Amino acid dipepetide frequency for Streptococcus phage Javan235

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.877AlaAla: 3.877 ± 1.583
0.293AlaCys: 0.293 ± 0.181
5.194AlaAsp: 5.194 ± 0.638
5.486AlaGlu: 5.486 ± 0.649
2.707AlaPhe: 2.707 ± 0.626
5.999AlaGly: 5.999 ± 1.471
0.878AlaHis: 0.878 ± 0.339
4.755AlaIle: 4.755 ± 0.817
6.95AlaLys: 6.95 ± 0.721
7.023AlaLeu: 7.023 ± 1.096
2.121AlaMet: 2.121 ± 0.428
7.023AlaAsn: 7.023 ± 1.161
2.341AlaPro: 2.341 ± 0.66
4.243AlaGln: 4.243 ± 0.82
1.902AlaArg: 1.902 ± 0.323
5.852AlaSer: 5.852 ± 1.426
5.706AlaThr: 5.706 ± 0.87
5.56AlaVal: 5.56 ± 0.841
1.024AlaTrp: 1.024 ± 0.342
1.756AlaTyr: 1.756 ± 0.432
0.0AlaXaa: 0.0 ± 0.0
Cys
0.512CysAla: 0.512 ± 0.214
0.146CysCys: 0.146 ± 0.119
0.293CysAsp: 0.293 ± 0.141
0.512CysGlu: 0.512 ± 0.206
0.293CysPhe: 0.293 ± 0.121
0.658CysGly: 0.658 ± 0.243
0.146CysHis: 0.146 ± 0.102
0.439CysIle: 0.439 ± 0.157
0.585CysLys: 0.585 ± 0.31
0.146CysLeu: 0.146 ± 0.101
0.293CysMet: 0.293 ± 0.133
0.366CysAsn: 0.366 ± 0.151
0.366CysPro: 0.366 ± 0.249
0.219CysGln: 0.219 ± 0.123
0.219CysArg: 0.219 ± 0.114
0.146CysSer: 0.146 ± 0.102
0.146CysThr: 0.146 ± 0.099
0.439CysVal: 0.439 ± 0.206
0.0CysTrp: 0.0 ± 0.0
0.146CysTyr: 0.146 ± 0.1
0.0CysXaa: 0.0 ± 0.0
Asp
3.365AspAla: 3.365 ± 0.455
0.732AspCys: 0.732 ± 0.265
5.121AspAsp: 5.121 ± 0.854
5.267AspGlu: 5.267 ± 0.859
2.78AspPhe: 2.78 ± 0.42
3.658AspGly: 3.658 ± 0.497
0.732AspHis: 0.732 ± 0.214
4.097AspIle: 4.097 ± 0.565
5.048AspLys: 5.048 ± 0.563
5.34AspLeu: 5.34 ± 0.633
1.463AspMet: 1.463 ± 0.389
3.584AspAsn: 3.584 ± 0.443
1.17AspPro: 1.17 ± 0.302
1.756AspGln: 1.756 ± 0.376
2.487AspArg: 2.487 ± 0.479
3.658AspSer: 3.658 ± 0.472
4.755AspThr: 4.755 ± 0.618
2.853AspVal: 2.853 ± 0.483
0.805AspTrp: 0.805 ± 0.227
3.95AspTyr: 3.95 ± 0.665
0.0AspXaa: 0.0 ± 0.0
Glu
4.682GluAla: 4.682 ± 0.612
0.366GluCys: 0.366 ± 0.173
3.731GluAsp: 3.731 ± 0.54
5.194GluGlu: 5.194 ± 0.891
2.341GluPhe: 2.341 ± 0.407
3.584GluGly: 3.584 ± 0.58
0.805GluHis: 0.805 ± 0.265
5.194GluIle: 5.194 ± 0.77
5.267GluLys: 5.267 ± 0.914
8.778GluLeu: 8.778 ± 1.091
1.902GluMet: 1.902 ± 0.533
4.243GluAsn: 4.243 ± 0.711
2.121GluPro: 2.121 ± 0.448
3.804GluGln: 3.804 ± 0.695
3.511GluArg: 3.511 ± 0.57
2.926GluSer: 2.926 ± 0.398
4.17GluThr: 4.17 ± 0.557
3.584GluVal: 3.584 ± 0.631
0.585GluTrp: 0.585 ± 0.19
2.414GluTyr: 2.414 ± 0.506
0.0GluXaa: 0.0 ± 0.0
Phe
3.072PheAla: 3.072 ± 0.394
0.073PheCys: 0.073 ± 0.06
2.926PheAsp: 2.926 ± 0.588
3.365PheGlu: 3.365 ± 0.565
1.244PhePhe: 1.244 ± 0.287
3.146PheGly: 3.146 ± 0.348
0.658PheHis: 0.658 ± 0.257
2.048PheIle: 2.048 ± 0.427
3.658PheLys: 3.658 ± 0.511
2.926PheLeu: 2.926 ± 0.662
1.17PheMet: 1.17 ± 0.4
2.853PheAsn: 2.853 ± 0.436
1.097PhePro: 1.097 ± 0.264
1.024PheGln: 1.024 ± 0.305
1.097PheArg: 1.097 ± 0.328
2.414PheSer: 2.414 ± 0.528
1.975PheThr: 1.975 ± 0.303
1.829PheVal: 1.829 ± 0.453
0.439PheTrp: 0.439 ± 0.254
1.39PheTyr: 1.39 ± 0.354
0.0PheXaa: 0.0 ± 0.0
Gly
4.462GlyAla: 4.462 ± 0.881
0.585GlyCys: 0.585 ± 0.197
3.438GlyAsp: 3.438 ± 0.605
2.853GlyGlu: 2.853 ± 0.37
2.707GlyPhe: 2.707 ± 0.485
3.804GlyGly: 3.804 ± 0.783
1.024GlyHis: 1.024 ± 0.309
3.877GlyIle: 3.877 ± 0.625
5.706GlyLys: 5.706 ± 0.631
4.755GlyLeu: 4.755 ± 1.207
1.829GlyMet: 1.829 ± 0.545
2.853GlyAsn: 2.853 ± 0.514
0.732GlyPro: 0.732 ± 0.232
2.487GlyGln: 2.487 ± 0.509
2.487GlyArg: 2.487 ± 0.456
4.023GlySer: 4.023 ± 0.723
5.048GlyThr: 5.048 ± 0.623
4.316GlyVal: 4.316 ± 0.792
0.878GlyTrp: 0.878 ± 0.267
2.78GlyTyr: 2.78 ± 0.388
0.0GlyXaa: 0.0 ± 0.0
His
0.951HisAla: 0.951 ± 0.27
0.0HisCys: 0.0 ± 0.0
0.805HisAsp: 0.805 ± 0.275
1.683HisGlu: 1.683 ± 0.353
1.097HisPhe: 1.097 ± 0.295
0.805HisGly: 0.805 ± 0.216
0.585HisHis: 0.585 ± 0.244
0.585HisIle: 0.585 ± 0.23
0.878HisLys: 0.878 ± 0.251
0.951HisLeu: 0.951 ± 0.297
0.219HisMet: 0.219 ± 0.168
1.39HisAsn: 1.39 ± 0.38
0.219HisPro: 0.219 ± 0.132
0.585HisGln: 0.585 ± 0.216
0.219HisArg: 0.219 ± 0.118
0.805HisSer: 0.805 ± 0.369
1.244HisThr: 1.244 ± 0.313
0.585HisVal: 0.585 ± 0.249
0.0HisTrp: 0.0 ± 0.0
0.658HisTyr: 0.658 ± 0.271
0.0HisXaa: 0.0 ± 0.0
Ile
6.218IleAla: 6.218 ± 0.858
0.439IleCys: 0.439 ± 0.201
4.755IleAsp: 4.755 ± 0.947
4.682IleGlu: 4.682 ± 0.819
2.195IlePhe: 2.195 ± 0.529
4.316IleGly: 4.316 ± 0.469
1.17IleHis: 1.17 ± 0.286
4.097IleIle: 4.097 ± 0.655
4.974IleLys: 4.974 ± 0.583
4.243IleLeu: 4.243 ± 0.614
1.097IleMet: 1.097 ± 0.231
3.804IleAsn: 3.804 ± 0.71
2.341IlePro: 2.341 ± 0.466
3.146IleGln: 3.146 ± 0.554
1.975IleArg: 1.975 ± 0.433
3.365IleSer: 3.365 ± 0.539
5.048IleThr: 5.048 ± 0.759
3.877IleVal: 3.877 ± 0.443
0.366IleTrp: 0.366 ± 0.171
2.78IleTyr: 2.78 ± 0.506
0.0IleXaa: 0.0 ± 0.0
Lys
6.803LysAla: 6.803 ± 0.666
0.512LysCys: 0.512 ± 0.277
3.658LysAsp: 3.658 ± 0.424
5.56LysGlu: 5.56 ± 0.82
2.634LysPhe: 2.634 ± 0.435
4.316LysGly: 4.316 ± 0.669
1.39LysHis: 1.39 ± 0.355
6.072LysIle: 6.072 ± 0.808
5.999LysLys: 5.999 ± 1.028
6.657LysLeu: 6.657 ± 0.798
1.829LysMet: 1.829 ± 0.306
3.804LysAsn: 3.804 ± 0.558
2.341LysPro: 2.341 ± 0.398
3.804LysGln: 3.804 ± 0.57
3.877LysArg: 3.877 ± 0.798
4.755LysSer: 4.755 ± 0.637
5.486LysThr: 5.486 ± 0.789
5.34LysVal: 5.34 ± 0.446
0.951LysTrp: 0.951 ± 0.285
3.365LysTyr: 3.365 ± 0.545
0.0LysXaa: 0.0 ± 0.0
Leu
5.486LeuAla: 5.486 ± 0.671
0.146LeuCys: 0.146 ± 0.155
6.511LeuAsp: 6.511 ± 0.93
6.072LeuGlu: 6.072 ± 1.025
2.634LeuPhe: 2.634 ± 0.438
4.682LeuGly: 4.682 ± 0.812
1.17LeuHis: 1.17 ± 0.346
5.194LeuIle: 5.194 ± 0.73
7.754LeuLys: 7.754 ± 0.95
6.95LeuLeu: 6.95 ± 1.031
1.39LeuMet: 1.39 ± 0.469
4.828LeuAsn: 4.828 ± 0.653
3.146LeuPro: 3.146 ± 0.48
3.365LeuGln: 3.365 ± 0.45
3.365LeuArg: 3.365 ± 0.435
7.096LeuSer: 7.096 ± 0.792
5.194LeuThr: 5.194 ± 0.661
5.486LeuVal: 5.486 ± 0.592
0.805LeuTrp: 0.805 ± 0.245
2.195LeuTyr: 2.195 ± 0.388
0.0LeuXaa: 0.0 ± 0.0
Met
2.048MetAla: 2.048 ± 0.429
0.146MetCys: 0.146 ± 0.104
1.317MetAsp: 1.317 ± 0.353
0.878MetGlu: 0.878 ± 0.259
0.805MetPhe: 0.805 ± 0.208
1.024MetGly: 1.024 ± 0.252
0.439MetHis: 0.439 ± 0.165
1.902MetIle: 1.902 ± 0.397
2.121MetLys: 2.121 ± 0.375
1.097MetLeu: 1.097 ± 0.287
0.293MetMet: 0.293 ± 0.178
1.536MetAsn: 1.536 ± 0.527
0.732MetPro: 0.732 ± 0.258
1.244MetGln: 1.244 ± 0.311
1.097MetArg: 1.097 ± 0.296
2.048MetSer: 2.048 ± 0.492
2.268MetThr: 2.268 ± 0.491
1.463MetVal: 1.463 ± 0.359
0.219MetTrp: 0.219 ± 0.131
0.732MetTyr: 0.732 ± 0.228
0.0MetXaa: 0.0 ± 0.0
Asn
5.852AsnAla: 5.852 ± 1.357
0.439AsnCys: 0.439 ± 0.181
3.584AsnAsp: 3.584 ± 0.607
3.95AsnGlu: 3.95 ± 0.746
2.268AsnPhe: 2.268 ± 0.402
5.706AsnGly: 5.706 ± 0.704
0.658AsnHis: 0.658 ± 0.24
3.365AsnIle: 3.365 ± 0.352
4.243AsnLys: 4.243 ± 0.584
5.925AsnLeu: 5.925 ± 0.628
1.463AsnMet: 1.463 ± 0.224
4.316AsnAsn: 4.316 ± 0.533
1.317AsnPro: 1.317 ± 0.334
2.56AsnGln: 2.56 ± 0.47
1.975AsnArg: 1.975 ± 0.444
4.389AsnSer: 4.389 ± 0.916
2.707AsnThr: 2.707 ± 0.77
3.072AsnVal: 3.072 ± 0.484
0.658AsnTrp: 0.658 ± 0.272
2.487AsnTyr: 2.487 ± 0.422
0.0AsnXaa: 0.0 ± 0.0
Pro
2.634ProAla: 2.634 ± 0.734
0.073ProCys: 0.073 ± 0.067
1.756ProAsp: 1.756 ± 0.321
2.926ProGlu: 2.926 ± 0.808
1.317ProPhe: 1.317 ± 0.347
1.024ProGly: 1.024 ± 0.38
0.219ProHis: 0.219 ± 0.13
1.463ProIle: 1.463 ± 0.33
1.536ProLys: 1.536 ± 0.376
2.487ProLeu: 2.487 ± 0.493
0.585ProMet: 0.585 ± 0.246
1.317ProAsn: 1.317 ± 0.252
0.439ProPro: 0.439 ± 0.196
1.902ProGln: 1.902 ± 0.69
0.658ProArg: 0.658 ± 0.241
1.317ProSer: 1.317 ± 0.313
1.829ProThr: 1.829 ± 0.37
1.39ProVal: 1.39 ± 0.275
0.146ProTrp: 0.146 ± 0.092
1.39ProTyr: 1.39 ± 0.365
0.0ProXaa: 0.0 ± 0.0
Gln
4.828GlnAla: 4.828 ± 0.508
0.219GlnCys: 0.219 ± 0.13
1.39GlnAsp: 1.39 ± 0.295
3.438GlnGlu: 3.438 ± 0.755
2.268GlnPhe: 2.268 ± 0.407
1.902GlnGly: 1.902 ± 0.403
0.805GlnHis: 0.805 ± 0.23
3.365GlnIle: 3.365 ± 0.573
2.634GlnLys: 2.634 ± 0.547
3.95GlnLeu: 3.95 ± 0.677
1.17GlnMet: 1.17 ± 0.32
2.999GlnAsn: 2.999 ± 0.618
1.902GlnPro: 1.902 ± 0.694
3.438GlnGln: 3.438 ± 0.851
1.829GlnArg: 1.829 ± 0.386
2.999GlnSer: 2.999 ± 0.503
3.365GlnThr: 3.365 ± 0.56
1.975GlnVal: 1.975 ± 0.39
0.219GlnTrp: 0.219 ± 0.106
1.756GlnTyr: 1.756 ± 0.38
0.0GlnXaa: 0.0 ± 0.0
Arg
2.853ArgAla: 2.853 ± 0.371
0.366ArgCys: 0.366 ± 0.156
1.536ArgAsp: 1.536 ± 0.401
2.268ArgGlu: 2.268 ± 0.423
1.024ArgPhe: 1.024 ± 0.321
1.609ArgGly: 1.609 ± 0.332
0.951ArgHis: 0.951 ± 0.354
2.56ArgIle: 2.56 ± 0.415
3.438ArgLys: 3.438 ± 0.728
3.438ArgLeu: 3.438 ± 0.615
1.17ArgMet: 1.17 ± 0.29
2.268ArgAsn: 2.268 ± 0.547
0.878ArgPro: 0.878 ± 0.337
1.17ArgGln: 1.17 ± 0.319
1.609ArgArg: 1.609 ± 0.413
1.902ArgSer: 1.902 ± 0.427
1.829ArgThr: 1.829 ± 0.337
2.78ArgVal: 2.78 ± 0.44
0.585ArgTrp: 0.585 ± 0.199
1.683ArgTyr: 1.683 ± 0.431
0.0ArgXaa: 0.0 ± 0.0
Ser
6.364SerAla: 6.364 ± 1.949
0.219SerCys: 0.219 ± 0.139
3.584SerAsp: 3.584 ± 0.622
4.17SerGlu: 4.17 ± 0.484
2.341SerPhe: 2.341 ± 0.347
3.804SerGly: 3.804 ± 0.872
0.658SerHis: 0.658 ± 0.198
4.389SerIle: 4.389 ± 0.682
5.925SerLys: 5.925 ± 0.667
5.925SerLeu: 5.925 ± 0.873
1.244SerMet: 1.244 ± 0.312
4.316SerAsn: 4.316 ± 0.693
0.732SerPro: 0.732 ± 0.246
3.072SerGln: 3.072 ± 0.43
1.829SerArg: 1.829 ± 0.389
5.048SerSer: 5.048 ± 1.553
5.194SerThr: 5.194 ± 0.664
4.682SerVal: 4.682 ± 0.54
0.585SerTrp: 0.585 ± 0.203
2.487SerTyr: 2.487 ± 0.551
0.0SerXaa: 0.0 ± 0.0
Thr
8.193ThrAla: 8.193 ± 1.303
0.293ThrCys: 0.293 ± 0.128
4.17ThrAsp: 4.17 ± 0.471
4.097ThrGlu: 4.097 ± 0.691
2.56ThrPhe: 2.56 ± 0.444
4.901ThrGly: 4.901 ± 0.711
0.732ThrHis: 0.732 ± 0.207
4.755ThrIle: 4.755 ± 0.536
4.755ThrLys: 4.755 ± 0.644
5.413ThrLeu: 5.413 ± 0.646
1.39ThrMet: 1.39 ± 0.446
3.584ThrAsn: 3.584 ± 0.675
1.829ThrPro: 1.829 ± 0.453
2.999ThrGln: 2.999 ± 0.566
1.609ThrArg: 1.609 ± 0.276
5.194ThrSer: 5.194 ± 1.279
5.267ThrThr: 5.267 ± 0.875
5.267ThrVal: 5.267 ± 0.738
0.585ThrTrp: 0.585 ± 0.173
2.926ThrTyr: 2.926 ± 0.669
0.0ThrXaa: 0.0 ± 0.0
Val
4.609ValAla: 4.609 ± 0.547
0.293ValCys: 0.293 ± 0.144
5.048ValAsp: 5.048 ± 0.558
3.877ValGlu: 3.877 ± 0.65
2.707ValPhe: 2.707 ± 0.523
3.438ValGly: 3.438 ± 0.925
0.732ValHis: 0.732 ± 0.263
3.584ValIle: 3.584 ± 0.617
4.097ValLys: 4.097 ± 0.534
4.243ValLeu: 4.243 ± 0.789
1.609ValMet: 1.609 ± 0.285
3.219ValAsn: 3.219 ± 0.415
1.609ValPro: 1.609 ± 0.375
3.219ValGln: 3.219 ± 0.688
2.268ValArg: 2.268 ± 0.383
4.974ValSer: 4.974 ± 0.75
5.779ValThr: 5.779 ± 0.645
3.731ValVal: 3.731 ± 0.616
0.219ValTrp: 0.219 ± 0.094
1.975ValTyr: 1.975 ± 0.399
0.0ValXaa: 0.0 ± 0.0
Trp
0.585TrpAla: 0.585 ± 0.245
0.146TrpCys: 0.146 ± 0.085
1.024TrpAsp: 1.024 ± 0.199
0.805TrpGlu: 0.805 ± 0.223
0.439TrpPhe: 0.439 ± 0.113
0.293TrpGly: 0.293 ± 0.121
0.146TrpHis: 0.146 ± 0.105
0.512TrpIle: 0.512 ± 0.198
0.732TrpLys: 0.732 ± 0.25
0.951TrpLeu: 0.951 ± 0.313
0.219TrpMet: 0.219 ± 0.183
0.293TrpAsn: 0.293 ± 0.15
0.073TrpPro: 0.073 ± 0.07
0.658TrpGln: 0.658 ± 0.308
0.366TrpArg: 0.366 ± 0.152
0.439TrpSer: 0.439 ± 0.162
0.805TrpThr: 0.805 ± 0.222
0.878TrpVal: 0.878 ± 0.236
0.0TrpTrp: 0.0 ± 0.0
0.512TrpTyr: 0.512 ± 0.163
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.292TyrAla: 3.292 ± 0.393
0.585TyrCys: 0.585 ± 0.313
2.78TyrAsp: 2.78 ± 0.534
2.121TyrGlu: 2.121 ± 0.523
2.048TyrPhe: 2.048 ± 0.345
1.975TyrGly: 1.975 ± 0.533
0.366TyrHis: 0.366 ± 0.168
2.707TyrIle: 2.707 ± 0.537
2.853TyrLys: 2.853 ± 0.506
2.268TyrLeu: 2.268 ± 0.396
0.878TyrMet: 0.878 ± 0.284
2.341TyrAsn: 2.341 ± 0.533
1.024TyrPro: 1.024 ± 0.315
1.756TyrGln: 1.756 ± 0.495
1.536TyrArg: 1.536 ± 0.41
3.219TyrSer: 3.219 ± 0.496
2.707TyrThr: 2.707 ± 0.566
2.121TyrVal: 2.121 ± 0.417
0.805TyrTrp: 0.805 ± 0.216
1.902TyrTyr: 1.902 ± 0.307
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (13671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski