Amino acid dipepetide frequency for Sphingobium baderi LL03

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.588AlaAla: 18.588 ± 0.166	1.103AlaCys: 1.103 ± 0.031	7.707AlaAsp: 7.707 ± 0.084	7.216AlaGlu: 7.216 ± 0.092	4.366AlaPhe: 4.366 ± 0.053	11.2AlaGly: 11.2 ± 0.117	2.403AlaHis: 2.403 ± 0.046	6.844AlaIle: 6.844 ± 0.076	3.966AlaLys: 3.966 ± 0.058	14.112AlaLeu: 14.112 ± 0.123	4.068AlaMet: 4.068 ± 0.053	3.039AlaAsn: 3.039 ± 0.053	5.971AlaPro: 5.971 ± 0.074	4.667AlaGln: 4.667 ± 0.071	10.127AlaArg: 10.127 ± 0.106	6.585AlaSer: 6.585 ± 0.078	5.879AlaThr: 5.879 ± 0.071	8.548AlaVal: 8.548 ± 0.078	1.561AlaTrp: 1.561 ± 0.037	2.569AlaTyr: 2.569 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.065CysAla: 1.065 ± 0.03	0.101CysCys: 0.101 ± 0.01	0.559CysAsp: 0.559 ± 0.022	0.436CysGlu: 0.436 ± 0.02	0.297CysPhe: 0.297 ± 0.015	0.853CysGly: 0.853 ± 0.026	0.223CysHis: 0.223 ± 0.015	0.4CysIle: 0.4 ± 0.017	0.204CysLys: 0.204 ± 0.011	0.751CysLeu: 0.751 ± 0.023	0.17CysMet: 0.17 ± 0.011	0.193CysAsn: 0.193 ± 0.013	0.489CysPro: 0.489 ± 0.02	0.21CysGln: 0.21 ± 0.012	0.621CysArg: 0.621 ± 0.027	0.454CysSer: 0.454 ± 0.02	0.393CysThr: 0.393 ± 0.017	0.584CysVal: 0.584 ± 0.022	0.127CysTrp: 0.127 ± 0.01	0.157CysTyr: 0.157 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.494AspAla: 7.494 ± 0.083	0.492AspCys: 0.492 ± 0.018	3.285AspAsp: 3.285 ± 0.05	3.394AspGlu: 3.394 ± 0.053	2.16AspPhe: 2.16 ± 0.041	5.572AspGly: 5.572 ± 0.069	1.438AspHis: 1.438 ± 0.035	3.244AspIle: 3.244 ± 0.051	1.727AspLys: 1.727 ± 0.037	5.808AspLeu: 5.808 ± 0.067	1.734AspMet: 1.734 ± 0.041	1.389AspAsn: 1.389 ± 0.035	3.632AspPro: 3.632 ± 0.056	1.823AspGln: 1.823 ± 0.039	5.017AspArg: 5.017 ± 0.066	2.403AspSer: 2.403 ± 0.045	2.475AspThr: 2.475 ± 0.047	4.002AspVal: 4.002 ± 0.06	1.076AspTrp: 1.076 ± 0.026	1.6AspTyr: 1.6 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.681GluAla: 7.681 ± 0.077	0.348GluCys: 0.348 ± 0.017	2.828GluAsp: 2.828 ± 0.056	3.33GluGlu: 3.33 ± 0.07	1.425GluPhe: 1.425 ± 0.039	4.696GluGly: 4.696 ± 0.062	1.16GluHis: 1.16 ± 0.035	3.076GluIle: 3.076 ± 0.055	2.151GluLys: 2.151 ± 0.043	4.896GluLeu: 4.896 ± 0.07	1.53GluMet: 1.53 ± 0.036	1.4GluAsn: 1.4 ± 0.033	2.435GluPro: 2.435 ± 0.048	2.244GluGln: 2.244 ± 0.047	5.288GluArg: 5.288 ± 0.07	2.366GluSer: 2.366 ± 0.044	3.119GluThr: 3.119 ± 0.048	3.34GluVal: 3.34 ± 0.053	0.741GluTrp: 0.741 ± 0.022	0.966GluTyr: 0.966 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.597PheAla: 4.597 ± 0.065	0.347PheCys: 0.347 ± 0.018	2.577PheAsp: 2.577 ± 0.043	2.006PheGlu: 2.006 ± 0.04	1.264PhePhe: 1.264 ± 0.032	3.391PheGly: 3.391 ± 0.055	0.829PheHis: 0.829 ± 0.025	1.478PheIle: 1.478 ± 0.034	0.84PheLys: 0.84 ± 0.025	3.205PheLeu: 3.205 ± 0.056	0.805PheMet: 0.805 ± 0.021	0.962PheAsn: 0.962 ± 0.034	1.508PhePro: 1.508 ± 0.037	0.899PheGln: 0.899 ± 0.024	2.307PheArg: 2.307 ± 0.034	2.103PheSer: 2.103 ± 0.042	1.93PheThr: 1.93 ± 0.04	2.372PheVal: 2.372 ± 0.051	0.511PheTrp: 0.511 ± 0.023	0.88PheTyr: 0.88 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.911GlyAla: 9.911 ± 0.127	0.81GlyCys: 0.81 ± 0.029	4.871GlyAsp: 4.871 ± 0.07	4.831GlyGlu: 4.831 ± 0.059	3.466GlyPhe: 3.466 ± 0.055	8.155GlyGly: 8.155 ± 0.183	1.964GlyHis: 1.964 ± 0.043	4.638GlyIle: 4.638 ± 0.067	3.405GlyLys: 3.405 ± 0.05	8.678GlyLeu: 8.678 ± 0.084	2.484GlyMet: 2.484 ± 0.045	2.242GlyAsn: 2.242 ± 0.045	3.476GlyPro: 3.476 ± 0.05	3.214GlyGln: 3.214 ± 0.051	6.77GlyArg: 6.77 ± 0.081	4.751GlySer: 4.751 ± 0.083	4.557GlyThr: 4.557 ± 0.08	6.075GlyVal: 6.075 ± 0.075	1.571GlyTrp: 1.571 ± 0.036	2.301GlyTyr: 2.301 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.51HisAla: 2.51 ± 0.045	0.229HisCys: 0.229 ± 0.013	1.261HisAsp: 1.261 ± 0.034	1.038HisGlu: 1.038 ± 0.027	0.874HisPhe: 0.874 ± 0.024	2.088HisGly: 2.088 ± 0.044	0.61HisHis: 0.61 ± 0.021	1.073HisIle: 1.073 ± 0.032	0.485HisLys: 0.485 ± 0.02	2.015HisLeu: 2.015 ± 0.039	0.548HisMet: 0.548 ± 0.021	0.432HisAsn: 0.432 ± 0.017	1.319HisPro: 1.319 ± 0.036	0.604HisGln: 0.604 ± 0.021	1.589HisArg: 1.589 ± 0.036	1.006HisSer: 1.006 ± 0.029	0.634HisThr: 0.634 ± 0.018	1.648HisVal: 1.648 ± 0.033	0.382HisTrp: 0.382 ± 0.018	0.613HisTyr: 0.613 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	8.026IleAla: 8.026 ± 0.082	0.473IleCys: 0.473 ± 0.02	3.912IleAsp: 3.912 ± 0.061	3.49IleGlu: 3.49 ± 0.053	1.773IlePhe: 1.773 ± 0.038	5.154IleGly: 5.154 ± 0.062	0.966IleHis: 0.966 ± 0.027	2.201IleIle: 2.201 ± 0.043	1.206IleLys: 1.206 ± 0.03	4.473IleLeu: 4.473 ± 0.063	1.001IleMet: 1.001 ± 0.03	1.367IleAsn: 1.367 ± 0.034	2.271IlePro: 2.271 ± 0.038	1.289IleGln: 1.289 ± 0.029	3.44IleArg: 3.44 ± 0.045	2.834IleSer: 2.834 ± 0.048	2.449IleThr: 2.449 ± 0.04	4.222IleVal: 4.222 ± 0.057	0.645IleTrp: 0.645 ± 0.022	1.032IleTyr: 1.032 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.327LysAla: 4.327 ± 0.056	0.169LysCys: 0.169 ± 0.011	1.708LysAsp: 1.708 ± 0.043	1.454LysGlu: 1.454 ± 0.033	0.736LysPhe: 0.736 ± 0.029	2.842LysGly: 2.842 ± 0.045	0.521LysHis: 0.521 ± 0.021	1.541LysIle: 1.541 ± 0.034	1.083LysLys: 1.083 ± 0.031	3.102LysLeu: 3.102 ± 0.05	0.772LysMet: 0.772 ± 0.025	0.733LysAsn: 0.733 ± 0.024	1.982LysPro: 1.982 ± 0.042	0.945LysGln: 0.945 ± 0.026	2.302LysArg: 2.302 ± 0.038	1.645LysSer: 1.645 ± 0.034	1.623LysThr: 1.623 ± 0.037	2.164LysVal: 2.164 ± 0.042	0.375LysTrp: 0.375 ± 0.014	0.528LysTyr: 0.528 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.812LeuAla: 13.812 ± 0.122	0.913LeuCys: 0.913 ± 0.026	6.055LeuAsp: 6.055 ± 0.07	5.067LeuGlu: 5.067 ± 0.062	3.81LeuPhe: 3.81 ± 0.059	8.198LeuGly: 8.198 ± 0.093	1.94LeuHis: 1.94 ± 0.04	5.079LeuIle: 5.079 ± 0.081	3.14LeuLys: 3.14 ± 0.044	9.913LeuLeu: 9.913 ± 0.138	2.3LeuMet: 2.3 ± 0.042	2.426LeuAsn: 2.426 ± 0.049	5.514LeuPro: 5.514 ± 0.066	2.508LeuGln: 2.508 ± 0.045	7.145LeuArg: 7.145 ± 0.075	6.443LeuSer: 6.443 ± 0.077	5.526LeuThr: 5.526 ± 0.074	6.834LeuVal: 6.834 ± 0.066	1.256LeuTrp: 1.256 ± 0.03	1.993LeuTyr: 1.993 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.585MetAla: 3.585 ± 0.052	0.169MetCys: 0.169 ± 0.011	1.323MetAsp: 1.323 ± 0.031	1.375MetGlu: 1.375 ± 0.034	0.708MetPhe: 0.708 ± 0.026	2.071MetGly: 2.071 ± 0.045	0.459MetHis: 0.459 ± 0.019	1.494MetIle: 1.494 ± 0.037	0.98MetLys: 0.98 ± 0.027	2.762MetLeu: 2.762 ± 0.046	0.803MetMet: 0.803 ± 0.026	0.716MetAsn: 0.716 ± 0.025	1.564MetPro: 1.564 ± 0.034	0.855MetGln: 0.855 ± 0.025	1.959MetArg: 1.959 ± 0.039	1.513MetSer: 1.513 ± 0.037	1.89MetThr: 1.89 ± 0.038	1.652MetVal: 1.652 ± 0.039	0.223MetTrp: 0.223 ± 0.014	0.256MetTyr: 0.256 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.315AsnAla: 3.315 ± 0.056	0.237AsnCys: 0.237 ± 0.013	1.433AsnAsp: 1.433 ± 0.035	1.134AsnGlu: 1.134 ± 0.031	0.836AsnPhe: 0.836 ± 0.03	2.469AsnGly: 2.469 ± 0.049	0.463AsnHis: 0.463 ± 0.018	1.379AsnIle: 1.379 ± 0.035	0.642AsnLys: 0.642 ± 0.026	2.437AsnLeu: 2.437 ± 0.048	0.595AsnMet: 0.595 ± 0.022	0.62AsnAsn: 0.62 ± 0.024	1.63AsnPro: 1.63 ± 0.034	0.777AsnGln: 0.777 ± 0.027	1.935AsnArg: 1.935 ± 0.043	1.212AsnSer: 1.212 ± 0.039	0.976AsnThr: 0.976 ± 0.029	1.813AsnVal: 1.813 ± 0.041	0.417AsnTrp: 0.417 ± 0.018	0.655AsnTyr: 0.655 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.635ProAla: 6.635 ± 0.086	0.338ProCys: 0.338 ± 0.016	3.877ProAsp: 3.877 ± 0.053	3.329ProGlu: 3.329 ± 0.049	1.863ProPhe: 1.863 ± 0.035	4.672ProGly: 4.672 ± 0.055	1.068ProHis: 1.068 ± 0.028	2.466ProIle: 2.466 ± 0.035	1.4ProLys: 1.4 ± 0.035	4.966ProLeu: 4.966 ± 0.065	1.331ProMet: 1.331 ± 0.032	1.118ProAsn: 1.118 ± 0.029	2.786ProPro: 2.786 ± 0.065	1.722ProGln: 1.722 ± 0.037	3.077ProArg: 3.077 ± 0.054	2.745ProSer: 2.745 ± 0.04	2.372ProThr: 2.372 ± 0.045	4.282ProVal: 4.282 ± 0.055	0.66ProTrp: 0.66 ± 0.023	1.031ProTyr: 1.031 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.545GlnAla: 4.545 ± 0.071	0.26GlnCys: 0.26 ± 0.016	1.541GlnAsp: 1.541 ± 0.037	1.52GlnGlu: 1.52 ± 0.035	1.05GlnPhe: 1.05 ± 0.025	2.625GlnGly: 2.625 ± 0.049	0.617GlnHis: 0.617 ± 0.021	1.898GlnIle: 1.898 ± 0.042	1.043GlnLys: 1.043 ± 0.031	2.968GlnLeu: 2.968 ± 0.051	0.878GlnMet: 0.878 ± 0.027	0.782GlnAsn: 0.782 ± 0.027	1.756GlnPro: 1.756 ± 0.037	1.274GlnGln: 1.274 ± 0.042	2.618GlnArg: 2.618 ± 0.05	1.819GlnSer: 1.819 ± 0.043	1.646GlnThr: 1.646 ± 0.039	2.271GlnVal: 2.271 ± 0.043	0.506GlnTrp: 0.506 ± 0.018	0.613GlnTyr: 0.613 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.948ArgAla: 8.948 ± 0.093	0.567ArgCys: 0.567 ± 0.019	4.472ArgAsp: 4.472 ± 0.061	4.25ArgGlu: 4.25 ± 0.062	3.086ArgPhe: 3.086 ± 0.054	5.067ArgGly: 5.067 ± 0.066	1.939ArgHis: 1.939 ± 0.043	4.413ArgIle: 4.413 ± 0.061	2.456ArgLys: 2.456 ± 0.051	8.587ArgLeu: 8.587 ± 0.084	2.092ArgMet: 2.092 ± 0.035	1.949ArgAsn: 1.949 ± 0.035	3.896ArgPro: 3.896 ± 0.056	2.772ArgGln: 2.772 ± 0.055	6.234ArgArg: 6.234 ± 0.083	3.912ArgSer: 3.912 ± 0.05	3.621ArgThr: 3.621 ± 0.05	4.654ArgVal: 4.654 ± 0.052	1.204ArgTrp: 1.204 ± 0.034	1.949ArgTyr: 1.949 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.562SerAla: 6.562 ± 0.087	0.464SerCys: 0.464 ± 0.022	3.025SerAsp: 3.025 ± 0.046	2.576SerGlu: 2.576 ± 0.038	2.131SerPhe: 2.131 ± 0.046	5.571SerGly: 5.571 ± 0.085	1.052SerHis: 1.052 ± 0.032	2.809SerIle: 2.809 ± 0.05	1.362SerLys: 1.362 ± 0.03	5.305SerLeu: 5.305 ± 0.071	1.404SerMet: 1.404 ± 0.031	1.369SerAsn: 1.369 ± 0.036	2.81SerPro: 2.81 ± 0.043	1.614SerGln: 1.614 ± 0.036	3.821SerArg: 3.821 ± 0.049	2.903SerSer: 2.903 ± 0.062	2.485SerThr: 2.485 ± 0.055	3.718SerVal: 3.718 ± 0.06	0.829SerTrp: 0.829 ± 0.025	1.37SerTyr: 1.37 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.973ThrAla: 5.973 ± 0.072	0.391ThrCys: 0.391 ± 0.017	2.836ThrAsp: 2.836 ± 0.052	2.295ThrGlu: 2.295 ± 0.04	1.654ThrPhe: 1.654 ± 0.037	5.143ThrGly: 5.143 ± 0.077	0.964ThrHis: 0.964 ± 0.026	2.899ThrIle: 2.899 ± 0.052	1.194ThrLys: 1.194 ± 0.03	5.663ThrLeu: 5.663 ± 0.071	1.238ThrMet: 1.238 ± 0.03	1.234ThrAsn: 1.234 ± 0.035	3.244ThrPro: 3.244 ± 0.05	1.46ThrGln: 1.46 ± 0.034	3.373ThrArg: 3.373 ± 0.045	2.484ThrSer: 2.484 ± 0.048	2.43ThrThr: 2.43 ± 0.054	3.985ThrVal: 3.985 ± 0.062	0.545ThrTrp: 0.545 ± 0.02	1.082ThrTyr: 1.082 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.987ValAla: 8.987 ± 0.089	0.511ValCys: 0.511 ± 0.019	4.257ValAsp: 4.257 ± 0.061	4.534ValGlu: 4.534 ± 0.056	1.989ValPhe: 1.989 ± 0.043	5.422ValGly: 5.422 ± 0.069	1.441ValHis: 1.441 ± 0.032	3.701ValIle: 3.701 ± 0.054	2.193ValLys: 2.193 ± 0.046	6.339ValLeu: 6.339 ± 0.085	1.748ValMet: 1.748 ± 0.043	1.982ValAsn: 1.982 ± 0.042	3.801ValPro: 3.801 ± 0.056	2.099ValGln: 2.099 ± 0.044	5.192ValArg: 5.192 ± 0.059	3.919ValSer: 3.919 ± 0.06	4.329ValThr: 4.329 ± 0.065	4.881ValVal: 4.881 ± 0.063	0.741ValTrp: 0.741 ± 0.024	1.356ValTyr: 1.356 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.373TrpAla: 1.373 ± 0.032	0.124TrpCys: 0.124 ± 0.009	0.72TrpAsp: 0.72 ± 0.022	0.6TrpGlu: 0.6 ± 0.025	0.519TrpPhe: 0.519 ± 0.02	0.9TrpGly: 0.9 ± 0.025	0.374TrpHis: 0.374 ± 0.017	0.729TrpIle: 0.729 ± 0.024	0.509TrpLys: 0.509 ± 0.019	1.741TrpLeu: 1.741 ± 0.04	0.383TrpMet: 0.383 ± 0.018	0.449TrpAsn: 0.449 ± 0.017	0.671TrpPro: 0.671 ± 0.022	0.564TrpGln: 0.564 ± 0.02	1.282TrpArg: 1.282 ± 0.031	0.881TrpSer: 0.881 ± 0.028	0.819TrpThr: 0.819 ± 0.024	0.821TrpVal: 0.821 ± 0.026	0.246TrpTrp: 0.246 ± 0.016	0.261TrpTyr: 0.261 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.586TyrAla: 2.586 ± 0.046	0.241TyrCys: 0.241 ± 0.013	1.518TyrAsp: 1.518 ± 0.038	1.147TyrGlu: 1.147 ± 0.029	0.803TyrPhe: 0.803 ± 0.026	2.084TyrGly: 2.084 ± 0.039	0.528TyrHis: 0.528 ± 0.019	0.864TyrIle: 0.864 ± 0.022	0.566TyrLys: 0.566 ± 0.021	2.15TyrLeu: 2.15 ± 0.042	0.469TyrMet: 0.469 ± 0.021	0.575TyrAsn: 0.575 ± 0.022	0.984TyrPro: 0.984 ± 0.026	0.689TyrGln: 0.689 ± 0.025	1.97TyrArg: 1.97 ± 0.037	1.199TyrSer: 1.199 ± 0.03	0.937TyrThr: 0.937 ± 0.031	1.555TyrVal: 1.555 ± 0.036	0.349TyrTrp: 0.349 ± 0.014	0.577TyrTyr: 0.577 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4697 proteins (1382595 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---