Amino acid dipepetide frequency for Sphingobium ummariense RL-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.952AlaAla: 18.952 ± 0.18
1.073AlaCys: 1.073 ± 0.029
7.759AlaAsp: 7.759 ± 0.083
7.449AlaGlu: 7.449 ± 0.09
4.468AlaPhe: 4.468 ± 0.067
11.434AlaGly: 11.434 ± 0.105
2.416AlaHis: 2.416 ± 0.04
6.622AlaIle: 6.622 ± 0.066
3.951AlaLys: 3.951 ± 0.067
14.35AlaLeu: 14.35 ± 0.129
4.034AlaMet: 4.034 ± 0.055
3.018AlaAsn: 3.018 ± 0.06
6.238AlaPro: 6.238 ± 0.076
4.761AlaGln: 4.761 ± 0.066
9.961AlaArg: 9.961 ± 0.106
6.345AlaSer: 6.345 ± 0.08
6.339AlaThr: 6.339 ± 0.081
8.644AlaVal: 8.644 ± 0.087
1.741AlaTrp: 1.741 ± 0.036
2.719AlaTyr: 2.719 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.022CysAla: 1.022 ± 0.035
0.094CysCys: 0.094 ± 0.009
0.491CysAsp: 0.491 ± 0.019
0.37CysGlu: 0.37 ± 0.016
0.29CysPhe: 0.29 ± 0.014
0.852CysGly: 0.852 ± 0.027
0.21CysHis: 0.21 ± 0.012
0.358CysIle: 0.358 ± 0.018
0.16CysLys: 0.16 ± 0.011
0.702CysLeu: 0.702 ± 0.022
0.152CysMet: 0.152 ± 0.011
0.178CysAsn: 0.178 ± 0.013
0.441CysPro: 0.441 ± 0.019
0.199CysGln: 0.199 ± 0.012
0.575CysArg: 0.575 ± 0.023
0.422CysSer: 0.422 ± 0.019
0.388CysThr: 0.388 ± 0.019
0.558CysVal: 0.558 ± 0.022
0.129CysTrp: 0.129 ± 0.01
0.19CysTyr: 0.19 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.619AspAla: 7.619 ± 0.081
0.455AspCys: 0.455 ± 0.02
3.288AspAsp: 3.288 ± 0.053
3.283AspGlu: 3.283 ± 0.057
2.199AspPhe: 2.199 ± 0.038
5.632AspGly: 5.632 ± 0.063
1.352AspHis: 1.352 ± 0.033
3.132AspIle: 3.132 ± 0.049
1.665AspLys: 1.665 ± 0.037
5.767AspLeu: 5.767 ± 0.076
1.581AspMet: 1.581 ± 0.032
1.406AspAsn: 1.406 ± 0.039
3.956AspPro: 3.956 ± 0.059
1.835AspGln: 1.835 ± 0.04
5.168AspArg: 5.168 ± 0.081
2.394AspSer: 2.394 ± 0.038
2.489AspThr: 2.489 ± 0.047
3.983AspVal: 3.983 ± 0.054
1.128AspTrp: 1.128 ± 0.033
1.721AspTyr: 1.721 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.75GluAla: 7.75 ± 0.09
0.302GluCys: 0.302 ± 0.016
2.769GluAsp: 2.769 ± 0.052
3.25GluGlu: 3.25 ± 0.06
1.373GluPhe: 1.373 ± 0.033
4.798GluGly: 4.798 ± 0.054
1.018GluHis: 1.018 ± 0.024
2.826GluIle: 2.826 ± 0.046
1.971GluLys: 1.971 ± 0.038
4.781GluLeu: 4.781 ± 0.074
1.423GluMet: 1.423 ± 0.031
1.327GluAsn: 1.327 ± 0.027
2.538GluPro: 2.538 ± 0.044
2.166GluGln: 2.166 ± 0.043
5.019GluArg: 5.019 ± 0.083
2.326GluSer: 2.326 ± 0.043
2.971GluThr: 2.971 ± 0.049
3.378GluVal: 3.378 ± 0.053
0.752GluTrp: 0.752 ± 0.025
0.928GluTyr: 0.928 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.754PheAla: 4.754 ± 0.063
0.336PheCys: 0.336 ± 0.017
2.606PheAsp: 2.606 ± 0.049
1.867PheGlu: 1.867 ± 0.036
1.278PhePhe: 1.278 ± 0.035
3.53PheGly: 3.53 ± 0.062
0.725PheHis: 0.725 ± 0.023
1.425PheIle: 1.425 ± 0.036
0.843PheLys: 0.843 ± 0.028
3.283PheLeu: 3.283 ± 0.058
0.745PheMet: 0.745 ± 0.025
1.011PheAsn: 1.011 ± 0.032
1.59PhePro: 1.59 ± 0.035
0.94PheGln: 0.94 ± 0.026
2.372PheArg: 2.372 ± 0.042
2.015PheSer: 2.015 ± 0.041
1.966PheThr: 1.966 ± 0.042
2.455PheVal: 2.455 ± 0.049
0.526PheTrp: 0.526 ± 0.022
0.934PheTyr: 0.934 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
9.906GlyAla: 9.906 ± 0.103
0.809GlyCys: 0.809 ± 0.022
4.97GlyAsp: 4.97 ± 0.061
4.764GlyGlu: 4.764 ± 0.061
3.596GlyPhe: 3.596 ± 0.056
7.96GlyGly: 7.96 ± 0.106
1.927GlyHis: 1.927 ± 0.04
4.51GlyIle: 4.51 ± 0.057
3.265GlyLys: 3.265 ± 0.049
8.724GlyLeu: 8.724 ± 0.09
2.437GlyMet: 2.437 ± 0.043
2.25GlyAsn: 2.25 ± 0.06
3.579GlyPro: 3.579 ± 0.052
3.126GlyGln: 3.126 ± 0.056
6.865GlyArg: 6.865 ± 0.083
4.821GlySer: 4.821 ± 0.077
4.867GlyThr: 4.867 ± 0.072
6.227GlyVal: 6.227 ± 0.079
1.653GlyTrp: 1.653 ± 0.035
2.419GlyTyr: 2.419 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.458HisAla: 2.458 ± 0.046
0.227HisCys: 0.227 ± 0.014
1.203HisAsp: 1.203 ± 0.033
0.963HisGlu: 0.963 ± 0.024
0.869HisPhe: 0.869 ± 0.026
1.982HisGly: 1.982 ± 0.039
0.598HisHis: 0.598 ± 0.026
0.916HisIle: 0.916 ± 0.028
0.457HisLys: 0.457 ± 0.019
1.901HisLeu: 1.901 ± 0.039
0.494HisMet: 0.494 ± 0.02
0.446HisAsn: 0.446 ± 0.015
1.281HisPro: 1.281 ± 0.035
0.546HisGln: 0.546 ± 0.02
1.529HisArg: 1.529 ± 0.036
0.976HisSer: 0.976 ± 0.032
0.61HisThr: 0.61 ± 0.02
1.617HisVal: 1.617 ± 0.032
0.368HisTrp: 0.368 ± 0.017
0.611HisTyr: 0.611 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.704IleAla: 7.704 ± 0.082
0.417IleCys: 0.417 ± 0.016
3.893IleAsp: 3.893 ± 0.049
3.378IleGlu: 3.378 ± 0.049
1.601IlePhe: 1.601 ± 0.042
5.045IleGly: 5.045 ± 0.065
0.86IleHis: 0.86 ± 0.026
1.985IleIle: 1.985 ± 0.046
1.175IleLys: 1.175 ± 0.028
4.199IleLeu: 4.199 ± 0.064
0.915IleMet: 0.915 ± 0.023
1.31IleAsn: 1.31 ± 0.032
2.26IlePro: 2.26 ± 0.044
1.18IleGln: 1.18 ± 0.032
3.218IleArg: 3.218 ± 0.049
2.504IleSer: 2.504 ± 0.047
2.442IleThr: 2.442 ± 0.052
4.069IleVal: 4.069 ± 0.059
0.615IleTrp: 0.615 ± 0.021
1.037IleTyr: 1.037 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.328LysAla: 4.328 ± 0.069
0.143LysCys: 0.143 ± 0.01
1.647LysAsp: 1.647 ± 0.036
1.356LysGlu: 1.356 ± 0.034
0.754LysPhe: 0.754 ± 0.026
2.853LysGly: 2.853 ± 0.049
0.482LysHis: 0.482 ± 0.02
1.399LysIle: 1.399 ± 0.037
1.036LysLys: 1.036 ± 0.034
3.017LysLeu: 3.017 ± 0.053
0.704LysMet: 0.704 ± 0.024
0.686LysAsn: 0.686 ± 0.024
1.99LysPro: 1.99 ± 0.038
0.88LysGln: 0.88 ± 0.027
2.192LysArg: 2.192 ± 0.042
1.453LysSer: 1.453 ± 0.037
1.629LysThr: 1.629 ± 0.035
2.285LysVal: 2.285 ± 0.039
0.393LysTrp: 0.393 ± 0.019
0.561LysTyr: 0.561 ± 0.021
0.001LysXaa: 0.001 ± 0.001
Leu
14.065LeuAla: 14.065 ± 0.117
0.884LeuCys: 0.884 ± 0.026
6.127LeuAsp: 6.127 ± 0.077
4.791LeuGlu: 4.791 ± 0.073
3.761LeuPhe: 3.761 ± 0.06
8.158LeuGly: 8.158 ± 0.083
1.88LeuHis: 1.88 ± 0.039
4.758LeuIle: 4.758 ± 0.063
3.069LeuLys: 3.069 ± 0.047
10.111LeuLeu: 10.111 ± 0.132
2.189LeuMet: 2.189 ± 0.046
2.382LeuAsn: 2.382 ± 0.046
5.821LeuPro: 5.821 ± 0.074
2.527LeuGln: 2.527 ± 0.044
7.195LeuArg: 7.195 ± 0.092
6.218LeuSer: 6.218 ± 0.081
5.473LeuThr: 5.473 ± 0.064
7.038LeuVal: 7.038 ± 0.083
1.359LeuTrp: 1.359 ± 0.039
2.102LeuTyr: 2.102 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.463MetAla: 3.463 ± 0.048
0.132MetCys: 0.132 ± 0.01
1.233MetAsp: 1.233 ± 0.031
1.193MetGlu: 1.193 ± 0.032
0.605MetPhe: 0.605 ± 0.02
1.967MetGly: 1.967 ± 0.034
0.442MetHis: 0.442 ± 0.018
1.353MetIle: 1.353 ± 0.034
1.002MetLys: 1.002 ± 0.027
2.722MetLeu: 2.722 ± 0.041
0.682MetMet: 0.682 ± 0.028
0.676MetAsn: 0.676 ± 0.023
1.509MetPro: 1.509 ± 0.036
0.79MetGln: 0.79 ± 0.025
1.874MetArg: 1.874 ± 0.034
1.385MetSer: 1.385 ± 0.032
1.794MetThr: 1.794 ± 0.036
1.671MetVal: 1.671 ± 0.036
0.201MetTrp: 0.201 ± 0.013
0.258MetTyr: 0.258 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.227AsnAla: 3.227 ± 0.051
0.215AsnCys: 0.215 ± 0.012
1.353AsnAsp: 1.353 ± 0.036
1.078AsnGlu: 1.078 ± 0.029
0.941AsnPhe: 0.941 ± 0.03
2.539AsnGly: 2.539 ± 0.05
0.46AsnHis: 0.46 ± 0.017
1.352AsnIle: 1.352 ± 0.037
0.644AsnLys: 0.644 ± 0.025
2.394AsnLeu: 2.394 ± 0.038
0.552AsnMet: 0.552 ± 0.02
0.696AsnAsn: 0.696 ± 0.027
1.737AsnPro: 1.737 ± 0.037
0.797AsnGln: 0.797 ± 0.024
1.915AsnArg: 1.915 ± 0.04
1.261AsnSer: 1.261 ± 0.031
1.022AsnThr: 1.022 ± 0.031
1.784AsnVal: 1.784 ± 0.042
0.426AsnTrp: 0.426 ± 0.02
0.691AsnTyr: 0.691 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
7.211ProAla: 7.211 ± 0.084
0.321ProCys: 0.321 ± 0.014
3.942ProAsp: 3.942 ± 0.062
3.334ProGlu: 3.334 ± 0.05
1.988ProPhe: 1.988 ± 0.045
4.772ProGly: 4.772 ± 0.065
1.071ProHis: 1.071 ± 0.031
2.429ProIle: 2.429 ± 0.048
1.474ProLys: 1.474 ± 0.036
5.024ProLeu: 5.024 ± 0.068
1.312ProMet: 1.312 ± 0.034
1.258ProAsn: 1.258 ± 0.03
2.937ProPro: 2.937 ± 0.055
1.829ProGln: 1.829 ± 0.039
3.134ProArg: 3.134 ± 0.051
2.775ProSer: 2.775 ± 0.048
2.57ProThr: 2.57 ± 0.044
4.459ProVal: 4.459 ± 0.07
0.724ProTrp: 0.724 ± 0.026
1.133ProTyr: 1.133 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.598GlnAla: 4.598 ± 0.069
0.268GlnCys: 0.268 ± 0.016
1.576GlnAsp: 1.576 ± 0.037
1.418GlnGlu: 1.418 ± 0.035
1.041GlnPhe: 1.041 ± 0.029
2.717GlnGly: 2.717 ± 0.047
0.614GlnHis: 0.614 ± 0.021
1.751GlnIle: 1.751 ± 0.039
0.966GlnLys: 0.966 ± 0.029
3.046GlnLeu: 3.046 ± 0.049
0.867GlnMet: 0.867 ± 0.026
0.806GlnAsn: 0.806 ± 0.024
1.835GlnPro: 1.835 ± 0.038
1.251GlnGln: 1.251 ± 0.037
2.619GlnArg: 2.619 ± 0.043
1.718GlnSer: 1.718 ± 0.036
1.633GlnThr: 1.633 ± 0.037
2.293GlnVal: 2.293 ± 0.048
0.469GlnTrp: 0.469 ± 0.018
0.644GlnTyr: 0.644 ± 0.023
0.001GlnXaa: 0.001 ± 0.001
Arg
9.044ArgAla: 9.044 ± 0.09
0.505ArgCys: 0.505 ± 0.016
4.45ArgAsp: 4.45 ± 0.069
4.103ArgGlu: 4.103 ± 0.062
3.167ArgPhe: 3.167 ± 0.049
5.134ArgGly: 5.134 ± 0.06
1.838ArgHis: 1.838 ± 0.037
4.369ArgIle: 4.369 ± 0.054
2.196ArgLys: 2.196 ± 0.041
8.518ArgLeu: 8.518 ± 0.096
2.044ArgMet: 2.044 ± 0.04
1.908ArgAsn: 1.908 ± 0.043
3.912ArgPro: 3.912 ± 0.056
2.759ArgGln: 2.759 ± 0.05
6.177ArgArg: 6.177 ± 0.079
3.746ArgSer: 3.746 ± 0.063
3.675ArgThr: 3.675 ± 0.052
4.69ArgVal: 4.69 ± 0.065
1.318ArgTrp: 1.318 ± 0.037
2.063ArgTyr: 2.063 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.312SerAla: 6.312 ± 0.076
0.399SerCys: 0.399 ± 0.021
3.022SerAsp: 3.022 ± 0.051
2.429SerGlu: 2.429 ± 0.045
2.184SerPhe: 2.184 ± 0.045
5.236SerGly: 5.236 ± 0.064
0.964SerHis: 0.964 ± 0.026
2.704SerIle: 2.704 ± 0.046
1.371SerLys: 1.371 ± 0.034
5.205SerLeu: 5.205 ± 0.065
1.227SerMet: 1.227 ± 0.032
1.325SerAsn: 1.325 ± 0.029
2.895SerPro: 2.895 ± 0.044
1.522SerGln: 1.522 ± 0.031
3.631SerArg: 3.631 ± 0.059
2.706SerSer: 2.706 ± 0.054
2.604SerThr: 2.604 ± 0.051
3.699SerVal: 3.699 ± 0.051
0.806SerTrp: 0.806 ± 0.024
1.402SerTyr: 1.402 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.211ThrAla: 6.211 ± 0.076
0.36ThrCys: 0.36 ± 0.015
2.922ThrAsp: 2.922 ± 0.053
2.214ThrGlu: 2.214 ± 0.05
1.708ThrPhe: 1.708 ± 0.04
5.267ThrGly: 5.267 ± 0.074
0.954ThrHis: 0.954 ± 0.026
2.847ThrIle: 2.847 ± 0.051
1.27ThrLys: 1.27 ± 0.031
5.764ThrLeu: 5.764 ± 0.07
1.133ThrMet: 1.133 ± 0.028
1.28ThrAsn: 1.28 ± 0.036
3.385ThrPro: 3.385 ± 0.057
1.514ThrGln: 1.514 ± 0.032
3.432ThrArg: 3.432 ± 0.054
2.524ThrSer: 2.524 ± 0.052
2.592ThrThr: 2.592 ± 0.054
4.181ThrVal: 4.181 ± 0.06
0.581ThrTrp: 0.581 ± 0.023
1.152ThrTyr: 1.152 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
9.383ValAla: 9.383 ± 0.095
0.49ValCys: 0.49 ± 0.02
4.396ValAsp: 4.396 ± 0.057
4.577ValGlu: 4.577 ± 0.056
2.002ValPhe: 2.002 ± 0.041
5.536ValGly: 5.536 ± 0.073
1.35ValHis: 1.35 ± 0.036
3.524ValIle: 3.524 ± 0.055
2.188ValLys: 2.188 ± 0.044
6.457ValLeu: 6.457 ± 0.076
1.646ValMet: 1.646 ± 0.035
2.014ValAsn: 2.014 ± 0.039
3.983ValPro: 3.983 ± 0.059
2.149ValGln: 2.149 ± 0.045
5.274ValArg: 5.274 ± 0.072
3.905ValSer: 3.905 ± 0.054
4.426ValThr: 4.426 ± 0.058
5.158ValVal: 5.158 ± 0.068
0.84ValTrp: 0.84 ± 0.021
1.425ValTyr: 1.425 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.486TrpAla: 1.486 ± 0.035
0.125TrpCys: 0.125 ± 0.01
0.748TrpAsp: 0.748 ± 0.025
0.631TrpGlu: 0.631 ± 0.023
0.514TrpPhe: 0.514 ± 0.023
0.991TrpGly: 0.991 ± 0.026
0.357TrpHis: 0.357 ± 0.016
0.7TrpIle: 0.7 ± 0.024
0.49TrpLys: 0.49 ± 0.019
1.81TrpLeu: 1.81 ± 0.041
0.375TrpMet: 0.375 ± 0.015
0.471TrpAsn: 0.471 ± 0.017
0.745TrpPro: 0.745 ± 0.025
0.624TrpGln: 0.624 ± 0.022
1.382TrpArg: 1.382 ± 0.035
0.92TrpSer: 0.92 ± 0.027
0.851TrpThr: 0.851 ± 0.025
0.86TrpVal: 0.86 ± 0.028
0.264TrpTrp: 0.264 ± 0.015
0.316TrpTyr: 0.316 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.78TyrAla: 2.78 ± 0.044
0.226TyrCys: 0.226 ± 0.014
1.659TyrAsp: 1.659 ± 0.039
1.217TyrGlu: 1.217 ± 0.029
0.863TyrPhe: 0.863 ± 0.026
2.271TyrGly: 2.271 ± 0.053
0.535TyrHis: 0.535 ± 0.022
0.849TyrIle: 0.849 ± 0.024
0.594TyrLys: 0.594 ± 0.022
2.131TyrLeu: 2.131 ± 0.042
0.437TyrMet: 0.437 ± 0.017
0.639TyrAsn: 0.639 ± 0.023
1.062TyrPro: 1.062 ± 0.029
0.737TyrGln: 0.737 ± 0.025
2.085TyrArg: 2.085 ± 0.044
1.232TyrSer: 1.232 ± 0.024
0.951TyrThr: 0.951 ± 0.027
1.673TyrVal: 1.673 ± 0.036
0.368TyrTrp: 0.368 ± 0.019
0.687TyrTyr: 0.687 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.001
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4462 proteins (1346903 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski