Amino acid dipepetide frequency for Yoonia sediminilitoris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.32AlaAla: 15.32 ± 0.151	1.141AlaCys: 1.141 ± 0.03	7.387AlaAsp: 7.387 ± 0.095	6.985AlaGlu: 6.985 ± 0.086	4.364AlaPhe: 4.364 ± 0.062	9.957AlaGly: 9.957 ± 0.122	2.301AlaHis: 2.301 ± 0.047	6.363AlaIle: 6.363 ± 0.068	4.129AlaLys: 4.129 ± 0.069	12.493AlaLeu: 12.493 ± 0.122	3.709AlaMet: 3.709 ± 0.057	3.146AlaAsn: 3.146 ± 0.053	5.296AlaPro: 5.296 ± 0.075	4.793AlaGln: 4.793 ± 0.062	7.397AlaArg: 7.397 ± 0.085	5.59AlaSer: 5.59 ± 0.066	6.353AlaThr: 6.353 ± 0.088	8.068AlaVal: 8.068 ± 0.083	1.335AlaTrp: 1.335 ± 0.034	2.512AlaTyr: 2.512 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.141CysAla: 1.141 ± 0.031	0.123CysCys: 0.123 ± 0.01	0.679CysAsp: 0.679 ± 0.022	0.479CysGlu: 0.479 ± 0.02	0.367CysPhe: 0.367 ± 0.017	1.0CysGly: 1.0 ± 0.03	0.288CysHis: 0.288 ± 0.016	0.469CysIle: 0.469 ± 0.018	0.252CysLys: 0.252 ± 0.014	0.893CysLeu: 0.893 ± 0.028	0.212CysMet: 0.212 ± 0.013	0.269CysAsn: 0.269 ± 0.016	0.504CysPro: 0.504 ± 0.022	0.282CysGln: 0.282 ± 0.013	0.519CysArg: 0.519 ± 0.022	0.497CysSer: 0.497 ± 0.02	0.482CysThr: 0.482 ± 0.018	0.659CysVal: 0.659 ± 0.025	0.13CysTrp: 0.13 ± 0.009	0.244CysTyr: 0.244 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.769AspAla: 7.769 ± 0.087	0.566AspCys: 0.566 ± 0.024	3.924AspAsp: 3.924 ± 0.076	3.429AspGlu: 3.429 ± 0.056	2.434AspPhe: 2.434 ± 0.04	5.721AspGly: 5.721 ± 0.082	1.45AspHis: 1.45 ± 0.035	3.628AspIle: 3.628 ± 0.062	1.857AspLys: 1.857 ± 0.037	6.48AspLeu: 6.48 ± 0.076	1.821AspMet: 1.821 ± 0.038	1.598AspAsn: 1.598 ± 0.043	3.641AspPro: 3.641 ± 0.053	2.246AspGln: 2.246 ± 0.039	4.114AspArg: 4.114 ± 0.053	2.39AspSer: 2.39 ± 0.049	3.194AspThr: 3.194 ± 0.064	4.761AspVal: 4.761 ± 0.063	1.157AspTrp: 1.157 ± 0.034	1.637AspTyr: 1.637 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.533GluAla: 6.533 ± 0.077	0.361GluCys: 0.361 ± 0.017	2.99GluAsp: 2.99 ± 0.052	3.09GluGlu: 3.09 ± 0.055	1.758GluPhe: 1.758 ± 0.036	4.134GluGly: 4.134 ± 0.063	1.027GluHis: 1.027 ± 0.032	3.526GluIle: 3.526 ± 0.051	2.264GluLys: 2.264 ± 0.045	4.941GluLeu: 4.941 ± 0.067	1.736GluMet: 1.736 ± 0.036	1.978GluAsn: 1.978 ± 0.042	2.243GluPro: 2.243 ± 0.047	2.043GluGln: 2.043 ± 0.039	3.565GluArg: 3.565 ± 0.068	2.216GluSer: 2.216 ± 0.044	3.616GluThr: 3.616 ± 0.044	3.978GluVal: 3.978 ± 0.055	0.66GluTrp: 0.66 ± 0.024	1.022GluTyr: 1.022 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.598PheAla: 4.598 ± 0.06	0.474PheCys: 0.474 ± 0.017	3.041PheAsp: 3.041 ± 0.049	2.242PheGlu: 2.242 ± 0.045	1.524PhePhe: 1.524 ± 0.039	3.905PheGly: 3.905 ± 0.061	0.79PheHis: 0.79 ± 0.024	1.789PheIle: 1.789 ± 0.036	1.025PheLys: 1.025 ± 0.03	3.468PheLeu: 3.468 ± 0.055	0.922PheMet: 0.922 ± 0.028	1.156PheAsn: 1.156 ± 0.029	1.574PhePro: 1.574 ± 0.033	1.163PheGln: 1.163 ± 0.027	2.011PheArg: 2.011 ± 0.039	2.2PheSer: 2.2 ± 0.04	2.069PheThr: 2.069 ± 0.039	2.873PheVal: 2.873 ± 0.047	0.61PheTrp: 0.61 ± 0.028	0.971PheTyr: 0.971 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.172GlyAla: 9.172 ± 0.102	0.883GlyCys: 0.883 ± 0.024	4.866GlyAsp: 4.866 ± 0.081	4.133GlyGlu: 4.133 ± 0.067	3.714GlyPhe: 3.714 ± 0.055	7.01GlyGly: 7.01 ± 0.119	1.905GlyHis: 1.905 ± 0.042	4.706GlyIle: 4.706 ± 0.065	3.242GlyLys: 3.242 ± 0.059	8.764GlyLeu: 8.764 ± 0.082	2.571GlyMet: 2.571 ± 0.044	2.361GlyAsn: 2.361 ± 0.056	3.675GlyPro: 3.675 ± 0.054	3.393GlyGln: 3.393 ± 0.061	5.134GlyArg: 5.134 ± 0.057	4.286GlySer: 4.286 ± 0.076	4.908GlyThr: 4.908 ± 0.091	6.233GlyVal: 6.233 ± 0.075	1.392GlyTrp: 1.392 ± 0.031	2.349GlyTyr: 2.349 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.291HisAla: 2.291 ± 0.049	0.231HisCys: 0.231 ± 0.013	1.38HisAsp: 1.38 ± 0.033	1.033HisGlu: 1.033 ± 0.031	0.87HisPhe: 0.87 ± 0.023	1.817HisGly: 1.817 ± 0.037	0.583HisHis: 0.583 ± 0.025	1.093HisIle: 1.093 ± 0.03	0.611HisLys: 0.611 ± 0.022	2.06HisLeu: 2.06 ± 0.038	0.569HisMet: 0.569 ± 0.02	0.511HisAsn: 0.511 ± 0.015	1.336HisPro: 1.336 ± 0.033	0.689HisGln: 0.689 ± 0.025	1.238HisArg: 1.238 ± 0.031	0.908HisSer: 0.908 ± 0.028	0.903HisThr: 0.903 ± 0.028	1.579HisVal: 1.579 ± 0.038	0.348HisTrp: 0.348 ± 0.017	0.574HisTyr: 0.574 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.543IleAla: 7.543 ± 0.069	0.701IleCys: 0.701 ± 0.023	3.905IleAsp: 3.905 ± 0.066	3.3IleGlu: 3.3 ± 0.049	1.968IlePhe: 1.968 ± 0.04	5.161IleGly: 5.161 ± 0.071	0.963IleHis: 0.963 ± 0.026	2.883IleIle: 2.883 ± 0.051	1.851IleLys: 1.851 ± 0.036	4.901IleLeu: 4.901 ± 0.055	1.366IleMet: 1.366 ± 0.027	1.731IleAsn: 1.731 ± 0.049	2.408IlePro: 2.408 ± 0.044	1.31IleGln: 1.31 ± 0.028	3.006IleArg: 3.006 ± 0.05	3.288IleSer: 3.288 ± 0.049	3.356IleThr: 3.356 ± 0.057	4.085IleVal: 4.085 ± 0.059	0.791IleTrp: 0.791 ± 0.024	1.354IleTyr: 1.354 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.046LysAla: 4.046 ± 0.058	0.214LysCys: 0.214 ± 0.011	1.944LysAsp: 1.944 ± 0.036	1.601LysGlu: 1.601 ± 0.039	1.007LysPhe: 1.007 ± 0.026	2.789LysGly: 2.789 ± 0.046	0.679LysHis: 0.679 ± 0.025	1.848LysIle: 1.848 ± 0.038	1.249LysLys: 1.249 ± 0.038	3.186LysLeu: 3.186 ± 0.057	0.983LysMet: 0.983 ± 0.024	0.912LysAsn: 0.912 ± 0.028	1.95LysPro: 1.95 ± 0.045	1.128LysGln: 1.128 ± 0.031	2.307LysArg: 2.307 ± 0.048	2.127LysSer: 2.127 ± 0.038	2.128LysThr: 2.128 ± 0.039	2.38LysVal: 2.38 ± 0.041	0.457LysTrp: 0.457 ± 0.018	0.691LysTyr: 0.691 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	11.728LeuAla: 11.728 ± 0.107	1.02LeuCys: 1.02 ± 0.028	6.046LeuAsp: 6.046 ± 0.072	4.954LeuGlu: 4.954 ± 0.069	3.594LeuPhe: 3.594 ± 0.067	8.078LeuGly: 8.078 ± 0.093	1.866LeuHis: 1.866 ± 0.038	5.519LeuIle: 5.519 ± 0.064	3.092LeuLys: 3.092 ± 0.054	8.719LeuLeu: 8.719 ± 0.112	2.676LeuMet: 2.676 ± 0.049	2.911LeuAsn: 2.911 ± 0.05	5.199LeuPro: 5.199 ± 0.068	3.149LeuGln: 3.149 ± 0.05	6.711LeuArg: 6.711 ± 0.078	6.558LeuSer: 6.558 ± 0.081	6.064LeuThr: 6.064 ± 0.081	6.52LeuVal: 6.52 ± 0.072	1.223LeuTrp: 1.223 ± 0.032	1.822LeuTyr: 1.822 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.371MetAla: 3.371 ± 0.049	0.214MetCys: 0.214 ± 0.011	1.479MetAsp: 1.479 ± 0.035	1.298MetGlu: 1.298 ± 0.033	0.911MetPhe: 0.911 ± 0.025	2.234MetGly: 2.234 ± 0.043	0.531MetHis: 0.531 ± 0.021	1.793MetIle: 1.793 ± 0.034	1.121MetLys: 1.121 ± 0.028	2.619MetLeu: 2.619 ± 0.052	0.839MetMet: 0.839 ± 0.025	0.99MetAsn: 0.99 ± 0.023	1.552MetPro: 1.552 ± 0.035	1.074MetGln: 1.074 ± 0.027	1.902MetArg: 1.902 ± 0.036	1.811MetSer: 1.811 ± 0.037	2.218MetThr: 2.218 ± 0.043	1.875MetVal: 1.875 ± 0.04	0.278MetTrp: 0.278 ± 0.015	0.359MetTyr: 0.359 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.58AsnAla: 3.58 ± 0.065	0.301AsnCys: 0.301 ± 0.015	1.827AsnAsp: 1.827 ± 0.043	1.285AsnGlu: 1.285 ± 0.033	1.075AsnPhe: 1.075 ± 0.032	2.685AsnGly: 2.685 ± 0.055	0.569AsnHis: 0.569 ± 0.021	1.678AsnIle: 1.678 ± 0.043	0.831AsnLys: 0.831 ± 0.026	2.832AsnLeu: 2.832 ± 0.048	0.838AsnMet: 0.838 ± 0.025	0.868AsnAsn: 0.868 ± 0.028	1.994AsnPro: 1.994 ± 0.038	0.892AsnGln: 0.892 ± 0.026	1.791AsnArg: 1.791 ± 0.033	1.437AsnSer: 1.437 ± 0.043	1.505AsnThr: 1.505 ± 0.041	2.085AsnVal: 2.085 ± 0.045	0.501AsnTrp: 0.501 ± 0.021	0.737AsnTyr: 0.737 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.446ProAla: 5.446 ± 0.075	0.389ProCys: 0.389 ± 0.018	4.159ProAsp: 4.159 ± 0.062	3.344ProGlu: 3.344 ± 0.06	2.033ProPhe: 2.033 ± 0.039	3.891ProGly: 3.891 ± 0.059	1.068ProHis: 1.068 ± 0.029	2.457ProIle: 2.457 ± 0.044	1.794ProLys: 1.794 ± 0.04	4.483ProLeu: 4.483 ± 0.057	1.332ProMet: 1.332 ± 0.034	1.461ProAsn: 1.461 ± 0.033	2.217ProPro: 2.217 ± 0.047	1.824ProGln: 1.824 ± 0.038	2.5ProArg: 2.5 ± 0.048	2.507ProSer: 2.507 ± 0.044	2.659ProThr: 2.659 ± 0.044	4.066ProVal: 4.066 ± 0.054	0.666ProTrp: 0.666 ± 0.02	1.149ProTyr: 1.149 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.183GlnAla: 4.183 ± 0.067	0.239GlnCys: 0.239 ± 0.013	1.945GlnAsp: 1.945 ± 0.044	1.713GlnGlu: 1.713 ± 0.036	1.269GlnPhe: 1.269 ± 0.027	2.683GlnGly: 2.683 ± 0.047	0.661GlnHis: 0.661 ± 0.022	2.327GlnIle: 2.327 ± 0.046	1.22GlnLys: 1.22 ± 0.033	3.235GlnLeu: 3.235 ± 0.05	1.221GlnMet: 1.221 ± 0.028	1.09GlnAsn: 1.09 ± 0.03	1.691GlnPro: 1.691 ± 0.033	1.296GlnGln: 1.296 ± 0.039	2.226GlnArg: 2.226 ± 0.043	2.173GlnSer: 2.173 ± 0.043	2.3GlnThr: 2.3 ± 0.043	2.499GlnVal: 2.499 ± 0.044	0.453GlnTrp: 0.453 ± 0.018	0.691GlnTyr: 0.691 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	6.925ArgAla: 6.925 ± 0.075	0.509ArgCys: 0.509 ± 0.02	4.09ArgAsp: 4.09 ± 0.055	3.242ArgGlu: 3.242 ± 0.053	2.58ArgPhe: 2.58 ± 0.046	4.084ArgGly: 4.084 ± 0.054	1.452ArgHis: 1.452 ± 0.034	3.725ArgIle: 3.725 ± 0.052	2.377ArgLys: 2.377 ± 0.046	6.381ArgLeu: 6.381 ± 0.077	1.818ArgMet: 1.818 ± 0.036	1.948ArgAsn: 1.948 ± 0.041	2.936ArgPro: 2.936 ± 0.052	2.329ArgGln: 2.329 ± 0.036	4.217ArgArg: 4.217 ± 0.07	3.192ArgSer: 3.192 ± 0.05	3.125ArgThr: 3.125 ± 0.04	4.245ArgVal: 4.245 ± 0.06	0.909ArgTrp: 0.909 ± 0.025	1.523ArgTyr: 1.523 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.855SerAla: 5.855 ± 0.068	0.476SerCys: 0.476 ± 0.02	3.636SerAsp: 3.636 ± 0.061	2.858SerGlu: 2.858 ± 0.055	2.386SerPhe: 2.386 ± 0.045	5.401SerGly: 5.401 ± 0.07	1.11SerHis: 1.11 ± 0.025	2.743SerIle: 2.743 ± 0.041	1.669SerLys: 1.669 ± 0.037	5.106SerLeu: 5.106 ± 0.062	1.437SerMet: 1.437 ± 0.029	1.601SerAsn: 1.601 ± 0.041	2.605SerPro: 2.605 ± 0.048	1.804SerGln: 1.804 ± 0.041	3.094SerArg: 3.094 ± 0.06	2.655SerSer: 2.655 ± 0.056	2.707SerThr: 2.707 ± 0.052	3.942SerVal: 3.942 ± 0.067	0.694SerTrp: 0.694 ± 0.021	1.381SerTyr: 1.381 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.434ThrAla: 6.434 ± 0.083	0.557ThrCys: 0.557 ± 0.022	3.675ThrAsp: 3.675 ± 0.056	2.859ThrGlu: 2.859 ± 0.045	2.165ThrPhe: 2.165 ± 0.039	5.417ThrGly: 5.417 ± 0.078	1.225ThrHis: 1.225 ± 0.03	3.194ThrIle: 3.194 ± 0.061	1.763ThrLys: 1.763 ± 0.031	6.06ThrLeu: 6.06 ± 0.074	1.381ThrMet: 1.381 ± 0.035	1.609ThrAsn: 1.609 ± 0.051	3.315ThrPro: 3.315 ± 0.058	1.895ThrGln: 1.895 ± 0.039	3.271ThrArg: 3.271 ± 0.046	3.007ThrSer: 3.007 ± 0.057	3.171ThrThr: 3.171 ± 0.059	4.516ThrVal: 4.516 ± 0.074	0.694ThrTrp: 0.694 ± 0.025	1.375ThrTyr: 1.375 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.739ValAla: 8.739 ± 0.085	0.695ValCys: 0.695 ± 0.024	4.293ValAsp: 4.293 ± 0.063	4.011ValGlu: 4.011 ± 0.051	2.837ValPhe: 2.837 ± 0.044	5.623ValGly: 5.623 ± 0.074	1.285ValHis: 1.285 ± 0.032	4.396ValIle: 4.396 ± 0.06	2.177ValLys: 2.177 ± 0.046	6.942ValLeu: 6.942 ± 0.08	2.124ValMet: 2.124 ± 0.041	2.088ValAsn: 2.088 ± 0.043	3.535ValPro: 3.535 ± 0.057	2.36ValGln: 2.36 ± 0.038	4.151ValArg: 4.151 ± 0.049	4.346ValSer: 4.346 ± 0.068	4.882ValThr: 4.882 ± 0.075	5.477ValVal: 5.477 ± 0.067	1.008ValTrp: 1.008 ± 0.031	1.412ValTyr: 1.412 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.365TrpAla: 1.365 ± 0.036	0.14TrpCys: 0.14 ± 0.01	0.866TrpAsp: 0.866 ± 0.027	0.641TrpGlu: 0.641 ± 0.023	0.593TrpPhe: 0.593 ± 0.021	1.017TrpGly: 1.017 ± 0.03	0.358TrpHis: 0.358 ± 0.016	0.749TrpIle: 0.749 ± 0.023	0.465TrpLys: 0.465 ± 0.017	1.541TrpLeu: 1.541 ± 0.038	0.408TrpMet: 0.408 ± 0.017	0.439TrpAsn: 0.439 ± 0.021	0.675TrpPro: 0.675 ± 0.025	0.638TrpGln: 0.638 ± 0.023	0.961TrpArg: 0.961 ± 0.026	0.757TrpSer: 0.757 ± 0.024	0.815TrpThr: 0.815 ± 0.024	0.932TrpVal: 0.932 ± 0.027	0.226TrpTrp: 0.226 ± 0.012	0.309TrpTyr: 0.309 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.6TyrAla: 2.6 ± 0.04	0.256TyrCys: 0.256 ± 0.014	1.686TyrAsp: 1.686 ± 0.038	1.181TyrGlu: 1.181 ± 0.03	0.959TyrPhe: 0.959 ± 0.026	2.089TyrGly: 2.089 ± 0.039	0.512TyrHis: 0.512 ± 0.019	0.985TyrIle: 0.985 ± 0.026	0.634TyrLys: 0.634 ± 0.021	2.344TyrLeu: 2.344 ± 0.046	0.505TyrMet: 0.505 ± 0.019	0.646TyrAsn: 0.646 ± 0.025	1.098TyrPro: 1.098 ± 0.032	0.808TyrGln: 0.808 ± 0.03	1.493TyrArg: 1.493 ± 0.035	1.217TyrSer: 1.217 ± 0.025	1.131TyrThr: 1.131 ± 0.027	1.607TyrVal: 1.607 ± 0.042	0.361TyrTrp: 0.361 ± 0.014	0.627TyrTyr: 0.627 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4606 proteins (1395618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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