Amino acid dipepetide frequency for Plasmodium gonderi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.156AlaAla: 1.156 ± 0.029	0.596AlaCys: 0.596 ± 0.014	1.675AlaAsp: 1.675 ± 0.03	2.148AlaGlu: 2.148 ± 0.044	1.193AlaPhe: 1.193 ± 0.017	1.201AlaGly: 1.201 ± 0.028	0.849AlaHis: 0.849 ± 0.014	2.035AlaIle: 2.035 ± 0.03	2.744AlaLys: 2.744 ± 0.038	2.431AlaLeu: 2.431 ± 0.037	0.559AlaMet: 0.559 ± 0.013	2.54AlaAsn: 2.54 ± 0.032	0.787AlaPro: 0.787 ± 0.017	1.024AlaGln: 1.024 ± 0.018	0.985AlaArg: 0.985 ± 0.018	2.402AlaSer: 2.402 ± 0.036	1.453AlaThr: 1.453 ± 0.024	1.299AlaVal: 1.299 ± 0.023	0.168AlaTrp: 0.168 ± 0.007	1.402AlaTyr: 1.402 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.723CysAla: 0.723 ± 0.015	0.4CysCys: 0.4 ± 0.012	1.166CysAsp: 1.166 ± 0.02	1.396CysGlu: 1.396 ± 0.023	0.927CysPhe: 0.927 ± 0.018	0.768CysGly: 0.768 ± 0.016	0.43CysHis: 0.43 ± 0.012	1.728CysIle: 1.728 ± 0.023	1.925CysLys: 1.925 ± 0.027	1.616CysLeu: 1.616 ± 0.022	0.458CysMet: 0.458 ± 0.01	1.867CysAsn: 1.867 ± 0.027	0.535CysPro: 0.535 ± 0.023	0.488CysGln: 0.488 ± 0.011	0.718CysArg: 0.718 ± 0.015	1.767CysSer: 1.767 ± 0.029	1.126CysThr: 1.126 ± 0.017	1.079CysVal: 1.079 ± 0.019	0.082CysTrp: 0.082 ± 0.004	0.857CysTyr: 0.857 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.01AspAla: 2.01 ± 0.025	0.749AspCys: 0.749 ± 0.016	4.387AspAsp: 4.387 ± 0.068	5.94AspGlu: 5.94 ± 0.065	2.319AspPhe: 2.319 ± 0.027	2.272AspGly: 2.272 ± 0.032	1.133AspHis: 1.133 ± 0.019	5.296AspIle: 5.296 ± 0.04	5.347AspLys: 5.347 ± 0.052	3.906AspLeu: 3.906 ± 0.031	1.525AspMet: 1.525 ± 0.023	4.962AspAsn: 4.962 ± 0.057	1.162AspPro: 1.162 ± 0.023	1.402AspGln: 1.402 ± 0.019	1.818AspArg: 1.818 ± 0.026	3.924AspSer: 3.924 ± 0.043	2.594AspThr: 2.594 ± 0.027	3.223AspVal: 3.223 ± 0.041	0.234AspTrp: 0.234 ± 0.01	2.459AspTyr: 2.459 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	2.373GluAla: 2.373 ± 0.048	1.304GluCys: 1.304 ± 0.029	4.498GluAsp: 4.498 ± 0.055	9.615GluGlu: 9.615 ± 0.133	2.401GluPhe: 2.401 ± 0.026	3.076GluGly: 3.076 ± 0.041	1.764GluHis: 1.764 ± 0.024	5.634GluIle: 5.634 ± 0.055	10.96GluLys: 10.96 ± 0.085	5.091GluLeu: 5.091 ± 0.055	1.925GluMet: 1.925 ± 0.032	8.598GluAsn: 8.598 ± 0.072	1.222GluPro: 1.222 ± 0.026	2.517GluGln: 2.517 ± 0.035	3.074GluArg: 3.074 ± 0.039	4.467GluSer: 4.467 ± 0.045	3.071GluThr: 3.071 ± 0.036	3.216GluVal: 3.216 ± 0.05	0.476GluTrp: 0.476 ± 0.016	3.102GluTyr: 3.102 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	1.114PheAla: 1.114 ± 0.019	1.049PheCys: 1.049 ± 0.019	2.513PheAsp: 2.513 ± 0.027	2.621PheGlu: 2.621 ± 0.027	3.518PhePhe: 3.518 ± 0.051	1.375PheGly: 1.375 ± 0.024	1.287PheHis: 1.287 ± 0.02	3.865PheIle: 3.865 ± 0.047	3.656PheLys: 3.656 ± 0.036	5.23PheLeu: 5.23 ± 0.058	1.018PheMet: 1.018 ± 0.017	3.761PheAsn: 3.761 ± 0.037	1.38PhePro: 1.38 ± 0.018	1.358PheGln: 1.358 ± 0.021	1.396PheArg: 1.396 ± 0.022	3.949PheSer: 3.949 ± 0.039	1.991PheThr: 1.991 ± 0.023	2.228PheVal: 2.228 ± 0.029	0.259PheTrp: 0.259 ± 0.009	2.77PheTyr: 2.77 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	1.374GlyAla: 1.374 ± 0.029	0.688GlyCys: 0.688 ± 0.018	2.352GlyAsp: 2.352 ± 0.032	3.699GlyGlu: 3.699 ± 0.051	1.331GlyPhe: 1.331 ± 0.02	2.63GlyGly: 2.63 ± 0.048	0.784GlyHis: 0.784 ± 0.018	3.086GlyIle: 3.086 ± 0.036	4.359GlyLys: 4.359 ± 0.039	2.215GlyLeu: 2.215 ± 0.03	0.892GlyMet: 0.892 ± 0.02	4.094GlyAsn: 4.094 ± 0.05	0.618GlyPro: 0.618 ± 0.014	0.896GlyGln: 0.896 ± 0.018	1.876GlyArg: 1.876 ± 0.031	3.345GlySer: 3.345 ± 0.047	2.124GlyThr: 2.124 ± 0.029	1.975GlyVal: 1.975 ± 0.03	0.2GlyTrp: 0.2 ± 0.007	1.534GlyTyr: 1.534 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	0.798HisAla: 0.798 ± 0.015	0.398HisCys: 0.398 ± 0.011	1.306HisAsp: 1.306 ± 0.022	1.599HisGlu: 1.599 ± 0.022	1.429HisPhe: 1.429 ± 0.024	0.991HisGly: 0.991 ± 0.018	0.731HisHis: 0.731 ± 0.015	2.23HisIle: 2.23 ± 0.028	2.133HisLys: 2.133 ± 0.027	2.281HisLeu: 2.281 ± 0.025	0.759HisMet: 0.759 ± 0.015	2.325HisAsn: 2.325 ± 0.031	0.717HisPro: 0.717 ± 0.015	0.665HisGln: 0.665 ± 0.015	0.892HisArg: 0.892 ± 0.016	1.88HisSer: 1.88 ± 0.024	1.235HisThr: 1.235 ± 0.02	1.424HisVal: 1.424 ± 0.021	0.119HisTrp: 0.119 ± 0.006	1.08HisTyr: 1.08 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	1.983IleAla: 1.983 ± 0.024	1.969IleCys: 1.969 ± 0.025	4.202IleAsp: 4.202 ± 0.034	4.917IleGlu: 4.917 ± 0.043	4.609IlePhe: 4.609 ± 0.053	2.704IleGly: 2.704 ± 0.028	2.197IleHis: 2.197 ± 0.024	6.442IleIle: 6.442 ± 0.059	7.932IleLys: 7.932 ± 0.071	7.549IleLeu: 7.549 ± 0.07	1.569IleMet: 1.569 ± 0.021	7.782IleAsn: 7.782 ± 0.059	2.417IlePro: 2.417 ± 0.028	2.535IleGln: 2.535 ± 0.024	2.715IleArg: 2.715 ± 0.032	6.329IleSer: 6.329 ± 0.044	3.434IleThr: 3.434 ± 0.029	3.083IleVal: 3.083 ± 0.032	0.467IleTrp: 0.467 ± 0.012	4.51IleTyr: 4.51 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	2.324LysAla: 2.324 ± 0.041	2.236LysCys: 2.236 ± 0.029	5.316LysAsp: 5.316 ± 0.052	9.243LysGlu: 9.243 ± 0.085	3.656LysPhe: 3.656 ± 0.031	4.321LysGly: 4.321 ± 0.04	2.281LysHis: 2.281 ± 0.027	8.552LysIle: 8.552 ± 0.061	16.996LysLys: 16.996 ± 0.133	7.409LysLeu: 7.409 ± 0.051	2.695LysMet: 2.695 ± 0.029	12.825LysAsn: 12.825 ± 0.077	1.516LysPro: 1.516 ± 0.024	2.894LysGln: 2.894 ± 0.029	4.972LysArg: 4.972 ± 0.045	6.737LysSer: 6.737 ± 0.051	4.309LysThr: 4.309 ± 0.035	3.856LysVal: 3.856 ± 0.036	0.801LysTrp: 0.801 ± 0.019	5.455LysTyr: 5.455 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	2.035LeuAla: 2.035 ± 0.029	1.924LeuCys: 1.924 ± 0.026	3.811LeuAsp: 3.811 ± 0.036	4.643LeuGlu: 4.643 ± 0.045	4.633LeuPhe: 4.633 ± 0.058	2.552LeuGly: 2.552 ± 0.032	2.292LeuHis: 2.292 ± 0.025	5.937LeuIle: 5.937 ± 0.057	8.888LeuLys: 8.888 ± 0.075	7.562LeuLeu: 7.562 ± 0.065	1.612LeuMet: 1.612 ± 0.022	7.884LeuAsn: 7.884 ± 0.053	2.12LeuPro: 2.12 ± 0.029	2.531LeuGln: 2.531 ± 0.029	3.002LeuArg: 3.002 ± 0.031	6.346LeuSer: 6.346 ± 0.043	3.386LeuThr: 3.386 ± 0.031	2.933LeuVal: 2.933 ± 0.03	0.486LeuTrp: 0.486 ± 0.012	4.373LeuTyr: 4.373 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	0.577MetAla: 0.577 ± 0.013	0.491MetCys: 0.491 ± 0.012	1.434MetAsp: 1.434 ± 0.023	1.901MetGlu: 1.901 ± 0.027	0.865MetPhe: 0.865 ± 0.016	0.945MetGly: 0.945 ± 0.018	0.766MetHis: 0.766 ± 0.016	1.357MetIle: 1.357 ± 0.016	2.845MetLys: 2.845 ± 0.029	1.693MetLeu: 1.693 ± 0.02	0.546MetMet: 0.546 ± 0.013	3.294MetAsn: 3.294 ± 0.052	0.499MetPro: 0.499 ± 0.015	0.826MetGln: 0.826 ± 0.02	0.851MetArg: 0.851 ± 0.018	1.66MetSer: 1.66 ± 0.023	0.836MetThr: 0.836 ± 0.018	0.755MetVal: 0.755 ± 0.015	0.148MetTrp: 0.148 ± 0.006	1.112MetTyr: 1.112 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.014AsnAla: 3.014 ± 0.041	1.921AsnCys: 1.921 ± 0.025	6.183AsnAsp: 6.183 ± 0.064	8.659AsnGlu: 8.659 ± 0.067	4.943AsnPhe: 4.943 ± 0.045	4.429AsnGly: 4.429 ± 0.057	2.18AsnHis: 2.18 ± 0.031	9.222AsnIle: 9.222 ± 0.069	9.757AsnLys: 9.757 ± 0.066	7.4AsnLeu: 7.4 ± 0.056	2.805AsnMet: 2.805 ± 0.043	11.29AsnAsn: 11.29 ± 0.154	2.121AsnPro: 2.121 ± 0.029	2.636AsnGln: 2.636 ± 0.038	3.379AsnArg: 3.379 ± 0.045	8.174AsnSer: 8.174 ± 0.087	4.542AsnThr: 4.542 ± 0.04	5.481AsnVal: 5.481 ± 0.047	0.472AsnTrp: 0.472 ± 0.011	5.16AsnTyr: 5.16 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	0.593ProAla: 0.593 ± 0.016	0.501ProCys: 0.501 ± 0.015	1.042ProAsp: 1.042 ± 0.019	1.294ProGlu: 1.294 ± 0.021	1.404ProPhe: 1.404 ± 0.022	0.729ProGly: 0.729 ± 0.017	0.732ProHis: 0.732 ± 0.016	1.842ProIle: 1.842 ± 0.027	1.768ProLys: 1.768 ± 0.025	2.151ProLeu: 2.151 ± 0.023	0.491ProMet: 0.491 ± 0.014	2.217ProAsn: 2.217 ± 0.033	0.932ProPro: 0.932 ± 0.025	0.816ProGln: 0.816 ± 0.016	0.79ProArg: 0.79 ± 0.017	2.133ProSer: 2.133 ± 0.026	1.17ProThr: 1.17 ± 0.019	1.082ProVal: 1.082 ± 0.019	0.167ProTrp: 0.167 ± 0.006	1.229ProTyr: 1.229 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	0.739GlnAla: 0.739 ± 0.017	0.497GlnCys: 0.497 ± 0.011	1.349GlnAsp: 1.349 ± 0.018	2.159GlnGlu: 2.159 ± 0.027	1.064GlnPhe: 1.064 ± 0.015	1.182GlnGly: 1.182 ± 0.017	0.75GlnHis: 0.75 ± 0.017	2.367GlnIle: 2.367 ± 0.029	3.447GlnLys: 3.447 ± 0.035	2.19GlnLeu: 2.19 ± 0.026	0.97GlnMet: 0.97 ± 0.022	3.64GlnAsn: 3.64 ± 0.042	0.573GlnPro: 0.573 ± 0.017	1.103GlnGln: 1.103 ± 0.029	1.199GlnArg: 1.199 ± 0.02	1.895GlnSer: 1.895 ± 0.028	1.245GlnThr: 1.245 ± 0.019	1.336GlnVal: 1.336 ± 0.021	0.202GlnTrp: 0.202 ± 0.009	1.127GlnTyr: 1.127 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	0.979ArgAla: 0.979 ± 0.02	0.703ArgCys: 0.703 ± 0.016	2.117ArgAsp: 2.117 ± 0.03	3.181ArgGlu: 3.181 ± 0.043	1.142ArgPhe: 1.142 ± 0.017	1.907ArgGly: 1.907 ± 0.029	0.845ArgHis: 0.845 ± 0.015	2.778ArgIle: 2.778 ± 0.029	5.082ArgLys: 5.082 ± 0.05	2.064ArgLeu: 2.064 ± 0.022	0.853ArgMet: 0.853 ± 0.016	4.373ArgAsn: 4.373 ± 0.048	0.571ArgPro: 0.571 ± 0.011	0.935ArgGln: 0.935 ± 0.018	2.291ArgArg: 2.291 ± 0.038	2.958ArgSer: 2.958 ± 0.05	1.741ArgThr: 1.741 ± 0.02	1.422ArgVal: 1.422 ± 0.024	0.221ArgTrp: 0.221 ± 0.008	1.451ArgTyr: 1.451 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	2.514SerAla: 2.514 ± 0.033	1.574SerCys: 1.574 ± 0.022	4.525SerAsp: 4.525 ± 0.044	5.027SerGlu: 5.027 ± 0.052	3.712SerPhe: 3.712 ± 0.032	3.38SerGly: 3.38 ± 0.049	1.87SerHis: 1.87 ± 0.021	5.726SerIle: 5.726 ± 0.043	6.686SerLys: 6.686 ± 0.054	5.956SerLeu: 5.956 ± 0.041	1.639SerMet: 1.639 ± 0.026	7.888SerAsn: 7.888 ± 0.077	1.956SerPro: 1.956 ± 0.031	2.054SerGln: 2.054 ± 0.029	2.838SerArg: 2.838 ± 0.042	7.995SerSer: 7.995 ± 0.086	4.051SerThr: 4.051 ± 0.034	3.568SerVal: 3.568 ± 0.036	0.382SerTrp: 0.382 ± 0.011	3.685SerTyr: 3.685 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	1.305ThrAla: 1.305 ± 0.025	1.118ThrCys: 1.118 ± 0.017	2.461ThrAsp: 2.461 ± 0.032	2.837ThrGlu: 2.837 ± 0.037	2.259ThrPhe: 2.259 ± 0.026	1.74ThrGly: 1.74 ± 0.025	1.402ThrHis: 1.402 ± 0.023	3.132ThrIle: 3.132 ± 0.036	4.099ThrLys: 4.099 ± 0.033	3.656ThrLeu: 3.656 ± 0.039	0.853ThrMet: 0.853 ± 0.015	4.797ThrAsn: 4.797 ± 0.052	1.488ThrPro: 1.488 ± 0.021	1.502ThrGln: 1.502 ± 0.022	1.521ThrArg: 1.521 ± 0.021	4.072ThrSer: 4.072 ± 0.043	2.465ThrThr: 2.465 ± 0.033	1.928ThrVal: 1.928 ± 0.025	0.292ThrTrp: 0.292 ± 0.009	2.298ThrTyr: 2.298 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	1.378ValAla: 1.378 ± 0.024	0.938ValCys: 0.938 ± 0.018	2.862ValAsp: 2.862 ± 0.029	3.677ValGlu: 3.677 ± 0.064	1.821ValPhe: 1.821 ± 0.025	1.925ValGly: 1.925 ± 0.037	1.459ValHis: 1.459 ± 0.021	3.169ValIle: 3.169 ± 0.03	4.497ValLys: 4.497 ± 0.042	3.735ValLeu: 3.735 ± 0.038	0.868ValMet: 0.868 ± 0.016	4.184ValAsn: 4.184 ± 0.038	1.251ValPro: 1.251 ± 0.019	1.577ValGln: 1.577 ± 0.023	1.595ValArg: 1.595 ± 0.024	3.252ValSer: 3.252 ± 0.033	2.024ValThr: 2.024 ± 0.023	2.135ValVal: 2.135 ± 0.029	0.232ValTrp: 0.232 ± 0.008	2.115ValTyr: 2.115 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.149TrpAla: 0.149 ± 0.007	0.127TrpCys: 0.127 ± 0.006	0.344TrpAsp: 0.344 ± 0.011	0.382TrpGlu: 0.382 ± 0.01	0.241TrpPhe: 0.241 ± 0.009	0.291TrpGly: 0.291 ± 0.009	0.112TrpHis: 0.112 ± 0.005	0.524TrpIle: 0.524 ± 0.014	0.751TrpLys: 0.751 ± 0.016	0.496TrpLeu: 0.496 ± 0.012	0.144TrpMet: 0.144 ± 0.007	0.656TrpAsn: 0.656 ± 0.013	0.112TrpPro: 0.112 ± 0.006	0.107TrpGln: 0.107 ± 0.005	0.244TrpArg: 0.244 ± 0.009	0.368TrpSer: 0.368 ± 0.009	0.225TrpThr: 0.225 ± 0.008	0.279TrpVal: 0.279 ± 0.009	0.048TrpTrp: 0.048 ± 0.004	0.194TrpTyr: 0.194 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.511TyrAla: 1.511 ± 0.019	0.876TyrCys: 0.876 ± 0.019	3.119TyrAsp: 3.119 ± 0.033	3.442TyrGlu: 3.442 ± 0.031	2.87TyrPhe: 2.87 ± 0.033	1.652TyrGly: 1.652 ± 0.023	1.128TyrHis: 1.128 ± 0.017	4.421TyrIle: 4.421 ± 0.049	4.521TyrLys: 4.521 ± 0.041	4.321TyrLeu: 4.321 ± 0.044	1.219TyrMet: 1.219 ± 0.019	4.789TyrAsn: 4.789 ± 0.049	1.109TyrPro: 1.109 ± 0.018	1.169TyrGln: 1.169 ± 0.018	1.457TyrArg: 1.457 ± 0.021	3.375TyrSer: 3.375 ± 0.033	2.202TyrThr: 2.202 ± 0.022	2.393TyrVal: 2.393 ± 0.027	0.338TyrTrp: 0.338 ± 0.011	2.604TyrTyr: 2.604 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5915 proteins (4048994 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---