Amino acid dipepetide frequency for Rhodococcus rhodnii LMG 5362

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.991AlaAla: 20.991 ± 0.202	0.961AlaCys: 0.961 ± 0.027	8.575AlaAsp: 8.575 ± 0.097	7.916AlaGlu: 7.916 ± 0.091	3.553AlaPhe: 3.553 ± 0.058	11.886AlaGly: 11.886 ± 0.111	2.755AlaHis: 2.755 ± 0.054	5.231AlaIle: 5.231 ± 0.06	2.317AlaLys: 2.317 ± 0.059	13.929AlaLeu: 13.929 ± 0.156	2.756AlaMet: 2.756 ± 0.044	2.12AlaAsn: 2.12 ± 0.037	6.987AlaPro: 6.987 ± 0.096	3.529AlaGln: 3.529 ± 0.051	10.148AlaArg: 10.148 ± 0.11	6.702AlaSer: 6.702 ± 0.065	7.72AlaThr: 7.72 ± 0.072	12.577AlaVal: 12.577 ± 0.141	1.634AlaTrp: 1.634 ± 0.033	2.213AlaTyr: 2.213 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.95CysAla: 0.95 ± 0.028	0.09CysCys: 0.09 ± 0.009	0.488CysAsp: 0.488 ± 0.022	0.374CysGlu: 0.374 ± 0.017	0.186CysPhe: 0.186 ± 0.012	0.939CysGly: 0.939 ± 0.03	0.156CysHis: 0.156 ± 0.011	0.226CysIle: 0.226 ± 0.012	0.076CysLys: 0.076 ± 0.008	0.54CysLeu: 0.54 ± 0.018	0.097CysMet: 0.097 ± 0.009	0.116CysAsn: 0.116 ± 0.009	0.43CysPro: 0.43 ± 0.019	0.124CysGln: 0.124 ± 0.012	0.568CysArg: 0.568 ± 0.024	0.506CysSer: 0.506 ± 0.02	0.484CysThr: 0.484 ± 0.017	0.561CysVal: 0.561 ± 0.023	0.097CysTrp: 0.097 ± 0.009	0.119CysTyr: 0.119 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.489AspAla: 9.489 ± 0.109	0.348AspCys: 0.348 ± 0.018	5.165AspAsp: 5.165 ± 0.069	4.703AspGlu: 4.703 ± 0.069	1.578AspPhe: 1.578 ± 0.034	6.748AspGly: 6.748 ± 0.083	1.462AspHis: 1.462 ± 0.037	2.234AspIle: 2.234 ± 0.045	0.942AspLys: 0.942 ± 0.033	6.312AspLeu: 6.312 ± 0.072	0.917AspMet: 0.917 ± 0.027	0.893AspAsn: 0.893 ± 0.03	4.812AspPro: 4.812 ± 0.066	1.35AspGln: 1.35 ± 0.033	5.351AspArg: 5.351 ± 0.068	2.977AspSer: 2.977 ± 0.047	3.622AspThr: 3.622 ± 0.059	6.323AspVal: 6.323 ± 0.083	0.853AspTrp: 0.853 ± 0.028	1.174AspTyr: 1.174 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.045GluAla: 6.045 ± 0.084	0.363GluCys: 0.363 ± 0.018	2.682GluAsp: 2.682 ± 0.05	2.48GluGlu: 2.48 ± 0.05	1.914GluPhe: 1.914 ± 0.037	3.663GluGly: 3.663 ± 0.057	1.652GluHis: 1.652 ± 0.038	2.959GluIle: 2.959 ± 0.044	1.252GluLys: 1.252 ± 0.036	6.302GluLeu: 6.302 ± 0.085	1.088GluMet: 1.088 ± 0.029	1.318GluAsn: 1.318 ± 0.033	3.413GluPro: 3.413 ± 0.069	2.149GluGln: 2.149 ± 0.045	5.57GluArg: 5.57 ± 0.078	3.259GluSer: 3.259 ± 0.05	3.216GluThr: 3.216 ± 0.056	4.286GluVal: 4.286 ± 0.071	0.859GluTrp: 0.859 ± 0.025	1.233GluTyr: 1.233 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.308PheAla: 4.308 ± 0.064	0.226PheCys: 0.226 ± 0.013	2.442PheAsp: 2.442 ± 0.043	1.703PheGlu: 1.703 ± 0.037	0.914PhePhe: 0.914 ± 0.032	3.435PheGly: 3.435 ± 0.054	0.592PheHis: 0.592 ± 0.02	0.612PheIle: 0.612 ± 0.026	0.335PheLys: 0.335 ± 0.017	2.402PheLeu: 2.402 ± 0.046	0.392PheMet: 0.392 ± 0.019	0.457PheAsn: 0.457 ± 0.017	1.371PhePro: 1.371 ± 0.036	0.586PheGln: 0.586 ± 0.022	1.703PheArg: 1.703 ± 0.042	1.443PheSer: 1.443 ± 0.034	1.984PheThr: 1.984 ± 0.038	3.23PheVal: 3.23 ± 0.056	0.399PheTrp: 0.399 ± 0.017	0.62PheTyr: 0.62 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.091GlyAla: 11.091 ± 0.102	0.725GlyCys: 0.725 ± 0.029	5.914GlyAsp: 5.914 ± 0.08	5.296GlyGlu: 5.296 ± 0.075	3.079GlyPhe: 3.079 ± 0.052	8.487GlyGly: 8.487 ± 0.101	1.994GlyHis: 1.994 ± 0.04	4.225GlyIle: 4.225 ± 0.06	1.916GlyLys: 1.916 ± 0.045	8.422GlyLeu: 8.422 ± 0.103	2.01GlyMet: 2.01 ± 0.042	1.698GlyAsn: 1.698 ± 0.041	4.534GlyPro: 4.534 ± 0.062	2.056GlyGln: 2.056 ± 0.045	7.026GlyArg: 7.026 ± 0.074	5.476GlySer: 5.476 ± 0.066	6.055GlyThr: 6.055 ± 0.064	8.042GlyVal: 8.042 ± 0.073	1.542GlyTrp: 1.542 ± 0.034	2.166GlyTyr: 2.166 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.572HisAla: 2.572 ± 0.043	0.184HisCys: 0.184 ± 0.012	1.647HisAsp: 1.647 ± 0.037	1.252HisGlu: 1.252 ± 0.034	0.589HisPhe: 0.589 ± 0.02	2.183HisGly: 2.183 ± 0.041	0.67HisHis: 0.67 ± 0.027	0.701HisIle: 0.701 ± 0.02	0.249HisLys: 0.249 ± 0.015	1.955HisLeu: 1.955 ± 0.041	0.38HisMet: 0.38 ± 0.016	0.339HisAsn: 0.339 ± 0.016	1.549HisPro: 1.549 ± 0.034	0.455HisGln: 0.455 ± 0.018	1.994HisArg: 1.994 ± 0.039	1.048HisSer: 1.048 ± 0.027	1.256HisThr: 1.256 ± 0.028	1.924HisVal: 1.924 ± 0.036	0.316HisTrp: 0.316 ± 0.016	0.423HisTyr: 0.423 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.203IleAla: 6.203 ± 0.081	0.25IleCys: 0.25 ± 0.014	3.219IleAsp: 3.219 ± 0.046	2.485IleGlu: 2.485 ± 0.046	0.879IlePhe: 0.879 ± 0.027	4.295IleGly: 4.295 ± 0.061	0.707IleHis: 0.707 ± 0.023	0.924IleIle: 0.924 ± 0.03	0.57IleLys: 0.57 ± 0.022	3.006IleLeu: 3.006 ± 0.056	0.505IleMet: 0.505 ± 0.022	0.616IleAsn: 0.616 ± 0.023	2.06IlePro: 2.06 ± 0.046	0.626IleGln: 0.626 ± 0.026	2.408IleArg: 2.408 ± 0.045	1.873IleSer: 1.873 ± 0.044	2.409IleThr: 2.409 ± 0.044	4.309IleVal: 4.309 ± 0.062	0.369IleTrp: 0.369 ± 0.019	0.606IleTyr: 0.606 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.076LysAla: 2.076 ± 0.058	0.082LysCys: 0.082 ± 0.008	0.911LysAsp: 0.911 ± 0.033	0.825LysGlu: 0.825 ± 0.029	0.425LysPhe: 0.425 ± 0.018	1.309LysGly: 1.309 ± 0.043	0.354LysHis: 0.354 ± 0.018	0.811LysIle: 0.811 ± 0.025	0.577LysLys: 0.577 ± 0.034	1.576LysLeu: 1.576 ± 0.045	0.354LysMet: 0.354 ± 0.019	0.458LysAsn: 0.458 ± 0.018	1.033LysPro: 1.033 ± 0.033	0.561LysGln: 0.561 ± 0.023	1.289LysArg: 1.289 ± 0.038	1.009LysSer: 1.009 ± 0.032	1.01LysThr: 1.01 ± 0.027	1.465LysVal: 1.465 ± 0.04	0.243LysTrp: 0.243 ± 0.013	0.39LysTyr: 0.39 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.664LeuAla: 14.664 ± 0.138	0.7LeuCys: 0.7 ± 0.027	7.454LeuAsp: 7.454 ± 0.089	4.605LeuGlu: 4.605 ± 0.068	2.619LeuPhe: 2.619 ± 0.041	9.28LeuGly: 9.28 ± 0.091	1.969LeuHis: 1.969 ± 0.037	2.727LeuIle: 2.727 ± 0.059	1.167LeuLys: 1.167 ± 0.035	9.182LeuLeu: 9.182 ± 0.113	1.456LeuMet: 1.456 ± 0.034	1.3LeuAsn: 1.3 ± 0.035	5.491LeuPro: 5.491 ± 0.075	2.006LeuGln: 2.006 ± 0.039	7.63LeuArg: 7.63 ± 0.091	5.096LeuSer: 5.096 ± 0.062	6.137LeuThr: 6.137 ± 0.074	9.892LeuVal: 9.892 ± 0.114	1.182LeuTrp: 1.182 ± 0.033	1.523LeuTyr: 1.523 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.127MetAla: 2.127 ± 0.044	0.159MetCys: 0.159 ± 0.01	0.828MetAsp: 0.828 ± 0.026	0.618MetGlu: 0.618 ± 0.022	0.596MetPhe: 0.596 ± 0.024	1.403MetGly: 1.403 ± 0.037	0.405MetHis: 0.405 ± 0.018	0.891MetIle: 0.891 ± 0.029	0.381MetLys: 0.381 ± 0.016	2.01MetLeu: 2.01 ± 0.039	0.362MetMet: 0.362 ± 0.017	0.494MetAsn: 0.494 ± 0.017	1.11MetPro: 1.11 ± 0.03	0.477MetGln: 0.477 ± 0.019	1.507MetArg: 1.507 ± 0.036	1.547MetSer: 1.547 ± 0.039	1.793MetThr: 1.793 ± 0.034	1.352MetVal: 1.352 ± 0.036	0.264MetTrp: 0.264 ± 0.012	0.333MetTyr: 0.333 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.175AsnAla: 2.175 ± 0.043	0.142AsnCys: 0.142 ± 0.009	0.975AsnAsp: 0.975 ± 0.025	0.87AsnGlu: 0.87 ± 0.03	0.468AsnPhe: 0.468 ± 0.019	1.607AsnGly: 1.607 ± 0.039	0.357AsnHis: 0.357 ± 0.017	0.714AsnIle: 0.714 ± 0.026	0.299AsnLys: 0.299 ± 0.016	1.735AsnLeu: 1.735 ± 0.039	0.329AsnMet: 0.329 ± 0.016	0.397AsnAsn: 0.397 ± 0.018	1.391AsnPro: 1.391 ± 0.031	0.452AsnGln: 0.452 ± 0.021	1.287AsnArg: 1.287 ± 0.03	0.947AsnSer: 0.947 ± 0.028	1.081AsnThr: 1.081 ± 0.032	1.434AsnVal: 1.434 ± 0.034	0.257AsnTrp: 0.257 ± 0.014	0.436AsnTyr: 0.436 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.423ProAla: 7.423 ± 0.085	0.287ProCys: 0.287 ± 0.015	4.715ProAsp: 4.715 ± 0.059	4.016ProGlu: 4.016 ± 0.061	1.599ProPhe: 1.599 ± 0.035	5.772ProGly: 5.772 ± 0.073	1.217ProHis: 1.217 ± 0.031	2.047ProIle: 2.047 ± 0.04	0.963ProLys: 0.963 ± 0.031	4.654ProLeu: 4.654 ± 0.065	1.035ProMet: 1.035 ± 0.025	0.986ProAsn: 0.986 ± 0.025	3.213ProPro: 3.213 ± 0.073	1.527ProGln: 1.527 ± 0.034	3.953ProArg: 3.953 ± 0.056	3.237ProSer: 3.237 ± 0.052	3.471ProThr: 3.471 ± 0.06	5.212ProVal: 5.212 ± 0.067	0.848ProTrp: 0.848 ± 0.029	1.06ProTyr: 1.06 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.713GlnAla: 2.713 ± 0.052	0.161GlnCys: 0.161 ± 0.012	1.113GlnAsp: 1.113 ± 0.03	1.044GlnGlu: 1.044 ± 0.027	0.779GlnPhe: 0.779 ± 0.025	1.822GlnGly: 1.822 ± 0.04	0.561GlnHis: 0.561 ± 0.022	1.239GlnIle: 1.239 ± 0.031	0.484GlnLys: 0.484 ± 0.021	2.658GlnLeu: 2.658 ± 0.047	0.543GlnMet: 0.543 ± 0.019	0.577GlnAsn: 0.577 ± 0.021	1.396GlnPro: 1.396 ± 0.034	1.172GlnGln: 1.172 ± 0.044	2.413GlnArg: 2.413 ± 0.043	1.288GlnSer: 1.288 ± 0.034	1.22GlnThr: 1.22 ± 0.032	2.047GlnVal: 2.047 ± 0.043	0.506GlnTrp: 0.506 ± 0.022	0.602GlnTyr: 0.602 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.426ArgAla: 9.426 ± 0.109	0.536ArgCys: 0.536 ± 0.021	5.14ArgAsp: 5.14 ± 0.072	4.694ArgGlu: 4.694 ± 0.064	2.516ArgPhe: 2.516 ± 0.044	6.122ArgGly: 6.122 ± 0.074	1.792ArgHis: 1.792 ± 0.041	3.84ArgIle: 3.84 ± 0.052	1.392ArgLys: 1.392 ± 0.04	7.08ArgLeu: 7.08 ± 0.076	1.876ArgMet: 1.876 ± 0.039	1.276ArgAsn: 1.276 ± 0.031	4.079ArgPro: 4.079 ± 0.062	1.752ArgGln: 1.752 ± 0.039	7.718ArgArg: 7.718 ± 0.099	4.908ArgSer: 4.908 ± 0.065	5.396ArgThr: 5.396 ± 0.071	6.238ArgVal: 6.238 ± 0.07	1.354ArgTrp: 1.354 ± 0.034	1.853ArgTyr: 1.853 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.019SerAla: 7.019 ± 0.083	0.392SerCys: 0.392 ± 0.017	3.411SerAsp: 3.411 ± 0.052	2.727SerGlu: 2.727 ± 0.049	1.762SerPhe: 1.762 ± 0.039	6.147SerGly: 6.147 ± 0.077	1.035SerHis: 1.035 ± 0.029	2.237SerIle: 2.237 ± 0.045	0.942SerLys: 0.942 ± 0.031	5.066SerLeu: 5.066 ± 0.06	1.335SerMet: 1.335 ± 0.028	1.04SerAsn: 1.04 ± 0.033	3.241SerPro: 3.241 ± 0.055	1.228SerGln: 1.228 ± 0.033	4.128SerArg: 4.128 ± 0.056	3.176SerSer: 3.176 ± 0.066	3.412SerThr: 3.412 ± 0.059	4.739SerVal: 4.739 ± 0.066	0.876SerTrp: 0.876 ± 0.03	1.078SerTyr: 1.078 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.382ThrAla: 8.382 ± 0.086	0.421ThrCys: 0.421 ± 0.019	3.994ThrAsp: 3.994 ± 0.056	3.462ThrGlu: 3.462 ± 0.051	1.776ThrPhe: 1.776 ± 0.038	6.097ThrGly: 6.097 ± 0.068	1.212ThrHis: 1.212 ± 0.03	2.539ThrIle: 2.539 ± 0.046	0.96ThrLys: 0.96 ± 0.033	5.943ThrLeu: 5.943 ± 0.068	1.149ThrMet: 1.149 ± 0.029	1.054ThrAsn: 1.054 ± 0.03	4.078ThrPro: 4.078 ± 0.054	1.316ThrGln: 1.316 ± 0.031	4.243ThrArg: 4.243 ± 0.051	3.62ThrSer: 3.62 ± 0.049	4.517ThrThr: 4.517 ± 0.072	6.252ThrVal: 6.252 ± 0.08	0.896ThrTrp: 0.896 ± 0.028	1.193ThrTyr: 1.193 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	13.109ValAla: 13.109 ± 0.146	0.766ValCys: 0.766 ± 0.029	6.445ValAsp: 6.445 ± 0.076	4.899ValGlu: 4.899 ± 0.071	2.727ValPhe: 2.727 ± 0.051	7.599ValGly: 7.599 ± 0.086	2.11ValHis: 2.11 ± 0.041	2.916ValIle: 2.916 ± 0.053	1.339ValLys: 1.339 ± 0.04	9.674ValLeu: 9.674 ± 0.103	1.483ValMet: 1.483 ± 0.033	1.492ValAsn: 1.492 ± 0.035	5.273ValPro: 5.273 ± 0.078	1.977ValGln: 1.977 ± 0.042	7.067ValArg: 7.067 ± 0.089	4.851ValSer: 4.851 ± 0.059	6.216ValThr: 6.216 ± 0.074	10.75ValVal: 10.75 ± 0.138	1.183ValTrp: 1.183 ± 0.029	1.527ValTyr: 1.527 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.504TrpAla: 1.504 ± 0.04	0.15TrpCys: 0.15 ± 0.01	0.772TrpAsp: 0.772 ± 0.025	0.661TrpGlu: 0.661 ± 0.024	0.558TrpPhe: 0.558 ± 0.025	1.017TrpGly: 1.017 ± 0.033	0.336TrpHis: 0.336 ± 0.017	0.699TrpIle: 0.699 ± 0.024	0.309TrpLys: 0.309 ± 0.014	1.598TrpLeu: 1.598 ± 0.042	0.316TrpMet: 0.316 ± 0.016	0.384TrpAsn: 0.384 ± 0.016	0.697TrpPro: 0.697 ± 0.02	0.503TrpGln: 0.503 ± 0.021	1.236TrpArg: 1.236 ± 0.035	0.875TrpSer: 0.875 ± 0.03	1.002TrpThr: 1.002 ± 0.031	1.074TrpVal: 1.074 ± 0.027	0.363TrpTrp: 0.363 ± 0.023	0.314TrpTyr: 0.314 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.233TyrAla: 2.233 ± 0.049	0.183TyrCys: 0.183 ± 0.011	1.362TyrAsp: 1.362 ± 0.038	1.071TyrGlu: 1.071 ± 0.03	0.639TyrPhe: 0.639 ± 0.024	1.941TyrGly: 1.941 ± 0.043	0.349TyrHis: 0.349 ± 0.017	0.547TyrIle: 0.547 ± 0.021	0.291TyrLys: 0.291 ± 0.015	2.034TyrLeu: 2.034 ± 0.036	0.27TyrMet: 0.27 ± 0.015	0.337TyrAsn: 0.337 ± 0.016	1.081TyrPro: 1.081 ± 0.028	0.495TyrGln: 0.495 ± 0.022	1.749TyrArg: 1.749 ± 0.036	1.153TyrSer: 1.153 ± 0.031	1.103TyrThr: 1.103 ± 0.029	1.697TyrVal: 1.697 ± 0.043	0.326TyrTrp: 0.326 ± 0.016	0.374TyrTyr: 0.374 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4412 proteins (1323253 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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