Amino acid dipepetide frequency for Phenylobacterium kunshanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.274AlaAla: 22.274 ± 0.221	1.254AlaCys: 1.254 ± 0.034	7.994AlaAsp: 7.994 ± 0.091	8.976AlaGlu: 8.976 ± 0.095	5.067AlaPhe: 5.067 ± 0.069	12.588AlaGly: 12.588 ± 0.118	2.346AlaHis: 2.346 ± 0.046	5.489AlaIle: 5.489 ± 0.081	4.17AlaLys: 4.17 ± 0.073	14.31AlaLeu: 14.31 ± 0.138	3.547AlaMet: 3.547 ± 0.058	2.81AlaAsn: 2.81 ± 0.044	7.445AlaPro: 7.445 ± 0.096	4.523AlaGln: 4.523 ± 0.068	10.976AlaArg: 10.976 ± 0.126	6.416AlaSer: 6.416 ± 0.077	6.321AlaThr: 6.321 ± 0.084	9.686AlaVal: 9.686 ± 0.099	2.1AlaTrp: 2.1 ± 0.045	2.972AlaTyr: 2.972 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.11CysAla: 1.11 ± 0.028	0.099CysCys: 0.099 ± 0.009	0.553CysAsp: 0.553 ± 0.02	0.447CysGlu: 0.447 ± 0.019	0.268CysPhe: 0.268 ± 0.014	0.884CysGly: 0.884 ± 0.026	0.224CysHis: 0.224 ± 0.016	0.271CysIle: 0.271 ± 0.016	0.166CysLys: 0.166 ± 0.011	0.665CysLeu: 0.665 ± 0.024	0.133CysMet: 0.133 ± 0.011	0.16CysAsn: 0.16 ± 0.012	0.43CysPro: 0.43 ± 0.021	0.223CysGln: 0.223 ± 0.015	0.584CysArg: 0.584 ± 0.022	0.378CysSer: 0.378 ± 0.02	0.346CysThr: 0.346 ± 0.016	0.603CysVal: 0.603 ± 0.018	0.1CysTrp: 0.1 ± 0.009	0.156CysTyr: 0.156 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.671AspAla: 7.671 ± 0.09	0.407AspCys: 0.407 ± 0.019	3.27AspAsp: 3.27 ± 0.064	3.419AspGlu: 3.419 ± 0.057	2.129AspPhe: 2.129 ± 0.043	5.627AspGly: 5.627 ± 0.081	1.149AspHis: 1.149 ± 0.034	2.336AspIle: 2.336 ± 0.041	1.395AspLys: 1.395 ± 0.035	6.556AspLeu: 6.556 ± 0.082	1.109AspMet: 1.109 ± 0.03	1.083AspAsn: 1.083 ± 0.031	4.126AspPro: 4.126 ± 0.063	1.774AspGln: 1.774 ± 0.036	4.733AspArg: 4.733 ± 0.062	1.917AspSer: 1.917 ± 0.037	2.433AspThr: 2.433 ± 0.049	4.447AspVal: 4.447 ± 0.056	1.047AspTrp: 1.047 ± 0.033	1.48AspTyr: 1.48 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	9.547GluAla: 9.547 ± 0.123	0.272GluCys: 0.272 ± 0.014	2.793GluAsp: 2.793 ± 0.057	2.85GluGlu: 2.85 ± 0.06	1.632GluPhe: 1.632 ± 0.035	4.935GluGly: 4.935 ± 0.062	1.059GluHis: 1.059 ± 0.029	3.066GluIle: 3.066 ± 0.065	1.843GluLys: 1.843 ± 0.04	5.555GluLeu: 5.555 ± 0.075	1.304GluMet: 1.304 ± 0.032	1.131GluAsn: 1.131 ± 0.033	3.104GluPro: 3.104 ± 0.06	1.916GluGln: 1.916 ± 0.045	5.291GluArg: 5.291 ± 0.071	2.095GluSer: 2.095 ± 0.043	3.448GluThr: 3.448 ± 0.05	4.409GluVal: 4.409 ± 0.055	0.683GluTrp: 0.683 ± 0.023	0.922GluTyr: 0.922 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.725PheAla: 4.725 ± 0.068	0.372PheCys: 0.372 ± 0.016	2.65PheAsp: 2.65 ± 0.055	2.305PheGlu: 2.305 ± 0.045	1.228PhePhe: 1.228 ± 0.038	3.527PheGly: 3.527 ± 0.054	0.688PheHis: 0.688 ± 0.024	1.287PheIle: 1.287 ± 0.029	0.897PheLys: 0.897 ± 0.034	3.005PheLeu: 3.005 ± 0.053	0.719PheMet: 0.719 ± 0.023	0.991PheAsn: 0.991 ± 0.03	1.464PhePro: 1.464 ± 0.036	1.057PheGln: 1.057 ± 0.027	2.316PheArg: 2.316 ± 0.041	1.889PheSer: 1.889 ± 0.043	1.931PheThr: 1.931 ± 0.043	2.625PheVal: 2.625 ± 0.05	0.517PheTrp: 0.517 ± 0.024	0.827PheTyr: 0.827 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.751GlyAla: 11.751 ± 0.125	0.833GlyCys: 0.833 ± 0.026	5.025GlyAsp: 5.025 ± 0.079	5.409GlyGlu: 5.409 ± 0.067	3.607GlyPhe: 3.607 ± 0.054	8.834GlyGly: 8.834 ± 0.146	1.705GlyHis: 1.705 ± 0.039	3.031GlyIle: 3.031 ± 0.046	2.912GlyLys: 2.912 ± 0.058	9.489GlyLeu: 9.489 ± 0.089	2.092GlyMet: 2.092 ± 0.045	1.651GlyAsn: 1.651 ± 0.06	4.563GlyPro: 4.563 ± 0.067	3.157GlyGln: 3.157 ± 0.057	7.466GlyArg: 7.466 ± 0.079	4.404GlySer: 4.404 ± 0.069	3.426GlyThr: 3.426 ± 0.061	7.789GlyVal: 7.789 ± 0.081	1.536GlyTrp: 1.536 ± 0.038	2.285GlyTyr: 2.285 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.368HisAla: 2.368 ± 0.049	0.182HisCys: 0.182 ± 0.01	1.026HisAsp: 1.026 ± 0.028	1.078HisGlu: 1.078 ± 0.028	0.636HisPhe: 0.636 ± 0.024	1.813HisGly: 1.813 ± 0.039	0.452HisHis: 0.452 ± 0.021	0.695HisIle: 0.695 ± 0.027	0.444HisLys: 0.444 ± 0.018	1.715HisLeu: 1.715 ± 0.038	0.44HisMet: 0.44 ± 0.02	0.377HisAsn: 0.377 ± 0.017	1.336HisPro: 1.336 ± 0.033	0.513HisGln: 0.513 ± 0.022	1.354HisArg: 1.354 ± 0.035	0.678HisSer: 0.678 ± 0.022	0.745HisThr: 0.745 ± 0.023	1.459HisVal: 1.459 ± 0.034	0.311HisTrp: 0.311 ± 0.016	0.471HisTyr: 0.471 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.896IleAla: 5.896 ± 0.073	0.408IleCys: 0.408 ± 0.019	2.885IleAsp: 2.885 ± 0.044	2.887IleGlu: 2.887 ± 0.058	1.302IlePhe: 1.302 ± 0.038	3.996IleGly: 3.996 ± 0.067	0.72IleHis: 0.72 ± 0.025	1.411IleIle: 1.411 ± 0.037	0.999IleLys: 0.999 ± 0.034	3.782IleLeu: 3.782 ± 0.059	0.7IleMet: 0.7 ± 0.023	1.029IleAsn: 1.029 ± 0.032	1.933IlePro: 1.933 ± 0.04	1.147IleGln: 1.147 ± 0.028	3.025IleArg: 3.025 ± 0.054	2.196IleSer: 2.196 ± 0.042	2.236IleThr: 2.236 ± 0.052	3.478IleVal: 3.478 ± 0.05	0.529IleTrp: 0.529 ± 0.022	0.892IleTyr: 0.892 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.589LysAla: 4.589 ± 0.074	0.134LysCys: 0.134 ± 0.011	1.698LysAsp: 1.698 ± 0.038	1.254LysGlu: 1.254 ± 0.036	0.842LysPhe: 0.842 ± 0.026	2.726LysGly: 2.726 ± 0.052	0.532LysHis: 0.532 ± 0.022	1.311LysIle: 1.311 ± 0.039	0.984LysLys: 0.984 ± 0.032	2.941LysLeu: 2.941 ± 0.055	0.598LysMet: 0.598 ± 0.023	0.66LysAsn: 0.66 ± 0.024	2.11LysPro: 2.11 ± 0.041	0.766LysGln: 0.766 ± 0.025	2.096LysArg: 2.096 ± 0.042	1.441LysSer: 1.441 ± 0.034	1.779LysThr: 1.779 ± 0.039	2.513LysVal: 2.513 ± 0.044	0.332LysTrp: 0.332 ± 0.019	0.522LysTyr: 0.522 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	15.163LeuAla: 15.163 ± 0.154	0.775LeuCys: 0.775 ± 0.025	6.081LeuAsp: 6.081 ± 0.076	5.611LeuGlu: 5.611 ± 0.08	3.225LeuPhe: 3.225 ± 0.054	8.412LeuGly: 8.412 ± 0.094	1.644LeuHis: 1.644 ± 0.041	4.122LeuIle: 4.122 ± 0.058	3.793LeuLys: 3.793 ± 0.055	8.331LeuLeu: 8.331 ± 0.103	2.234LeuMet: 2.234 ± 0.044	2.394LeuAsn: 2.394 ± 0.045	5.252LeuPro: 5.252 ± 0.068	2.71LeuGln: 2.71 ± 0.051	7.115LeuArg: 7.115 ± 0.087	5.798LeuSer: 5.798 ± 0.064	5.674LeuThr: 5.674 ± 0.074	7.407LeuVal: 7.407 ± 0.085	1.152LeuTrp: 1.152 ± 0.031	1.926LeuTyr: 1.926 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.127MetAla: 3.127 ± 0.055	0.148MetCys: 0.148 ± 0.01	1.187MetAsp: 1.187 ± 0.032	0.987MetGlu: 0.987 ± 0.027	0.638MetPhe: 0.638 ± 0.026	1.908MetGly: 1.908 ± 0.04	0.325MetHis: 0.325 ± 0.018	1.044MetIle: 1.044 ± 0.027	0.835MetLys: 0.835 ± 0.025	2.077MetLeu: 2.077 ± 0.044	0.526MetMet: 0.526 ± 0.02	0.643MetAsn: 0.643 ± 0.02	1.308MetPro: 1.308 ± 0.031	0.651MetGln: 0.651 ± 0.022	1.73MetArg: 1.73 ± 0.038	1.54MetSer: 1.54 ± 0.036	1.598MetThr: 1.598 ± 0.038	1.476MetVal: 1.476 ± 0.033	0.202MetTrp: 0.202 ± 0.013	0.268MetTyr: 0.268 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.902AsnAla: 2.902 ± 0.053	0.197AsnCys: 0.197 ± 0.013	1.259AsnAsp: 1.259 ± 0.043	0.918AsnGlu: 0.918 ± 0.029	0.835AsnPhe: 0.835 ± 0.035	2.119AsnGly: 2.119 ± 0.047	0.38AsnHis: 0.38 ± 0.017	1.021AsnIle: 1.021 ± 0.034	0.466AsnLys: 0.466 ± 0.022	2.406AsnLeu: 2.406 ± 0.05	0.481AsnMet: 0.481 ± 0.019	0.544AsnAsn: 0.544 ± 0.023	1.739AsnPro: 1.739 ± 0.044	0.582AsnGln: 0.582 ± 0.022	1.589AsnArg: 1.589 ± 0.036	0.968AsnSer: 0.968 ± 0.028	1.113AsnThr: 1.113 ± 0.036	1.781AsnVal: 1.781 ± 0.042	0.34AsnTrp: 0.34 ± 0.016	0.616AsnTyr: 0.616 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.888ProAla: 7.888 ± 0.091	0.331ProCys: 0.331 ± 0.016	3.85ProAsp: 3.85 ± 0.054	4.016ProGlu: 4.016 ± 0.062	1.994ProPhe: 1.994 ± 0.039	5.451ProGly: 5.451 ± 0.066	1.026ProHis: 1.026 ± 0.031	2.196ProIle: 2.196 ± 0.043	1.903ProLys: 1.903 ± 0.045	4.864ProLeu: 4.864 ± 0.069	1.205ProMet: 1.205 ± 0.031	1.305ProAsn: 1.305 ± 0.035	3.603ProPro: 3.603 ± 0.079	1.756ProGln: 1.756 ± 0.034	3.523ProArg: 3.523 ± 0.06	2.662ProSer: 2.662 ± 0.057	2.927ProThr: 2.927 ± 0.057	4.204ProVal: 4.204 ± 0.055	0.77ProTrp: 0.77 ± 0.023	1.079ProTyr: 1.079 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.997GlnAla: 4.997 ± 0.062	0.174GlnCys: 0.174 ± 0.013	1.406GlnAsp: 1.406 ± 0.041	1.31GlnGlu: 1.31 ± 0.033	0.911GlnPhe: 0.911 ± 0.028	2.623GlnGly: 2.623 ± 0.047	0.567GlnHis: 0.567 ± 0.022	1.494GlnIle: 1.494 ± 0.037	0.926GlnLys: 0.926 ± 0.027	2.799GlnLeu: 2.799 ± 0.05	0.756GlnMet: 0.756 ± 0.023	0.675GlnAsn: 0.675 ± 0.025	1.867GlnPro: 1.867 ± 0.038	1.024GlnGln: 1.024 ± 0.029	2.427GlnArg: 2.427 ± 0.038	1.405GlnSer: 1.405 ± 0.041	1.663GlnThr: 1.663 ± 0.034	2.568GlnVal: 2.568 ± 0.047	0.353GlnTrp: 0.353 ± 0.016	0.539GlnTyr: 0.539 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.725ArgAla: 9.725 ± 0.095	0.491ArgCys: 0.491 ± 0.02	4.333ArgAsp: 4.333 ± 0.07	4.55ArgGlu: 4.55 ± 0.064	2.965ArgPhe: 2.965 ± 0.054	5.673ArgGly: 5.673 ± 0.066	1.6ArgHis: 1.6 ± 0.036	3.717ArgIle: 3.717 ± 0.052	2.184ArgLys: 2.184 ± 0.044	9.058ArgLeu: 9.058 ± 0.115	1.964ArgMet: 1.964 ± 0.037	1.693ArgAsn: 1.693 ± 0.042	4.485ArgPro: 4.485 ± 0.08	2.597ArgGln: 2.597 ± 0.051	7.19ArgArg: 7.19 ± 0.103	3.521ArgSer: 3.521 ± 0.058	3.911ArgThr: 3.911 ± 0.058	5.272ArgVal: 5.272 ± 0.076	1.241ArgTrp: 1.241 ± 0.03	1.798ArgTyr: 1.798 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.186SerAla: 6.186 ± 0.074	0.334SerCys: 0.334 ± 0.019	2.683SerAsp: 2.683 ± 0.048	2.566SerGlu: 2.566 ± 0.043	1.787SerPhe: 1.787 ± 0.042	5.216SerGly: 5.216 ± 0.07	0.901SerHis: 0.901 ± 0.025	2.024SerIle: 2.024 ± 0.047	1.315SerLys: 1.315 ± 0.034	4.777SerLeu: 4.777 ± 0.061	1.046SerMet: 1.046 ± 0.029	1.178SerAsn: 1.178 ± 0.034	2.984SerPro: 2.984 ± 0.047	1.436SerGln: 1.436 ± 0.038	3.606SerArg: 3.606 ± 0.053	2.379SerSer: 2.379 ± 0.049	2.37SerThr: 2.37 ± 0.053	3.536SerVal: 3.536 ± 0.055	0.709SerTrp: 0.709 ± 0.029	1.151SerTyr: 1.151 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.627ThrAla: 6.627 ± 0.078	0.406ThrCys: 0.406 ± 0.02	2.72ThrAsp: 2.72 ± 0.046	2.427ThrGlu: 2.427 ± 0.045	2.001ThrPhe: 2.001 ± 0.048	5.077ThrGly: 5.077 ± 0.075	0.918ThrHis: 0.918 ± 0.026	2.129ThrIle: 2.129 ± 0.047	1.256ThrLys: 1.256 ± 0.031	5.409ThrLeu: 5.409 ± 0.072	0.88ThrMet: 0.88 ± 0.025	1.197ThrAsn: 1.197 ± 0.036	3.883ThrPro: 3.883 ± 0.066	1.372ThrGln: 1.372 ± 0.031	3.435ThrArg: 3.435 ± 0.048	2.505ThrSer: 2.505 ± 0.049	2.66ThrThr: 2.66 ± 0.054	4.088ThrVal: 4.088 ± 0.06	0.802ThrTrp: 0.802 ± 0.027	1.238ThrTyr: 1.238 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.311ValAla: 10.311 ± 0.097	0.664ValCys: 0.664 ± 0.019	4.456ValAsp: 4.456 ± 0.068	4.951ValGlu: 4.951 ± 0.069	2.652ValPhe: 2.652 ± 0.046	6.358ValGly: 6.358 ± 0.078	1.248ValHis: 1.248 ± 0.03	3.431ValIle: 3.431 ± 0.053	2.332ValLys: 2.332 ± 0.056	7.406ValLeu: 7.406 ± 0.077	1.736ValMet: 1.736 ± 0.036	1.814ValAsn: 1.814 ± 0.04	3.172ValPro: 3.172 ± 0.051	2.201ValGln: 2.201 ± 0.054	6.146ValArg: 6.146 ± 0.08	4.101ValSer: 4.101 ± 0.065	4.558ValThr: 4.558 ± 0.069	6.44ValVal: 6.44 ± 0.091	1.052ValTrp: 1.052 ± 0.032	1.392ValTyr: 1.392 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.621TrpAla: 1.621 ± 0.043	0.128TrpCys: 0.128 ± 0.01	0.699TrpAsp: 0.699 ± 0.024	0.617TrpGlu: 0.617 ± 0.022	0.489TrpPhe: 0.489 ± 0.023	1.011TrpGly: 1.011 ± 0.032	0.231TrpHis: 0.231 ± 0.014	0.692TrpIle: 0.692 ± 0.022	0.487TrpLys: 0.487 ± 0.02	1.612TrpLeu: 1.612 ± 0.036	0.378TrpMet: 0.378 ± 0.018	0.388TrpAsn: 0.388 ± 0.019	0.754TrpPro: 0.754 ± 0.025	0.397TrpGln: 0.397 ± 0.018	1.579TrpArg: 1.579 ± 0.037	0.907TrpSer: 0.907 ± 0.028	0.955TrpThr: 0.955 ± 0.03	0.891TrpVal: 0.891 ± 0.028	0.241TrpTrp: 0.241 ± 0.014	0.273TrpTyr: 0.273 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.789TyrAla: 2.789 ± 0.045	0.191TyrCys: 0.191 ± 0.012	1.539TyrAsp: 1.539 ± 0.039	1.276TyrGlu: 1.276 ± 0.03	0.814TyrPhe: 0.814 ± 0.028	2.187TyrGly: 2.187 ± 0.043	0.375TyrHis: 0.375 ± 0.02	0.682TyrIle: 0.682 ± 0.023	0.521TyrLys: 0.521 ± 0.023	2.065TyrLeu: 2.065 ± 0.038	0.37TyrMet: 0.37 ± 0.018	0.533TyrAsn: 0.533 ± 0.023	0.993TyrPro: 0.993 ± 0.029	0.682TyrGln: 0.682 ± 0.027	1.789TyrArg: 1.789 ± 0.039	0.986TyrSer: 0.986 ± 0.03	0.935TyrThr: 0.935 ± 0.034	1.747TyrVal: 1.747 ± 0.04	0.332TyrTrp: 0.332 ± 0.018	0.52TyrTyr: 0.52 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4047 proteins (1261893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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