Amino acid dipepetide frequency for Paenibacillus sambharensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.886AlaAla: 11.886 ± 0.12	0.809AlaCys: 0.809 ± 0.028	5.146AlaAsp: 5.146 ± 0.067	6.78AlaGlu: 6.78 ± 0.079	3.372AlaPhe: 3.372 ± 0.044	8.591AlaGly: 8.591 ± 0.092	1.434AlaHis: 1.434 ± 0.03	4.842AlaIle: 4.842 ± 0.062	3.795AlaLys: 3.795 ± 0.046	8.352AlaLeu: 8.352 ± 0.08	2.361AlaMet: 2.361 ± 0.042	2.519AlaAsn: 2.519 ± 0.047	2.809AlaPro: 2.809 ± 0.039	2.621AlaGln: 2.621 ± 0.045	4.099AlaArg: 4.099 ± 0.055	5.402AlaSer: 5.402 ± 0.07	3.05AlaThr: 3.05 ± 0.05	8.023AlaVal: 8.023 ± 0.096	0.994AlaTrp: 0.994 ± 0.024	3.004AlaTyr: 3.004 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.568CysAla: 0.568 ± 0.019	0.132CysCys: 0.132 ± 0.01	0.346CysAsp: 0.346 ± 0.015	0.447CysGlu: 0.447 ± 0.018	0.329CysPhe: 0.329 ± 0.015	0.788CysGly: 0.788 ± 0.027	0.179CysHis: 0.179 ± 0.013	0.441CysIle: 0.441 ± 0.017	0.28CysLys: 0.28 ± 0.014	0.792CysLeu: 0.792 ± 0.022	0.241CysMet: 0.241 ± 0.013	0.216CysAsn: 0.216 ± 0.011	0.359CysPro: 0.359 ± 0.016	0.212CysGln: 0.212 ± 0.011	0.58CysArg: 0.58 ± 0.018	0.64CysSer: 0.64 ± 0.02	0.411CysThr: 0.411 ± 0.017	0.485CysVal: 0.485 ± 0.017	0.102CysTrp: 0.102 ± 0.008	0.267CysTyr: 0.267 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.969AspAla: 3.969 ± 0.057	0.387AspCys: 0.387 ± 0.016	2.302AspAsp: 2.302 ± 0.046	3.896AspGlu: 3.896 ± 0.054	1.922AspPhe: 1.922 ± 0.035	4.221AspGly: 4.221 ± 0.068	1.108AspHis: 1.108 ± 0.027	3.468AspIle: 3.468 ± 0.049	2.727AspLys: 2.727 ± 0.045	4.754AspLeu: 4.754 ± 0.059	1.449AspMet: 1.449 ± 0.029	1.86AspAsn: 1.86 ± 0.036	2.504AspPro: 2.504 ± 0.058	1.861AspGln: 1.861 ± 0.03	3.18AspArg: 3.18 ± 0.053	2.906AspSer: 2.906 ± 0.044	2.584AspThr: 2.584 ± 0.042	3.389AspVal: 3.389 ± 0.054	0.846AspTrp: 0.846 ± 0.023	2.223AspTyr: 2.223 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.012GluAla: 7.012 ± 0.076	0.38GluCys: 0.38 ± 0.015	3.341GluAsp: 3.341 ± 0.057	5.857GluGlu: 5.857 ± 0.071	1.954GluPhe: 1.954 ± 0.036	4.919GluGly: 4.919 ± 0.055	1.657GluHis: 1.657 ± 0.036	3.974GluIle: 3.974 ± 0.054	3.203GluLys: 3.203 ± 0.056	7.79GluLeu: 7.79 ± 0.08	1.905GluMet: 1.905 ± 0.029	2.009GluAsn: 2.009 ± 0.035	2.645GluPro: 2.645 ± 0.044	4.224GluGln: 4.224 ± 0.063	4.53GluArg: 4.53 ± 0.063	3.397GluSer: 3.397 ± 0.044	3.433GluThr: 3.433 ± 0.044	4.404GluVal: 4.404 ± 0.057	0.955GluTrp: 0.955 ± 0.026	2.006GluTyr: 2.006 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.171PheAla: 3.171 ± 0.048	0.356PheCys: 0.356 ± 0.016	2.174PheAsp: 2.174 ± 0.049	2.396PheGlu: 2.396 ± 0.042	1.636PhePhe: 1.636 ± 0.041	3.096PheGly: 3.096 ± 0.046	0.892PheHis: 0.892 ± 0.025	2.597PheIle: 2.597 ± 0.041	1.686PheLys: 1.686 ± 0.036	3.463PheLeu: 3.463 ± 0.054	1.113PheMet: 1.113 ± 0.026	1.441PheAsn: 1.441 ± 0.029	1.479PhePro: 1.479 ± 0.039	1.228PheGln: 1.228 ± 0.028	2.182PheArg: 2.182 ± 0.04	2.478PheSer: 2.478 ± 0.044	2.389PheThr: 2.389 ± 0.041	2.689PheVal: 2.689 ± 0.043	0.504PheTrp: 0.504 ± 0.019	1.408PheTyr: 1.408 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.077GlyAla: 6.077 ± 0.079	0.798GlyCys: 0.798 ± 0.029	3.597GlyAsp: 3.597 ± 0.055	5.023GlyGlu: 5.023 ± 0.062	3.139GlyPhe: 3.139 ± 0.043	6.258GlyGly: 6.258 ± 0.085	1.548GlyHis: 1.548 ± 0.033	5.465GlyIle: 5.465 ± 0.063	4.14GlyLys: 4.14 ± 0.058	7.502GlyLeu: 7.502 ± 0.084	2.629GlyMet: 2.629 ± 0.043	2.477GlyAsn: 2.477 ± 0.045	2.133GlyPro: 2.133 ± 0.038	2.909GlyGln: 2.909 ± 0.045	4.537GlyArg: 4.537 ± 0.067	5.477GlySer: 5.477 ± 0.064	4.776GlyThr: 4.776 ± 0.066	5.191GlyVal: 5.191 ± 0.067	1.17GlyTrp: 1.17 ± 0.029	3.049GlyTyr: 3.049 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.767HisAla: 1.767 ± 0.036	0.186HisCys: 0.186 ± 0.012	1.064HisAsp: 1.064 ± 0.023	1.335HisGlu: 1.335 ± 0.027	0.928HisPhe: 0.928 ± 0.023	1.514HisGly: 1.514 ± 0.035	0.642HisHis: 0.642 ± 0.029	1.402HisIle: 1.402 ± 0.03	0.824HisLys: 0.824 ± 0.024	1.985HisLeu: 1.985 ± 0.044	0.588HisMet: 0.588 ± 0.016	0.735HisAsn: 0.735 ± 0.022	1.238HisPro: 1.238 ± 0.029	0.783HisGln: 0.783 ± 0.021	1.124HisArg: 1.124 ± 0.029	1.228HisSer: 1.228 ± 0.027	1.133HisThr: 1.133 ± 0.027	1.436HisVal: 1.436 ± 0.027	0.276HisTrp: 0.276 ± 0.012	0.928HisTyr: 0.928 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.663IleAla: 5.663 ± 0.071	0.545IleCys: 0.545 ± 0.02	3.254IleAsp: 3.254 ± 0.048	4.095IleGlu: 4.095 ± 0.055	2.045IlePhe: 2.045 ± 0.039	5.027IleGly: 5.027 ± 0.072	1.353IleHis: 1.353 ± 0.033	3.798IleIle: 3.798 ± 0.059	2.567IleLys: 2.567 ± 0.045	5.24IleLeu: 5.24 ± 0.071	1.693IleMet: 1.693 ± 0.037	2.183IleAsn: 2.183 ± 0.039	2.891IlePro: 2.891 ± 0.047	2.291IleGln: 2.291 ± 0.05	4.09IleArg: 4.09 ± 0.05	3.897IleSer: 3.897 ± 0.053	3.693IleThr: 3.693 ± 0.052	4.757IleVal: 4.757 ± 0.066	0.666IleTrp: 0.666 ± 0.025	1.931IleTyr: 1.931 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.105LysAla: 4.105 ± 0.053	0.225LysCys: 0.225 ± 0.011	2.572LysAsp: 2.572 ± 0.05	3.637LysGlu: 3.637 ± 0.055	1.32LysPhe: 1.32 ± 0.027	3.324LysGly: 3.324 ± 0.044	1.067LysHis: 1.067 ± 0.026	2.433LysIle: 2.433 ± 0.043	2.374LysLys: 2.374 ± 0.049	5.269LysLeu: 5.269 ± 0.068	1.263LysMet: 1.263 ± 0.03	1.578LysAsn: 1.578 ± 0.033	2.286LysPro: 2.286 ± 0.043	2.425LysGln: 2.425 ± 0.039	2.777LysArg: 2.777 ± 0.044	2.536LysSer: 2.536 ± 0.042	2.389LysThr: 2.389 ± 0.042	3.21LysVal: 3.21 ± 0.048	0.631LysTrp: 0.631 ± 0.019	1.394LysTyr: 1.394 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	9.29LeuAla: 9.29 ± 0.104	0.81LeuCys: 0.81 ± 0.024	5.178LeuAsp: 5.178 ± 0.058	6.522LeuGlu: 6.522 ± 0.069	4.297LeuPhe: 4.297 ± 0.062	6.895LeuGly: 6.895 ± 0.079	2.244LeuHis: 2.244 ± 0.041	6.114LeuIle: 6.114 ± 0.08	4.769LeuLys: 4.769 ± 0.065	11.435LeuLeu: 11.435 ± 0.133	2.67LeuMet: 2.67 ± 0.042	3.55LeuAsn: 3.55 ± 0.05	4.694LeuPro: 4.694 ± 0.061	4.136LeuGln: 4.136 ± 0.057	5.234LeuArg: 5.234 ± 0.064	6.742LeuSer: 6.742 ± 0.066	5.763LeuThr: 5.763 ± 0.066	6.569LeuVal: 6.569 ± 0.065	1.066LeuTrp: 1.066 ± 0.029	3.332LeuTyr: 3.332 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.422MetAla: 2.422 ± 0.041	0.173MetCys: 0.173 ± 0.009	1.513MetAsp: 1.513 ± 0.028	1.981MetGlu: 1.981 ± 0.032	1.035MetPhe: 1.035 ± 0.03	1.747MetGly: 1.747 ± 0.035	0.503MetHis: 0.503 ± 0.016	1.85MetIle: 1.85 ± 0.033	1.881MetLys: 1.881 ± 0.034	3.245MetLeu: 3.245 ± 0.046	0.852MetMet: 0.852 ± 0.022	1.44MetAsn: 1.44 ± 0.029	1.234MetPro: 1.234 ± 0.029	1.143MetGln: 1.143 ± 0.025	1.475MetArg: 1.475 ± 0.034	1.73MetSer: 1.73 ± 0.034	1.742MetThr: 1.742 ± 0.032	1.844MetVal: 1.844 ± 0.041	0.252MetTrp: 0.252 ± 0.013	0.764MetTyr: 0.764 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.698AsnAla: 2.698 ± 0.047	0.241AsnCys: 0.241 ± 0.013	1.677AsnAsp: 1.677 ± 0.034	2.298AsnGlu: 2.298 ± 0.039	1.095AsnPhe: 1.095 ± 0.028	3.052AsnGly: 3.052 ± 0.053	0.764AsnHis: 0.764 ± 0.021	1.982AsnIle: 1.982 ± 0.038	1.722AsnLys: 1.722 ± 0.04	3.034AsnLeu: 3.034 ± 0.047	0.978AsnMet: 0.978 ± 0.027	1.412AsnAsn: 1.412 ± 0.037	2.027AsnPro: 2.027 ± 0.033	1.312AsnGln: 1.312 ± 0.027	2.157AsnArg: 2.157 ± 0.041	1.961AsnSer: 1.961 ± 0.044	1.805AsnThr: 1.805 ± 0.036	2.339AsnVal: 2.339 ± 0.037	0.5AsnTrp: 0.5 ± 0.019	1.264AsnTyr: 1.264 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.287ProAla: 4.287 ± 0.06	0.253ProCys: 0.253 ± 0.014	2.84ProAsp: 2.84 ± 0.05	3.628ProGlu: 3.628 ± 0.057	1.775ProPhe: 1.775 ± 0.033	3.532ProGly: 3.532 ± 0.06	0.892ProHis: 0.892 ± 0.025	2.072ProIle: 2.072 ± 0.037	1.563ProLys: 1.563 ± 0.032	4.092ProLeu: 4.092 ± 0.061	0.995ProMet: 0.995 ± 0.026	1.297ProAsn: 1.297 ± 0.029	1.326ProPro: 1.326 ± 0.033	1.409ProGln: 1.409 ± 0.038	1.537ProArg: 1.537 ± 0.038	2.494ProSer: 2.494 ± 0.042	1.624ProThr: 1.624 ± 0.037	3.846ProVal: 3.846 ± 0.05	0.492ProTrp: 0.492 ± 0.019	1.587ProTyr: 1.587 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.87GlnAla: 3.87 ± 0.055	0.182GlnCys: 0.182 ± 0.011	1.797GlnAsp: 1.797 ± 0.031	2.858GlnGlu: 2.858 ± 0.047	1.394GlnPhe: 1.394 ± 0.031	2.646GlnGly: 2.646 ± 0.042	0.889GlnHis: 0.889 ± 0.026	2.26GlnIle: 2.26 ± 0.045	1.573GlnLys: 1.573 ± 0.036	4.523GlnLeu: 4.523 ± 0.064	1.171GlnMet: 1.171 ± 0.027	1.148GlnAsn: 1.148 ± 0.029	1.781GlnPro: 1.781 ± 0.045	2.026GlnGln: 2.026 ± 0.046	2.025GlnArg: 2.025 ± 0.041	2.276GlnSer: 2.276 ± 0.038	2.065GlnThr: 2.065 ± 0.038	2.618GlnVal: 2.618 ± 0.042	0.536GlnTrp: 0.536 ± 0.021	1.278GlnTyr: 1.278 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	3.807ArgAla: 3.807 ± 0.049	0.421ArgCys: 0.421 ± 0.016	2.66ArgAsp: 2.66 ± 0.045	4.215ArgGlu: 4.215 ± 0.053	2.305ArgPhe: 2.305 ± 0.04	3.28ArgGly: 3.28 ± 0.041	1.204ArgHis: 1.204 ± 0.033	3.847ArgIle: 3.847 ± 0.05	3.039ArgLys: 3.039 ± 0.038	6.175ArgLeu: 6.175 ± 0.083	1.969ArgMet: 1.969 ± 0.034	1.937ArgAsn: 1.937 ± 0.035	2.028ArgPro: 2.028 ± 0.041	2.432ArgGln: 2.432 ± 0.04	3.318ArgArg: 3.318 ± 0.052	3.664ArgSer: 3.664 ± 0.05	3.052ArgThr: 3.052 ± 0.043	3.502ArgVal: 3.502 ± 0.042	0.748ArgTrp: 0.748 ± 0.023	2.236ArgTyr: 2.236 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.271SerAla: 5.271 ± 0.063	0.529SerCys: 0.529 ± 0.017	2.932SerAsp: 2.932 ± 0.046	3.645SerGlu: 3.645 ± 0.051	2.776SerPhe: 2.776 ± 0.046	5.95SerGly: 5.95 ± 0.073	1.185SerHis: 1.185 ± 0.024	3.877SerIle: 3.877 ± 0.053	2.627SerLys: 2.627 ± 0.043	6.201SerLeu: 6.201 ± 0.072	1.821SerMet: 1.821 ± 0.036	1.96SerAsn: 1.96 ± 0.031	2.465SerPro: 2.465 ± 0.045	1.971SerGln: 1.971 ± 0.039	3.672SerArg: 3.672 ± 0.058	4.389SerSer: 4.389 ± 0.062	2.999SerThr: 2.999 ± 0.047	4.49SerVal: 4.49 ± 0.055	0.881SerTrp: 0.881 ± 0.023	2.373SerTyr: 2.373 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.364ThrAla: 5.364 ± 0.071	0.331ThrCys: 0.331 ± 0.015	2.999ThrAsp: 2.999 ± 0.053	3.307ThrGlu: 3.307 ± 0.045	2.179ThrPhe: 2.179 ± 0.036	5.107ThrGly: 5.107 ± 0.06	0.986ThrHis: 0.986 ± 0.027	3.553ThrIle: 3.553 ± 0.053	2.09ThrLys: 2.09 ± 0.037	5.092ThrLeu: 5.092 ± 0.061	1.392ThrMet: 1.392 ± 0.028	1.749ThrAsn: 1.749 ± 0.039	2.398ThrPro: 2.398 ± 0.04	1.401ThrGln: 1.401 ± 0.031	2.385ThrArg: 2.385 ± 0.037	3.109ThrSer: 3.109 ± 0.051	2.617ThrThr: 2.617 ± 0.055	4.504ThrVal: 4.504 ± 0.059	0.577ThrTrp: 0.577 ± 0.019	1.811ThrTyr: 1.811 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	4.997ValAla: 4.997 ± 0.063	0.648ValCys: 0.648 ± 0.021	3.598ValAsp: 3.598 ± 0.05	4.509ValGlu: 4.509 ± 0.059	2.832ValPhe: 2.832 ± 0.049	4.368ValGly: 4.368 ± 0.058	1.548ValHis: 1.548 ± 0.029	4.804ValIle: 4.804 ± 0.056	3.73ValLys: 3.73 ± 0.057	7.457ValLeu: 7.457 ± 0.076	2.276ValMet: 2.276 ± 0.042	2.779ValAsn: 2.779 ± 0.049	3.211ValPro: 3.211 ± 0.045	2.745ValGln: 2.745 ± 0.049	3.997ValArg: 3.997 ± 0.051	4.781ValSer: 4.781 ± 0.061	4.714ValThr: 4.714 ± 0.077	5.063ValVal: 5.063 ± 0.069	0.917ValTrp: 0.917 ± 0.025	2.509ValTyr: 2.509 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.866TrpAla: 0.866 ± 0.028	0.102TrpCys: 0.102 ± 0.008	0.674TrpAsp: 0.674 ± 0.025	0.782TrpGlu: 0.782 ± 0.024	0.589TrpPhe: 0.589 ± 0.021	0.83TrpGly: 0.83 ± 0.02	0.273TrpHis: 0.273 ± 0.012	0.817TrpIle: 0.817 ± 0.025	0.681TrpLys: 0.681 ± 0.021	1.522TrpLeu: 1.522 ± 0.032	0.443TrpMet: 0.443 ± 0.014	0.626TrpAsn: 0.626 ± 0.018	0.383TrpPro: 0.383 ± 0.016	0.536TrpGln: 0.536 ± 0.019	0.7TrpArg: 0.7 ± 0.024	0.831TrpSer: 0.831 ± 0.024	0.733TrpThr: 0.733 ± 0.022	0.793TrpVal: 0.793 ± 0.027	0.202TrpTrp: 0.202 ± 0.012	0.43TrpTyr: 0.43 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.8TyrAla: 2.8 ± 0.049	0.308TyrCys: 0.308 ± 0.014	1.893TyrAsp: 1.893 ± 0.041	2.385TyrGlu: 2.385 ± 0.04	1.456TyrPhe: 1.456 ± 0.029	2.748TyrGly: 2.748 ± 0.049	0.749TyrHis: 0.749 ± 0.02	2.082TyrIle: 2.082 ± 0.036	1.544TyrLys: 1.544 ± 0.031	3.385TyrLeu: 3.385 ± 0.047	1.015TyrMet: 1.015 ± 0.024	1.402TyrAsn: 1.402 ± 0.03	1.647TyrPro: 1.647 ± 0.033	1.252TyrGln: 1.252 ± 0.028	2.236TyrArg: 2.236 ± 0.042	2.08TyrSer: 2.08 ± 0.035	1.98TyrThr: 1.98 ± 0.034	2.332TyrVal: 2.332 ± 0.039	0.497TyrTrp: 0.497 ± 0.017	1.466TyrTyr: 1.466 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4979 proteins (1622395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---