Amino acid dipepetide frequency for Faecalicoccus pleomorphus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.238AlaAla: 4.238 ± 0.107
1.275AlaCys: 1.275 ± 0.046
3.219AlaAsp: 3.219 ± 0.087
2.636AlaGlu: 2.636 ± 0.07
3.072AlaPhe: 3.072 ± 0.073
4.541AlaGly: 4.541 ± 0.11
1.46AlaHis: 1.46 ± 0.052
5.504AlaIle: 5.504 ± 0.113
4.899AlaLys: 4.899 ± 0.092
7.302AlaLeu: 7.302 ± 0.121
2.146AlaMet: 2.146 ± 0.066
2.767AlaAsn: 2.767 ± 0.071
1.772AlaPro: 1.772 ± 0.058
3.042AlaGln: 3.042 ± 0.076
2.55AlaArg: 2.55 ± 0.072
4.095AlaSer: 4.095 ± 0.081
3.072AlaThr: 3.072 ± 0.093
3.958AlaVal: 3.958 ± 0.1
0.534AlaTrp: 0.534 ± 0.036
2.925AlaTyr: 2.925 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.14CysAla: 1.14 ± 0.036
0.246CysCys: 0.246 ± 0.021
0.897CysAsp: 0.897 ± 0.04
0.778CysGlu: 0.778 ± 0.037
0.798CysPhe: 0.798 ± 0.039
1.199CysGly: 1.199 ± 0.05
0.441CysHis: 0.441 ± 0.031
1.336CysIle: 1.336 ± 0.051
0.946CysLys: 0.946 ± 0.043
1.488CysLeu: 1.488 ± 0.054
0.525CysMet: 0.525 ± 0.031
0.514CysAsn: 0.514 ± 0.03
0.69CysPro: 0.69 ± 0.035
0.616CysGln: 0.616 ± 0.03
0.545CysArg: 0.545 ± 0.028
1.032CysSer: 1.032 ± 0.038
0.908CysThr: 0.908 ± 0.038
1.019CysVal: 1.019 ± 0.048
0.127CysTrp: 0.127 ± 0.015
0.472CysTyr: 0.472 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.2AspAla: 4.2 ± 0.087
0.877AspCys: 0.877 ± 0.04
2.689AspAsp: 2.689 ± 0.084
4.402AspGlu: 4.402 ± 0.104
2.935AspPhe: 2.935 ± 0.08
3.759AspGly: 3.759 ± 0.125
1.387AspHis: 1.387 ± 0.053
4.44AspIle: 4.44 ± 0.084
3.464AspLys: 3.464 ± 0.077
5.659AspLeu: 5.659 ± 0.093
1.62AspMet: 1.62 ± 0.05
1.741AspAsn: 1.741 ± 0.061
2.339AspPro: 2.339 ± 0.062
2.689AspGln: 2.689 ± 0.072
2.18AspArg: 2.18 ± 0.06
3.074AspSer: 3.074 ± 0.087
3.404AspThr: 3.404 ± 0.086
4.113AspVal: 4.113 ± 0.081
0.623AspTrp: 0.623 ± 0.036
2.724AspTyr: 2.724 ± 0.081
0.0AspXaa: 0.0 ± 0.0
Glu
4.603GluAla: 4.603 ± 0.104
0.849GluCys: 0.849 ± 0.038
4.418GluAsp: 4.418 ± 0.106
6.46GluGlu: 6.46 ± 0.134
2.354GluPhe: 2.354 ± 0.067
3.647GluGly: 3.647 ± 0.099
1.511GluHis: 1.511 ± 0.051
5.418GluIle: 5.418 ± 0.104
6.391GluLys: 6.391 ± 0.119
5.708GluLeu: 5.708 ± 0.101
2.278GluMet: 2.278 ± 0.062
4.304GluAsn: 4.304 ± 0.091
1.766GluPro: 1.766 ± 0.067
3.218GluGln: 3.218 ± 0.082
2.486GluArg: 2.486 ± 0.07
3.374GluSer: 3.374 ± 0.072
3.553GluThr: 3.553 ± 0.077
4.374GluVal: 4.374 ± 0.104
0.616GluTrp: 0.616 ± 0.038
2.661GluTyr: 2.661 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
2.659PheAla: 2.659 ± 0.068
0.722PheCys: 0.722 ± 0.031
3.158PheAsp: 3.158 ± 0.07
2.948PheGlu: 2.948 ± 0.067
2.137PhePhe: 2.137 ± 0.081
3.028PheGly: 3.028 ± 0.073
1.014PheHis: 1.014 ± 0.041
3.183PheIle: 3.183 ± 0.088
2.418PheLys: 2.418 ± 0.065
4.334PheLeu: 4.334 ± 0.106
1.278PheMet: 1.278 ± 0.051
1.642PheAsn: 1.642 ± 0.055
1.191PhePro: 1.191 ± 0.047
1.619PheGln: 1.619 ± 0.067
1.302PheArg: 1.302 ± 0.05
3.137PheSer: 3.137 ± 0.086
2.453PheThr: 2.453 ± 0.066
3.26PheVal: 3.26 ± 0.085
0.398PheTrp: 0.398 ± 0.025
1.776PheTyr: 1.776 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
4.055GlyAla: 4.055 ± 0.101
1.196GlyCys: 1.196 ± 0.046
3.001GlyAsp: 3.001 ± 0.099
2.95GlyGlu: 2.95 ± 0.08
3.145GlyPhe: 3.145 ± 0.074
3.867GlyGly: 3.867 ± 0.114
1.292GlyHis: 1.292 ± 0.052
5.765GlyIle: 5.765 ± 0.112
4.873GlyLys: 4.873 ± 0.107
5.817GlyLeu: 5.817 ± 0.103
2.238GlyMet: 2.238 ± 0.068
2.717GlyAsn: 2.717 ± 0.075
1.343GlyPro: 1.343 ± 0.043
2.329GlyGln: 2.329 ± 0.066
2.099GlyArg: 2.099 ± 0.081
3.754GlySer: 3.754 ± 0.077
3.698GlyThr: 3.698 ± 0.107
4.43GlyVal: 4.43 ± 0.092
0.712GlyTrp: 0.712 ± 0.057
3.15GlyTyr: 3.15 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.414HisAla: 1.414 ± 0.047
0.41HisCys: 0.41 ± 0.027
1.141HisAsp: 1.141 ± 0.041
1.269HisGlu: 1.269 ± 0.043
1.064HisPhe: 1.064 ± 0.04
1.435HisGly: 1.435 ± 0.05
0.638HisHis: 0.638 ± 0.033
1.761HisIle: 1.761 ± 0.063
1.207HisLys: 1.207 ± 0.047
2.055HisLeu: 2.055 ± 0.06
0.608HisMet: 0.608 ± 0.034
0.74HisAsn: 0.74 ± 0.037
1.136HisPro: 1.136 ± 0.043
1.074HisGln: 1.074 ± 0.045
0.97HisArg: 0.97 ± 0.037
1.173HisSer: 1.173 ± 0.043
1.278HisThr: 1.278 ± 0.048
1.534HisVal: 1.534 ± 0.053
0.195HisTrp: 0.195 ± 0.017
0.899HisTyr: 0.899 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.345IleAla: 5.345 ± 0.105
1.417IleCys: 1.417 ± 0.053
5.01IleAsp: 5.01 ± 0.105
5.769IleGlu: 5.769 ± 0.092
3.199IlePhe: 3.199 ± 0.083
5.043IleGly: 5.043 ± 0.108
1.994IleHis: 1.994 ± 0.059
4.782IleIle: 4.782 ± 0.113
4.276IleLys: 4.276 ± 0.08
8.254IleLeu: 8.254 ± 0.184
1.79IleMet: 1.79 ± 0.067
2.971IleAsn: 2.971 ± 0.078
3.095IlePro: 3.095 ± 0.078
4.048IleGln: 4.048 ± 0.086
3.166IleArg: 3.166 ± 0.08
4.96IleSer: 4.96 ± 0.101
3.916IleThr: 3.916 ± 0.088
5.565IleVal: 5.565 ± 0.114
0.563IleTrp: 0.563 ± 0.033
2.94IleTyr: 2.94 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.972LysAla: 4.972 ± 0.096
0.643LysCys: 0.643 ± 0.036
4.868LysAsp: 4.868 ± 0.106
8.44LysGlu: 8.44 ± 0.136
1.599LysPhe: 1.599 ± 0.056
4.223LysGly: 4.223 ± 0.084
1.288LysHis: 1.288 ± 0.049
5.17LysIle: 5.17 ± 0.098
6.784LysLys: 6.784 ± 0.123
5.039LysLeu: 5.039 ± 0.082
2.302LysMet: 2.302 ± 0.071
3.68LysAsn: 3.68 ± 0.077
2.269LysPro: 2.269 ± 0.071
3.054LysGln: 3.054 ± 0.075
3.156LysArg: 3.156 ± 0.08
3.416LysSer: 3.416 ± 0.077
4.133LysThr: 4.133 ± 0.092
4.61LysVal: 4.61 ± 0.107
0.563LysTrp: 0.563 ± 0.032
2.494LysTyr: 2.494 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
6.125LeuAla: 6.125 ± 0.123
1.675LeuCys: 1.675 ± 0.057
5.646LeuAsp: 5.646 ± 0.096
6.775LeuGlu: 6.775 ± 0.129
4.4LeuPhe: 4.4 ± 0.111
5.495LeuGly: 5.495 ± 0.116
2.126LeuHis: 2.126 ± 0.063
6.779LeuIle: 6.779 ± 0.155
7.137LeuLys: 7.137 ± 0.112
8.957LeuLeu: 8.957 ± 0.16
2.831LeuMet: 2.831 ± 0.073
3.926LeuAsn: 3.926 ± 0.074
3.35LeuPro: 3.35 ± 0.078
4.21LeuGln: 4.21 ± 0.092
3.361LeuArg: 3.361 ± 0.077
6.744LeuSer: 6.744 ± 0.119
4.39LeuThr: 4.39 ± 0.101
5.892LeuVal: 5.892 ± 0.115
0.813LeuTrp: 0.813 ± 0.039
3.632LeuTyr: 3.632 ± 0.102
0.0LeuXaa: 0.0 ± 0.0
Met
2.344MetAla: 2.344 ± 0.056
0.34MetCys: 0.34 ± 0.025
2.184MetAsp: 2.184 ± 0.057
2.476MetGlu: 2.476 ± 0.06
0.96MetPhe: 0.96 ± 0.04
1.746MetGly: 1.746 ± 0.057
0.657MetHis: 0.657 ± 0.032
2.525MetIle: 2.525 ± 0.062
2.63MetLys: 2.63 ± 0.063
2.507MetLeu: 2.507 ± 0.073
1.021MetMet: 1.021 ± 0.048
1.612MetAsn: 1.612 ± 0.049
1.145MetPro: 1.145 ± 0.042
1.297MetGln: 1.297 ± 0.046
1.143MetArg: 1.143 ± 0.045
1.688MetSer: 1.688 ± 0.054
1.487MetThr: 1.487 ± 0.053
1.873MetVal: 1.873 ± 0.062
0.164MetTrp: 0.164 ± 0.02
0.932MetTyr: 0.932 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.201AsnAla: 3.201 ± 0.083
0.573AsnCys: 0.573 ± 0.031
2.474AsnAsp: 2.474 ± 0.074
3.145AsnGlu: 3.145 ± 0.073
1.544AsnPhe: 1.544 ± 0.058
3.112AsnGly: 3.112 ± 0.077
1.021AsnHis: 1.021 ± 0.043
3.272AsnIle: 3.272 ± 0.071
2.848AsnLys: 2.848 ± 0.066
3.901AsnLeu: 3.901 ± 0.079
1.32AsnMet: 1.32 ± 0.048
1.716AsnAsn: 1.716 ± 0.078
1.853AsnPro: 1.853 ± 0.057
2.045AsnGln: 2.045 ± 0.068
1.807AsnArg: 1.807 ± 0.052
2.208AsnSer: 2.208 ± 0.063
2.575AsnThr: 2.575 ± 0.08
3.097AsnVal: 3.097 ± 0.074
0.454AsnTrp: 0.454 ± 0.03
1.734AsnTyr: 1.734 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
1.913ProAla: 1.913 ± 0.072
0.527ProCys: 0.527 ± 0.035
2.071ProAsp: 2.071 ± 0.064
2.712ProGlu: 2.712 ± 0.066
1.672ProPhe: 1.672 ± 0.055
1.977ProGly: 1.977 ± 0.06
0.581ProHis: 0.581 ± 0.031
2.559ProIle: 2.559 ± 0.059
2.127ProLys: 2.127 ± 0.067
2.905ProLeu: 2.905 ± 0.062
0.951ProMet: 0.951 ± 0.041
1.521ProAsn: 1.521 ± 0.043
0.52ProPro: 0.52 ± 0.035
1.189ProGln: 1.189 ± 0.05
0.97ProArg: 0.97 ± 0.039
2.035ProSer: 2.035 ± 0.066
1.711ProThr: 1.711 ± 0.063
2.674ProVal: 2.674 ± 0.077
0.284ProTrp: 0.284 ± 0.023
1.553ProTyr: 1.553 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
3.08GlnAla: 3.08 ± 0.075
0.553GlnCys: 0.553 ± 0.036
2.582GlnAsp: 2.582 ± 0.073
3.644GlnGlu: 3.644 ± 0.087
1.582GlnPhe: 1.582 ± 0.053
2.598GlnGly: 2.598 ± 0.074
0.695GlnHis: 0.695 ± 0.035
3.597GlnIle: 3.597 ± 0.076
4.181GlnLys: 4.181 ± 0.081
3.366GlnLeu: 3.366 ± 0.091
1.371GlnMet: 1.371 ± 0.046
2.387GlnAsn: 2.387 ± 0.068
1.12GlnPro: 1.12 ± 0.049
1.685GlnGln: 1.685 ± 0.062
1.825GlnArg: 1.825 ± 0.06
2.502GlnSer: 2.502 ± 0.07
2.243GlnThr: 2.243 ± 0.064
2.573GlnVal: 2.573 ± 0.062
0.355GlnTrp: 0.355 ± 0.024
1.724GlnTyr: 1.724 ± 0.072
0.0GlnXaa: 0.0 ± 0.0
Arg
2.01ArgAla: 2.01 ± 0.065
0.553ArgCys: 0.553 ± 0.03
1.822ArgAsp: 1.822 ± 0.059
2.497ArgGlu: 2.497 ± 0.069
1.842ArgPhe: 1.842 ± 0.056
1.918ArgGly: 1.918 ± 0.059
0.839ArgHis: 0.839 ± 0.04
3.444ArgIle: 3.444 ± 0.081
3.376ArgLys: 3.376 ± 0.089
3.718ArgLeu: 3.718 ± 0.087
1.407ArgMet: 1.407 ± 0.053
1.795ArgAsn: 1.795 ± 0.065
1.098ArgPro: 1.098 ± 0.037
1.703ArgGln: 1.703 ± 0.061
1.516ArgArg: 1.516 ± 0.057
2.005ArgSer: 2.005 ± 0.06
1.739ArgThr: 1.739 ± 0.057
2.218ArgVal: 2.218 ± 0.072
0.339ArgTrp: 0.339 ± 0.025
1.764ArgTyr: 1.764 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.487SerAla: 3.487 ± 0.072
0.923SerCys: 0.923 ± 0.044
3.138SerAsp: 3.138 ± 0.085
2.976SerGlu: 2.976 ± 0.078
3.336SerPhe: 3.336 ± 0.079
4.058SerGly: 4.058 ± 0.089
1.252SerHis: 1.252 ± 0.046
5.18SerIle: 5.18 ± 0.1
4.266SerLys: 4.266 ± 0.098
6.31SerLeu: 6.31 ± 0.119
2.084SerMet: 2.084 ± 0.055
2.654SerAsn: 2.654 ± 0.077
1.536SerPro: 1.536 ± 0.051
2.412SerGln: 2.412 ± 0.07
2.088SerArg: 2.088 ± 0.063
3.72SerSer: 3.72 ± 0.088
2.996SerThr: 2.996 ± 0.07
4.121SerVal: 4.121 ± 0.086
0.601SerTrp: 0.601 ± 0.036
2.568SerTyr: 2.568 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
2.966ThrAla: 2.966 ± 0.092
0.773ThrCys: 0.773 ± 0.039
2.684ThrAsp: 2.684 ± 0.09
2.826ThrGlu: 2.826 ± 0.077
2.42ThrPhe: 2.42 ± 0.071
3.746ThrGly: 3.746 ± 0.083
1.135ThrHis: 1.135 ± 0.046
4.759ThrIle: 4.759 ± 0.098
3.768ThrLys: 3.768 ± 0.081
5.327ThrLeu: 5.327 ± 0.096
1.653ThrMet: 1.653 ± 0.05
2.304ThrAsn: 2.304 ± 0.072
2.063ThrPro: 2.063 ± 0.066
2.01ThrGln: 2.01 ± 0.055
1.85ThrArg: 1.85 ± 0.057
3.341ThrSer: 3.341 ± 0.083
2.996ThrThr: 2.996 ± 0.086
3.497ThrVal: 3.497 ± 0.084
0.547ThrTrp: 0.547 ± 0.036
2.34ThrTyr: 2.34 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
3.953ValAla: 3.953 ± 0.101
1.411ValCys: 1.411 ± 0.045
3.986ValAsp: 3.986 ± 0.093
4.278ValGlu: 4.278 ± 0.096
3.138ValPhe: 3.138 ± 0.066
3.822ValGly: 3.822 ± 0.099
1.47ValHis: 1.47 ± 0.053
4.911ValIle: 4.911 ± 0.1
3.996ValLys: 3.996 ± 0.087
7.147ValLeu: 7.147 ± 0.125
1.895ValMet: 1.895 ± 0.052
2.76ValAsn: 2.76 ± 0.072
2.342ValPro: 2.342 ± 0.089
2.907ValGln: 2.907 ± 0.072
2.507ValArg: 2.507 ± 0.064
4.593ValSer: 4.593 ± 0.088
3.576ValThr: 3.576 ± 0.101
4.694ValVal: 4.694 ± 0.111
0.543ValTrp: 0.543 ± 0.028
2.748ValTyr: 2.748 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.031
0.126TrpCys: 0.126 ± 0.014
0.532TrpAsp: 0.532 ± 0.031
0.467TrpGlu: 0.467 ± 0.03
0.439TrpPhe: 0.439 ± 0.028
0.497TrpGly: 0.497 ± 0.031
0.193TrpHis: 0.193 ± 0.018
0.948TrpIle: 0.948 ± 0.045
0.621TrpLys: 0.621 ± 0.035
0.854TrpLeu: 0.854 ± 0.038
0.372TrpMet: 0.372 ± 0.024
0.55TrpAsn: 0.55 ± 0.031
0.223TrpPro: 0.223 ± 0.019
0.415TrpGln: 0.415 ± 0.033
0.253TrpArg: 0.253 ± 0.019
0.492TrpSer: 0.492 ± 0.028
0.467TrpThr: 0.467 ± 0.03
0.492TrpVal: 0.492 ± 0.03
0.106TrpTrp: 0.106 ± 0.014
0.319TrpTyr: 0.319 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.775TyrAla: 2.775 ± 0.069
0.631TyrCys: 0.631 ± 0.031
2.8TyrAsp: 2.8 ± 0.074
2.539TyrGlu: 2.539 ± 0.07
2.02TyrPhe: 2.02 ± 0.063
2.72TyrGly: 2.72 ± 0.072
1.004TyrHis: 1.004 ± 0.04
2.775TyrIle: 2.775 ± 0.087
2.497TyrLys: 2.497 ± 0.068
3.614TyrLeu: 3.614 ± 0.094
1.036TyrMet: 1.036 ± 0.045
1.599TyrAsn: 1.599 ± 0.051
1.601TyrPro: 1.601 ± 0.054
2.104TyrGln: 2.104 ± 0.067
1.83TyrArg: 1.83 ± 0.07
2.364TyrSer: 2.364 ± 0.068
2.408TyrThr: 2.408 ± 0.082
2.682TyrVal: 2.682 ± 0.077
0.357TyrTrp: 0.357 ± 0.028
1.817TyrTyr: 1.817 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1976 proteins (605430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski