Amino acid dipepetide frequency for Penicillium decumbens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.649AlaAla: 8.649 ± 0.071	0.965AlaCys: 0.965 ± 0.018	4.379AlaAsp: 4.379 ± 0.041	5.319AlaGlu: 5.319 ± 0.055	3.071AlaPhe: 3.071 ± 0.033	5.718AlaGly: 5.718 ± 0.047	1.802AlaHis: 1.802 ± 0.024	4.155AlaIle: 4.155 ± 0.037	3.966AlaLys: 3.966 ± 0.048	7.67AlaLeu: 7.67 ± 0.047	2.071AlaMet: 2.071 ± 0.028	2.935AlaAsn: 2.935 ± 0.03	4.979AlaPro: 4.979 ± 0.056	3.491AlaGln: 3.491 ± 0.038	4.969AlaArg: 4.969 ± 0.05	7.443AlaSer: 7.443 ± 0.056	5.118AlaThr: 5.118 ± 0.045	5.23AlaVal: 5.23 ± 0.042	1.12AlaTrp: 1.12 ± 0.018	2.099AlaTyr: 2.099 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.864CysAla: 0.864 ± 0.018	0.202CysCys: 0.202 ± 0.009	0.607CysAsp: 0.607 ± 0.015	0.559CysGlu: 0.559 ± 0.014	0.518CysPhe: 0.518 ± 0.013	0.85CysGly: 0.85 ± 0.017	0.317CysHis: 0.317 ± 0.01	0.65CysIle: 0.65 ± 0.014	0.446CysLys: 0.446 ± 0.011	1.165CysLeu: 1.165 ± 0.021	0.265CysMet: 0.265 ± 0.008	0.392CysAsn: 0.392 ± 0.01	0.613CysPro: 0.613 ± 0.014	0.412CysGln: 0.412 ± 0.011	0.705CysArg: 0.705 ± 0.017	0.839CysSer: 0.839 ± 0.018	0.606CysThr: 0.606 ± 0.014	0.732CysVal: 0.732 ± 0.016	0.176CysTrp: 0.176 ± 0.007	0.321CysTyr: 0.321 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.719AspAla: 4.719 ± 0.04	0.575AspCys: 0.575 ± 0.015	4.162AspAsp: 4.162 ± 0.043	4.593AspGlu: 4.593 ± 0.047	2.213AspPhe: 2.213 ± 0.024	3.882AspGly: 3.882 ± 0.037	1.282AspHis: 1.282 ± 0.019	3.131AspIle: 3.131 ± 0.036	2.358AspLys: 2.358 ± 0.027	5.248AspLeu: 5.248 ± 0.039	1.346AspMet: 1.346 ± 0.019	1.9AspAsn: 1.9 ± 0.027	3.517AspPro: 3.517 ± 0.039	2.071AspGln: 2.071 ± 0.027	3.225AspArg: 3.225 ± 0.039	4.343AspSer: 4.343 ± 0.038	3.002AspThr: 3.002 ± 0.031	3.656AspVal: 3.656 ± 0.032	0.873AspTrp: 0.873 ± 0.017	1.633AspTyr: 1.633 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	5.45GluAla: 5.45 ± 0.053	0.562GluCys: 0.562 ± 0.013	4.381GluAsp: 4.381 ± 0.042	5.588GluGlu: 5.588 ± 0.063	2.004GluPhe: 2.004 ± 0.025	3.684GluGly: 3.684 ± 0.037	1.426GluHis: 1.426 ± 0.02	3.14GluIle: 3.14 ± 0.034	3.77GluLys: 3.77 ± 0.042	5.156GluLeu: 5.156 ± 0.042	1.551GluMet: 1.551 ± 0.02	2.339GluAsn: 2.339 ± 0.025	3.003GluPro: 3.003 ± 0.063	2.587GluGln: 2.587 ± 0.029	4.026GluArg: 4.026 ± 0.043	4.629GluSer: 4.629 ± 0.047	3.535GluThr: 3.535 ± 0.033	3.481GluVal: 3.481 ± 0.036	0.883GluTrp: 0.883 ± 0.017	1.694GluTyr: 1.694 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.033PheAla: 3.033 ± 0.028	0.533PheCys: 0.533 ± 0.014	2.306PheAsp: 2.306 ± 0.026	2.169PheGlu: 2.169 ± 0.027	1.62PhePhe: 1.62 ± 0.025	2.856PheGly: 2.856 ± 0.038	0.918PheHis: 0.918 ± 0.015	1.81PheIle: 1.81 ± 0.025	1.476PheLys: 1.476 ± 0.023	3.507PheLeu: 3.507 ± 0.038	0.848PheMet: 0.848 ± 0.014	1.448PheAsn: 1.448 ± 0.021	1.981PhePro: 1.981 ± 0.026	1.408PheGln: 1.408 ± 0.02	1.985PheArg: 1.985 ± 0.024	3.063PheSer: 3.063 ± 0.034	2.109PheThr: 2.109 ± 0.023	2.385PheVal: 2.385 ± 0.033	0.611PheTrp: 0.611 ± 0.014	1.128PheTyr: 1.128 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.257GlyAla: 5.257 ± 0.046	0.804GlyCys: 0.804 ± 0.017	3.659GlyAsp: 3.659 ± 0.035	3.576GlyGlu: 3.576 ± 0.038	2.774GlyPhe: 2.774 ± 0.025	5.318GlyGly: 5.318 ± 0.063	1.655GlyHis: 1.655 ± 0.026	3.535GlyIle: 3.535 ± 0.037	3.381GlyLys: 3.381 ± 0.036	6.096GlyLeu: 6.096 ± 0.05	1.64GlyMet: 1.64 ± 0.024	2.517GlyAsn: 2.517 ± 0.028	3.472GlyPro: 3.472 ± 0.038	2.613GlyGln: 2.613 ± 0.033	4.072GlyArg: 4.072 ± 0.042	5.885GlySer: 5.885 ± 0.055	3.873GlyThr: 3.873 ± 0.037	4.249GlyVal: 4.249 ± 0.044	1.102GlyTrp: 1.102 ± 0.02	2.112GlyTyr: 2.112 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.849HisAla: 1.849 ± 0.024	0.299HisCys: 0.299 ± 0.009	1.339HisAsp: 1.339 ± 0.017	1.359HisGlu: 1.359 ± 0.021	0.924HisPhe: 0.924 ± 0.016	1.698HisGly: 1.698 ± 0.022	0.801HisHis: 0.801 ± 0.018	1.23HisIle: 1.23 ± 0.021	0.864HisLys: 0.864 ± 0.018	2.242HisLeu: 2.242 ± 0.025	0.51HisMet: 0.51 ± 0.013	0.852HisAsn: 0.852 ± 0.016	1.723HisPro: 1.723 ± 0.023	0.974HisGln: 0.974 ± 0.018	1.614HisArg: 1.614 ± 0.021	1.939HisSer: 1.939 ± 0.024	1.222HisThr: 1.222 ± 0.017	1.429HisVal: 1.429 ± 0.02	0.338HisTrp: 0.338 ± 0.01	0.681HisTyr: 0.681 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.099IleAla: 4.099 ± 0.037	0.732IleCys: 0.732 ± 0.017	2.921IleAsp: 2.921 ± 0.032	2.898IleGlu: 2.898 ± 0.03	2.024IlePhe: 2.024 ± 0.028	3.171IleGly: 3.171 ± 0.034	1.217IleHis: 1.217 ± 0.018	2.469IleIle: 2.469 ± 0.032	2.121IleLys: 2.121 ± 0.027	4.503IleLeu: 4.503 ± 0.042	1.074IleMet: 1.074 ± 0.016	1.774IleAsn: 1.774 ± 0.025	3.218IlePro: 3.218 ± 0.035	1.935IleGln: 1.935 ± 0.027	2.857IleArg: 2.857 ± 0.026	3.887IleSer: 3.887 ± 0.034	2.721IleThr: 2.721 ± 0.028	3.087IleVal: 3.087 ± 0.034	0.703IleTrp: 0.703 ± 0.013	1.42IleTyr: 1.42 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	4.231LysAla: 4.231 ± 0.048	0.456LysCys: 0.456 ± 0.013	2.773LysAsp: 2.773 ± 0.031	3.4LysGlu: 3.4 ± 0.045	1.408LysPhe: 1.408 ± 0.021	2.893LysGly: 2.893 ± 0.029	1.102LysHis: 1.102 ± 0.017	2.213LysIle: 2.213 ± 0.027	3.356LysLys: 3.356 ± 0.059	3.992LysLeu: 3.992 ± 0.034	1.032LysMet: 1.032 ± 0.017	1.703LysAsn: 1.703 ± 0.02	2.729LysPro: 2.729 ± 0.036	1.894LysGln: 1.894 ± 0.028	3.42LysArg: 3.42 ± 0.038	3.568LysSer: 3.568 ± 0.034	2.748LysThr: 2.748 ± 0.027	2.773LysVal: 2.773 ± 0.03	0.65LysTrp: 0.65 ± 0.014	1.352LysTyr: 1.352 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.711LeuAla: 7.711 ± 0.047	1.126LeuCys: 1.126 ± 0.018	5.215LeuAsp: 5.215 ± 0.039	5.511LeuGlu: 5.511 ± 0.048	3.383LeuPhe: 3.383 ± 0.038	5.937LeuGly: 5.937 ± 0.044	2.191LeuHis: 2.191 ± 0.027	3.906LeuIle: 3.906 ± 0.04	4.149LeuLys: 4.149 ± 0.037	8.139LeuLeu: 8.139 ± 0.073	1.832LeuMet: 1.832 ± 0.026	3.226LeuAsn: 3.226 ± 0.034	5.434LeuPro: 5.434 ± 0.038	3.833LeuGln: 3.833 ± 0.044	5.836LeuArg: 5.836 ± 0.048	7.43LeuSer: 7.43 ± 0.053	4.7LeuThr: 4.7 ± 0.039	5.391LeuVal: 5.391 ± 0.039	1.147LeuTrp: 1.147 ± 0.022	2.319LeuTyr: 2.319 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.284MetAla: 2.284 ± 0.027	0.236MetCys: 0.236 ± 0.007	1.381MetAsp: 1.381 ± 0.022	1.378MetGlu: 1.378 ± 0.022	0.777MetPhe: 0.777 ± 0.016	1.565MetGly: 1.565 ± 0.024	0.516MetHis: 0.516 ± 0.012	1.059MetIle: 1.059 ± 0.017	1.034MetLys: 1.034 ± 0.017	1.857MetLeu: 1.857 ± 0.023	0.571MetMet: 0.571 ± 0.016	0.858MetAsn: 0.858 ± 0.015	1.351MetPro: 1.351 ± 0.024	0.953MetGln: 0.953 ± 0.018	1.301MetArg: 1.301 ± 0.018	2.03MetSer: 2.03 ± 0.024	1.351MetThr: 1.351 ± 0.02	1.348MetVal: 1.348 ± 0.02	0.252MetTrp: 0.252 ± 0.008	0.532MetTyr: 0.532 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.138AsnAla: 3.138 ± 0.032	0.425AsnCys: 0.425 ± 0.012	2.002AsnAsp: 2.002 ± 0.025	2.081AsnGlu: 2.081 ± 0.029	1.381AsnPhe: 1.381 ± 0.019	2.899AsnGly: 2.899 ± 0.039	0.845AsnHis: 0.845 ± 0.016	1.97AsnIle: 1.97 ± 0.024	1.517AsnLys: 1.517 ± 0.023	3.22AsnLeu: 3.22 ± 0.03	0.903AsnMet: 0.903 ± 0.016	1.424AsnAsn: 1.424 ± 0.024	2.58AsnPro: 2.58 ± 0.03	1.396AsnGln: 1.396 ± 0.023	2.016AsnArg: 2.016 ± 0.026	2.684AsnSer: 2.684 ± 0.028	2.183AsnThr: 2.183 ± 0.027	2.335AsnVal: 2.335 ± 0.023	0.551AsnTrp: 0.551 ± 0.014	1.074AsnTyr: 1.074 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	5.452ProAla: 5.452 ± 0.063	0.47ProCys: 0.47 ± 0.014	3.324ProAsp: 3.324 ± 0.033	4.057ProGlu: 4.057 ± 0.051	2.152ProPhe: 2.152 ± 0.026	4.092ProGly: 4.092 ± 0.043	1.341ProHis: 1.341 ± 0.02	2.655ProIle: 2.655 ± 0.03	2.679ProLys: 2.679 ± 0.033	4.728ProLeu: 4.728 ± 0.037	1.174ProMet: 1.174 ± 0.02	2.262ProAsn: 2.262 ± 0.027	5.079ProPro: 5.079 ± 0.086	2.554ProGln: 2.554 ± 0.034	3.602ProArg: 3.602 ± 0.039	6.465ProSer: 6.465 ± 0.06	4.082ProThr: 4.082 ± 0.039	3.785ProVal: 3.785 ± 0.04	0.746ProTrp: 0.746 ± 0.016	1.528ProTyr: 1.528 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.504GlnAla: 3.504 ± 0.039	0.419GlnCys: 0.419 ± 0.011	2.083GlnAsp: 2.083 ± 0.025	2.544GlnGlu: 2.544 ± 0.031	1.35GlnPhe: 1.35 ± 0.02	2.451GlnGly: 2.451 ± 0.029	1.061GlnHis: 1.061 ± 0.021	1.923GlnIle: 1.923 ± 0.026	2.076GlnLys: 2.076 ± 0.026	3.494GlnLeu: 3.494 ± 0.035	0.964GlnMet: 0.964 ± 0.017	1.602GlnAsn: 1.602 ± 0.023	2.694GlnPro: 2.694 ± 0.028	2.339GlnGln: 2.339 ± 0.053	2.687GlnArg: 2.687 ± 0.031	3.392GlnSer: 3.392 ± 0.037	2.329GlnThr: 2.329 ± 0.026	2.224GlnVal: 2.224 ± 0.025	0.56GlnTrp: 0.56 ± 0.013	1.156GlnTyr: 1.156 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.81ArgAla: 4.81 ± 0.039	0.664ArgCys: 0.664 ± 0.016	3.466ArgAsp: 3.466 ± 0.044	3.935ArgGlu: 3.935 ± 0.039	2.201ArgPhe: 2.201 ± 0.025	3.801ArgGly: 3.801 ± 0.047	1.585ArgHis: 1.585 ± 0.026	2.872ArgIle: 2.872 ± 0.033	3.459ArgLys: 3.459 ± 0.036	5.5ArgLeu: 5.5 ± 0.047	1.359ArgMet: 1.359 ± 0.02	2.302ArgAsn: 2.302 ± 0.029	3.732ArgPro: 3.732 ± 0.04	2.689ArgGln: 2.689 ± 0.029	5.237ArgArg: 5.237 ± 0.064	5.084ArgSer: 5.084 ± 0.057	3.224ArgThr: 3.224 ± 0.034	3.476ArgVal: 3.476 ± 0.035	0.912ArgTrp: 0.912 ± 0.017	1.644ArgTyr: 1.644 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.852SerAla: 6.852 ± 0.048	0.78SerCys: 0.78 ± 0.019	4.407SerAsp: 4.407 ± 0.04	4.453SerGlu: 4.453 ± 0.041	3.083SerPhe: 3.083 ± 0.031	5.74SerGly: 5.74 ± 0.045	2.062SerHis: 2.062 ± 0.027	3.993SerIle: 3.993 ± 0.035	3.844SerLys: 3.844 ± 0.038	7.352SerLeu: 7.352 ± 0.049	1.861SerMet: 1.861 ± 0.026	3.102SerAsn: 3.102 ± 0.033	5.89SerPro: 5.89 ± 0.062	3.515SerGln: 3.515 ± 0.037	5.315SerArg: 5.315 ± 0.059	9.001SerSer: 9.001 ± 0.089	5.638SerThr: 5.638 ± 0.06	4.807SerVal: 4.807 ± 0.04	1.098SerTrp: 1.098 ± 0.019	2.043SerTyr: 2.043 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	4.992ThrAla: 4.992 ± 0.046	0.671ThrCys: 0.671 ± 0.015	2.974ThrAsp: 2.974 ± 0.034	3.308ThrGlu: 3.308 ± 0.038	2.154ThrPhe: 2.154 ± 0.025	4.211ThrGly: 4.211 ± 0.043	1.275ThrHis: 1.275 ± 0.017	2.982ThrIle: 2.982 ± 0.033	2.561ThrLys: 2.561 ± 0.031	5.109ThrLeu: 5.109 ± 0.039	1.231ThrMet: 1.231 ± 0.02	2.014ThrAsn: 2.014 ± 0.024	4.429ThrPro: 4.429 ± 0.052	2.096ThrGln: 2.096 ± 0.026	3.135ThrArg: 3.135 ± 0.03	5.192ThrSer: 5.192 ± 0.061	3.831ThrThr: 3.831 ± 0.046	3.733ThrVal: 3.733 ± 0.038	0.788ThrTrp: 0.788 ± 0.017	1.555ThrTyr: 1.555 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	5.078ValAla: 5.078 ± 0.039	0.769ValCys: 0.769 ± 0.016	3.809ValAsp: 3.809 ± 0.033	3.781ValGlu: 3.781 ± 0.035	2.474ValPhe: 2.474 ± 0.028	3.902ValGly: 3.902 ± 0.043	1.405ValHis: 1.405 ± 0.023	2.997ValIle: 2.997 ± 0.034	2.796ValLys: 2.796 ± 0.028	5.478ValLeu: 5.478 ± 0.048	1.379ValMet: 1.379 ± 0.019	2.258ValAsn: 2.258 ± 0.026	3.711ValPro: 3.711 ± 0.037	2.41ValGln: 2.41 ± 0.03	3.439ValArg: 3.439 ± 0.04	4.827ValSer: 4.827 ± 0.039	3.538ValThr: 3.538 ± 0.035	4.089ValVal: 4.089 ± 0.043	0.805ValTrp: 0.805 ± 0.014	1.717ValTyr: 1.717 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.081TrpAla: 1.081 ± 0.02	0.178TrpCys: 0.178 ± 0.006	0.878TrpAsp: 0.878 ± 0.016	0.838TrpGlu: 0.838 ± 0.017	0.528TrpPhe: 0.528 ± 0.012	0.884TrpGly: 0.884 ± 0.016	0.337TrpHis: 0.337 ± 0.01	0.757TrpIle: 0.757 ± 0.015	0.784TrpLys: 0.784 ± 0.016	1.305TrpLeu: 1.305 ± 0.02	0.38TrpMet: 0.38 ± 0.011	0.619TrpAsn: 0.619 ± 0.013	0.563TrpPro: 0.563 ± 0.013	0.542TrpGln: 0.542 ± 0.011	0.903TrpArg: 0.903 ± 0.017	1.036TrpSer: 1.036 ± 0.019	0.878TrpThr: 0.878 ± 0.019	0.845TrpVal: 0.845 ± 0.017	0.268TrpTrp: 0.268 ± 0.009	0.39TrpTyr: 0.39 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.096TyrAla: 2.096 ± 0.024	0.374TyrCys: 0.374 ± 0.011	1.663TyrAsp: 1.663 ± 0.022	1.542TyrGlu: 1.542 ± 0.022	1.159TyrPhe: 1.159 ± 0.018	2.034TyrGly: 2.034 ± 0.031	0.748TyrHis: 0.748 ± 0.016	1.386TyrIle: 1.386 ± 0.022	1.052TyrLys: 1.052 ± 0.019	2.653TyrLeu: 2.653 ± 0.029	0.643TyrMet: 0.643 ± 0.013	1.096TyrAsn: 1.096 ± 0.019	1.53TyrPro: 1.53 ± 0.021	1.139TyrGln: 1.139 ± 0.02	1.609TyrArg: 1.609 ± 0.021	2.098TyrSer: 2.098 ± 0.026	1.554TyrThr: 1.554 ± 0.019	1.61TyrVal: 1.61 ± 0.023	0.413TyrTrp: 0.413 ± 0.011	0.946TyrTyr: 0.946 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.01XaaXaa: 0.01 ± 0.011

Statistics based on 7144 proteins (3565102 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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