Amino acid dipepetide frequency for Macacine gammaherpesvirus 4 (Rhesus lymphocryptovirus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.855AlaAla: 11.855 ± 1.729
1.739AlaCys: 1.739 ± 0.215
3.16AlaAsp: 3.16 ± 0.315
4.801AlaGlu: 4.801 ± 0.506
3.282AlaPhe: 3.282 ± 0.337
7.446AlaGly: 7.446 ± 0.541
2.008AlaHis: 2.008 ± 0.201
2.915AlaIle: 2.915 ± 0.282
2.057AlaLys: 2.057 ± 0.226
9.013AlaLeu: 9.013 ± 0.797
1.543AlaMet: 1.543 ± 0.202
2.131AlaAsn: 2.131 ± 0.259
9.65AlaPro: 9.65 ± 0.954
3.405AlaGln: 3.405 ± 0.374
6.417AlaArg: 6.417 ± 0.664
7.887AlaSer: 7.887 ± 0.612
5.168AlaThr: 5.168 ± 0.672
6.515AlaVal: 6.515 ± 0.558
1.372AlaTrp: 1.372 ± 0.205
2.155AlaTyr: 2.155 ± 0.274
0.0AlaXaa: 0.0 ± 0.0
Cys
1.421CysAla: 1.421 ± 0.227
0.514CysCys: 0.514 ± 0.12
0.661CysAsp: 0.661 ± 0.112
1.004CysGlu: 1.004 ± 0.181
0.735CysPhe: 0.735 ± 0.183
1.298CysGly: 1.298 ± 0.238
0.563CysHis: 0.563 ± 0.163
0.588CysIle: 0.588 ± 0.13
0.588CysLys: 0.588 ± 0.139
2.645CysLeu: 2.645 ± 0.365
0.343CysMet: 0.343 ± 0.099
0.563CysAsn: 0.563 ± 0.119
1.372CysPro: 1.372 ± 0.206
0.906CysGln: 0.906 ± 0.136
1.421CysArg: 1.421 ± 0.194
1.029CysSer: 1.029 ± 0.162
0.833CysThr: 0.833 ± 0.152
1.519CysVal: 1.519 ± 0.198
0.171CysTrp: 0.171 ± 0.075
0.588CysTyr: 0.588 ± 0.123
0.0CysXaa: 0.0 ± 0.0
Asp
4.017AspAla: 4.017 ± 0.35
0.71AspCys: 0.71 ± 0.161
2.106AspAsp: 2.106 ± 0.322
2.939AspGlu: 2.939 ± 0.349
1.543AspPhe: 1.543 ± 0.185
3.845AspGly: 3.845 ± 0.602
0.857AspHis: 0.857 ± 0.177
1.69AspIle: 1.69 ± 0.213
0.955AspLys: 0.955 ± 0.169
4.825AspLeu: 4.825 ± 0.398
1.249AspMet: 1.249 ± 0.208
1.151AspAsn: 1.151 ± 0.187
3.894AspPro: 3.894 ± 0.365
0.931AspGln: 0.931 ± 0.147
2.4AspArg: 2.4 ± 0.266
2.719AspSer: 2.719 ± 0.288
2.008AspThr: 2.008 ± 0.251
2.768AspVal: 2.768 ± 0.251
0.514AspTrp: 0.514 ± 0.112
1.445AspTyr: 1.445 ± 0.201
0.0AspXaa: 0.0 ± 0.0
Glu
6.638GluAla: 6.638 ± 0.617
0.71GluCys: 0.71 ± 0.155
3.87GluAsp: 3.87 ± 0.336
5.315GluGlu: 5.315 ± 0.656
1.617GluPhe: 1.617 ± 0.196
4.482GluGly: 4.482 ± 0.522
1.274GluHis: 1.274 ± 0.17
2.204GluIle: 2.204 ± 0.237
1.298GluLys: 1.298 ± 0.172
5.193GluLeu: 5.193 ± 0.421
1.127GluMet: 1.127 ± 0.18
2.18GluAsn: 2.18 ± 0.318
3.282GluPro: 3.282 ± 0.457
1.641GluGln: 1.641 ± 0.235
4.017GluArg: 4.017 ± 0.603
3.209GluSer: 3.209 ± 0.351
3.87GluThr: 3.87 ± 0.354
3.037GluVal: 3.037 ± 0.272
0.416GluTrp: 0.416 ± 0.089
1.053GluTyr: 1.053 ± 0.192
0.0GluXaa: 0.0 ± 0.0
Phe
2.351PheAla: 2.351 ± 0.285
0.882PheCys: 0.882 ± 0.194
1.347PheAsp: 1.347 ± 0.181
1.69PheGlu: 1.69 ± 0.238
1.861PhePhe: 1.861 ± 0.213
2.131PheGly: 2.131 ± 0.344
0.931PheHis: 0.931 ± 0.121
1.91PheIle: 1.91 ± 0.291
1.347PheLys: 1.347 ± 0.236
5.046PheLeu: 5.046 ± 0.445
0.882PheMet: 0.882 ± 0.127
1.053PheAsn: 1.053 ± 0.16
2.008PhePro: 2.008 ± 0.226
1.421PheGln: 1.421 ± 0.166
1.69PheArg: 1.69 ± 0.188
2.988PheSer: 2.988 ± 0.267
1.837PheThr: 1.837 ± 0.208
3.013PheVal: 3.013 ± 0.31
0.416PheTrp: 0.416 ± 0.097
1.641PheTyr: 1.641 ± 0.209
0.0PheXaa: 0.0 ± 0.0
Gly
6.589GlyAla: 6.589 ± 0.588
1.127GlyCys: 1.127 ± 0.189
3.772GlyAsp: 3.772 ± 0.729
4.482GlyGlu: 4.482 ± 0.356
1.91GlyPhe: 1.91 ± 0.228
8.989GlyGly: 8.989 ± 1.61
2.523GlyHis: 2.523 ± 0.765
1.617GlyIle: 1.617 ± 0.255
1.91GlyLys: 1.91 ± 0.225
8.034GlyLeu: 8.034 ± 0.52
0.833GlyMet: 0.833 ± 0.18
2.572GlyAsn: 2.572 ± 0.657
7.789GlyPro: 7.789 ± 1.548
3.6GlyGln: 3.6 ± 0.68
5.878GlyArg: 5.878 ± 0.746
5.584GlySer: 5.584 ± 0.737
4.384GlyThr: 4.384 ± 0.627
3.747GlyVal: 3.747 ± 0.389
0.931GlyTrp: 0.931 ± 0.15
1.543GlyTyr: 1.543 ± 0.203
0.0GlyXaa: 0.0 ± 0.0
His
2.278HisAla: 2.278 ± 0.256
0.392HisCys: 0.392 ± 0.101
0.882HisAsp: 0.882 ± 0.146
1.249HisGlu: 1.249 ± 0.155
0.759HisPhe: 0.759 ± 0.119
1.494HisGly: 1.494 ± 0.183
0.833HisHis: 0.833 ± 0.284
0.71HisIle: 0.71 ± 0.138
0.661HisLys: 0.661 ± 0.098
2.694HisLeu: 2.694 ± 0.343
0.465HisMet: 0.465 ± 0.117
0.784HisAsn: 0.784 ± 0.172
2.915HisPro: 2.915 ± 0.7
0.931HisGln: 0.931 ± 0.145
1.592HisArg: 1.592 ± 0.186
1.715HisSer: 1.715 ± 0.193
1.372HisThr: 1.372 ± 0.203
1.984HisVal: 1.984 ± 0.286
0.269HisTrp: 0.269 ± 0.072
0.612HisTyr: 0.612 ± 0.126
0.0HisXaa: 0.0 ± 0.0
Ile
2.057IleAla: 2.057 ± 0.287
0.686IleCys: 0.686 ± 0.12
1.2IleAsp: 1.2 ± 0.169
1.69IleGlu: 1.69 ± 0.183
1.763IlePhe: 1.763 ± 0.198
0.98IleGly: 0.98 ± 0.168
0.784IleHis: 0.784 ± 0.131
1.886IleIle: 1.886 ± 0.345
1.617IleLys: 1.617 ± 0.247
4.409IleLeu: 4.409 ± 0.508
0.857IleMet: 0.857 ± 0.142
1.176IleAsn: 1.176 ± 0.235
2.449IlePro: 2.449 ± 0.297
1.323IleGln: 1.323 ± 0.194
1.568IleArg: 1.568 ± 0.215
2.621IleSer: 2.621 ± 0.324
1.861IleThr: 1.861 ± 0.22
2.498IleVal: 2.498 ± 0.262
0.441IleTrp: 0.441 ± 0.12
1.445IleTyr: 1.445 ± 0.158
0.0IleXaa: 0.0 ± 0.0
Lys
2.67LysAla: 2.67 ± 0.253
0.563LysCys: 0.563 ± 0.103
1.347LysAsp: 1.347 ± 0.216
1.69LysGlu: 1.69 ± 0.263
1.029LysPhe: 1.029 ± 0.181
1.641LysGly: 1.641 ± 0.251
0.98LysHis: 0.98 ± 0.177
1.323LysIle: 1.323 ± 0.17
1.421LysLys: 1.421 ± 0.236
2.596LysLeu: 2.596 ± 0.252
0.49LysMet: 0.49 ± 0.138
1.2LysAsn: 1.2 ± 0.18
2.082LysPro: 2.082 ± 0.264
1.347LysGln: 1.347 ± 0.201
2.523LysArg: 2.523 ± 0.232
1.812LysSer: 1.812 ± 0.219
1.935LysThr: 1.935 ± 0.285
1.984LysVal: 1.984 ± 0.253
0.171LysTrp: 0.171 ± 0.068
0.784LysTyr: 0.784 ± 0.165
0.0LysXaa: 0.0 ± 0.0
Leu
10.189LeuAla: 10.189 ± 0.871
2.547LeuCys: 2.547 ± 0.284
3.796LeuAsp: 3.796 ± 0.375
5.658LeuGlu: 5.658 ± 0.483
4.556LeuPhe: 4.556 ± 0.438
7.078LeuGly: 7.078 ± 0.43
2.523LeuHis: 2.523 ± 0.268
2.939LeuIle: 2.939 ± 0.38
3.037LeuLys: 3.037 ± 0.291
11.463LeuLeu: 11.463 ± 1.093
2.204LeuMet: 2.204 ± 0.227
3.062LeuAsn: 3.062 ± 0.282
7.176LeuPro: 7.176 ± 0.507
3.943LeuGln: 3.943 ± 0.271
7.299LeuArg: 7.299 ± 0.597
7.323LeuSer: 7.323 ± 0.583
6.834LeuThr: 6.834 ± 0.464
6.172LeuVal: 6.172 ± 0.506
1.176LeuTrp: 1.176 ± 0.177
3.184LeuTyr: 3.184 ± 0.461
0.0LeuXaa: 0.0 ± 0.0
Met
2.376MetAla: 2.376 ± 0.253
0.49MetCys: 0.49 ± 0.133
0.833MetAsp: 0.833 ± 0.158
1.078MetGlu: 1.078 ± 0.208
0.906MetPhe: 0.906 ± 0.185
0.955MetGly: 0.955 ± 0.179
0.514MetHis: 0.514 ± 0.111
0.808MetIle: 0.808 ± 0.146
0.661MetLys: 0.661 ± 0.117
1.788MetLeu: 1.788 ± 0.207
0.22MetMet: 0.22 ± 0.08
0.416MetAsn: 0.416 ± 0.11
1.176MetPro: 1.176 ± 0.192
0.661MetGln: 0.661 ± 0.122
1.176MetArg: 1.176 ± 0.168
1.151MetSer: 1.151 ± 0.169
1.421MetThr: 1.421 ± 0.218
1.004MetVal: 1.004 ± 0.159
0.22MetTrp: 0.22 ± 0.074
0.563MetTyr: 0.563 ± 0.141
0.0MetXaa: 0.0 ± 0.0
Asn
2.596AsnAla: 2.596 ± 0.311
0.563AsnCys: 0.563 ± 0.121
0.735AsnAsp: 0.735 ± 0.134
1.421AsnGlu: 1.421 ± 0.219
1.2AsnPhe: 1.2 ± 0.224
1.715AsnGly: 1.715 ± 0.482
0.661AsnHis: 0.661 ± 0.136
1.837AsnIle: 1.837 ± 0.261
1.421AsnLys: 1.421 ± 0.239
3.405AsnLeu: 3.405 ± 0.31
0.514AsnMet: 0.514 ± 0.15
1.078AsnAsn: 1.078 ± 0.194
1.886AsnPro: 1.886 ± 0.181
1.004AsnGln: 1.004 ± 0.131
1.47AsnArg: 1.47 ± 0.274
2.155AsnSer: 2.155 ± 0.311
1.519AsnThr: 1.519 ± 0.186
2.351AsnVal: 2.351 ± 0.255
0.196AsnTrp: 0.196 ± 0.073
0.784AsnTyr: 0.784 ± 0.136
0.0AsnXaa: 0.0 ± 0.0
Pro
8.646ProAla: 8.646 ± 0.844
1.445ProCys: 1.445 ± 0.185
3.184ProAsp: 3.184 ± 0.316
5.462ProGlu: 5.462 ± 0.71
2.204ProPhe: 2.204 ± 0.245
7.813ProGly: 7.813 ± 0.853
1.568ProHis: 1.568 ± 0.27
2.278ProIle: 2.278 ± 0.244
2.008ProLys: 2.008 ± 0.232
6.613ProLeu: 6.613 ± 0.504
1.127ProMet: 1.127 ± 0.172
1.519ProAsn: 1.519 ± 0.207
12.1ProPro: 12.1 ± 2.424
4.384ProGln: 4.384 ± 0.874
6.442ProArg: 6.442 ± 0.683
7.299ProSer: 7.299 ± 0.827
5.364ProThr: 5.364 ± 0.699
5.021ProVal: 5.021 ± 0.503
1.445ProTrp: 1.445 ± 0.277
1.666ProTyr: 1.666 ± 0.352
0.0ProXaa: 0.0 ± 0.0
Gln
4.188GlnAla: 4.188 ± 0.464
0.539GlnCys: 0.539 ± 0.115
2.057GlnAsp: 2.057 ± 0.243
2.204GlnGlu: 2.204 ± 0.252
1.298GlnPhe: 1.298 ± 0.227
2.817GlnGly: 2.817 ± 0.373
0.833GlnHis: 0.833 ± 0.248
1.225GlnIle: 1.225 ± 0.174
1.641GlnLys: 1.641 ± 0.208
2.743GlnLeu: 2.743 ± 0.235
0.833GlnMet: 0.833 ± 0.141
1.151GlnAsn: 1.151 ± 0.187
3.845GlnPro: 3.845 ± 0.682
2.057GlnGln: 2.057 ± 0.303
4.384GlnArg: 4.384 ± 1.388
1.739GlnSer: 1.739 ± 0.254
2.278GlnThr: 2.278 ± 0.196
2.4GlnVal: 2.4 ± 0.277
0.367GlnTrp: 0.367 ± 0.092
1.151GlnTyr: 1.151 ± 0.167
0.0GlnXaa: 0.0 ± 0.0
Arg
6.932ArgAla: 6.932 ± 0.697
1.323ArgCys: 1.323 ± 0.193
3.356ArgAsp: 3.356 ± 0.333
4.188ArgGlu: 4.188 ± 0.459
1.543ArgPhe: 1.543 ± 0.167
7.225ArgGly: 7.225 ± 1.594
2.106ArgHis: 2.106 ± 0.246
1.568ArgIle: 1.568 ± 0.178
2.057ArgLys: 2.057 ± 0.269
6.466ArgLeu: 6.466 ± 0.611
1.176ArgMet: 1.176 ± 0.184
1.592ArgAsn: 1.592 ± 0.174
7.054ArgPro: 7.054 ± 1.34
3.086ArgGln: 3.086 ± 0.651
6.981ArgArg: 6.981 ± 0.95
4.139ArgSer: 4.139 ± 0.358
4.188ArgThr: 4.188 ± 1.374
4.531ArgVal: 4.531 ± 0.46
0.931ArgTrp: 0.931 ± 0.166
1.519ArgTyr: 1.519 ± 0.216
0.0ArgXaa: 0.0 ± 0.0
Ser
5.731SerAla: 5.731 ± 0.512
1.249SerCys: 1.249 ± 0.204
3.405SerAsp: 3.405 ± 0.363
3.551SerGlu: 3.551 ± 0.316
2.474SerPhe: 2.474 ± 0.283
6.393SerGly: 6.393 ± 0.735
1.886SerHis: 1.886 ± 0.231
2.082SerIle: 2.082 ± 0.232
1.788SerLys: 1.788 ± 0.268
8.009SerLeu: 8.009 ± 0.548
1.249SerMet: 1.249 ± 0.183
1.959SerAsn: 1.959 ± 0.292
6.074SerPro: 6.074 ± 0.565
2.841SerGln: 2.841 ± 0.384
5.584SerArg: 5.584 ± 0.688
6.417SerSer: 6.417 ± 0.802
4.629SerThr: 4.629 ± 0.507
4.874SerVal: 4.874 ± 0.361
0.735SerTrp: 0.735 ± 0.137
1.788SerTyr: 1.788 ± 0.218
0.0SerXaa: 0.0 ± 0.0
Thr
4.874ThrAla: 4.874 ± 0.499
0.98ThrCys: 0.98 ± 0.15
2.449ThrAsp: 2.449 ± 0.294
2.376ThrGlu: 2.376 ± 0.266
2.4ThrPhe: 2.4 ± 0.286
4.948ThrGly: 4.948 ± 0.793
1.298ThrHis: 1.298 ± 0.164
1.666ThrIle: 1.666 ± 0.226
1.617ThrLys: 1.617 ± 0.227
6.491ThrLeu: 6.491 ± 0.449
1.078ThrMet: 1.078 ± 0.202
1.666ThrAsn: 1.666 ± 0.299
5.609ThrPro: 5.609 ± 0.799
2.425ThrGln: 2.425 ± 0.32
4.58ThrArg: 4.58 ± 1.323
4.899ThrSer: 4.899 ± 0.602
3.845ThrThr: 3.845 ± 0.601
3.968ThrVal: 3.968 ± 0.391
0.882ThrTrp: 0.882 ± 0.167
2.253ThrTyr: 2.253 ± 0.253
0.0ThrXaa: 0.0 ± 0.0
Val
5.462ValAla: 5.462 ± 0.417
1.666ValCys: 1.666 ± 0.223
2.743ValAsp: 2.743 ± 0.305
3.625ValGlu: 3.625 ± 0.301
3.429ValPhe: 3.429 ± 0.343
3.772ValGly: 3.772 ± 0.379
1.372ValHis: 1.372 ± 0.233
2.204ValIle: 2.204 ± 0.251
2.18ValLys: 2.18 ± 0.273
6.197ValLeu: 6.197 ± 0.471
1.543ValMet: 1.543 ± 0.157
1.812ValAsn: 1.812 ± 0.305
4.605ValPro: 4.605 ± 0.405
2.645ValGln: 2.645 ± 0.406
4.041ValArg: 4.041 ± 0.391
5.682ValSer: 5.682 ± 0.38
4.36ValThr: 4.36 ± 0.426
4.433ValVal: 4.433 ± 0.447
0.857ValTrp: 0.857 ± 0.154
2.204ValTyr: 2.204 ± 0.302
0.0ValXaa: 0.0 ± 0.0
Trp
1.176TrpAla: 1.176 ± 0.181
0.122TrpCys: 0.122 ± 0.05
0.49TrpAsp: 0.49 ± 0.124
0.612TrpGlu: 0.612 ± 0.135
0.441TrpPhe: 0.441 ± 0.124
0.906TrpGly: 0.906 ± 0.174
0.367TrpHis: 0.367 ± 0.096
0.514TrpIle: 0.514 ± 0.108
0.343TrpLys: 0.343 ± 0.099
1.592TrpLeu: 1.592 ± 0.245
0.245TrpMet: 0.245 ± 0.07
0.392TrpAsn: 0.392 ± 0.099
0.98TrpPro: 0.98 ± 0.217
0.392TrpGln: 0.392 ± 0.096
0.882TrpArg: 0.882 ± 0.149
0.539TrpSer: 0.539 ± 0.13
0.882TrpThr: 0.882 ± 0.133
0.661TrpVal: 0.661 ± 0.139
0.122TrpTrp: 0.122 ± 0.059
0.367TrpTyr: 0.367 ± 0.093
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.474TyrAla: 2.474 ± 0.285
0.514TyrCys: 0.514 ± 0.108
1.176TyrAsp: 1.176 ± 0.199
1.396TyrGlu: 1.396 ± 0.199
1.494TyrPhe: 1.494 ± 0.233
1.886TyrGly: 1.886 ± 0.258
0.71TyrHis: 0.71 ± 0.138
1.347TyrIle: 1.347 ± 0.178
0.98TyrLys: 0.98 ± 0.18
2.939TyrLeu: 2.939 ± 0.303
0.416TyrMet: 0.416 ± 0.126
1.053TyrAsn: 1.053 ± 0.163
1.641TyrPro: 1.641 ± 0.236
0.808TyrGln: 0.808 ± 0.167
1.617TyrArg: 1.617 ± 0.211
1.812TyrSer: 1.812 ± 0.262
1.715TyrThr: 1.715 ± 0.195
2.376TyrVal: 2.376 ± 0.3
0.392TyrTrp: 0.392 ± 0.101
0.955TyrTyr: 0.955 ± 0.155
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (40829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski