Amino acid dipepetide frequency for Clostridium collagenovorans DSM 3089

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.493AlaAla: 3.493 ± 0.089	0.669AlaCys: 0.669 ± 0.031	2.462AlaAsp: 2.462 ± 0.051	3.516AlaGlu: 3.516 ± 0.07	2.398AlaPhe: 2.398 ± 0.059	3.412AlaGly: 3.412 ± 0.079	0.741AlaHis: 0.741 ± 0.03	5.828AlaIle: 5.828 ± 0.097	4.608AlaLys: 4.608 ± 0.079	6.097AlaLeu: 6.097 ± 0.109	1.732AlaMet: 1.732 ± 0.051	2.538AlaAsn: 2.538 ± 0.047	1.411AlaPro: 1.411 ± 0.043	1.461AlaGln: 1.461 ± 0.044	1.735AlaArg: 1.735 ± 0.049	3.216AlaSer: 3.216 ± 0.067	2.859AlaThr: 2.859 ± 0.078	3.838AlaVal: 3.838 ± 0.077	0.351AlaTrp: 0.351 ± 0.019	2.125AlaTyr: 2.125 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.603CysAla: 0.603 ± 0.025	0.218CysCys: 0.218 ± 0.022	0.789CysAsp: 0.789 ± 0.038	0.9CysGlu: 0.9 ± 0.031	0.527CysPhe: 0.527 ± 0.022	1.1CysGly: 1.1 ± 0.038	0.215CysHis: 0.215 ± 0.017	1.233CysIle: 1.233 ± 0.038	1.212CysLys: 1.212 ± 0.039	0.891CysLeu: 0.891 ± 0.032	0.292CysMet: 0.292 ± 0.018	0.875CysAsn: 0.875 ± 0.035	0.446CysPro: 0.446 ± 0.026	0.179CysGln: 0.179 ± 0.014	0.411CysArg: 0.411 ± 0.023	0.852CysSer: 0.852 ± 0.034	0.632CysThr: 0.632 ± 0.026	0.718CysVal: 0.718 ± 0.029	0.059CysTrp: 0.059 ± 0.008	0.462CysTyr: 0.462 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.59AspAla: 2.59 ± 0.062	0.611AspCys: 0.611 ± 0.025	2.515AspAsp: 2.515 ± 0.072	4.63AspGlu: 4.63 ± 0.075	2.763AspPhe: 2.763 ± 0.065	3.076AspGly: 3.076 ± 0.061	0.525AspHis: 0.525 ± 0.025	6.049AspIle: 6.049 ± 0.081	5.709AspLys: 5.709 ± 0.078	5.114AspLeu: 5.114 ± 0.084	1.506AspMet: 1.506 ± 0.046	3.302AspAsn: 3.302 ± 0.068	1.423AspPro: 1.423 ± 0.046	0.695AspGln: 0.695 ± 0.026	1.682AspArg: 1.682 ± 0.048	3.238AspSer: 3.238 ± 0.058	2.54AspThr: 2.54 ± 0.054	3.389AspVal: 3.389 ± 0.066	0.319AspTrp: 0.319 ± 0.018	2.53AspTyr: 2.53 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.351GluAla: 4.351 ± 0.074	0.783GluCys: 0.783 ± 0.026	4.773GluAsp: 4.773 ± 0.065	8.139GluGlu: 8.139 ± 0.12	3.28GluPhe: 3.28 ± 0.067	4.345GluGly: 4.345 ± 0.069	0.967GluHis: 0.967 ± 0.034	7.008GluIle: 7.008 ± 0.1	7.755GluLys: 7.755 ± 0.095	7.477GluLeu: 7.477 ± 0.102	1.895GluMet: 1.895 ± 0.045	5.741GluAsn: 5.741 ± 0.102	1.4GluPro: 1.4 ± 0.041	1.679GluGln: 1.679 ± 0.048	2.673GluArg: 2.673 ± 0.055	4.161GluSer: 4.161 ± 0.072	2.858GluThr: 2.858 ± 0.057	5.797GluVal: 5.797 ± 0.089	0.392GluTrp: 0.392 ± 0.021	3.145GluTyr: 3.145 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.158PheAla: 2.158 ± 0.057	0.528PheCys: 0.528 ± 0.024	2.331PheAsp: 2.331 ± 0.049	2.798PheGlu: 2.798 ± 0.057	1.972PhePhe: 1.972 ± 0.053	2.743PheGly: 2.743 ± 0.068	0.562PheHis: 0.562 ± 0.024	4.81PheIle: 4.81 ± 0.099	4.031PheLys: 4.031 ± 0.059	4.155PheLeu: 4.155 ± 0.08	1.245PheMet: 1.245 ± 0.038	3.103PheAsn: 3.103 ± 0.063	1.074PhePro: 1.074 ± 0.032	0.921PheGln: 0.921 ± 0.029	1.246PheArg: 1.246 ± 0.037	3.234PheSer: 3.234 ± 0.06	2.393PheThr: 2.393 ± 0.044	2.594PheVal: 2.594 ± 0.049	0.296PheTrp: 0.296 ± 0.018	1.729PheTyr: 1.729 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	3.962GlyAla: 3.962 ± 0.084	0.939GlyCys: 0.939 ± 0.039	3.245GlyAsp: 3.245 ± 0.074	4.689GlyGlu: 4.689 ± 0.065	3.002GlyPhe: 3.002 ± 0.063	4.118GlyGly: 4.118 ± 0.093	0.889GlyHis: 0.889 ± 0.034	6.474GlyIle: 6.474 ± 0.097	5.474GlyLys: 5.474 ± 0.084	5.374GlyLeu: 5.374 ± 0.084	1.739GlyMet: 1.739 ± 0.051	3.29GlyAsn: 3.29 ± 0.08	1.15GlyPro: 1.15 ± 0.037	1.38GlyGln: 1.38 ± 0.042	2.147GlyArg: 2.147 ± 0.046	3.713GlySer: 3.713 ± 0.064	3.436GlyThr: 3.436 ± 0.065	4.8GlyVal: 4.8 ± 0.077	0.41GlyTrp: 0.41 ± 0.021	2.932GlyTyr: 2.932 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.594HisAla: 0.594 ± 0.027	0.213HisCys: 0.213 ± 0.018	0.688HisAsp: 0.688 ± 0.028	0.923HisGlu: 0.923 ± 0.031	0.542HisPhe: 0.542 ± 0.023	1.006HisGly: 1.006 ± 0.039	0.28HisHis: 0.28 ± 0.019	1.25HisIle: 1.25 ± 0.039	1.067HisLys: 1.067 ± 0.033	1.081HisLeu: 1.081 ± 0.033	0.367HisMet: 0.367 ± 0.022	0.824HisAsn: 0.824 ± 0.033	0.498HisPro: 0.498 ± 0.026	0.293HisGln: 0.293 ± 0.019	0.547HisArg: 0.547 ± 0.025	0.902HisSer: 0.902 ± 0.031	0.559HisThr: 0.559 ± 0.024	0.722HisVal: 0.722 ± 0.031	0.078HisTrp: 0.078 ± 0.009	0.484HisTyr: 0.484 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.834IleAla: 5.834 ± 0.091	1.328IleCys: 1.328 ± 0.043	5.498IleAsp: 5.498 ± 0.084	7.492IleGlu: 7.492 ± 0.103	4.447IlePhe: 4.447 ± 0.086	6.097IleGly: 6.097 ± 0.101	1.194IleHis: 1.194 ± 0.035	9.308IleIle: 9.308 ± 0.145	8.531IleLys: 8.531 ± 0.092	9.304IleLeu: 9.304 ± 0.128	2.412IleMet: 2.412 ± 0.055	6.063IleAsn: 6.063 ± 0.096	3.182IlePro: 3.182 ± 0.068	2.012IleGln: 2.012 ± 0.045	2.925IleArg: 2.925 ± 0.063	7.161IleSer: 7.161 ± 0.1	4.871IleThr: 4.871 ± 0.073	6.284IleVal: 6.284 ± 0.092	0.499IleTrp: 0.499 ± 0.027	3.437IleTyr: 3.437 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	4.751LysAla: 4.751 ± 0.073	0.976LysCys: 0.976 ± 0.035	5.998LysAsp: 5.998 ± 0.085	9.488LysGlu: 9.488 ± 0.115	3.366LysPhe: 3.366 ± 0.059	5.098LysGly: 5.098 ± 0.071	1.15LysHis: 1.15 ± 0.035	7.77LysIle: 7.77 ± 0.095	7.742LysLys: 7.742 ± 0.104	7.8LysLeu: 7.8 ± 0.088	2.25LysMet: 2.25 ± 0.053	6.29LysAsn: 6.29 ± 0.105	2.047LysPro: 2.047 ± 0.053	2.069LysGln: 2.069 ± 0.045	3.155LysArg: 3.155 ± 0.069	5.555LysSer: 5.555 ± 0.083	3.934LysThr: 3.934 ± 0.075	6.261LysVal: 6.261 ± 0.092	0.561LysTrp: 0.561 ± 0.027	3.979LysTyr: 3.979 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	5.059LeuAla: 5.059 ± 0.093	1.318LeuCys: 1.318 ± 0.046	5.187LeuAsp: 5.187 ± 0.091	6.961LeuGlu: 6.961 ± 0.102	3.684LeuPhe: 3.684 ± 0.08	6.46LeuGly: 6.46 ± 0.096	1.096LeuHis: 1.096 ± 0.035	8.49LeuIle: 8.49 ± 0.135	8.759LeuLys: 8.759 ± 0.11	8.019LeuLeu: 8.019 ± 0.103	2.525LeuMet: 2.525 ± 0.059	6.049LeuAsn: 6.049 ± 0.09	2.807LeuPro: 2.807 ± 0.058	2.213LeuGln: 2.213 ± 0.04	3.293LeuArg: 3.293 ± 0.07	7.266LeuSer: 7.266 ± 0.094	4.37LeuThr: 4.37 ± 0.072	5.832LeuVal: 5.832 ± 0.09	0.57LeuTrp: 0.57 ± 0.026	3.339LeuTyr: 3.339 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.688MetAla: 1.688 ± 0.049	0.3MetCys: 0.3 ± 0.019	1.578MetAsp: 1.578 ± 0.047	1.906MetGlu: 1.906 ± 0.046	1.004MetPhe: 1.004 ± 0.036	1.833MetGly: 1.833 ± 0.043	0.31MetHis: 0.31 ± 0.018	2.273MetIle: 2.273 ± 0.053	2.616MetLys: 2.616 ± 0.053	2.264MetLeu: 2.264 ± 0.054	0.668MetMet: 0.668 ± 0.034	1.687MetAsn: 1.687 ± 0.044	0.867MetPro: 0.867 ± 0.029	0.661MetGln: 0.661 ± 0.027	0.951MetArg: 0.951 ± 0.035	1.793MetSer: 1.793 ± 0.039	1.243MetThr: 1.243 ± 0.033	1.761MetVal: 1.761 ± 0.046	0.15MetTrp: 0.15 ± 0.012	0.943MetTyr: 0.943 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.694AsnAla: 2.694 ± 0.06	0.79AsnCys: 0.79 ± 0.035	2.903AsnAsp: 2.903 ± 0.059	4.475AsnGlu: 4.475 ± 0.076	2.653AsnPhe: 2.653 ± 0.057	3.527AsnGly: 3.527 ± 0.068	0.75AsnHis: 0.75 ± 0.029	6.883AsnIle: 6.883 ± 0.097	6.341AsnLys: 6.341 ± 0.092	6.166AsnLeu: 6.166 ± 0.089	1.677AsnMet: 1.677 ± 0.047	4.517AsnAsn: 4.517 ± 0.103	2.159AsnPro: 2.159 ± 0.05	1.282AsnGln: 1.282 ± 0.037	1.915AsnArg: 1.915 ± 0.05	4.019AsnSer: 4.019 ± 0.079	2.97AsnThr: 2.97 ± 0.075	3.497AsnVal: 3.497 ± 0.059	0.415AsnTrp: 0.415 ± 0.021	2.789AsnTyr: 2.789 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.235ProAla: 1.235 ± 0.038	0.372ProCys: 0.372 ± 0.025	1.277ProAsp: 1.277 ± 0.041	2.207ProGlu: 2.207 ± 0.052	1.242ProPhe: 1.242 ± 0.038	1.677ProGly: 1.677 ± 0.047	0.445ProHis: 0.445 ± 0.022	2.732ProIle: 2.732 ± 0.061	2.271ProLys: 2.271 ± 0.051	2.403ProLeu: 2.403 ± 0.048	0.747ProMet: 0.747 ± 0.033	1.507ProAsn: 1.507 ± 0.056	0.56ProPro: 0.56 ± 0.033	0.74ProGln: 0.74 ± 0.028	0.796ProArg: 0.796 ± 0.031	1.806ProSer: 1.806 ± 0.046	1.613ProThr: 1.613 ± 0.048	1.974ProVal: 1.974 ± 0.049	0.22ProTrp: 0.22 ± 0.018	1.188ProTyr: 1.188 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.232GlnAla: 1.232 ± 0.041	0.376GlnCys: 0.376 ± 0.022	1.162GlnAsp: 1.162 ± 0.035	1.768GlnGlu: 1.768 ± 0.045	0.895GlnPhe: 0.895 ± 0.034	1.58GlnGly: 1.58 ± 0.049	0.285GlnHis: 0.285 ± 0.019	1.888GlnIle: 1.888 ± 0.05	1.725GlnLys: 1.725 ± 0.042	2.044GlnLeu: 2.044 ± 0.044	0.591GlnMet: 0.591 ± 0.028	1.313GlnAsn: 1.313 ± 0.041	0.535GlnPro: 0.535 ± 0.027	0.612GlnGln: 0.612 ± 0.029	1.015GlnArg: 1.015 ± 0.037	1.445GlnSer: 1.445 ± 0.038	0.832GlnThr: 0.832 ± 0.029	1.477GlnVal: 1.477 ± 0.039	0.224GlnTrp: 0.224 ± 0.016	1.032GlnTyr: 1.032 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.854ArgAla: 1.854 ± 0.048	0.432ArgCys: 0.432 ± 0.029	1.851ArgAsp: 1.851 ± 0.045	3.113ArgGlu: 3.113 ± 0.07	1.395ArgPhe: 1.395 ± 0.041	2.021ArgGly: 2.021 ± 0.055	0.444ArgHis: 0.444 ± 0.021	3.058ArgIle: 3.058 ± 0.057	2.878ArgLys: 2.878 ± 0.056	2.814ArgLeu: 2.814 ± 0.056	0.839ArgMet: 0.839 ± 0.029	1.961ArgAsn: 1.961 ± 0.049	0.763ArgPro: 0.763 ± 0.029	0.768ArgGln: 0.768 ± 0.03	1.367ArgArg: 1.367 ± 0.042	1.636ArgSer: 1.636 ± 0.047	1.422ArgThr: 1.422 ± 0.04	2.499ArgVal: 2.499 ± 0.057	0.181ArgTrp: 0.181 ± 0.014	1.424ArgTyr: 1.424 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.204SerAla: 3.204 ± 0.065	0.744SerCys: 0.744 ± 0.026	2.971SerAsp: 2.971 ± 0.056	4.247SerGlu: 4.247 ± 0.079	3.284SerPhe: 3.284 ± 0.076	4.402SerGly: 4.402 ± 0.083	0.926SerHis: 0.926 ± 0.032	6.889SerIle: 6.889 ± 0.098	6.28SerLys: 6.28 ± 0.088	6.4SerLeu: 6.4 ± 0.093	1.822SerMet: 1.822 ± 0.046	3.937SerAsn: 3.937 ± 0.069	1.594SerPro: 1.594 ± 0.045	1.601SerGln: 1.601 ± 0.042	2.058SerArg: 2.058 ± 0.049	4.596SerSer: 4.596 ± 0.085	3.447SerThr: 3.447 ± 0.078	4.035SerVal: 4.035 ± 0.067	0.432SerTrp: 0.432 ± 0.024	2.849SerTyr: 2.849 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	2.844ThrAla: 2.844 ± 0.065	0.498ThrCys: 0.498 ± 0.026	2.22ThrAsp: 2.22 ± 0.055	3.127ThrGlu: 3.127 ± 0.058	2.127ThrPhe: 2.127 ± 0.051	3.383ThrGly: 3.383 ± 0.063	0.737ThrHis: 0.737 ± 0.026	4.869ThrIle: 4.869 ± 0.075	3.592ThrLys: 3.592 ± 0.058	5.178ThrLeu: 5.178 ± 0.081	1.251ThrMet: 1.251 ± 0.037	2.517ThrAsn: 2.517 ± 0.059	1.808ThrPro: 1.808 ± 0.048	1.135ThrGln: 1.135 ± 0.033	1.416ThrArg: 1.416 ± 0.042	3.312ThrSer: 3.312 ± 0.059	2.817ThrThr: 2.817 ± 0.075	3.435ThrVal: 3.435 ± 0.09	0.354ThrTrp: 0.354 ± 0.021	1.989ThrTyr: 1.989 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.061ValAla: 4.061 ± 0.076	0.877ValCys: 0.877 ± 0.032	3.885ValAsp: 3.885 ± 0.073	4.845ValGlu: 4.845 ± 0.075	2.963ValPhe: 2.963 ± 0.053	4.196ValGly: 4.196 ± 0.078	0.802ValHis: 0.802 ± 0.031	6.464ValIle: 6.464 ± 0.087	5.593ValLys: 5.593 ± 0.073	6.522ValLeu: 6.522 ± 0.089	1.712ValMet: 1.712 ± 0.044	3.724ValAsn: 3.724 ± 0.068	1.945ValPro: 1.945 ± 0.048	1.465ValGln: 1.465 ± 0.038	1.873ValArg: 1.873 ± 0.052	4.46ValSer: 4.46 ± 0.069	3.535ValThr: 3.535 ± 0.071	4.798ValVal: 4.798 ± 0.085	0.371ValTrp: 0.371 ± 0.021	2.422ValTyr: 2.422 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.326TrpAla: 0.326 ± 0.019	0.097TrpCys: 0.097 ± 0.011	0.369TrpAsp: 0.369 ± 0.018	0.389TrpGlu: 0.389 ± 0.022	0.318TrpPhe: 0.318 ± 0.017	0.458TrpGly: 0.458 ± 0.023	0.12TrpHis: 0.12 ± 0.012	0.592TrpIle: 0.592 ± 0.03	0.459TrpLys: 0.459 ± 0.02	0.531TrpLeu: 0.531 ± 0.026	0.162TrpMet: 0.162 ± 0.013	0.443TrpAsn: 0.443 ± 0.025	0.13TrpPro: 0.13 ± 0.012	0.202TrpGln: 0.202 ± 0.017	0.216TrpArg: 0.216 ± 0.015	0.417TrpSer: 0.417 ± 0.02	0.263TrpThr: 0.263 ± 0.018	0.388TrpVal: 0.388 ± 0.018	0.075TrpTrp: 0.075 ± 0.009	0.251TrpTyr: 0.251 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.957TyrAla: 1.957 ± 0.045	0.543TyrCys: 0.543 ± 0.025	2.505TyrAsp: 2.505 ± 0.061	3.007TyrGlu: 3.007 ± 0.07	2.06TyrPhe: 2.06 ± 0.048	2.632TyrGly: 2.632 ± 0.053	0.481TyrHis: 0.481 ± 0.024	4.01TyrIle: 4.01 ± 0.068	3.596TyrLys: 3.596 ± 0.072	3.66TyrLeu: 3.66 ± 0.067	1.063TyrMet: 1.063 ± 0.033	2.74TyrAsn: 2.74 ± 0.056	1.215TyrPro: 1.215 ± 0.036	0.66TyrGln: 0.66 ± 0.027	1.299TyrArg: 1.299 ± 0.04	2.939TyrSer: 2.939 ± 0.06	2.017TyrThr: 2.017 ± 0.05	2.418TyrVal: 2.418 ± 0.049	0.25TyrTrp: 0.25 ± 0.016	1.868TyrTyr: 1.868 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2997 proteins (939149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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