Amino acid dipepetide frequency for Listeria phage LP-HM00113468

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.427AlaAla: 4.427 ± 1.684
0.354AlaCys: 0.354 ± 0.182
5.224AlaAsp: 5.224 ± 1.312
5.135AlaGlu: 5.135 ± 0.763
3.01AlaPhe: 3.01 ± 0.474
5.046AlaGly: 5.046 ± 1.682
1.151AlaHis: 1.151 ± 0.285
4.781AlaIle: 4.781 ± 0.81
6.463AlaLys: 6.463 ± 1.131
4.958AlaLeu: 4.958 ± 0.906
2.036AlaMet: 2.036 ± 0.39
5.046AlaAsn: 5.046 ± 1.499
1.771AlaPro: 1.771 ± 0.307
2.568AlaGln: 2.568 ± 0.492
1.948AlaArg: 1.948 ± 0.476
4.427AlaSer: 4.427 ± 0.86
3.541AlaThr: 3.541 ± 0.575
4.161AlaVal: 4.161 ± 0.772
1.239AlaTrp: 1.239 ± 0.257
1.771AlaTyr: 1.771 ± 0.31
0.0AlaXaa: 0.0 ± 0.0
Cys
0.797CysAla: 0.797 ± 0.826
0.266CysCys: 0.266 ± 0.179
0.62CysAsp: 0.62 ± 0.211
0.797CysGlu: 0.797 ± 0.251
0.354CysPhe: 0.354 ± 0.169
0.797CysGly: 0.797 ± 0.297
0.089CysHis: 0.089 ± 0.09
0.531CysIle: 0.531 ± 0.23
0.62CysLys: 0.62 ± 0.23
0.266CysLeu: 0.266 ± 0.151
0.177CysMet: 0.177 ± 0.14
0.62CysAsn: 0.62 ± 0.28
0.266CysPro: 0.266 ± 0.153
0.177CysGln: 0.177 ± 0.135
0.177CysArg: 0.177 ± 0.165
0.354CysSer: 0.354 ± 0.153
0.089CysThr: 0.089 ± 0.083
0.62CysVal: 0.62 ± 0.248
0.089CysTrp: 0.089 ± 0.078
0.089CysTyr: 0.089 ± 0.1
0.0CysXaa: 0.0 ± 0.0
Asp
3.63AspAla: 3.63 ± 0.439
0.885AspCys: 0.885 ± 0.313
4.338AspAsp: 4.338 ± 0.611
6.02AspGlu: 6.02 ± 1.012
2.922AspPhe: 2.922 ± 0.51
4.515AspGly: 4.515 ± 0.722
0.62AspHis: 0.62 ± 0.294
5.312AspIle: 5.312 ± 0.741
4.781AspLys: 4.781 ± 0.689
6.109AspLeu: 6.109 ± 1.311
2.125AspMet: 2.125 ± 0.454
3.453AspAsn: 3.453 ± 0.503
1.505AspPro: 1.505 ± 0.428
0.885AspGln: 0.885 ± 0.284
1.948AspArg: 1.948 ± 0.484
2.479AspSer: 2.479 ± 0.472
3.01AspThr: 3.01 ± 0.482
4.515AspVal: 4.515 ± 0.516
1.151AspTrp: 1.151 ± 0.324
3.364AspTyr: 3.364 ± 0.593
0.0AspXaa: 0.0 ± 0.0
Glu
5.224GluAla: 5.224 ± 0.607
0.62GluCys: 0.62 ± 0.284
3.896GluAsp: 3.896 ± 0.673
4.427GluGlu: 4.427 ± 0.79
3.01GluPhe: 3.01 ± 0.595
3.718GluGly: 3.718 ± 0.686
2.036GluHis: 2.036 ± 0.46
5.312GluIle: 5.312 ± 0.82
6.817GluLys: 6.817 ± 0.881
7.437GluLeu: 7.437 ± 0.667
2.036GluMet: 2.036 ± 0.43
4.427GluAsn: 4.427 ± 0.509
1.594GluPro: 1.594 ± 0.382
2.656GluGln: 2.656 ± 0.476
3.099GluArg: 3.099 ± 0.645
3.453GluSer: 3.453 ± 0.574
3.276GluThr: 3.276 ± 0.385
4.604GluVal: 4.604 ± 0.603
0.885GluTrp: 0.885 ± 0.265
4.161GluTyr: 4.161 ± 0.642
0.0GluXaa: 0.0 ± 0.0
Phe
3.541PheAla: 3.541 ± 0.439
0.177PheCys: 0.177 ± 0.122
3.364PheAsp: 3.364 ± 0.518
2.833PheGlu: 2.833 ± 0.396
2.39PhePhe: 2.39 ± 0.622
3.099PheGly: 3.099 ± 0.384
0.708PheHis: 0.708 ± 0.253
3.364PheIle: 3.364 ± 0.677
3.364PheLys: 3.364 ± 0.425
3.541PheLeu: 3.541 ± 0.654
1.239PheMet: 1.239 ± 0.342
2.656PheAsn: 2.656 ± 0.493
1.151PhePro: 1.151 ± 0.345
1.505PheGln: 1.505 ± 0.446
1.948PheArg: 1.948 ± 0.508
2.833PheSer: 2.833 ± 0.468
2.39PheThr: 2.39 ± 0.531
2.479PheVal: 2.479 ± 0.464
0.443PheTrp: 0.443 ± 0.186
1.948PheTyr: 1.948 ± 0.451
0.0PheXaa: 0.0 ± 0.0
Gly
4.338GlyAla: 4.338 ± 1.161
0.354GlyCys: 0.354 ± 0.172
3.099GlyAsp: 3.099 ± 0.504
4.604GlyGlu: 4.604 ± 0.567
3.807GlyPhe: 3.807 ± 0.561
4.338GlyGly: 4.338 ± 0.866
0.974GlyHis: 0.974 ± 0.292
3.63GlyIle: 3.63 ± 0.618
5.932GlyLys: 5.932 ± 0.924
5.224GlyLeu: 5.224 ± 0.903
1.505GlyMet: 1.505 ± 0.346
3.187GlyAsn: 3.187 ± 0.501
0.797GlyPro: 0.797 ± 0.275
2.39GlyGln: 2.39 ± 0.482
2.302GlyArg: 2.302 ± 0.477
3.896GlySer: 3.896 ± 0.634
3.718GlyThr: 3.718 ± 0.733
3.276GlyVal: 3.276 ± 0.584
0.62GlyTrp: 0.62 ± 0.227
2.479GlyTyr: 2.479 ± 0.448
0.0GlyXaa: 0.0 ± 0.0
His
0.885HisAla: 0.885 ± 0.222
0.177HisCys: 0.177 ± 0.114
1.328HisAsp: 1.328 ± 0.417
0.62HisGlu: 0.62 ± 0.243
0.531HisPhe: 0.531 ± 0.291
0.62HisGly: 0.62 ± 0.211
0.531HisHis: 0.531 ± 0.234
1.328HisIle: 1.328 ± 0.376
0.974HisLys: 0.974 ± 0.27
1.771HisLeu: 1.771 ± 0.587
0.089HisMet: 0.089 ± 0.089
1.239HisAsn: 1.239 ± 0.39
0.708HisPro: 0.708 ± 0.237
0.443HisGln: 0.443 ± 0.211
0.62HisArg: 0.62 ± 0.212
0.708HisSer: 0.708 ± 0.268
0.797HisThr: 0.797 ± 0.352
1.505HisVal: 1.505 ± 0.353
0.089HisTrp: 0.089 ± 0.103
0.708HisTyr: 0.708 ± 0.309
0.0HisXaa: 0.0 ± 0.0
Ile
4.869IleAla: 4.869 ± 0.744
0.708IleCys: 0.708 ± 0.267
5.666IleAsp: 5.666 ± 0.992
5.932IleGlu: 5.932 ± 0.997
2.833IlePhe: 2.833 ± 0.522
3.453IleGly: 3.453 ± 0.615
0.797IleHis: 0.797 ± 0.248
5.312IleIle: 5.312 ± 0.786
4.958IleLys: 4.958 ± 0.677
3.718IleLeu: 3.718 ± 0.603
1.239IleMet: 1.239 ± 0.346
6.197IleAsn: 6.197 ± 0.64
1.948IlePro: 1.948 ± 0.425
3.187IleGln: 3.187 ± 0.638
2.568IleArg: 2.568 ± 0.487
4.073IleSer: 4.073 ± 0.918
5.755IleThr: 5.755 ± 0.776
3.276IleVal: 3.276 ± 0.55
1.062IleTrp: 1.062 ± 0.338
2.922IleTyr: 2.922 ± 0.543
0.0IleXaa: 0.0 ± 0.0
Lys
6.729LysAla: 6.729 ± 1.24
0.266LysCys: 0.266 ± 0.161
5.489LysAsp: 5.489 ± 0.551
7.968LysGlu: 7.968 ± 1.246
2.302LysPhe: 2.302 ± 0.367
4.958LysGly: 4.958 ± 0.856
1.239LysHis: 1.239 ± 0.407
5.755LysIle: 5.755 ± 0.85
8.588LysLys: 8.588 ± 1.235
6.552LysLeu: 6.552 ± 0.843
3.541LysMet: 3.541 ± 0.584
5.932LysAsn: 5.932 ± 0.801
2.302LysPro: 2.302 ± 0.432
3.453LysGln: 3.453 ± 0.401
4.338LysArg: 4.338 ± 0.638
4.161LysSer: 4.161 ± 0.565
5.312LysThr: 5.312 ± 0.627
6.286LysVal: 6.286 ± 0.665
1.151LysTrp: 1.151 ± 0.25
3.984LysTyr: 3.984 ± 0.619
0.0LysXaa: 0.0 ± 0.0
Leu
5.489LeuAla: 5.489 ± 0.934
0.443LeuCys: 0.443 ± 0.224
5.755LeuAsp: 5.755 ± 0.745
5.932LeuGlu: 5.932 ± 1.02
3.364LeuPhe: 3.364 ± 0.576
4.515LeuGly: 4.515 ± 0.638
0.885LeuHis: 0.885 ± 0.277
5.401LeuIle: 5.401 ± 0.774
7.348LeuLys: 7.348 ± 0.965
6.463LeuLeu: 6.463 ± 0.951
1.859LeuMet: 1.859 ± 0.335
5.224LeuAsn: 5.224 ± 0.672
2.302LeuPro: 2.302 ± 0.464
2.833LeuGln: 2.833 ± 0.502
3.453LeuArg: 3.453 ± 1.058
8.765LeuSer: 8.765 ± 1.853
3.896LeuThr: 3.896 ± 0.45
3.807LeuVal: 3.807 ± 0.747
0.885LeuTrp: 0.885 ± 0.268
3.01LeuTyr: 3.01 ± 0.691
0.0LeuXaa: 0.0 ± 0.0
Met
2.036MetAla: 2.036 ± 0.47
0.266MetCys: 0.266 ± 0.214
1.505MetAsp: 1.505 ± 0.271
1.239MetGlu: 1.239 ± 0.337
1.417MetPhe: 1.417 ± 0.328
0.974MetGly: 0.974 ± 0.273
0.354MetHis: 0.354 ± 0.16
1.505MetIle: 1.505 ± 0.325
3.541MetLys: 3.541 ± 0.66
2.036MetLeu: 2.036 ± 0.369
0.443MetMet: 0.443 ± 0.267
1.505MetAsn: 1.505 ± 0.392
0.885MetPro: 0.885 ± 0.279
0.885MetGln: 0.885 ± 0.304
1.328MetArg: 1.328 ± 0.348
1.771MetSer: 1.771 ± 0.423
1.151MetThr: 1.151 ± 0.312
0.885MetVal: 0.885 ± 0.248
0.531MetTrp: 0.531 ± 0.197
0.797MetTyr: 0.797 ± 0.254
0.0MetXaa: 0.0 ± 0.0
Asn
3.984AsnAla: 3.984 ± 0.753
0.266AsnCys: 0.266 ± 0.165
4.515AsnAsp: 4.515 ± 0.568
4.338AsnGlu: 4.338 ± 0.714
2.39AsnPhe: 2.39 ± 0.537
4.781AsnGly: 4.781 ± 0.66
1.062AsnHis: 1.062 ± 0.244
4.073AsnIle: 4.073 ± 0.586
5.666AsnLys: 5.666 ± 0.819
5.932AsnLeu: 5.932 ± 1.398
1.328AsnMet: 1.328 ± 0.361
3.807AsnAsn: 3.807 ± 0.615
2.656AsnPro: 2.656 ± 0.604
2.656AsnGln: 2.656 ± 0.456
1.771AsnArg: 1.771 ± 0.381
4.781AsnSer: 4.781 ± 0.596
4.25AsnThr: 4.25 ± 0.694
3.099AsnVal: 3.099 ± 0.541
1.062AsnTrp: 1.062 ± 0.34
2.745AsnTyr: 2.745 ± 0.544
0.0AsnXaa: 0.0 ± 0.0
Pro
1.859ProAla: 1.859 ± 0.396
0.0ProCys: 0.0 ± 0.0
1.771ProAsp: 1.771 ± 0.373
2.833ProGlu: 2.833 ± 0.477
1.239ProPhe: 1.239 ± 0.386
1.239ProGly: 1.239 ± 0.382
0.443ProHis: 0.443 ± 0.219
0.885ProIle: 0.885 ± 0.238
1.328ProLys: 1.328 ± 0.319
2.833ProLeu: 2.833 ± 0.532
0.177ProMet: 0.177 ± 0.136
1.151ProAsn: 1.151 ± 0.298
0.531ProPro: 0.531 ± 0.197
1.328ProGln: 1.328 ± 0.346
1.682ProArg: 1.682 ± 0.477
1.417ProSer: 1.417 ± 0.407
1.417ProThr: 1.417 ± 0.407
2.745ProVal: 2.745 ± 0.519
0.266ProTrp: 0.266 ± 0.154
1.062ProTyr: 1.062 ± 0.273
0.0ProXaa: 0.0 ± 0.0
Gln
2.656GlnAla: 2.656 ± 0.53
0.266GlnCys: 0.266 ± 0.135
1.151GlnAsp: 1.151 ± 0.327
2.125GlnGlu: 2.125 ± 0.432
1.859GlnPhe: 1.859 ± 0.45
1.682GlnGly: 1.682 ± 0.547
0.62GlnHis: 0.62 ± 0.221
3.364GlnIle: 3.364 ± 0.7
3.63GlnLys: 3.63 ± 0.532
3.718GlnLeu: 3.718 ± 0.487
0.797GlnMet: 0.797 ± 0.235
1.948GlnAsn: 1.948 ± 0.361
0.708GlnPro: 0.708 ± 0.255
2.125GlnGln: 2.125 ± 0.493
1.682GlnArg: 1.682 ± 0.362
2.656GlnSer: 2.656 ± 0.5
2.479GlnThr: 2.479 ± 0.655
1.417GlnVal: 1.417 ± 0.326
0.0GlnTrp: 0.0 ± 0.0
0.974GlnTyr: 0.974 ± 0.341
0.0GlnXaa: 0.0 ± 0.0
Arg
2.656ArgAla: 2.656 ± 0.627
0.266ArgCys: 0.266 ± 0.145
1.859ArgAsp: 1.859 ± 0.511
3.187ArgGlu: 3.187 ± 0.649
1.859ArgPhe: 1.859 ± 0.482
2.213ArgGly: 2.213 ± 0.583
0.797ArgHis: 0.797 ± 0.311
2.39ArgIle: 2.39 ± 0.598
3.541ArgLys: 3.541 ± 0.568
2.833ArgLeu: 2.833 ± 0.577
1.328ArgMet: 1.328 ± 0.348
2.302ArgAsn: 2.302 ± 0.516
0.974ArgPro: 0.974 ± 0.316
1.062ArgGln: 1.062 ± 0.355
1.062ArgArg: 1.062 ± 0.314
2.656ArgSer: 2.656 ± 0.601
2.036ArgThr: 2.036 ± 0.369
2.125ArgVal: 2.125 ± 0.319
0.443ArgTrp: 0.443 ± 0.201
1.594ArgTyr: 1.594 ± 0.431
0.0ArgXaa: 0.0 ± 0.0
Ser
3.099SerAla: 3.099 ± 1.013
1.239SerCys: 1.239 ± 0.855
3.364SerAsp: 3.364 ± 0.758
3.984SerGlu: 3.984 ± 0.628
3.807SerPhe: 3.807 ± 0.659
5.046SerGly: 5.046 ± 0.902
0.531SerHis: 0.531 ± 0.224
4.604SerIle: 4.604 ± 0.826
5.312SerLys: 5.312 ± 0.777
5.401SerLeu: 5.401 ± 0.81
1.151SerMet: 1.151 ± 0.281
5.046SerAsn: 5.046 ± 0.486
1.948SerPro: 1.948 ± 0.41
2.125SerGln: 2.125 ± 0.39
1.594SerArg: 1.594 ± 0.471
5.312SerSer: 5.312 ± 1.006
3.63SerThr: 3.63 ± 0.736
3.453SerVal: 3.453 ± 0.49
0.62SerTrp: 0.62 ± 0.217
3.276SerTyr: 3.276 ± 0.78
0.0SerXaa: 0.0 ± 0.0
Thr
4.692ThrAla: 4.692 ± 0.786
0.354ThrCys: 0.354 ± 0.186
2.568ThrAsp: 2.568 ± 0.493
3.276ThrGlu: 3.276 ± 0.708
1.682ThrPhe: 1.682 ± 0.37
3.364ThrGly: 3.364 ± 0.585
0.974ThrHis: 0.974 ± 0.283
4.073ThrIle: 4.073 ± 0.516
6.463ThrLys: 6.463 ± 0.852
5.401ThrLeu: 5.401 ± 0.647
0.62ThrMet: 0.62 ± 0.249
3.63ThrAsn: 3.63 ± 0.762
1.771ThrPro: 1.771 ± 0.451
1.594ThrGln: 1.594 ± 0.315
0.974ThrArg: 0.974 ± 0.271
3.984ThrSer: 3.984 ± 0.613
4.073ThrThr: 4.073 ± 0.619
3.718ThrVal: 3.718 ± 0.573
1.328ThrTrp: 1.328 ± 0.327
1.771ThrTyr: 1.771 ± 0.475
0.0ThrXaa: 0.0 ± 0.0
Val
4.338ValAla: 4.338 ± 0.876
0.531ValCys: 0.531 ± 0.257
4.161ValAsp: 4.161 ± 0.612
3.453ValGlu: 3.453 ± 0.5
3.453ValPhe: 3.453 ± 0.571
3.099ValGly: 3.099 ± 0.487
1.062ValHis: 1.062 ± 0.332
4.781ValIle: 4.781 ± 0.54
5.312ValLys: 5.312 ± 0.679
3.187ValLeu: 3.187 ± 0.548
1.682ValMet: 1.682 ± 0.423
4.692ValAsn: 4.692 ± 0.689
1.594ValPro: 1.594 ± 0.324
2.302ValGln: 2.302 ± 0.512
2.568ValArg: 2.568 ± 0.501
3.276ValSer: 3.276 ± 0.493
2.39ValThr: 2.39 ± 0.418
4.515ValVal: 4.515 ± 0.658
0.62ValTrp: 0.62 ± 0.235
1.859ValTyr: 1.859 ± 0.444
0.0ValXaa: 0.0 ± 0.0
Trp
1.151TrpAla: 1.151 ± 0.373
0.089TrpCys: 0.089 ± 0.078
1.239TrpAsp: 1.239 ± 0.258
1.239TrpGlu: 1.239 ± 0.338
0.708TrpPhe: 0.708 ± 0.283
0.62TrpGly: 0.62 ± 0.235
0.089TrpHis: 0.089 ± 0.102
0.531TrpIle: 0.531 ± 0.235
1.594TrpLys: 1.594 ± 0.45
1.239TrpLeu: 1.239 ± 0.393
0.531TrpMet: 0.531 ± 0.195
0.354TrpAsn: 0.354 ± 0.193
0.0TrpPro: 0.0 ± 0.0
0.443TrpGln: 0.443 ± 0.185
0.531TrpArg: 0.531 ± 0.167
0.797TrpSer: 0.797 ± 0.294
0.797TrpThr: 0.797 ± 0.281
0.531TrpVal: 0.531 ± 0.204
0.089TrpTrp: 0.089 ± 0.086
0.354TrpTyr: 0.354 ± 0.203
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.656TyrAla: 2.656 ± 0.834
0.266TyrCys: 0.266 ± 0.216
2.656TyrAsp: 2.656 ± 0.538
2.745TyrGlu: 2.745 ± 0.544
2.036TyrPhe: 2.036 ± 0.581
2.39TyrGly: 2.39 ± 0.499
0.708TyrHis: 0.708 ± 0.226
3.541TyrIle: 3.541 ± 0.567
4.073TyrLys: 4.073 ± 0.529
3.01TyrLeu: 3.01 ± 0.403
1.062TyrMet: 1.062 ± 0.315
2.745TyrAsn: 2.745 ± 0.413
0.797TyrPro: 0.797 ± 0.274
1.239TyrGln: 1.239 ± 0.325
1.594TyrArg: 1.594 ± 0.305
2.745TyrSer: 2.745 ± 0.639
2.302TyrThr: 2.302 ± 0.432
1.859TyrVal: 1.859 ± 0.479
0.354TyrTrp: 0.354 ± 0.19
2.479TyrTyr: 2.479 ± 0.562
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11296 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski