Amino acid dipepetide frequency for Tsuneonella aeria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.027AlaAla: 21.027 ± 0.225	1.164AlaCys: 1.164 ± 0.042	8.277AlaAsp: 8.277 ± 0.115	8.513AlaGlu: 8.513 ± 0.122	4.525AlaPhe: 4.525 ± 0.085	12.606AlaGly: 12.606 ± 0.163	2.443AlaHis: 2.443 ± 0.061	6.997AlaIle: 6.997 ± 0.102	3.564AlaLys: 3.564 ± 0.083	14.371AlaLeu: 14.371 ± 0.159	4.099AlaMet: 4.099 ± 0.075	3.123AlaAsn: 3.123 ± 0.07	6.737AlaPro: 6.737 ± 0.114	4.49AlaGln: 4.49 ± 0.088	11.056AlaArg: 11.056 ± 0.133	6.476AlaSer: 6.476 ± 0.099	6.379AlaThr: 6.379 ± 0.108	9.291AlaVal: 9.291 ± 0.12	1.864AlaTrp: 1.864 ± 0.053	2.504AlaTyr: 2.504 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.121CysAla: 1.121 ± 0.043	0.097CysCys: 0.097 ± 0.012	0.589CysAsp: 0.589 ± 0.027	0.442CysGlu: 0.442 ± 0.029	0.29CysPhe: 0.29 ± 0.018	0.884CysGly: 0.884 ± 0.037	0.217CysHis: 0.217 ± 0.019	0.338CysIle: 0.338 ± 0.02	0.171CysLys: 0.171 ± 0.014	0.639CysLeu: 0.639 ± 0.028	0.13CysMet: 0.13 ± 0.013	0.197CysAsn: 0.197 ± 0.014	0.453CysPro: 0.453 ± 0.03	0.204CysGln: 0.204 ± 0.015	0.563CysArg: 0.563 ± 0.029	0.452CysSer: 0.452 ± 0.024	0.425CysThr: 0.425 ± 0.023	0.544CysVal: 0.544 ± 0.031	0.09CysTrp: 0.09 ± 0.011	0.163CysTyr: 0.163 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.074AspAla: 8.074 ± 0.105	0.514AspCys: 0.514 ± 0.027	3.443AspAsp: 3.443 ± 0.076	3.511AspGlu: 3.511 ± 0.069	2.088AspPhe: 2.088 ± 0.046	5.839AspGly: 5.839 ± 0.111	1.299AspHis: 1.299 ± 0.043	2.581AspIle: 2.581 ± 0.058	1.594AspLys: 1.594 ± 0.048	5.874AspLeu: 5.874 ± 0.082	1.409AspMet: 1.409 ± 0.041	1.288AspAsn: 1.288 ± 0.05	3.973AspPro: 3.973 ± 0.066	1.74AspGln: 1.74 ± 0.043	5.3AspArg: 5.3 ± 0.08	2.498AspSer: 2.498 ± 0.061	2.799AspThr: 2.799 ± 0.072	4.099AspVal: 4.099 ± 0.075	1.119AspTrp: 1.119 ± 0.038	1.472AspTyr: 1.472 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.876GluAla: 7.876 ± 0.133	0.383GluCys: 0.383 ± 0.021	2.964GluAsp: 2.964 ± 0.063	3.159GluGlu: 3.159 ± 0.079	1.662GluPhe: 1.662 ± 0.052	4.924GluGly: 4.924 ± 0.08	1.226GluHis: 1.226 ± 0.04	2.885GluIle: 2.885 ± 0.066	1.854GluLys: 1.854 ± 0.056	5.339GluLeu: 5.339 ± 0.099	1.456GluMet: 1.456 ± 0.043	1.425GluAsn: 1.425 ± 0.045	2.838GluPro: 2.838 ± 0.065	2.059GluGln: 2.059 ± 0.051	5.378GluArg: 5.378 ± 0.087	2.428GluSer: 2.428 ± 0.057	3.27GluThr: 3.27 ± 0.077	3.822GluVal: 3.822 ± 0.061	0.845GluTrp: 0.845 ± 0.034	1.043GluTyr: 1.043 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	5.193PheAla: 5.193 ± 0.08	0.314PheCys: 0.314 ± 0.018	2.708PheAsp: 2.708 ± 0.063	2.032PheGlu: 2.032 ± 0.051	1.218PhePhe: 1.218 ± 0.046	3.464PheGly: 3.464 ± 0.071	0.709PheHis: 0.709 ± 0.032	1.389PheIle: 1.389 ± 0.039	0.705PheLys: 0.705 ± 0.031	2.978PheLeu: 2.978 ± 0.066	0.728PheMet: 0.728 ± 0.029	0.917PheAsn: 0.917 ± 0.039	1.538PhePro: 1.538 ± 0.048	0.813PheGln: 0.813 ± 0.034	2.242PheArg: 2.242 ± 0.058	1.806PheSer: 1.806 ± 0.054	1.942PheThr: 1.942 ± 0.059	2.706PheVal: 2.706 ± 0.064	0.488PheTrp: 0.488 ± 0.028	0.879PheTyr: 0.879 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.065GlyAla: 11.065 ± 0.138	0.8GlyCys: 0.8 ± 0.035	5.216GlyAsp: 5.216 ± 0.105	5.305GlyGlu: 5.305 ± 0.091	3.523GlyPhe: 3.523 ± 0.063	8.44GlyGly: 8.44 ± 0.129	1.892GlyHis: 1.892 ± 0.055	4.37GlyIle: 4.37 ± 0.077	3.179GlyLys: 3.179 ± 0.072	8.552GlyLeu: 8.552 ± 0.119	2.474GlyMet: 2.474 ± 0.057	2.342GlyAsn: 2.342 ± 0.064	3.94GlyPro: 3.94 ± 0.072	2.972GlyGln: 2.972 ± 0.065	6.684GlyArg: 6.684 ± 0.091	4.781GlySer: 4.781 ± 0.071	5.128GlyThr: 5.128 ± 0.113	6.257GlyVal: 6.257 ± 0.098	1.594GlyTrp: 1.594 ± 0.047	2.214GlyTyr: 2.214 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.611HisAla: 2.611 ± 0.057	0.227HisCys: 0.227 ± 0.017	1.176HisAsp: 1.176 ± 0.04	0.998HisGlu: 0.998 ± 0.038	0.807HisPhe: 0.807 ± 0.028	1.988HisGly: 1.988 ± 0.054	0.56HisHis: 0.56 ± 0.03	0.794HisIle: 0.794 ± 0.032	0.41HisLys: 0.41 ± 0.022	1.853HisLeu: 1.853 ± 0.045	0.455HisMet: 0.455 ± 0.024	0.446HisAsn: 0.446 ± 0.024	1.316HisPro: 1.316 ± 0.043	0.517HisGln: 0.517 ± 0.025	1.489HisArg: 1.489 ± 0.04	0.9HisSer: 0.9 ± 0.034	0.75HisThr: 0.75 ± 0.03	1.441HisVal: 1.441 ± 0.045	0.346HisTrp: 0.346 ± 0.021	0.523HisTyr: 0.523 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.907IleAla: 7.907 ± 0.103	0.386IleCys: 0.386 ± 0.021	3.863IleAsp: 3.863 ± 0.072	3.421IleGlu: 3.421 ± 0.068	1.317IlePhe: 1.317 ± 0.042	4.842IleGly: 4.842 ± 0.082	0.825IleHis: 0.825 ± 0.034	1.576IleIle: 1.576 ± 0.052	1.013IleLys: 1.013 ± 0.04	3.504IleLeu: 3.504 ± 0.064	0.84IleMet: 0.84 ± 0.031	1.147IleAsn: 1.147 ± 0.04	2.237IlePro: 2.237 ± 0.05	1.059IleGln: 1.059 ± 0.041	3.089IleArg: 3.089 ± 0.057	2.236IleSer: 2.236 ± 0.054	2.236IleThr: 2.236 ± 0.057	4.26IleVal: 4.26 ± 0.08	0.545IleTrp: 0.545 ± 0.029	0.965IleTyr: 0.965 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.637LysAla: 3.637 ± 0.087	0.166LysCys: 0.166 ± 0.014	1.471LysAsp: 1.471 ± 0.044	1.174LysGlu: 1.174 ± 0.041	0.768LysPhe: 0.768 ± 0.032	2.369LysGly: 2.369 ± 0.062	0.488LysHis: 0.488 ± 0.026	1.171LysIle: 1.171 ± 0.043	0.936LysLys: 0.936 ± 0.042	2.767LysLeu: 2.767 ± 0.068	0.675LysMet: 0.675 ± 0.032	0.669LysAsn: 0.669 ± 0.026	1.676LysPro: 1.676 ± 0.049	0.755LysGln: 0.755 ± 0.034	2.056LysArg: 2.056 ± 0.049	1.435LysSer: 1.435 ± 0.039	1.359LysThr: 1.359 ± 0.041	2.109LysVal: 2.109 ± 0.057	0.381LysTrp: 0.381 ± 0.025	0.533LysTyr: 0.533 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.285LeuAla: 15.285 ± 0.169	0.721LeuCys: 0.721 ± 0.033	5.898LeuAsp: 5.898 ± 0.092	5.156LeuGlu: 5.156 ± 0.092	3.349LeuPhe: 3.349 ± 0.076	8.297LeuGly: 8.297 ± 0.108	1.755LeuHis: 1.755 ± 0.045	4.336LeuIle: 4.336 ± 0.084	2.665LeuLys: 2.665 ± 0.067	9.06LeuLeu: 9.06 ± 0.156	2.087LeuMet: 2.087 ± 0.063	2.089LeuAsn: 2.089 ± 0.052	5.451LeuPro: 5.451 ± 0.082	2.488LeuGln: 2.488 ± 0.054	6.952LeuArg: 6.952 ± 0.106	5.539LeuSer: 5.539 ± 0.086	5.302LeuThr: 5.302 ± 0.088	7.635LeuVal: 7.635 ± 0.113	1.194LeuTrp: 1.194 ± 0.048	1.807LeuTyr: 1.807 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.382MetAla: 3.382 ± 0.065	0.169MetCys: 0.169 ± 0.012	1.187MetAsp: 1.187 ± 0.04	1.163MetGlu: 1.163 ± 0.037	0.65MetPhe: 0.65 ± 0.032	2.021MetGly: 2.021 ± 0.056	0.467MetHis: 0.467 ± 0.027	1.352MetIle: 1.352 ± 0.04	0.883MetLys: 0.883 ± 0.032	2.583MetLeu: 2.583 ± 0.061	0.648MetMet: 0.648 ± 0.029	0.715MetAsn: 0.715 ± 0.03	1.457MetPro: 1.457 ± 0.042	0.715MetGln: 0.715 ± 0.028	1.919MetArg: 1.919 ± 0.056	1.358MetSer: 1.358 ± 0.044	1.733MetThr: 1.733 ± 0.051	1.612MetVal: 1.612 ± 0.043	0.226MetTrp: 0.226 ± 0.017	0.281MetTyr: 0.281 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.299AsnAla: 3.299 ± 0.07	0.239AsnCys: 0.239 ± 0.018	1.289AsnAsp: 1.289 ± 0.042	1.113AsnGlu: 1.113 ± 0.036	0.813AsnPhe: 0.813 ± 0.031	2.231AsnGly: 2.231 ± 0.056	0.452AsnHis: 0.452 ± 0.024	1.123AsnIle: 1.123 ± 0.038	0.513AsnLys: 0.513 ± 0.022	2.36AsnLeu: 2.36 ± 0.062	0.493AsnMet: 0.493 ± 0.025	0.58AsnAsn: 0.58 ± 0.031	1.775AsnPro: 1.775 ± 0.049	0.74AsnGln: 0.74 ± 0.034	1.891AsnArg: 1.891 ± 0.047	1.085AsnSer: 1.085 ± 0.037	1.098AsnThr: 1.098 ± 0.041	1.805AsnVal: 1.805 ± 0.053	0.38AsnTrp: 0.38 ± 0.02	0.583AsnTyr: 0.583 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.932ProAla: 7.932 ± 0.132	0.335ProCys: 0.335 ± 0.02	3.896ProAsp: 3.896 ± 0.076	3.601ProGlu: 3.601 ± 0.071	1.902ProPhe: 1.902 ± 0.05	5.228ProGly: 5.228 ± 0.081	1.067ProHis: 1.067 ± 0.036	2.314ProIle: 2.314 ± 0.055	1.206ProLys: 1.206 ± 0.035	5.01ProLeu: 5.01 ± 0.072	1.232ProMet: 1.232 ± 0.039	1.137ProAsn: 1.137 ± 0.035	3.005ProPro: 3.005 ± 0.073	1.723ProGln: 1.723 ± 0.044	3.543ProArg: 3.543 ± 0.075	2.654ProSer: 2.654 ± 0.052	2.447ProThr: 2.447 ± 0.057	4.379ProVal: 4.379 ± 0.083	0.682ProTrp: 0.682 ± 0.028	1.087ProTyr: 1.087 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	4.373GlnAla: 4.373 ± 0.083	0.232GlnCys: 0.232 ± 0.016	1.418GlnAsp: 1.418 ± 0.035	1.358GlnGlu: 1.358 ± 0.039	1.078GlnPhe: 1.078 ± 0.035	2.521GlnGly: 2.521 ± 0.059	0.536GlnHis: 0.536 ± 0.027	1.519GlnIle: 1.519 ± 0.04	0.806GlnLys: 0.806 ± 0.035	2.786GlnLeu: 2.786 ± 0.06	0.845GlnMet: 0.845 ± 0.033	0.681GlnAsn: 0.681 ± 0.029	1.836GlnPro: 1.836 ± 0.043	1.12GlnGln: 1.12 ± 0.044	2.419GlnArg: 2.419 ± 0.063	1.59GlnSer: 1.59 ± 0.044	1.505GlnThr: 1.505 ± 0.048	2.399GlnVal: 2.399 ± 0.063	0.442GlnTrp: 0.442 ± 0.026	0.594GlnTyr: 0.594 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.694ArgAla: 9.694 ± 0.126	0.518ArgCys: 0.518 ± 0.023	4.539ArgAsp: 4.539 ± 0.085	4.551ArgGlu: 4.551 ± 0.082	3.124ArgPhe: 3.124 ± 0.061	5.528ArgGly: 5.528 ± 0.092	1.686ArgHis: 1.686 ± 0.049	4.137ArgIle: 4.137 ± 0.069	2.176ArgLys: 2.176 ± 0.053	8.236ArgLeu: 8.236 ± 0.11	2.087ArgMet: 2.087 ± 0.049	1.845ArgAsn: 1.845 ± 0.054	3.961ArgPro: 3.961 ± 0.074	2.511ArgGln: 2.511 ± 0.059	6.141ArgArg: 6.141 ± 0.111	3.734ArgSer: 3.734 ± 0.065	3.826ArgThr: 3.826 ± 0.076	5.091ArgVal: 5.091 ± 0.085	1.268ArgTrp: 1.268 ± 0.049	1.819ArgTyr: 1.819 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.397SerAla: 6.397 ± 0.095	0.371SerCys: 0.371 ± 0.023	3.09SerAsp: 3.09 ± 0.071	2.721SerGlu: 2.721 ± 0.057	1.884SerPhe: 1.884 ± 0.048	5.427SerGly: 5.427 ± 0.082	0.908SerHis: 0.908 ± 0.034	2.288SerIle: 2.288 ± 0.053	1.207SerLys: 1.207 ± 0.04	4.854SerLeu: 4.854 ± 0.081	1.186SerMet: 1.186 ± 0.039	1.203SerAsn: 1.203 ± 0.039	2.836SerPro: 2.836 ± 0.066	1.575SerGln: 1.575 ± 0.042	3.558SerArg: 3.558 ± 0.072	2.494SerSer: 2.494 ± 0.066	2.457SerThr: 2.457 ± 0.06	3.513SerVal: 3.513 ± 0.065	0.729SerTrp: 0.729 ± 0.031	1.164SerTyr: 1.164 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.648ThrAla: 6.648 ± 0.098	0.451ThrCys: 0.451 ± 0.026	2.881ThrAsp: 2.881 ± 0.081	2.379ThrGlu: 2.379 ± 0.058	1.884ThrPhe: 1.884 ± 0.052	5.375ThrGly: 5.375 ± 0.1	0.873ThrHis: 0.873 ± 0.033	2.849ThrIle: 2.849 ± 0.066	1.042ThrLys: 1.042 ± 0.038	5.443ThrLeu: 5.443 ± 0.105	1.283ThrMet: 1.283 ± 0.039	1.167ThrAsn: 1.167 ± 0.041	3.313ThrPro: 3.313 ± 0.066	1.35ThrGln: 1.35 ± 0.038	3.602ThrArg: 3.602 ± 0.069	2.423ThrSer: 2.423 ± 0.059	2.535ThrThr: 2.535 ± 0.063	4.312ThrVal: 4.312 ± 0.09	0.673ThrTrp: 0.673 ± 0.031	1.171ThrTyr: 1.171 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	9.903ValAla: 9.903 ± 0.124	0.549ValCys: 0.549 ± 0.026	4.389ValAsp: 4.389 ± 0.083	4.509ValGlu: 4.509 ± 0.082	2.459ValPhe: 2.459 ± 0.063	5.717ValGly: 5.717 ± 0.101	1.406ValHis: 1.406 ± 0.041	3.761ValIle: 3.761 ± 0.074	1.806ValLys: 1.806 ± 0.053	6.993ValLeu: 6.993 ± 0.107	1.665ValMet: 1.665 ± 0.05	1.934ValAsn: 1.934 ± 0.054	4.324ValPro: 4.324 ± 0.071	1.986ValGln: 1.986 ± 0.051	5.406ValArg: 5.406 ± 0.089	3.969ValSer: 3.969 ± 0.084	4.658ValThr: 4.658 ± 0.102	5.451ValVal: 5.451 ± 0.104	0.913ValTrp: 0.913 ± 0.035	1.253ValTyr: 1.253 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.489TrpAla: 1.489 ± 0.044	0.135TrpCys: 0.135 ± 0.015	0.729TrpAsp: 0.729 ± 0.037	0.619TrpGlu: 0.619 ± 0.027	0.62TrpPhe: 0.62 ± 0.027	0.984TrpGly: 0.984 ± 0.036	0.351TrpHis: 0.351 ± 0.021	0.703TrpIle: 0.703 ± 0.031	0.394TrpLys: 0.394 ± 0.022	1.87TrpLeu: 1.87 ± 0.059	0.357TrpMet: 0.357 ± 0.021	0.427TrpAsn: 0.427 ± 0.02	0.687TrpPro: 0.687 ± 0.03	0.621TrpGln: 0.621 ± 0.025	1.376TrpArg: 1.376 ± 0.044	0.842TrpSer: 0.842 ± 0.031	0.753TrpThr: 0.753 ± 0.031	0.835TrpVal: 0.835 ± 0.032	0.255TrpTrp: 0.255 ± 0.017	0.285TrpTyr: 0.285 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.594TyrAla: 2.594 ± 0.055	0.239TyrCys: 0.239 ± 0.016	1.491TyrAsp: 1.491 ± 0.046	1.113TyrGlu: 1.113 ± 0.043	0.809TyrPhe: 0.809 ± 0.029	2.041TyrGly: 2.041 ± 0.059	0.446TyrHis: 0.446 ± 0.026	0.786TyrIle: 0.786 ± 0.032	0.47TyrLys: 0.47 ± 0.024	1.996TyrLeu: 1.996 ± 0.048	0.371TyrMet: 0.371 ± 0.023	0.53TyrAsn: 0.53 ± 0.026	1.03TyrPro: 1.03 ± 0.035	0.618TyrGln: 0.618 ± 0.029	1.809TyrArg: 1.809 ± 0.052	1.164TyrSer: 1.164 ± 0.043	1.051TyrThr: 1.051 ± 0.051	1.487TyrVal: 1.487 ± 0.045	0.297TyrTrp: 0.297 ± 0.019	0.57TyrTyr: 0.57 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2648 proteins (832301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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