012 ± 0.076
3.214IlePhe: 3.214 ± 0.073
4.852IleGly: 4.852 ± 0.087
1.289IleHis: 1.289 ± 0.043
5.184IleIle: 5.184 ± 0.103
5.732IleLys: 5.732 ± 0.097
6.386IleLeu: 6.386 ± 0.112
1.374IleMet: 1.374 ± 0.041
4.532IleAsn: 4.532 ± 0.086
3.09IlePro: 3.09 ± 0.067
2.329IleGln: 2.329 ± 0.061
2.136IleArg: 2.136 ± 0.054
5.028IleSer: 5.028 ± 0.078
4.994IleThr: 4.994 ± 0.1
4.663IleVal: 4.663 ± 0.086
0.554IleTrp: 0.554 ± 0.028
2.435IleTyr: 2.435 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
6.158LysAla: 6.158 ± 0.11
0.289LysCys: 0.289 ± 0.018
4.239LysAsp: 4.239 ± 0.089
5.045LysGlu: 5.045 ± 0.107
2.569LysPhe: 2.569 ± 0.062
4.31LysGly: 4.31 ± 0.079
1.974LysHis: 1.974 ± 0.055
5.174LysIle: 5.174 ± 0.097
6.123LysLys: 6.123 ± 0.111
6.628LysLeu: 6.628 ± 0.105
1.814LysMet: 1.814 ± 0.049
4.622LysAsn: 4.622 ± 0.092
2.619LysPro: 2.619 ± 0.062
3.442LysGln: 3.442 ± 0.091
3.166LysArg: 3.166 ± 0.065
4.017LysSer: 4.017 ± 0.081
5.575LysThr: 5.575 ± 0.094
4.515LysVal: 4.515 ± 0.077
0.719LysTrp: 0.719 ± 0.027
2.773LysTyr: 2.773 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
6.429LeuAla: 6.429 ± 0.114
0.71LeuCys: 0.71 ± 0.032
5.117LeuAsp: 5.117 ± 0.092
6.24LeuGlu: 6.24 ± 0.092
4.783LeuPhe: 4.783 ± 0.098
6.087LeuGly: 6.087 ± 0.098
1.697LeuHis: 1.697 ± 0.047
6.778LeuIle: 6.778 ± 0.112
8.012LeuLys: 8.012 ± 0.137
8.727LeuLeu: 8.727 ± 0.13
2.116LeuMet: 2.116 ± 0.052
5.803LeuAsn: 5.803 ± 0.099
3.664LeuPro: 3.664 ± 0.071
3.307LeuGln: 3.307 ± 0.076
3.077LeuArg: 3.077 ± 0.07
6.483LeuSer: 6.483 ± 0.106
5.451LeuThr: 5.451 ± 0.086
5.92LeuVal: 5.92 ± 0.107
0.83LeuTrp: 0.83 ± 0.031
3.26LeuTyr: 3.26 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.017MetAla: 2.017 ± 0.06
0.133MetCys: 0.133 ± 0.014
1.113MetAsp: 1.113 ± 0.038
1.271MetGlu: 1.271 ± 0.051
0.955MetPhe: 0.955 ± 0.035
1.411MetGly: 1.411 ± 0.045
0.439MetHis: 0.439 ± 0.025
1.352MetIle: 1.352 ± 0.042
1.991MetLys: 1.991 ± 0.055
2.185MetLeu: 2.185 ± 0.064
0.518MetMet: 0.518 ± 0.031
1.098MetAsn: 1.098 ± 0.035
0.936MetPro: 0.936 ± 0.036
0.883MetGln: 0.883 ± 0.037
0.843MetArg: 0.843 ± 0.033
1.344MetSer: 1.344 ± 0.038
1.231MetThr: 1.231 ± 0.042
1.53MetVal: 1.53 ± 0.045
0.164MetTrp: 0.164 ± 0.015
0.713MetTyr: 0.713 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
4.207AsnAla: 4.207 ± 0.08
0.551AsnCys: 0.551 ± 0.045
3.36AsnAsp: 3.36 ± 0.09
3.402AsnGlu: 3.402 ± 0.081
2.58AsnPhe: 2.58 ± 0.058
3.959AsnGly: 3.959 ± 0.093
1.272AsnHis: 1.272 ± 0.043
4.737AsnIle: 4.737 ± 0.079
4.207AsnLys: 4.207 ± 0.076
5.078AsnLeu: 5.078 ± 0.096
1.331AsnMet: 1.331 ± 0.04
4.191AsnAsn: 4.191 ± 0.11
2.693AsnPro: 2.693 ± 0.061
2.378AsnGln: 2.378 ± 0.065
2.112AsnArg: 2.112 ± 0.066
3.25AsnSer: 3.25 ± 0.072
4.305AsnThr: 4.305 ± 0.096
3.542AsnVal: 3.542 ± 0.084
0.717AsnTrp: 0.717 ± 0.029
2.675AsnTyr: 2.675 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
1.889ProAla: 1.889 ± 0.056
0.216ProCys: 0.216 ± 0.019
1.974ProAsp: 1.974 ± 0.061
3.03ProGlu: 3.03 ± 0.066
1.948ProPhe: 1.948 ± 0.05
1.848ProGly: 1.848 ± 0.066
0.653ProHis: 0.653 ± 0.03
2.735ProIle: 2.735 ± 0.063
2.817ProLys: 2.817 ± 0.06
3.082ProLeu: 3.082 ± 0.057
0.808ProMet: 0.808 ± 0.032
2.403ProAsn: 2.403 ± 0.063
0.821ProPro: 0.821 ± 0.042
1.283ProGln: 1.283 ± 0.045
0.949ProArg: 0.949 ± 0.036
2.061ProSer: 2.061 ± 0.057
2.069ProThr: 2.069 ± 0.065
2.4ProVal: 2.4 ± 0.069
0.297ProTrp: 0.297 ± 0.021
1.444ProTyr: 1.444 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.874GlnAla: 2.874 ± 0.066
0.198GlnCys: 0.198 ± 0.023
2.067GlnAsp: 2.067 ± 0.056
2.497GlnGlu: 2.497 ± 0.06
1.65GlnPhe: 1.65 ± 0.041
2.099GlnGly: 2.099 ± 0.057
0.779GlnHis: 0.779 ± 0.032
2.589GlnIle: 2.589 ± 0.06
2.634GlnLys: 2.634 ± 0.06
3.805GlnLeu: 3.805 ± 0.084
0.873GlnMet: 0.873 ± 0.035
2.001GlnAsn: 2.001 ± 0.049
1.37GlnPro: 1.37 ± 0.043
1.792GlnGln: 1.792 ± 0.063
1.268GlnArg: 1.268 ± 0.044
1.786GlnSer: 1.786 ± 0.052
2.265GlnThr: 2.265 ± 0.064
2.261GlnVal: 2.261 ± 0.059
0.347GlnTrp: 0.347 ± 0.021
1.361GlnTyr: 1.361 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.222ArgAla: 2.222 ± 0.061
0.201ArgCys: 0.201 ± 0.015
1.677ArgAsp: 1.677 ± 0.055
2.116ArgGlu: 2.116 ± 0.057
1.917ArgPhe: 1.917 ± 0.057
1.866ArgGly: 1.866 ± 0.05
0.706ArgHis: 0.706 ± 0.028
2.582ArgIle: 2.582 ± 0.057
2.535ArgLys: 2.535 ± 0.066
3.402ArgLeu: 3.402 ± 0.06
0.9ArgMet: 0.9 ± 0.029
1.769ArgAsn: 1.769 ± 0.043
1.108ArgPro: 1.108 ± 0.033
1.26ArgGln: 1.26 ± 0.041
1.311ArgArg: 1.311 ± 0.048
1.673ArgSer: 1.673 ± 0.054
1.768ArgThr: 1.768 ± 0.041
2.218ArgVal: 2.218 ± 0.05
0.349ArgTrp: 0.349 ± 0.019
1.551ArgTyr: 1.551 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.752SerAla: 3.752 ± 0.071
0.66SerCys: 0.66 ± 0.038
3.134SerAsp: 3.134 ± 0.087
3.737SerGlu: 3.737 ± 0.078
3.198SerPhe: 3.198 ± 0.073
4.46SerGly: 4.46 ± 0.09
1.136SerHis: 1.136 ± 0.04
4.245SerIle: 4.245 ± 0.083
4.644SerLys: 4.644 ± 0.092
5.422SerLeu: 5.422 ± 0.096
1.205SerMet: 1.205 ± 0.041
3.662SerAsn: 3.662 ± 0.087
2.025SerPro: 2.025 ± 0.048
2.221SerGln: 2.221 ± 0.052
2.0SerArg: 2.0 ± 0.054
3.533SerSer: 3.533 ± 0.079
3.276SerThr: 3.276 ± 0.074
3.803SerVal: 3.803 ± 0.077
0.634SerTrp: 0.634 ± 0.035
2.471SerTyr: 2.471 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.483ThrAla: 4.483 ± 0.102
0.427ThrCys: 0.427 ± 0.033
3.22ThrAsp: 3.22 ± 0.088
3.355ThrGlu: 3.355 ± 0.065
3.37ThrPhe: 3.37 ± 0.069
3.986ThrGly: 3.986 ± 0.094
1.304ThrHis: 1.304 ± 0.041
5.08ThrIle: 5.08 ± 0.096
3.925ThrLys: 3.925 ± 0.083
6.442ThrLeu: 6.442 ± 0.097
1.092ThrMet: 1.092 ± 0.044
3.4ThrAsn: 3.4 ± 0.087
2.815ThrPro: 2.815 ± 0.085
2.238ThrGln: 2.238 ± 0.061
1.613ThrArg: 1.613 ± 0.051
3.713ThrSer: 3.713 ± 0.085
4.083ThrThr: 4.083 ± 0.099
4.174ThrVal: 4.174 ± 0.088
0.558ThrTrp: 0.558 ± 0.032
2.719ThrTyr: 2.719 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
4.788ValAla: 4.788 ± 0.088
0.589ValCys: 0.589 ± 0.031
3.64ValAsp: 3.64 ± 0.073
4.025ValGlu: 4.025 ± 0.08
3.694ValPhe: 3.694 ± 0.084
3.982ValGly: 3.982 ± 0.077
1.06ValHis: 1.06 ± 0.042
4.731ValIle: 4.731 ± 0.081
4.611ValLys: 4.611 ± 0.087
6.448ValLeu: 6.448 ± 0.11
1.459ValMet: 1.459 ± 0.041
3.654ValAsn: 3.654 ± 0.081
2.265ValPro: 2.265 ± 0.062
1.8ValGln: 1.8 ± 0.047
2.026ValArg: 2.026 ± 0.053
4.468ValSer: 4.468 ± 0.077
4.092ValThr: 4.092 ± 0.111
5.176ValVal: 5.176 ± 0.104
0.62ValTrp: 0.62 ± 0.032
2.536ValTyr: 2.536 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.585TrpAla: 0.585 ± 0.03
0.101TrpCys: 0.101 ± 0.01
0.519TrpAsp: 0.519 ± 0.024
0.607TrpGlu: 0.607 ± 0.028
0.519TrpPhe: 0.519 ± 0.025
0.563TrpGly: 0.563 ± 0.027
0.236TrpHis: 0.236 ± 0.019
0.653TrpIle: 0.653 ± 0.033
0.668TrpLys: 0.668 ± 0.028
1.063TrpLeu: 1.063 ± 0.04
0.305TrpMet: 0.305 ± 0.019
0.633TrpAsn: 0.633 ± 0.031
0.227TrpPro: 0.227 ± 0.021
0.414TrpGln: 0.414 ± 0.024
0.364TrpArg: 0.364 ± 0.021
0.537TrpSer: 0.537 ± 0.03
0.506TrpThr: 0.506 ± 0.032
0.612TrpVal: 0.612 ± 0.027
0.127TrpTrp: 0.127 ± 0.013
0.448TrpTyr: 0.448 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.641TyrAla: 2.641 ± 0.061
0.306TyrCys: 0.306 ± 0.02
2.337TyrAsp: 2.337 ± 0.062
2.096TyrGlu: 2.096 ± 0.05
2.297TyrPhe: 2.297 ± 0.056
2.701TyrGly: 2.701 ± 0.068
0.864TyrHis: 0.864 ± 0.035
2.653TyrIle: 2.653 ± 0.07
3.029TyrLys: 3.029 ± 0.073
3.693TyrLeu: 3.693 ± 0.085
0.726TyrMet: 0.726 ± 0.033
2.833TyrAsn: 2.833 ± 0.075
1.441TyrPro: 1.441 ± 0.05
1.642TyrGln: 1.642 ± 0.053
1.578TyrArg: 1.578 ± 0.049
2.318TyrSer: 2.318 ± 0.061
2.518TyrThr: 2.518 ± 0.074
2.356TyrVal: 2.356 ± 0.059
0.418TyrTrp: 0.418 ± 0.026
1.814TyrTyr: 1.814 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2307 proteins (774474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski