Amino acid dipepetide frequency for Skermanella aerolata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.537AlaAla: 16.537 ± 0.127	1.138AlaCys: 1.138 ± 0.023	6.966AlaAsp: 6.966 ± 0.055	7.732AlaGlu: 7.732 ± 0.064	3.991AlaPhe: 3.991 ± 0.042	11.197AlaGly: 11.197 ± 0.086	2.02AlaHis: 2.02 ± 0.028	5.646AlaIle: 5.646 ± 0.056	3.523AlaLys: 3.523 ± 0.042	12.758AlaLeu: 12.758 ± 0.081	3.341AlaMet: 3.341 ± 0.033	2.599AlaAsn: 2.599 ± 0.035	5.22AlaPro: 5.22 ± 0.05	3.512AlaGln: 3.512 ± 0.041	8.116AlaArg: 8.116 ± 0.067	6.323AlaSer: 6.323 ± 0.055	5.76AlaThr: 5.76 ± 0.057	9.68AlaVal: 9.68 ± 0.064	1.435AlaTrp: 1.435 ± 0.025	2.281AlaTyr: 2.281 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.019	0.119CysCys: 0.119 ± 0.007	0.505CysAsp: 0.505 ± 0.014	0.41CysGlu: 0.41 ± 0.015	0.327CysPhe: 0.327 ± 0.014	0.952CysGly: 0.952 ± 0.019	0.289CysHis: 0.289 ± 0.011	0.417CysIle: 0.417 ± 0.014	0.168CysLys: 0.168 ± 0.008	0.869CysLeu: 0.869 ± 0.02	0.186CysMet: 0.186 ± 0.01	0.207CysAsn: 0.207 ± 0.011	0.494CysPro: 0.494 ± 0.017	0.249CysGln: 0.249 ± 0.011	0.757CysArg: 0.757 ± 0.019	0.474CysSer: 0.474 ± 0.015	0.433CysThr: 0.433 ± 0.014	0.594CysVal: 0.594 ± 0.017	0.117CysTrp: 0.117 ± 0.007	0.21CysTyr: 0.21 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.594AspAla: 6.594 ± 0.055	0.47AspCys: 0.47 ± 0.014	3.305AspAsp: 3.305 ± 0.045	3.402AspGlu: 3.402 ± 0.037	2.095AspPhe: 2.095 ± 0.034	5.393AspGly: 5.393 ± 0.053	1.306AspHis: 1.306 ± 0.025	3.01AspIle: 3.01 ± 0.037	1.582AspLys: 1.582 ± 0.026	6.662AspLeu: 6.662 ± 0.068	1.425AspMet: 1.425 ± 0.027	1.222AspAsn: 1.222 ± 0.026	3.77AspPro: 3.77 ± 0.044	1.824AspGln: 1.824 ± 0.028	4.903AspArg: 4.903 ± 0.048	2.307AspSer: 2.307 ± 0.03	2.759AspThr: 2.759 ± 0.038	4.044AspVal: 4.044 ± 0.043	0.943AspTrp: 0.943 ± 0.021	1.455AspTyr: 1.455 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.27GluAla: 7.27 ± 0.061	0.33GluCys: 0.33 ± 0.012	2.797GluAsp: 2.797 ± 0.039	3.174GluGlu: 3.174 ± 0.044	1.761GluPhe: 1.761 ± 0.024	3.982GluGly: 3.982 ± 0.044	1.229GluHis: 1.229 ± 0.025	3.415GluIle: 3.415 ± 0.042	1.941GluLys: 1.941 ± 0.031	5.551GluLeu: 5.551 ± 0.052	1.503GluMet: 1.503 ± 0.025	1.444GluAsn: 1.444 ± 0.024	2.945GluPro: 2.945 ± 0.047	2.306GluGln: 2.306 ± 0.034	5.176GluArg: 5.176 ± 0.053	2.372GluSer: 2.372 ± 0.029	3.38GluThr: 3.38 ± 0.04	4.086GluVal: 4.086 ± 0.039	0.664GluTrp: 0.664 ± 0.016	0.995GluTyr: 0.995 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.974PheAla: 3.974 ± 0.043	0.401PheCys: 0.401 ± 0.013	2.527PheAsp: 2.527 ± 0.032	1.921PheGlu: 1.921 ± 0.029	1.301PhePhe: 1.301 ± 0.025	3.585PheGly: 3.585 ± 0.041	0.786PheHis: 0.786 ± 0.019	1.642PheIle: 1.642 ± 0.027	0.936PheLys: 0.936 ± 0.021	3.325PheLeu: 3.325 ± 0.043	0.812PheMet: 0.812 ± 0.017	1.01PheAsn: 1.01 ± 0.02	1.615PhePro: 1.615 ± 0.028	1.086PheGln: 1.086 ± 0.02	2.297PheArg: 2.297 ± 0.027	2.138PheSer: 2.138 ± 0.029	2.011PheThr: 2.011 ± 0.029	2.676PheVal: 2.676 ± 0.035	0.545PheTrp: 0.545 ± 0.017	0.863PheTyr: 0.863 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.003GlyAla: 9.003 ± 0.077	0.911GlyCys: 0.911 ± 0.02	4.63GlyAsp: 4.63 ± 0.053	4.526GlyGlu: 4.526 ± 0.048	3.518GlyPhe: 3.518 ± 0.038	7.679GlyGly: 7.679 ± 0.083	1.904GlyHis: 1.904 ± 0.031	4.987GlyIle: 4.987 ± 0.044	3.166GlyLys: 3.166 ± 0.036	9.099GlyLeu: 9.099 ± 0.065	2.602GlyMet: 2.602 ± 0.031	2.304GlyAsn: 2.304 ± 0.036	3.539GlyPro: 3.539 ± 0.041	2.921GlyGln: 2.921 ± 0.031	6.394GlyArg: 6.394 ± 0.056	4.996GlySer: 4.996 ± 0.047	5.159GlyThr: 5.159 ± 0.058	6.154GlyVal: 6.154 ± 0.059	1.403GlyTrp: 1.403 ± 0.026	2.302GlyTyr: 2.302 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.298HisAla: 2.298 ± 0.03	0.254HisCys: 0.254 ± 0.01	1.321HisAsp: 1.321 ± 0.026	1.05HisGlu: 1.05 ± 0.022	0.791HisPhe: 0.791 ± 0.017	2.057HisGly: 2.057 ± 0.034	0.618HisHis: 0.618 ± 0.015	0.928HisIle: 0.928 ± 0.022	0.495HisLys: 0.495 ± 0.016	2.203HisLeu: 2.203 ± 0.033	0.497HisMet: 0.497 ± 0.015	0.48HisAsn: 0.48 ± 0.014	1.424HisPro: 1.424 ± 0.024	0.623HisGln: 0.623 ± 0.015	1.599HisArg: 1.599 ± 0.028	0.977HisSer: 0.977 ± 0.018	0.886HisThr: 0.886 ± 0.02	1.492HisVal: 1.492 ± 0.026	0.331HisTrp: 0.331 ± 0.012	0.506HisTyr: 0.506 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.599IleAla: 6.599 ± 0.054	0.47IleCys: 0.47 ± 0.013	3.707IleAsp: 3.707 ± 0.041	3.321IleGlu: 3.321 ± 0.038	1.565IlePhe: 1.565 ± 0.026	5.051IleGly: 5.051 ± 0.042	1.017IleHis: 1.017 ± 0.017	1.967IleIle: 1.967 ± 0.03	1.428IleLys: 1.428 ± 0.029	4.513IleLeu: 4.513 ± 0.044	1.011IleMet: 1.011 ± 0.023	1.338IleAsn: 1.338 ± 0.023	2.525IlePro: 2.525 ± 0.036	1.458IleGln: 1.458 ± 0.028	3.486IleArg: 3.486 ± 0.039	2.806IleSer: 2.806 ± 0.038	2.582IleThr: 2.582 ± 0.039	4.259IleVal: 4.259 ± 0.043	0.603IleTrp: 0.603 ± 0.017	1.042IleTyr: 1.042 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.775LysAla: 3.775 ± 0.046	0.143LysCys: 0.143 ± 0.008	1.528LysAsp: 1.528 ± 0.027	1.411LysGlu: 1.411 ± 0.028	0.917LysPhe: 0.917 ± 0.022	2.368LysGly: 2.368 ± 0.033	0.579LysHis: 0.579 ± 0.014	1.505LysIle: 1.505 ± 0.027	0.978LysLys: 0.978 ± 0.027	3.18LysLeu: 3.18 ± 0.035	0.722LysMet: 0.722 ± 0.019	0.729LysAsn: 0.729 ± 0.018	2.107LysPro: 2.107 ± 0.029	1.017LysGln: 1.017 ± 0.022	2.243LysArg: 2.243 ± 0.03	1.719LysSer: 1.719 ± 0.026	1.649LysThr: 1.649 ± 0.028	2.387LysVal: 2.387 ± 0.038	0.308LysTrp: 0.308 ± 0.012	0.594LysTyr: 0.594 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	13.256LeuAla: 13.256 ± 0.085	0.933LeuCys: 0.933 ± 0.02	6.41LeuAsp: 6.41 ± 0.053	5.524LeuGlu: 5.524 ± 0.051	3.617LeuPhe: 3.617 ± 0.046	8.637LeuGly: 8.637 ± 0.063	2.026LeuHis: 2.026 ± 0.028	5.216LeuIle: 5.216 ± 0.054	3.377LeuLys: 3.377 ± 0.035	10.321LeuLeu: 10.321 ± 0.089	2.486LeuMet: 2.486 ± 0.029	2.805LeuAsn: 2.805 ± 0.032	5.856LeuPro: 5.856 ± 0.049	2.551LeuGln: 2.551 ± 0.031	7.385LeuArg: 7.385 ± 0.072	6.329LeuSer: 6.329 ± 0.049	6.076LeuThr: 6.076 ± 0.054	7.634LeuVal: 7.634 ± 0.067	1.181LeuTrp: 1.181 ± 0.022	2.046LeuTyr: 2.046 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	3.299MetAla: 3.299 ± 0.035	0.158MetCys: 0.158 ± 0.008	1.233MetAsp: 1.233 ± 0.024	1.199MetGlu: 1.199 ± 0.022	0.708MetPhe: 0.708 ± 0.019	1.813MetGly: 1.813 ± 0.027	0.434MetHis: 0.434 ± 0.014	1.366MetIle: 1.366 ± 0.025	0.867MetLys: 0.867 ± 0.019	2.664MetLeu: 2.664 ± 0.037	0.664MetMet: 0.664 ± 0.017	0.725MetAsn: 0.725 ± 0.019	1.636MetPro: 1.636 ± 0.022	0.674MetGln: 0.674 ± 0.017	1.796MetArg: 1.796 ± 0.032	1.581MetSer: 1.581 ± 0.025	1.992MetThr: 1.992 ± 0.027	1.954MetVal: 1.954 ± 0.028	0.213MetTrp: 0.213 ± 0.009	0.337MetTyr: 0.337 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.929AsnAla: 2.929 ± 0.036	0.251AsnCys: 0.251 ± 0.011	1.424AsnAsp: 1.424 ± 0.028	1.188AsnGlu: 1.188 ± 0.022	0.872AsnPhe: 0.872 ± 0.021	2.255AsnGly: 2.255 ± 0.032	0.536AsnHis: 0.536 ± 0.014	1.284AsnIle: 1.284 ± 0.027	0.691AsnLys: 0.691 ± 0.018	2.76AsnLeu: 2.76 ± 0.036	0.555AsnMet: 0.555 ± 0.014	0.681AsnAsn: 0.681 ± 0.018	1.867AsnPro: 1.867 ± 0.03	0.807AsnGln: 0.807 ± 0.02	1.938AsnArg: 1.938 ± 0.03	1.281AsnSer: 1.281 ± 0.025	1.235AsnThr: 1.235 ± 0.025	1.778AsnVal: 1.778 ± 0.03	0.381AsnTrp: 0.381 ± 0.013	0.611AsnTyr: 0.611 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.68ProAla: 6.68 ± 0.068	0.332ProCys: 0.332 ± 0.011	4.052ProAsp: 4.052 ± 0.045	3.879ProGlu: 3.879 ± 0.047	1.868ProPhe: 1.868 ± 0.03	4.864ProGly: 4.864 ± 0.047	1.051ProHis: 1.051 ± 0.02	2.236ProIle: 2.236 ± 0.035	1.541ProLys: 1.541 ± 0.025	4.986ProLeu: 4.986 ± 0.044	1.271ProMet: 1.271 ± 0.028	1.318ProAsn: 1.318 ± 0.025	3.059ProPro: 3.059 ± 0.056	1.531ProGln: 1.531 ± 0.032	2.929ProArg: 2.929 ± 0.037	2.851ProSer: 2.851 ± 0.034	2.598ProThr: 2.598 ± 0.038	4.788ProVal: 4.788 ± 0.043	0.744ProTrp: 0.744 ± 0.016	1.119ProTyr: 1.119 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	4.142GlnAla: 4.142 ± 0.037	0.213GlnCys: 0.213 ± 0.011	1.485GlnAsp: 1.485 ± 0.027	1.571GlnGlu: 1.571 ± 0.029	1.013GlnPhe: 1.013 ± 0.023	2.469GlnGly: 2.469 ± 0.031	0.655GlnHis: 0.655 ± 0.016	1.772GlnIle: 1.772 ± 0.028	0.914GlnLys: 0.914 ± 0.021	2.685GlnLeu: 2.685 ± 0.036	0.801GlnMet: 0.801 ± 0.016	0.797GlnAsn: 0.797 ± 0.022	1.917GlnPro: 1.917 ± 0.031	1.235GlnGln: 1.235 ± 0.027	2.458GlnArg: 2.458 ± 0.037	1.779GlnSer: 1.779 ± 0.028	1.732GlnThr: 1.732 ± 0.029	2.497GlnVal: 2.497 ± 0.031	0.381GlnTrp: 0.381 ± 0.013	0.6GlnTyr: 0.6 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.225ArgAla: 7.225 ± 0.058	0.621ArgCys: 0.621 ± 0.016	4.339ArgAsp: 4.339 ± 0.044	4.113ArgGlu: 4.113 ± 0.047	2.961ArgPhe: 2.961 ± 0.03	4.781ArgGly: 4.781 ± 0.053	1.907ArgHis: 1.907 ± 0.028	4.378ArgIle: 4.378 ± 0.049	2.171ArgLys: 2.171 ± 0.034	8.407ArgLeu: 8.407 ± 0.079	1.984ArgMet: 1.984 ± 0.029	1.994ArgAsn: 1.994 ± 0.031	3.659ArgPro: 3.659 ± 0.045	2.808ArgGln: 2.808 ± 0.038	6.434ArgArg: 6.434 ± 0.062	4.055ArgSer: 4.055 ± 0.047	3.967ArgThr: 3.967 ± 0.041	4.873ArgVal: 4.873 ± 0.044	1.048ArgTrp: 1.048 ± 0.023	1.768ArgTyr: 1.768 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.256SerAla: 6.256 ± 0.059	0.462SerCys: 0.462 ± 0.014	3.024SerAsp: 3.024 ± 0.039	2.565SerGlu: 2.565 ± 0.031	2.154SerPhe: 2.154 ± 0.028	5.749SerGly: 5.749 ± 0.058	1.175SerHis: 1.175 ± 0.021	2.72SerIle: 2.72 ± 0.036	1.475SerLys: 1.475 ± 0.026	5.691SerLeu: 5.691 ± 0.051	1.395SerMet: 1.395 ± 0.025	1.345SerAsn: 1.345 ± 0.028	2.917SerPro: 2.917 ± 0.036	1.624SerGln: 1.624 ± 0.029	3.919SerArg: 3.919 ± 0.042	3.119SerSer: 3.119 ± 0.043	2.644SerThr: 2.644 ± 0.04	4.082SerVal: 4.082 ± 0.048	0.765SerTrp: 0.765 ± 0.019	1.253SerTyr: 1.253 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	6.536ThrAla: 6.536 ± 0.064	0.453ThrCys: 0.453 ± 0.014	2.99ThrAsp: 2.99 ± 0.035	2.746ThrGlu: 2.746 ± 0.035	1.839ThrPhe: 1.839 ± 0.032	5.575ThrGly: 5.575 ± 0.059	0.988ThrHis: 0.988 ± 0.023	2.859ThrIle: 2.859 ± 0.035	1.393ThrLys: 1.393 ± 0.023	5.871ThrLeu: 5.871 ± 0.047	1.263ThrMet: 1.263 ± 0.023	1.291ThrAsn: 1.291 ± 0.024	3.253ThrPro: 3.253 ± 0.039	1.414ThrGln: 1.414 ± 0.028	3.355ThrArg: 3.355 ± 0.031	2.858ThrSer: 2.858 ± 0.033	2.852ThrThr: 2.852 ± 0.037	4.98ThrVal: 4.98 ± 0.048	0.671ThrTrp: 0.671 ± 0.017	1.132ThrTyr: 1.132 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	9.082ValAla: 9.082 ± 0.076	0.691ValCys: 0.691 ± 0.017	4.122ValAsp: 4.122 ± 0.041	4.899ValGlu: 4.899 ± 0.049	2.748ValPhe: 2.748 ± 0.038	5.805ValGly: 5.805 ± 0.053	1.471ValHis: 1.471 ± 0.02	3.881ValIle: 3.881 ± 0.044	2.189ValLys: 2.189 ± 0.032	8.193ValLeu: 8.193 ± 0.062	2.017ValMet: 2.017 ± 0.027	2.006ValAsn: 2.006 ± 0.032	4.134ValPro: 4.134 ± 0.042	2.189ValGln: 2.189 ± 0.029	5.377ValArg: 5.377 ± 0.046	4.405ValSer: 4.405 ± 0.041	4.741ValThr: 4.741 ± 0.052	6.351ValVal: 6.351 ± 0.057	0.917ValTrp: 0.917 ± 0.022	1.457ValTyr: 1.457 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.137TrpAla: 1.137 ± 0.022	0.136TrpCys: 0.136 ± 0.008	0.667TrpAsp: 0.667 ± 0.017	0.601TrpGlu: 0.601 ± 0.016	0.565TrpPhe: 0.565 ± 0.017	0.917TrpGly: 0.917 ± 0.018	0.352TrpHis: 0.352 ± 0.014	0.689TrpIle: 0.689 ± 0.017	0.411TrpLys: 0.411 ± 0.015	1.641TrpLeu: 1.641 ± 0.026	0.342TrpMet: 0.342 ± 0.012	0.428TrpAsn: 0.428 ± 0.013	0.69TrpPro: 0.69 ± 0.017	0.535TrpGln: 0.535 ± 0.014	1.127TrpArg: 1.127 ± 0.027	0.819TrpSer: 0.819 ± 0.018	0.789TrpThr: 0.789 ± 0.021	0.85TrpVal: 0.85 ± 0.019	0.23TrpTrp: 0.23 ± 0.011	0.313TrpTyr: 0.313 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.246TyrAla: 2.246 ± 0.032	0.224TyrCys: 0.224 ± 0.01	1.439TyrAsp: 1.439 ± 0.021	1.091TyrGlu: 1.091 ± 0.021	0.839TyrPhe: 0.839 ± 0.02	2.069TyrGly: 2.069 ± 0.033	0.489TyrHis: 0.489 ± 0.016	0.834TyrIle: 0.834 ± 0.019	0.612TyrLys: 0.612 ± 0.016	2.286TyrLeu: 2.286 ± 0.029	0.433TyrMet: 0.433 ± 0.014	0.602TyrAsn: 0.602 ± 0.016	1.066TyrPro: 1.066 ± 0.02	0.75TyrGln: 0.75 ± 0.021	1.807TyrArg: 1.807 ± 0.028	1.144TyrSer: 1.144 ± 0.023	1.073TyrThr: 1.073 ± 0.024	1.519TyrVal: 1.519 ± 0.028	0.359TyrTrp: 0.359 ± 0.013	0.583TyrTyr: 0.583 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7916 proteins (2418692 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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